Effect of Nonlinearity on Adiabatic Evolution of Light

We investigate the effect of nonlinearity in a system described by an adiabatically evolving Hamiltonian. Experiments are conducted in a three-core waveguide structure that is adiabatically varying with distance, in analogy to the stimulated Raman adiabatic passage process in atomic physics. In the linear regime, the system exhibits an adiabatic power transfer between two waveguides which are not directly coupled, with negligible power recorded in the intermediate coupling waveguide. In the presence of nonlinearity the adiabatic light passage is found to critically depend on the excitation power. We show how this effect is related to the destruction of the dark state formed in this configuration

p22phox C242T Single-Nucleotide Polymorphism Inhibits Inflammatory Oxidative Damage to Endothelial Cells and Vessels.

BACKGROUND: The NADPH oxidase, by generating reactive oxygen species, is involved in the pathophysiology of many cardiovascular diseases and represents a therapeutic target for the development of novel drugs. A single-nucleotide polymorphism, C242T of the p22(phox) subunit of NADPH oxidase, has been reported to be negatively associated with coronary heart disease and may predict disease prevalence. However, the underlying mechanisms remain unknown. METHODS AND RESULTS: With the use of computer molecular modeling, we discovered that C242T single-nucleotide polymorphism causes significant structural changes in the extracellular loop of p22(phox) and reduces its interaction stability with Nox2 subunit. Gene transfection of human pulmonary microvascular endothelial cells showed that C242T p22(phox) significantly reduced Nox2 expression but had no significant effect on basal endothelial O2 (.-) production or the expression of Nox1 and Nox4. When cells were stimulated with tumor necrosis factor-α (or high glucose), C242T p22(phox) significantly inhibited tumor necrosis factor-α-induced Nox2 maturation, O2 (.-) production, mitogen-activated protein kinases and nuclear factor κB activation, and inflammation (all P<0.05). These C242T effects were further confirmed using p22(phox) short-hairpin RNA-engineered HeLa cells and Nox2(-/-) coronary microvascular endothelial cells. Clinical significance was investigated by using saphenous vein segments from non-coronary heart disease subjects after phlebotomies. TT (C242T) allele was common (prevalence of ≈22%) and, in comparison with CC, veins bearing TT allele had significantly lower levels of Nox2 expression and O2 (.-) generation in response to high-glucose challenge. CONCLUSIONS: C242T single-nucleotide polymorphism causes p22(phox) structural changes that inhibit endothelial Nox2 activation and oxidative response to tumor necrosis factor-α or high-glucose stimulation. C242T single-nucleotide polymorphism may represent a natural protective mechanism against inflammatory cardiovascular diseases

Tapasin gene polymorphism in systemic onset juvenile rheumatoid arthritis: a family-based case-control study

Juvenile rheumatoid arthritis (JRA) comprises a group of chronic systemic inflammatory disorders that primarily affect joints and can cause long-term disability. JRA is likely to be a complex genetic trait, or a series of such traits, with both genetic and environmental factors contributing to the risk for developing the disease and to its progression. The HLA region on the short arm of chromosome 6 has been intensively evaluated for genetic contributors to JRA, and multiple associations, and more recently linkage, has been detected. Other genes involved in innate and acquired immunity also map to near the HLA cluster on 6p, and it is possible that variation within these genes also confers risk for developing JRA. We examined the TPSN gene, which encodes tapasin, an endoplasmic reticulum chaperone that is involved in antigen processing, to elucidate its involvement, if any, in JRA. We employed both a case-control approach and the transmission disequilibrium test, and found linkage and association between the TPSN allele (Arg260) and the systemic onset subtype of JRA. Two independent JRA cohorts were used, one recruited from the Rheumatology Clinic at Cincinnati Children's Hospital Medical Center (82 simplex families) and one collected by the British Paediatric Rheumatology Group in London, England (74 simplex families). The transmission disequilibrium test for these cohorts combined was statistically significant (chi(2) = 4.2, one degree of freedom; P = 0.04). Linkage disequilibrium testing between the HLA alleles that are known to be associated with systemic onset JRA did not reveal linkage disequilibrium with the Arg260 allele, either in the Cincinnati systemic onset JRA cohort or in 113 Caucasian healthy individuals. These results suggest that there is a weak association between systemic onset JRA and the TPSN polymorphism, possibly due to linkage disequilibrium with an as yet unknown susceptibility allele in the centromeric part of chromosome 6

Jamming attack on in-band full-duplex communications: Detection and countermeasures

