89 research outputs found
Socio-Cultural Impact of Church Building in Russia (the Case of the Cathedral of Saint Martyr Catherine in Ekaterinburg)
In recent years, Russia has been going through a boom of church building. In 2009, the Russian Orthodox Church (ROC) had 29,263 parishes and by 2019 this figure had risen to 38,649. In the last decade, the growth in the number of Orthodox religious organizations and places of worship has by far exceeded that of other assets of social infrastructure. While the number of churches is growing, however, the number of schools, kindergartens and hospitals is steadily falling. Unlike other elements of social infrastructure, church building is funded not from the state budget but is financed by donors, sponsors and by the ROC itself, with some of the funds coming from payments for religious rites (baptism, weddings etc). This article analyzes the historical significance and socio-economic impact of church building by focusing on the case of the Cathedral of Saint Martyr Catherine in Ekaterinburg. The right choice of the construction site for the cathedral-the choice that would be agreeable to the metropolitan bishop, municipal government, businesses and sponsors, local community and opinion leaders-will ensure not only that the project will be duly completed but also underline the fact that local communities are able to establish consensus and recognize each other's interests in local decision-making. One of the possible locations considered for building St.Catherine's Cathedral in Ekaterinburg was a former industrial site in the centre of the city. Eventually, it was chosen as the most suitable place for this large-scale project. Redevelopment of an underused or abandoned industrial site, resulting in the improvement in the quality of urban environment, can be seen as an effective instrument of project realization, contributing to the building's social and economic significance. Β© Published under licence by IOP Publishing Ltd
Lower pole obstructive megaureter of duplex kidney: an exception to the Weigert-Meyer rule
Introduction. Anatomical features of the urinary tract in patients with duplicate kidneys are described using the Weigert-Meyer rule, since the orifice of the upper ureter has an ectopic location (inferomedial) and the orifice of the lower ureter has an orthotopic location (superolateral). However, there are rare cases of violation of this rule, complicated by obstructive megaureter, ectopic ureteral orifice, the presence of ureterocele.Objective. To report the rare clinical case of a lower pole obstructive megaureter as a violation of the Meyer-Weigert rule in the patient with complete ureteral duplication and to describe the use of ureteroureterostomy as an effective and safe method of surgical correction of the presented anomaly.Clinical case. We present a case of the infant (5 months old) with a lower pole obstructive megaureter. This pathology was identified through intravenous urography and voiding cystourethrography. Laparoscopic proximal end-to-side ureteroureteroanastomosis was chosen as a surgical treatment. Postoperative control intravenous urography showed the effectiveness (a reduction in the lower pole collecting system of the duplex kidney was revealed) and the safety of this method of correction.Conclusion. Β There are only several clinical cases about exceptions to the Weigert-Meyer rule reported in literature, and most of them are about adult patients. The main surgical method of treatment in such cases is heminephrectomy. To our knowledge, this is the only reported case of using ureteroureterostomy in the patient with a lower pole obstructive megaureter. This technique has shown its effectiveness and safety for restoring the patency of the urinary tract, confirmed during the control postoperative examination
INFLUENCE OF SPD AND THERMAL PROCESSING ON MICROSTRUCTURE AND FUNCTIONAL PROPERTIES OF BEARING STEEL 110Cr18Mo
