Carst marble on Tyrnyauz deposit

The karst of marbles is considered as the least studied type of karst. Here we have pinpointed the karst area of the ore field of the Tyrnyauz deposit. Lithological and petrographic characteristics of the skarned marbles of Tyrnyauz are given, their chemical activity is determined. Tectonogenic fissure-karst drainage system of the deposit is analyzed. The main factors of karst formation have been determined and the development of the karst marbles of the Tyrnyauz ore field at various depths is predicte

The effect of post-procedure care on the effectiveness of skin restoration and correction of side effects after aesthetic procedures

Introduction. The  duration of  the  skin  healing period and the  final result of  cosmetic procedures are influenced not only by the treatment protocol and the type of therapy chosen, but also by skin care in the early post-treatment period.Aim of study. Тo study the effectiveness and safety of the use of the topical agent “Traumeel® Cosmo gel” in patients in the early post-treatment period after cosmetic procedures, accompanied by traumatization of the skin.Materials and methods. 20 female patients aged 19 to 49 years, who sought help for the correction of age-related skin changes, acne vulgaris, scarring of the skin and received the procedure of cosmetological therapy, accompanied by damage to the skin. All patients were assigned to group 1 (20 patients). Depending on the method of cosmetological treatment, the external remedy “Traumeel® Cosmo gel” was applied from 2 to 3 times a day at the treated area for 7 ± 2 days.Results. According to the patients’ assessment of the effectiveness and comfort of the treatment, the use of the “Traumeel® Cosmo gel” in  the  early post-treatment period is an effective and safe method of  regenerative therapy of  the  skin  and has a  high therapeutic effectiveness, which was confirmed by the results of the study.Conclusions. Based on the results of the evaluation of the effectiveness by the doctor and patients, as well as the evaluation of the monitoring of the dermatological status, the quality of life index, the patient’s subjective assessment of their response to therapy, consider the therapeutic effectiveness to be high, significantly contributing to the improvement of the quality of life

Mechanism of making legislative decisions in the Russian Federation as a method of economic regulation: based on the analysis of quantitative data of LAWSTREAM.RU database

Objective: to consider the use of legislative decision-making mechanisms in the Russian Federation as a tool of economic regulation on the basis of quantitative data of LAWSTREAM.RU database and to confirm or refute the hypothesis that the failures in the GDP growth dynamics encourage the state regulator to intensify rulemaking.Methods: abstract-logical method, comparison, correlation analysis.Results: the mechanism of legislative decision-making can and should be considered as a tool for the economic regulation policy implementation. The effectiveness of reforms is determined by the way in which the government, as the regulatory body of the economic system, uses the existing mechanisms of legislative decision-making in the field of economic regulation. The paper analyzes the institutional aspects of economic reforms. The authors compare the quantitative dynamics of the law drafts in the sphere of economic relations submitted to the State Duma and adopted by it, and the dynamics of the Russian GDP growth in 1994-2018. The correlation is shown between the macroeconomic situation and the legislative activity of the President and government in economic sphere; the hypothesis is confirmed about the influence of the GDP growth on the President and government’s legislative activity in the sphere of economy and finance regulation in case of sharply negative GDP values. It is established that the peak of the state regulator’s activity in the regulatory sphere is the system reaction to shock, expressed in a sharp drop in GDP growth.Scientific novelty: the article is the first attempt to compare the quantitative indicators of the adopted law drafts in the sphere of economy regulation and the GDP dynamics.Practical significance: the results obtained by the authors are useful for describing the model of legislative influence of the Russian executive authorities on the economic environment, taking into account the current macroeconomic indicators

Application of systems of hinged ventilated facades in different climatic conditions of Russia

A study of ventilated facades has been carried out to determine the effect of the dependence of the diffusion transfer of water vapor on the thermal and moisture properties of the enclosing structures in the three climatic zones of Russia.Проведено исследование вентилируемых фасадов с целью установить влияние зависимости фактора диффузионного переноса водяного пара на тепловлажностные свойства ограждающих конструкций в трех климатический зонах России

A Mathematical Model for Complete Morphological Regression in Primary Operable HER2-Positive Breast Cancer

Background. Breast cancer (BC) is distinguished with its biological tumour subtypes as luminal A, B, HER2-positive and triple-negative. The current clinical guidelines of the Russian Ministry of Health prescribe neoadjuvant targeted chemotherapy as combined treatment in the HER2-positive cancer subtype. An adequate model for treatment efficacy prediction in such patients had been missing to date.Aim. Development of a mathematical model and its computer realisation for complete morphological regression estimation in patients with primary operable HER2-positive breast cancer.Materials and methods. Statistically significant predictors were estimated with the treatment outcome data on 103 HER2- positive breast cancer cases with neoadjuvant targeted chemotherapy. A binary logistic regression model was developed to account for a dichotomous variable dependency on certain predictors.Results and discussion. Multivariate analysis laid out a mathematical model and software “Complete morphological regression estimation in primary operable EGFR-expressing breast cancer under neoadjuvant chemotherapy”. Our results attest that the program correctly automates a systematic estimation of complete morphological regression achieved prior to neoadjuvant targeted chemotherapy and is clinically justified for optimising treatment regimens in primary operable HER2-positive BC.Conclusion. The mathematical model and computer program developed estimate the rate of complete morphological regression achieved prior to neoadjuvant targeted chemotherapy with a high 92 % sensitivity, 97.33 % specificity and 93.21% accuracy

