c-Axis Transport and Resistivity Anisotropy of Lightly- to Moderately-Doped La_{2-x}Sr_{x}CuO_{4} Single Crystals: Implications on the Charge Transport Mechanism

Both the in-plane and the out-of-plane resistivities (\rho_{ab} and \rho_{c}) are measured in high-quality La_{2-x}Sr_{x}CuO_{4} (LSCO) single crystals in the lightly- to moderately-doped region, x = 0.01 to 0.10, and the resistivity anisotropy is determined. In all the samples studied, the anisotropy ratio \rho _{c}/\rho_{ab} quickly increases with decreasing temperature, although in non-superconducting samples the strong localization effect causes \rho _{c}/\rho_{ab} to decrease at low temperatures. Most notably, it is found that \rho_{c}/\rho_{ab} at moderate temperatures (100 - 300 K) is almost completely independent of doping in the non-superconducting regime (x = 0.01 to 0.05); this indicates that the same charge confinement mechanism that renormalizes the c-axis hopping rate is at work down to x = 0.01. It is discussed that this striking x-independence of \rho_{c}/\rho_{ab} is consistent with the idea that holes form a self-organized network of hole-rich regions, which also explains the unusually metallic in-plane transport of the holes in the lightly-doped region. Furthermore, the data for x > 0.05 suggest that the emergence of the superconductivity is related to an increase in the c-axis coupling.Comment: 7 pages, 5 figures, submitted to Phys. Rev.

Development and potential role of type-2 sodium-glucose transporter inhibitors for management of type 2 diabetes

There is a recognized need for new treatment options for type 2 diabetes mellitus (T2DM). Recovery of glucose from the glomerular filtrate represents an important mechanism in maintaining glucose homeostasis and represents a novel target for the management of T2DM. Recovery of glucose from the glomerular filtrate is executed principally by the type 2 sodium-glucose cotransporter (SGLT2). Inhibition of SGLT2 promotes glucose excretion and normalizes glycemia in animal models. First reports of specifically designed SGLT2 inhibitors began to appear in the second half of the 1990s. Several candidate SGLT2 inhibitors are currently under development, with four in the later stages of clinical testing. The safety profile of SGLT2 inhibitors is expected to be good, as their target is a highly specific membrane transporter expressed almost exclusively within the renal tubules. One safety concern is that of glycosuria, which could predispose patients to increased urinary tract infections. So far the reported safety profile of SGLT2 inhibitors in clinical studies appears to confirm that the class is well tolerated. Where SGLT2 inhibitors will fit in the current cascade of treatments for T2DM has yet to be established. The expected favorable safety profile and insulin-independent mechanism of action appear to support their use in combination with other antidiabetic drugs. Promotion of glucose excretion introduces the opportunity to clear calories (80–90 g [300–400 calories] of glucose per day) in patients that are generally overweight, and is expected to work synergistically with weight reduction programs. Experience will most likely lead to better understanding of which patients are likely to respond best to SGLT2 inhibitors, and under what circumstances

Diving into the vertical dimension of elasmobranch movement ecology

Knowledge of the three-dimensional movement patterns of elasmobranchs is vital to understand their ecological roles and exposure to anthropogenic pressures. To date, comparative studies among species at global scales have mostly focused on horizontal movements. Our study addresses the knowledge gap of vertical movements by compiling the first global synthesis of vertical habitat use by elasmobranchs from data obtained by deployment of 989 biotelemetry tags on 38 elasmobranch species. Elasmobranchs displayed high intra- and interspecific variability in vertical movement patterns. Substantial vertical overlap was observed for many epipelagic elasmobranchs, indicating an increased likelihood to display spatial overlap, biologically interact, and share similar risk to anthropogenic threats that vary on a vertical gradient. We highlight the critical next steps toward incorporating vertical movement into global management and monitoring strategies for elasmobranchs, emphasizing the need to address geographic and taxonomic biases in deployments and to concurrently consider both horizontal and vertical movements

Field evaluation of switchgrass seedlings divergently selected for crown node placement

Excessive crown node elevation of warm-season grass seedlings is a major limitation to successful establishment. Crown node placement at or above the soil surface limits the opportunity for adventitious root development at the crown node. Switchgrass (Panicum virgatum L.) germplasm selected for low- (LC) and elevated- (EC) crown node placement (at 1.5 (μmol m−1 s−1 photosynthetic photon flux density), has been developed from ‘Alamo’ Switchgrass. The objective of this study was to determine if differences in crown node placement and other seedling morphological traits exist among Alamo (nonselected, parental), LC, and EC germplasm and if these differences affect seedling establishment in the field. Seeds were planted during April and May at Beeville, Stephenville, and College Station, TX. Each location was established with six blocks each consisting of a 2-m row of Alamo, LC, or EC seed. Seeds were planted at a 1-cm depth. Three to 10 seedlings were marked at soil level, then dug for detailed seedling measurements. There were no genotype by location interactions for any trait measured. Emergence was more rapid at Beeville for all entries because of prewatering and better soil conditions. Averaged for the three locations, final emergence was 47, 37, and 30% for LC, EC, and Alamo. Mesocotyl length of LC germplasm averaged 5.9 mm compared with 8.4 and 9.1 mm for Alamo and EC germplasm, respectively. Even though LC seedlings had shorter mesocotyles and consequently lower crown node placement than EC or Alamo seedlings, these traits may not be directly responsible for greater establishment success

Anomalous vortex liquid in charge-ordered cuprate superconductors

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Twice weekly vs. daily chemotherapy for childhood tuberculosis

Background. Treating childhood tuberculosis places a large burden on health services, and ways of lessening this were sought. Methods. A randomized controlled trial was conducted to determine the effectiveness of fully intermittent twice weekly treatment for intrathoracic childhood tuberculosis and its effect on adherence to treatment, in comparison with daily (weekday) treatment. The setting was a district of Cape Town, South Africa, an area of high incident tuberculosis. We randomized 206 children with confirmed (4%), probable (94%) and suspected (2%) intrathoracic tuberculosis: 89 (median age, 25 months) received intermittent treatment; and 117 (median age, 28 months) received daily treatment. Intermittent treatment (twice weekly for 6 months) was isoniazid 15 mg/kg/dose, rifampin 15 mg/kg/dose and pyrazinamide 55 mg/kg/dose for 2 months, followed by isoniazid and rifampin only for 4 months. Daily treatment was isoniazid 10 mg/kg/day, rifampin 10 mg/kg/day and pyrazinamide 25 mg/kg/day on weekdays for 6 months. Results. At 6 months 97% of subjects were discharged, with treatment outcomes in the two groups equivalent at that time (P = 0.90) and at the 18- to 30- month follow-up. One relapse occurred in the twice weekly group (P = 0.25). Adherence was equivalent; 70 children (79%) on intermittent and 90 (77%) on daily treatment took 75% or more of the prescribed doses (P = 0.90). Nonadherence over the full course of therapy was significantly associated with nonadherence during the first month of treatment (P = 0.0002) and household crowding (P = 0.002). Conclusions. Six month fully intermittent antituberculosis treatment is an effective and acceptable alternative to daily treatment.Articl

Putative Hall response of the strange metal component in FeSe1-xSx

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