The effect of severe plastic deformation (SPD) and subsequent thermal treatment on the microstructure and functional properties of 110Cr18Mo bearing steel was investigated. An increase in the number of cycles of the SPD before the standard heat treatment leads to a reduction in the coefficient of friction while maintaining the hardness at the same level as after heat treatment.Π ΡΠ°Π±ΠΎΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΠΉ ΠΏΠ»Π°ΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π΄Π΅ΡΠΎΡΠΌΠ°ΡΠΈΠΈ (ΠΠΠ) ΠΈ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠ΅ΠΉ ΡΠ΅ΡΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΎΠ±ΡΠ°Π±ΠΎΡΠΊΠΈ Π½Π° ΠΌΠΈΠΊΡΠΎΡΡΡΡΠΊΡΡΡΡ ΠΈ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° ΠΏΠΎΠ΄ΡΠΈΠΏΠ½ΠΈΠΊΠΎΠ²ΠΎΠΉ ΡΡΠ°Π»ΠΈ 110Π₯18Π. Π£Π²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ ΡΠΈΡΠ»Π° ΡΠΈΠΊΠ»ΠΎΠ² ΠΠΠ ΠΏΠ΅ΡΠ΅Π΄ ΡΡΠ°Π½Π΄Π°ΡΡΠ½ΠΎΠΉ ΡΠ΅ΡΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΎΠ±ΡΠ°Π±ΠΎΡΠΊΠΎΠΉ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ ΠΊΠΎΡΡΡΠΈΡΠΈΠ΅Π½ΡΠ° ΡΡΠ΅Π½ΠΈΡ ΠΏΡΠΈ ΡΠΎΡ
ΡΠ°Π½Π΅Π½ΠΈΠΈ ΡΠ²Π΅ΡΠ΄ΠΎΡΡΠΈ Π½Π° ΡΠΎΠΌ ΠΆΠ΅ ΡΡΠΎΠ²Π½Π΅, ΡΡΠΎ ΠΈ ΠΏΠΎΡΠ»Π΅ ΡΠ΅ΡΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΎΠ±ΡΠ°Π±ΠΎΡΠΊΠΈ.Π Π°Π±ΠΎΡΠ° Π²ΡΠΏΠΎΠ»Π½Π΅Π½Π° ΠΏΡΠΈ ΡΠΈΠ½Π°Π½ΡΠΎΠ²ΠΎΠΉ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΊΠ΅ Π Π€Π€Πβ 17-48-020253
EFFECT OF PRE-TEMPERING TEMPERATURE ON THE MECHANICAL PROPERTIES OF HIGH-CARBON BEARING STEEL AFTER ECAP
Π ΡΠ°Π±ΠΎΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π° Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ Π΄Π΅ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π·Π°ΠΊΠ°Π»Π΅Π½Π½ΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ Π²ΡΡΠΎΠΊΠΎΡΠ³Π»Π΅ΡΠΎΠ΄ΠΈΡΡΠΎΠΉ ΠΏΠΎΠ΄ΡΠΈΠΏΠ½ΠΈΠΊΠΎΠ²ΠΎΠΉ ΡΡΠ°Π»ΠΈ ΠΏΠΎΡΠ»Π΅ ΠΎΡΠΏΡΡΠΊΠ° ΠΏΡΠΈ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΠ°Ρ
. ΠΠ΅ΡΠΎΡΠΌΠ°ΡΠΈΡ ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΠ»ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΡΠ°Π²Π½ΠΎΠΊΠ°Π½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ³Π»ΠΎΠ²ΠΎΠ³ΠΎ ΠΏΡΠ΅ΡΡΠΎΠ²Π°Π½ΠΈΡ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π² ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΡ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΡ ΠΏΡΠ΅Π΄Π²Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΡΠΏΡΡΠΊΠ° Π½Π°Π±Π»ΡΠ΄Π°Π΅ΡΡΡ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ ΠΏΡΠΎΡΠ½ΠΎΡΡΠ½ΡΡ
Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊ: ΠΏΡΠ΅Π΄Π΅Π»Π° ΠΏΡΠΎΡΠ½ΠΎΡΡΠΈ ΠΈ ΠΏΡΠ΅Π΄Π΅Π»Π° ΡΠ΅ΠΊΡΡΠ΅ΡΡΠΈ, ΡΠ²Π΅ΡΠ΄ΠΎΡΡΠΈ ΡΡΠ°Π»ΠΈ.The possibility of deformation of the quenched state of high-carbon bearing steel after tempering at different temperatures has been investigated. The deformation was carried out by equal-channel angular pressing. It is shown the increasing of the temperature of the preliminary tempering results in a decrease in the strength characteristics: the tensile strength and yield strength, and the hardness of the steel.Π Π°Π±ΠΎΡΠ° Π²ΡΠΏΠΎΠ»Π½Π΅Π½Π° ΠΏΡΠΈ ΡΠΈΠ½Π°Π½ΡΠΎΠ²ΠΎΠΉ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΊΠ΅ Π Π€Π€Π β 17-48-020253
Organisational and methodological challenges of CAR-T manufacturing in the Russian Federation
Despite their widespread clinical implementation, chimeric antigen receptor T-cell (CAR-T) therapy products, including those manufactured by industrial processes, are still not legally available or used in the Russian Federation.The aim of the study was to describe the current challenges associated with specific aspects of CAR-T manufacturing in the Russian Federation and the potential ways to overcome them.This article discusses the regulatory, legal, organisational, and methodological challenges of CAR-T manufacturing. It analyses differences in the interpretation of CAR-T therapy products under national and supranational law. According to Russian Federal Law No. 180-FZ βOn Biomedical Cell Productsβ of 23 June 2016, CAR-T therapy products are considered biomedical cell products. However, according to Decision No. 78 of the Council of the Eurasian Economic Commission βOn the Rules of Marketing Authorisation and Assessment of Medicinal Products for Human Useβ of 3 November 2016, CAR-T