Determination of the actual value of the resistance of the heat transduction to the controlling construction on the basis of the results of the national experiment

To improve the thermal protection of buildings, multilayered enclosing structures are currently used. In connection with this, the question of determining the thermophysical properties is topical. The paper presents the results of a full-scale experiment, the purpose of which is to determine the actual value of the resistance to heat transfer. During the research, the heat flow through the enclosing structure was determined, and the necessary air and wall temperatures were removed. Based on the results of the studies, the experimental value of the resistance to heat transfer is obtained and compared with the calculated value.Для повышения тепловой защиты зданий в настоящее время применяют многослойные ограждающие конструкции. В связи с этим вопрос определения теплофизических свойств является актуальным. В работе представлены результаты натурного эксперимента, целью которого является определение фактического значения сопротивления теплопередаче. В ходе экспериментального исследования были определены плотность теплового потока через ограждающую конструкцию, температуры воздуха и поверхности стен. По результатам исследований получено экспериментальное значение сопротивления теплопередаче, сопоставлено с расчетным

First πK\pi K atom lifetime and πK\pi K scattering length measurements

The results of a search for hydrogen-like atoms consisting of $\pi^{\mp}K^{\pm}$ mesons are presented. Evidence for $\pi K$ atom production by 24 GeV/c protons from CERN PS interacting with a nickel target has been seen in terms of characteristic $\pi K$ pairs from their breakup in the same target ($178 \pm 49$) and from Coulomb final state interaction ($653 \pm 42$). Using these results the analysis yields a first value for the $\pi K$ atom lifetime of $\tau=(2.5_{-1.8}^{+3.0})$ fs and a first model-independent measurement of the S-wave isospin-odd $\pi K$ scattering length $\left|a_0^-\right|=\frac{1}{3}\left|a_{1/2}-a_{3/2}\right|= \left(0.11_{-0.04}^{+0.09} \right)M_{\pi}^{-1}$ ($a_I$ for isospin $I$).Comment: 14 pages, 8 figure

Determination of ππ\pi\pi scattering lengths from measurement of π+π−\pi^+\pi^- atom lifetime

The DIRAC experiment at CERN has achieved a sizeable production of $\pi^+\pi^-$ atoms and has significantly improved the precision on its lifetime determination. From a sample of 21227 atomic pairs, a 4% measurement of the S-wave $\pi\pi$ scattering length difference $|a_0-a_2| = (.0.2533^{+0.0080}_{-0.0078}|_\mathrm{stat}.{}^{+0.0078}_{-0.0073}|_\mathrm{syst})M_{\pi^+}^{-1}$ has been attained, providing an important test of Chiral Perturbation Theory.Comment: 6 pages, 6 figure

Quality of colonoscopy in an emerging country: A prospective, multicentre study in Russia

Background: The quality of colonoscopy has been related to a higher risk of interval cancer, and this issue has been addressed extensively in developed countries. The aim of our study was to explore the main quality indicators of colonoscopy in a large emerging country. Methods: Consecutive patients referred for colonoscopy in 14 centres were prospectively included between July and October 2014. Before colonoscopy, several clinical and demographic variables were collected. Main quality indicators (i.e. caecal intubation rate, (advanced) adenoma detection rate, rate of adequate cleansing and sedation) were collected. Data were analysed at per patient and per centre level (only for those with at least 100 cases). Factors associated with caecal intubation rate and adenoma detection rate were explored at multivariate analysis. Results: A total of 8829 (males: 35%; mean age: 57 + 14 years) patients were included, with 11 centres enrolling at least 100 patients. Screening (including non-alarm symptoms) accounted for 59% (5188/8829) of the indications. Sedation and split preparation were used in 26% (2294/8829) and 25% (2187/8829) of the patients. Caecal intubation was achieved in 7616 patients (86%), and it was ≥85% in 8/11 (73%) centres. Adenoma detection rate was 18% (1550/8829), and it was higher than 20% in five (45%) centres, whilst it was lower than 10% in four (33%) centres. At multivariate analysis, age (OR: 1.020, 95% CI: 1.015–1.024), male sex (OR: 1.2, 95% CI: 1.1–1.3), alarm symptoms (OR: 1.8, 95% CI: 1.7–2), split preparation (OR: 1.4, 95% CI: 1.2–1.6), caecal intubation rate (OR: 1.6, 95% CI: 1.3–1.9) and withdrawal time measurement (OR: 1.2, 95% CI: 1.6–2.1) were predictors of a higher adenoma detection rate, while adequate preparation (OR: 3.4: 95% CI: 2.9–3.9) and sedation (OR: 1.3; 95% CI: 1.1–1.6) were the strongest predictors of caecal intubation rate. Conclusions: According to our study, there is a substantial intercentre variability in the main quality indicators. Overall, the caecal intubation rate appears to be acceptable in most centres, whilst the overall level of adenoma detection appears low, with less than half of the centres being higher than 20%. Educational and quality assurance programs, including higher rates of sedation and split regimen of preparation, may be necessary to increase the key quality indicators