Crystal structure of 3,3-bis(tert-butyl-cyclopentadienyl)-bicyclo[3.1.0] hex-3-zircona-1(5)-ene-6-nickela-6,6-bis(triphenylphosphine), (C 9H13)2(ZrC4H4)Ni(C 18H15P)2

C58H60NiP2Zr, monoclinic, P12 1/n1 (no. 14), a = 12.378(3) Å = 10.353(2) Å, c = 38.031(8) Å, β = 95.74(3)°, V= 4849.2 Å, Z = 4, R gt(F) = 0.023, wRref(F2) = 0.054, T = 200 K. © by Oldenbourg Wissenschaftsverlag

Crystal structure of μ-oxo-bis(σ- 1,2-bis(trimethylsilyl) vinylhafnocene) benzene solvate, [C2H{Si(CH3) 3}2Hf(C5H5)2] 2O ·C6H6

C42H64Hf2OSi4, monoclinic, P121/c1 (no. 14), a = 11.442(1) Å = 9.7998(6) Å, c = 19.827(2) Å, β = 95.229(7)°, V = 2213.9 Å, Z = 2, R gt(F) = 0.017, wRref(F2)=0.037, T=200K. © by Oldenbourg Wissenschaftsverlag,

Does time equal vision in the acute treatment of a cohort of AQP4 and MOG optic neuritis?

Objective To investigate whether visual disability which is known to accumulate by poor recovery from optic neuritis (ON) attacks can be lessened by early treatment, we investigated whether the time from symptom onset to high-dose IV methylprednisolone (IVMP) affected visual recovery. Methods: A retrospective study was performed in a consecutive cohort of patients following their first aquaporin-4 (AQP4)-IgG or myelin oligodendrocyte glycoprotein (MOG)-IgG-ON. Best-corrected visual acuity (BCVA) in ON eyes at 3 months (BCVA3mo) was correlated with time to IVMP (days). In cases of bilateral ON, 1 eye was randomly selected. Results: A total of 29 of 37 patients had ON (27 AQP4-seropositive neuromyelitis optica spectrum disorder [NMOSD] and 9 MOG-IgG-ON), 2 of whom refused treatment. Of the 27 patients included, 10 presented later than 7 days from onset. The median BCVA3mo of patients treated >7 days was 20/100 (interquartile range 20/100–20/200). Patients treated >7 days had an OR of 5.50 (95% CI 0.88–34.46, p = 0.051) of failure to regain 0.0 logMAR vision (20/20) and an OR of 10.0 (95% CI 1.39–71.9) of failure to regain 0.2 logMAR vision (20/30) (p = 0.01) compared with patients treated within 7 days. ROC analysis revealed that the optimal criterion of delay in IVMP initiation was ≤4 days, with a sensitivity and specificity of 71.4% and 76.9%, respectively. Conclusions: In this retrospective study of ON with AQP4 and MOG-IgG, even a 7-day delay in IVMP initiation was detrimental to vision. These results highlight the importance of early treatment for the long-term visual recovery in this group of patients. A prospective, multicenter study of the effects of timing of IVMP is currently underway. Classification of evidence: This study provides Class IV evidence that hyperacute treatment of AQP4 and MOG-ON with IVMP increases the chance for good visual recovery (20/20 vision) and that even a greater than 7-day delay in treatment is associated with a higher risk for poor visual recovery

The species-specific regenerative effects of notochordal cell-conditioned medium on chondrocyte-like cells derived from degenerated human intervertebral discs

During intervertebral disc (IVD) maturation, the main cell type shifts from notochordal cells (NCs) to chondrocytelike cells (CLCs). NCs secrete factors with regenerative potential, making them an interesting focus for regenerative treatments. During initial development, these strategies preferably employ non-human donors due to easy availability of their NC-rich nucleus pulposus (NP) tissue. To increase the success of translating these strategies for clinical application, this study aimed to delineate whether NC-secreted factors of different species have a regenerative effect on human CLCs. Human, canine and porcine NC-rich NP tissue and NC-conditioned medium (NCCM) were analysed biochemically and histologically. Human CLC micro-aggregates from degenerated IVDs were cultured in human, canine or porcine NCCM. Collagen, glycosaminoglycan (GAG) and DNA content was determined and histology was performed. Canine and porcine NPs were richer in NCs than human NPs. Human NPs contained the highest collagen content, whereas the DNA and GAG content of canine NPs was significantly higher than that of human or porcine NPs. NCCM from all species significantly increased the DNA and GAG content of the human CLC micro-aggregates. Porcine and canine NCCM were significantly more potent than human NCCM in inducing GAG deposition, whereas only human NCCM induced collagen type II production. Secreted factors from human, canine and porcine NC-rich NPs exerted regenerative effects on human CLCs, indicating a cross-species effect. Bioactive compound(s) are present in NCCM of different species that may reverse human IVD degeneration, supporting further research into strategies based on NC-technology employing canine or porcine models for their translation into humans.</p

