Característica de la preparación del personal para la gestión de conflictos en la organización

The analysis of the personnel competence, reflected in the professional standards, allows us to identify the main areas of training that have a positive impact on the challenges of the external environment. At the same time, employees of the organization, as a rule, have different professional training and practical experience. From this perspective, the phenomenon of in-house training of the personnel is updated, under which the training is carried out on the basis of the organization and aimed at achieving the objectives to develop it. Communication, as a mechanism of using communicative skills that can have both positive and negative effects, occupies a leading position in the professional activities of the personnel. Thus, it is connected, in most cases, with conflicts, in particular, the lack of personnel preparedness and readiness to manage them. Researchers are actively engaged in finding the ways to prevent and resolve conflicts, using various forms of post-graduate training, including in-house training of adult audience.El análisis de la competencia del personal, reflejado en los estándares profesionales, nos permite identificar las principales áreas de capacitación que tienen un impacto positivo en los desafíos del entorno externo. Al mismo tiempo, los empleados de la organización, por regla general, tienen diferente formación profesional y experiencia práctica. Desde esta perspectiva, se actualiza el fenómeno de la capacitación interna del personal, en virtud del cual la capacitación se lleva a cabo sobre la base de la organización y dirigida a lograr los objetivos para desarrollarla. La comunicación, como mecanismo para utilizar habilidades comunicativas que pueden tener efectos tanto positivos como negativos, ocupa una posición de liderazgo en las actividades profesionales del personal. Por lo tanto, está relacionado, en la mayoría de los casos, con conflictos, en particular, la falta de preparación y preparación del personal para manejarlos. Los investigadores participan activamente en la búsqueda de formas de prevenir y resolver conflictos, utilizando diversas formas de capacitación de posgrado, incluida la capacitación interna de la audiencia adulta

The recombinant fusion protein CFP10–ESAT6–dIFN has protective effect against tuberculosis in guinea pigs

Development of effective vaccine candidates against tuberculosis (TB) is currently the most important challenge in the prevention of this disease since the BCG vaccine fails to guarantee a lifelong protection, while any other approved vaccine with better efficiency is still absent. The protective effect of the recombinant fusion protein CFP10–ESAT6–dIFN produced in a prokaryotic expression system (Escherichia coli) has been assessed in a guinea pig model of acute TB. The tested antigen comprises the Mycobacterium tuberculosis (Mtb) proteins ESAT6 and CFP10 as well as modified human γ-interferon (dIFN) for boosting the immune response. Double intradermal immunization of guinea pigs with the tested fusion protein (2 × 0.5 µg) induces a protective effect against subsequent Mtb infection. The immunized guinea pigs do not develop the symptoms of acute TB and their body weight gain was five times more as compared with the non-immunized infected guinea pigs. The animal group immunized with this dose of antigen displays the minimum morphological changes in the internal organs and insignificant inflammatory lesions in the liver tissue, which complies with a decrease in the bacterial load in the spleen and average Mtb counts in macrophages