Thymosin β4 as basis for creation of a reparation preparation of new generation

On the basis of its multipurpose activities during regeneration of fabrics in various experiments on animals, Thymosin β4 has the potential for new researches, in kidneys and a liver, and also recovery of a spinal cord, bones and injury of ligaments. Besides, it can be useful in case of treatment of a wide range of other diseases, including concerning consequences of old bacterial damages and viral infection

Audio-band coating thermal noise measurement for advanced LIGO with a multi-mode optical resonator

In modern high precision optical instruments, such as in gravitational wave detectors or frequency references, thermally induced fluctuations in the reflective coatings can be a limiting noise source. This noise, known as coating thermal noise, can be reduced by choosing materials with low mechanical loss. Examination of new materials becomes a necessity in order to further minimize the coating thermal noise and thus improve sensitivity of next generation instruments. We present a novel approach to directly measure coating thermal noise using a high finesse folded cavity in which multiple Hermite-Gaussian modes co-resonate. This method is used to probe surface fluctuations on the order 10^-17 m\rtHz in the frequency range 30-400 Hz. We applied this technique to measure thermal noise and loss angle of the coating used in Advanced LIGO

Modern problems of antibiotic resistance gram-negative nosocomial infections in the Rostov region

Objectives: to analyze the prevalence of strains of gram-negative bacteria - pathogens of infectious complications resistant to carbapenems, including through the production of carbapenemases isolated from various clinical biomaterials in hospitalized patients of hospitals in the city of Rostov-on-Don.Materials and methods: 366 gram-negative bacterial isolates were studied, from patients from 16 wards, 9 treatment-and-prophylactic institutions of the city of Rostov-on-Don and the region. The study was conducted by traditional microbiological method. Species identification of strains and sensitivity to antimicrobial drugs were determined on a Vitek 2 automatic analyzer (BioMerieux, France). The strains insensitive to carbapenems were tested for the presence of carbapenemases using CIM-test. MBL was detected by the effect of suppression of their activity in the presence of EDTA. MBL genes were detected by PCR-RV test kit “AmpliSens MDR MBL-FL”, “AmpliSens MDR KPC/OXA-48-FL”. The conclusion about the production of BLRS was made by the presence of synergism of cephalosporins of III-IV generation with clavulanic acid by the method of double discs.Results: of the 366 isolates tested, gram-negative bacteria accounted for 74.2 %: Klebsiella pneumoniae — 33.0 %, Escherichia coli — 19.0 %, Acinetobacter baumannii — 18.0 %, Pseudomonas aeruginosa — 15.0 %. Resistance to carbapenems was detected in 90.9 % of A.baumannii strains, more than 50 % of P.aeruginosa and K.pneumoniae. LBR production was detected in more than 90 % of K.pneumoniae and about 80 % of E. coli. In A. baumannii and K.pneumoniae isolates, the presence of OXA and NDM genes was found, and in P.aeruginosa, VIM groups.Conclusion: enterobacteria resistant to beta-lactams, producing extended-spectrum beta-lactamases and carbapenemases are one of the leading causative agents of infectious complications in hospitals of Rostov-on-don and the region, almost not inferior in frequency of occurrence of bacteria of the genus Acinetobacter spp. and Paeruginosa. This determines the importance of detection of resistance mechanisms not only for the purpose of optimal etiotropic therapy, but also for epidemiological control of the spread of resistant strains and the development of infection control measures

Competing ideologies of Russia's civil society

Many analysts and public opinion makers in the West conflate the notions of Russia’s non-systemic liberal opposition and the country’s civil society. Indeed, despite garnering the support of a minority of Russia’s population, non-systemic liberal opposition represents a well-organized civic group with a clearly articulated agenda and the ability to take action. Yet, does Russia’s civil society end there? A closer look at the country’s politics shows that Russia has a substantial conservative-traditionalist faction that has also developed agenda for action and formulated opinions. This group is anti-liberal rather than illiberal ideologically and pro-strong state/pro a geopolitically independent Russia rather than pro-Kremlin politically. The interaction between liberal and conservative civic groups represents the battle of meanings, ideas, and ethics, and ultimately determines the future trajectory of Russia’s evolution. Thus, the analysis of Russia’s civil society must represent a rather more nuanced picture than a mere study of the liberal non-systemic opposition. This article will examine the complexity of Russia’s civil society scene with reference to the interplay between the liberal opposition and conservative majority factions. The paper will argue that such complexity stems from ideological value pluralism that falls far beyond the boundaries of the liberal consensus, often skewing our understanding of political practice in Russia

Benchmarks for the Forward Observables at RHIC, the Tevatron-run II and the LHC

We present predictions on the total cross sections and on the ratio of the real part to the imaginary part of the elastic amplitude (rho parameter) for present and future pp and pbar p colliders, and on total cross sections for gamma p -> hadrons at cosmic-ray energies and for gamma gamma-> hadrons up to sqrt{s}=1 TeV. These predictions are based on an extensive study of possible analytic parametrisations invoking the biggest hadronic dataset available at t=0. The uncertainties on total cross sections, including the systematic errors due to contradictory data points from FNAL, can reach 1.9% at RHIC, 3.1% at the Tevatron, and 4.8% at the LHC, whereas those on the rho parameter are respectively 5.4%, 5.2%, and 5.4%.Comment: 11 pages, 2 figures, 4 tables, RevTeX

Optimization of the snowflake diverted equilibria in the TCV tokamak

In support of the TCV experimental campaign aiming at studying H-mode plasmas with snowflake (SF) divertor, free boundary equilibrium and stability studies were performed with the SPIDER and KINX codes. Due to the high flexibility of plasma shaping capabilities of TCV, SF divertor conditions can be reached for various plasma geometries. However, at high plasma current some configurations require poloidal field (PF) coil currents close to the machine limit. This is particularly important when the equilibrium sensitivity to the edge pedestal profiles, which is higher than for standard X-point configurations, is taken into account. That is why the configuration optimization should also include the profile sensitivity study when planning the shot scenario

Comparison of the calculations of the stability properties of a specific stellarator equilibrium with different MHD stability codes

A particular configuration of the LHD stellarator with an unusually flat pressure profile has been chosen to be a test case for comparison of the MHD stability property predictions of different three-dimensional and averaged codes for the purpose of code comparison and validation. In particular, two relatively localized instabilities, the fastest growing modes with toroidal mode number n = 2 and n = 3 were studied using several different codes, with the good agreement that has been found providing justification for the use of any of them for equilibria of the type considered

Edge Stability and Pedestal Profile Sensitivity of Snowflake Diverted Equilibria in the TCV Tokamak

A second order null divertor (snowflake) has been successfully created and controlled in the TCV Tokamak. The results of ideal MHD edge stability computations show an enhancement of the edge stability properties of the snowflake equilibria compared to standard X-point configurations...

P-P Total Cross Sections at VHE from Accelerator Data

Comparison of P-P total cross-sections estimations at very high energies - from accelerators and cosmic rays - shows a disagreement amounting to more than 10 %, a discrepancy which is beyond statistical errors. Here we use a phenomenological model based on the Multiple-Diffraction approach to successfully describe data at accelerator energies. The predictions of the model are compared with data On the basis of regression analysis we determine confident error bands, analyzing the sensitivity of our predictions to the employed data for extrapolation. : using data at 546 and 1.8 TeV, our extrapolations for p-p total cross-sections are only compatible with the Akeno cosmic ray data, predicting a slower rise with energy than other cosmic ray results and other extrapolation methods. We discuss our results within the context of constraints in the light of future accelerator and cosmic ray experimental results.Comment: 26 pages aqnd 11 figure