Analyticity of The Ground State Energy For Massless Nelson Models

We show that the ground state energy of the translationally invariant Nelson model, describing a particle coupled to a relativistic field of massless bosons, is an analytic function of the coupling constant and the total momentum. We derive an explicit expression for the ground state energy which is used to determine the effective mass.Comment: 33 pages, 1 figure, added a section on the calculation of the effective mas

Holons on a meandering stripe: quantum numbers

We attempt to access the regime of strong coupling between charge carriers and transverse dynamics of an isolated conducting ``stripe'', such as those found in cuprate superconductors. A stripe is modeled as a partially doped domain wall in an antiferromagnet (AF), introduced in the context of two different models: the t-J model with strong Ising anisotropy, and the Hubbard model in the Hartree-Fock approximation. The domain walls with a given linear charge density are supported artificially by boundary conditions. In both models we find a regime of parameters where doped holes lose their spin and become holons (charge Q=1, spin S_z=0), which can move along the stripe without frustrating AF environment. One aspect in which the holons on the AF domain wall differ from those in an ordinary one-dimensional electron gas is their transverse degree of freedom: a mobile holon always resides on a transverse kink (or antikink) of the domain wall. This gives rise to two holon flavors and to a strong coupling between doped charges and transverse fluctuations of a stripe.Comment: Minor revisions: references update

Soluble and pelletable factors in porcine, canine and human notochordal cell-conditioned medium: implications for IVD regeneration

During intervertebral disc (IVD) maturation, notochordal cells (NCs) are replaced by chondrocyte-like cells (CLCs) in the nucleus pulposus, suggesting that NCs play a role in maintaining tissue health. Affirmatively, NC-conditioned medium (NCCM) exerts regenerative effects on CLC proliferation and extracellular matrix (ECM) production. The aim of this study was to identify NC-secreted substances that stimulate IVD regeneration. By mass spectrometry of porcine, canine and human NCCM, 149, 170 and 217 proteins were identified, respectively, with 66 proteins in common. Mainly ECM-related proteins were identified, but also organelle-derived and membrane-bound vesicle proteins. To determine whether the effect of NCCM was mediated by soluble and/or pelletable factors, porcine and canine NCCM were separated into a soluble (NCCM-S; peptides and proteins) and pelletable (NCCM-P; protein aggregates and extracellular vesicles) fraction by ultracentrifugation, and tested on bovine and canine CLCs in vitro, respectively. In each model, NCCM-S exerted a more pronounced anabolic effect than NCCM-P. However, glycosaminoglycan (GAG) uptake from the medium into the carrier gel prevented more definite conclusions. While the effect of porcine NCCM-P on bovine CLCs was negligible, canine NCCM-P appeared to enhance GAG and collagen type II deposition by canine CLCs. In conclusion, porcine and canine NCCM exerted their anabolic effects mainly through soluble factors, but also the pelletable NCCM factors showed moderate regenerative potential. Although the regenerative potential of NCCM-P should not be overlooked, future studies should focus on unraveling the protein-based regenerative mechanism from NCCM produced from isolated NCs, e.g. by NCCM fractionation and pathway blocking studies

The gene coding for variant hepatic nuclear factor 1 ( Tcf-2 ), maps between the Edp-1 and Erba genes on mouse Chromosome 11

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46992/1/335_2004_Article_BF00352466.pd

Quantum walks: a comprehensive review

Quantum walks, the quantum mechanical counterpart of classical random walks, is an advanced tool for building quantum algorithms that has been recently shown to constitute a universal model of quantum computation. Quantum walks is now a solid field of research of quantum computation full of exciting open problems for physicists, computer scientists, mathematicians and engineers. In this paper we review theoretical advances on the foundations of both discrete- and continuous-time quantum walks, together with the role that randomness plays in quantum walks, the connections between the mathematical models of coined discrete quantum walks and continuous quantum walks, the quantumness of quantum walks, a summary of papers published on discrete quantum walks and entanglement as well as a succinct review of experimental proposals and realizations of discrete-time quantum walks. Furthermore, we have reviewed several algorithms based on both discrete- and continuous-time quantum walks as well as a most important result: the computational universality of both continuous- and discrete- time quantum walks.Comment: Paper accepted for publication in Quantum Information Processing Journa