© 2016 IEEE. Recent advances in the design of in-band full-duplex (IBFD) radios promise to double the throughput of a wireless link. However, IBFD-capable nodes are more vulnerable to jamming attacks than their out-of-band full-duplex (OBFD) counterparts, and any advantages offered by them over the OBFD nodes can be jeopardized by such attacks. A jammer needs to attack both the uplink and the downlink channels to completely break the communication link between two OBFD nodes. In contrast, he only needs to jam one channel (used for both uplink and downlink) in the case of two IBFD nodes. Even worse, a jammer with the IBFD capability can learn the transmitters' activity while injecting interference, allowing it to react instantly with the transmitter's strategies. In this paper, we investigate frequency hopping (FH) technique for countering jamming attacks in the context of IBFD wireless radios. Specifically, we develop an optimal strategy for IBFD radios to combat an IBFD reactive sweep jammer. First, we introduce two operational modes for IBFD radios: transmission reception and transmission-detection. These modes are intended to boost the anti-jamming capability of IBFD radios. We then jointly optimize the decision of when to switch between the modes and when to hop to a new channel using Markov decision processes. Numerical investigations show that our policy significantly improves the throughput of IBFD nodes under jamming attacks

Price-based friendly jamming in a MISO interference wiretap channel

© 2016 IEEE. In this paper, we expand the scope of PHY-layer security by investigating TX-based friendly jamming (FJ) for the wiretap channel in multi-link settings. For the single-link scenario, creating a TX-based FJ is an effective and practical method in improving the secrecy rate. In a multi-link setting, several information signals must be transmitted simultaneously. Thus, the design must guarantee that the FJ signal of a given transmitter does not interfere with unintended but legitimate receivers. Under the assumption of exact knowledge of the eavesdropping channel, we first propose a distributed price-based approach to improve the secrecy sum-rate of a two-link network with one eavesdropper while satisfying an information-rate constraint for both link. Simulations show that price-based FJ control outperforms greedy FJ, and is close to the performance of a centralized approach. Next, we propose a method based on mixed strategic games that can offer robust solutions to the distributed secrecy sum-rate maximization problem under the assumption of an unknown eavesdropping channel. Lastly, we use simulations to show that in addition to outperforming the greedy approach, our robust optimization also satisfies practical network considerations. In particular, the transmission time for the robust optimization can be determined flexibly to match the channel's coherence time

Quantum advantage by relational queries about physically realizable equivalence classes

Relational quantum queries are sometimes capable to effectively decide between collections of mutually exclusive elementary cases without completely resolving and determining those individual instances. Thereby the set of mutually exclusive elementary cases is effectively partitioned into equivalence classes pertinent to the respective query. In the second part of the paper, we review recent progress in theoretical certifications (relative to the assumptions made) of quantum value indeterminacy as a means to build quantum oracles for randomness.Comment: 8 Pages, one figure, invited contribution to TopHPC2019, Tehran, Iran, April 22-25, 201

Cognitive Networks with In-Band Full-Duplex Radios: Jamming Attacks and Countermeasures

© 2015 IEEE. Although in-band full-duplex (IBFD) radios promise to double the throughput of a wireless link, they are more vulnerable to jamming attacks than their out-of-band full-duplex (OBFD) counterparts. For two communicating OBFD nodes, a jammer needs to attack both the uplink and the downlink channels to completely break the communication link. In contrast, only one common channel needs to be jammed in the case of two IBFD nodes. Even worse, a jammer with self-interference suppression (SIS) capabilities (the underlying technique of IBFD radios) can learn the transmitters' activity while injecting interference, allowing it to react instantly to the transmitter's strategies. In this work, we consider a power-constrained IBFD 'reactive-sweep' jammer that sweeps through the set of channels by jamming a subset of them simultaneously. We model the interactions between the IBFD radios and the jammer as a stochastic constrained zero-sum Markov game in which nodes adopt the frequency hopping (FH) technique as their strategies to counter jamming attacks. Beside the IBFD transmission-reception (TR) mode, we introduce an additional operation mode, called transmission-detection (TD), in which an IBFD radio transmits and leverages its SIS capability to detect jammers. The aim of the TD mode is to make IBFD radios more cognitive to jamming. The nodes' optimal defense strategy that guides them when to hop and which operational mode (TD or TR) to use is then established from the equilibrium of the stochastic Markov game. We prove that this optimal policy has a threshold structure, in which IBFD nodes stay on the same channel up to a certain number of time slots before hopping. Simulation results show that our policy significantly improves the throughput of IBFD nodes under jamming attacks