Social networking as an advertising tool in Russia and abroad

This study contrasts the behavioural patterns of users on Facebook with those on VKontakte using data collected by Facebook and a survey of Russian VKontakte users. The authors analyse the key differences between the two popular social networks, including what users perceived to be the most attractive options, the amount of time spent online and attitudes toward advertising. The results have been used to evaluate the potential of social networks (SMM) for business promotion in Russia

Cancer invasion: patterns and mechanisms

Cancer invasion and the ability of malignant tumor cells for directed migration and metastasis have remained a focus of research for many years. Numerous studies have confirmed the existence of two main patterns of cancer cell invasion: collective cell migration and individual cell migration, by which tumor cells overcome barriers of the extracellular matrix and spread into surrounding tissues. Each pattern of cell migration displays specific morphological features and the biochemical/molecular genetic mechanisms underlying cell migration. Two types of migrating tumor cells, mesenchymal (fibroblast-like) and amoeboid, are observed in each pattern of cancer cell invasion. This review describes the key differences between the variants of cancer cell migration, the role of epithelial-mesenchymal, collective-amoeboid, mesenchymal-amoeboid, and amoeboid- mesenchymal transitions, as well as the significance of different tumor factors and stromal molecules in tumor invasion. The data and facts collected are essential to the understanding of how the patterns of cancer cell invasion are related to cancer progression and therapy efficacy. Convincing evidence is provided that morphological manifestations of the invasion patterns are characterized by a variety of tissue (tumor) structures. The results of our own studies are presented to show the association of breast cancer progression with intratumoral morphological heterogeneity, which most likely reflects the types of cancer cell migration and results from different activities of cell adhesion molecules in tumor cells of distinct morphological structures

Model of the modern geography teacher as a competitive specialist

The teacher remains a key figure in the transfer of knowledge and social experience to young generations, therefore the quality of training and education ultimately depends on the level of his professionalism. Clear an understanding of the competency requirements for a geography teacher is necessary for an objective assessment of the quality of teacher’s work, the successful organization of a training and retraining system for teachers. Conducted the work certainly does not exhaust the problem of developing the professional competence of geography teachers as a model modern teacher, and provides for the continuation of scientific and research work

Cybernetic welness of the youth: Psychological aspect

The ever more growing relevance of the issue under evaluation is explained by the wide expansion of digital technology that leads to the necessity to ensure cybernetic wellness of the population, especially the young. The goal of this article is to detect the psychological peculiarities of the Internet dependence of the youth. The leading approach to this issue is the empirical one (psychological evaluation); it allows detection of differences in socialization levels depending on severity of the Internet dependence among the students and the connection between the level of the Internet dependence and socialization for the young. The article analyzes the severity of the modern youth’s Internet dependence, describes the main criteria of the Internet addictions, forms of appearance and motives for development of addictive behavior among the young, stages of Internet addictions. This article may be used by the psychologists that perform psychological follow-up within the framework of psychocorrective, training and consulting jobs with students and the youth suffering of or damaged by Internet dependence, or fighting the consequences of Internet-addiction-based behavior. The article may also interest other specialists working with the young (teachers, social workers). © 2016 Zinnatova et al

Techniques for upgrading educational standards in tourism: how to integrate business circles into university research?

Methodology of developing modern educational standards has to comply with the new economic trends. Meeting the requirements of the market is conditioned by the integration of higher professional education and business all over the world. For the implementation of this integration strategy it is efficient to use the module education principle. This paper considers the main components of the module educational program: projective, innovative, and learner-centered. It has been shown that integration of business into research university programs can provide the necessary synthesis of theoretical and practical aspects of training professionals in tourism

Premalignant changes in the bronchial epithelium are prognostic factors of distant metastasis in non-small cell lung cancer patients

Background: The study assessed the possibility of dividing patients into groups based on the assessment of morphological changes in the epithelium of small-caliber bronchi located near the primary tumor in order to predict high and low risks of distant metastasis of non-small cell lung cancer. Methods: In 171 patients with non-small cell lung cancer (T1-4N0-3M0) in small-caliber bronchi taken at a distance of 3–5 cm from the tumor, various variants of morphological changes in the bronchial epithelium (basal cell hyperplasia (BCH), squamous cell metaplasia (SM), and dysplasia (D)) were assessed. Long-term results of treatment, namely, distant metastasis, were assessed after 2 and 5 years. Results: During the follow-up period, distant metastases were found in 35.1% (60/171) of patients. Most often, they were observed in patients of the high-risk group: BCH+SM−D−(51.6%, 40/95) and BCH−SM+D+ (54.4%, 6/11). Less often, distant metastases were observed in low-risk group patients: BCH+SM+D− (6.7%, 3/45) and BCH−SM−D−(10.0%, 2/20). Tumor size, grade, and stage were significant predictors of metastasis only in the high-risk group. The 5-year metastasis-free survival was better in the low-risk group of distant metastases. Conclusions: Isolated BCH or dysplasia in small bronchi distant from foci of tumor isassociated with a high-risk distant metastasis and less 5-year metastasis-free survival

Navigation infrastructure for people with disabilities

The importance of navigation support for people with disability has been demonstrated by convention on the Rights of Persons with Disabilities. This paper presents the navigation infrastructure for people with disabilities. The infrastructure includes map generation service, web interface, mobile services. Also we purpose method of target area examination by volunteers. Using a modified Openstreetmap road graph allows you to build more precise routes. Introduced classification of obstacles types allows you to identify problems in the path of a person with disabilities. Application of Dijkstra's-based algorithm with modified edge weights allows you to find safe traffic routes. The results of testing on the pilot region allow us to estimate the amount of work required to improve the quality of people's live with disabilities

Characteristics of humic acids in sod-podzolic soil under long-term exposure to different fertilization systems

The elemental composition and structure of humic acids in the soddy-podzolic heavy loamy soil of the Cis-Urals were studied during long-term application of organic, mineral and organo-mineral fertilizers under conditions of a long-term stationary experiment. Mineral fertilizers contributed to the formation of humic acids with increased content of aliphatic components, the ratio H : C = 1.45 and a high degree of oxidation (ω = 0.41). The low content of nitrogen in humic acids (from 2.0 to 2.6 at.%), with various fertilizer systems, is primarily due to its low content in the plant biomass of crops cultivated in crop rotation.The organic fertilizer system resulted in the enrichment of the structural aggregates of humic acids with aromatic groups and nitrogen. The high intensity of absorption of the >C=O group of carboxylic acids in the region of 1 717 cm-1 and double bonds of carbon atoms at 1 627 cm-1 confirms this position. Humic acids of the “manure 10 t/ha” and “manure 5 t/ha + equiv. NPK” have the largest number of carboxyl groups in their composition. The vibrations of the >C=O group of carboxylic acids are most weakly expressed in soil humic acids with a mineral fertilizer system. Organo-mineral fertilizer system demonstrates intermediate results in terms of the content of the main constitutional elements in humic acids. Mineral fertilizers application reduces the amount and thermal stability of the structural components of humic acids, thereby contributing to the degradation of the most stable part of macromolecule, which can lead to the loss of potential soil fertility. Тhe use of mineral fertilizers on sod-podzolic heavy loamy soil led to the enrichment of humic acids with aliphatic fragments, and of organic ones – increased the content of stable components of aromatic nature, but lowered their thermal stability. According to thermographic analysis the ratio of weight loss in the low-temperature zone and the weight loss in the high-temperature zone (Z) during long-term use of mineral fertilizers is 0.9, i. e. the proportion of components of aliphatic nature in the structure of humic acids increases in comparison with unfertilized or manure fertilized soil