therapy products are considered advanced therapy medicinal products (ATMPs). This article provides a detailed overview of the difficulties in obtaining starting biological materials (i.e. the inability to consider the patient as a donor) and transferring the materials for CAR-T manufacturing (i.e. the inapplicability of national law). In addition, this article describes export aspects specific to biological materials. The authors reckon that CAR-T therapy products should be categorised as ATMPs and that the corresponding active pharmaceutical ingredients, genetically modified autologous lymphocytes, should be defined as starting materials. Therefore, genetically modified autologous lymphocytes should be regulated under the requirements for starting materials for the manufacturing of active pharmaceutical ingredients that are set forth in Decision No. 77 of the Council of the Eurasian Economic Commission βOn the Adoption of the Rules of Good Manufacturing Practice of the Eurasian Economic Unionβ of 3 November 2016. In conclusion, the authors recognise the need for national and supranational law harmonisation. For this task, it is necessary to establish expert groups that will include clinicians, legal experts, and representatives from the relevant authorities and the pharmaceutical industry
ΠΠΠΠΠ’ΠΠΠΠΠΠ§ΠΠ‘ΠΠΠ ΠΠ ΠΠ’ΠΠ ΠΠ ΠΠ ΠΠΠΠΠΠΠ ΠΠΠΠΠΠ― Π’ΠΠ§ΠΠΠΠ― ΠΠΠ‘ΠΠΠΠΠΠΠ ΠΠΠΠ©ΠΠΠΠΠ ΠΠΠ Π ΠΠΠΠΠΠ Π£ ΠΠΠ’ΠΠ
The study involved 224 patients with Lyme borreliosis children with erythema (103) and without erythema (121 children) forms. The analysis of the clinical symptoms and hematological parameters in the course of the disease was prosecute. A comprehensive statistical analysis of the results allowed to highlight blood count (content stab and segmented neutrophils, erythrocyte sedimentation rate) and the number of symptoms at admission prognostic criteria of severity, chronicity of the Lyme borreliosis. This allows to make a correction in the treatment of patients with Lyme borreliosis.Β ΠΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΎ 224 Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΠΠ Π΄Π΅ΡΠ΅ΠΉ Ρ ΡΡΠΈΡΠ΅ΠΌΠ½ΠΎΠΉ (103) ΠΈ Π±Π΅Π·ΡΡΠΈΡΠ΅ΠΌΠ½ΠΎΠΉ (121 ΡΠ΅Π±Π΅Π½ΠΎΠΊ) ΡΠΎΡΠΌΠ°ΠΌΠΈ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ Π°Π½Π°Π»ΠΈΠ· ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΈΠΌΠΏΡΠΎΠΌΠΎΠ² ΠΈ Π³Π΅ΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ Π² Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ. ΠΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½Π°Ρ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΎΠ±ΡΠ°Π±ΠΎΡΠΊΠ° ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ»Π° Π²ΡΠ΄Π΅Π»ΠΈΡΡ ΠΏΠΎ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°ΠΌ ΠΎΠ±ΡΠ΅Π³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° ΠΊΡΠΎΠ²ΠΈ (ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ ΠΏΠ°Π»ΠΎΡΠΊΠΎΡΠ΄Π΅ΡΠ½ΡΡ
ΠΈ ΡΠ΅Π³ΠΌΠ΅Π½ΡΠΎΡΠ΄Π΅ΡΠ½ΡΡ
Π½Π΅ΠΉΡΡΠΎΡΠΈΠ»ΠΎΠ², Π‘ΠΠ) ΠΈ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Ρ ΡΠΈΠΌΠΏΡΠΎΠΌΠΎΠ² Π±ΠΎΠ»Π΅Π·Π½ΠΈ ΠΏΡΠΈ ΠΏΠΎΡΡΡΠΏΠ»Π΅Π½ΠΈΠΈ Π² ΡΡΠ°ΡΠΈΠΎΠ½Π°Ρ ΠΏΡΠΎΠ³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΊΡΠΈΡΠ΅ΡΠΈΠΈ ΡΡΠΆΠ΅ΡΡΠΈ, Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΠΠ. ΠΡΠΎ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΡΠ²ΠΎΠ΅Π²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎ Π²Π½Π΅ΡΡΠΈ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΡ Π² ΡΠ΅ΡΠ°ΠΏΠΈΡ Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΠΠ.
ΠΠ·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·Ρ Π½Π΅ΠΊΠΎΡΠΎΡΡΡ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ² ΠΌΡΠΊΠΎΠ·Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅ΡΠ° ΠΏΠΎΠ»ΠΎΡΡΠΈ ΡΡΠ° Ρ ΡΡΠΎΠ²Π½Π΅ΠΌ Π²ΠΈΡΠ°ΠΌΠΈΠ½Π° D Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΌΠ½ΠΎΠΆΠ΅ΡΡΠ²Π΅Π½Π½ΡΠΌ ΠΊΠ°ΡΠΈΠ΅ΡΠΎΠΌ
Aim. To determine the saliva level of immunoregulatory proteins in patients with rampant caries and 25-hydroxyvitamin D (25(OH)D) deficiency and evaluate the association of their concentration with 25(OH)D plasma level.Materials and methods. The study was performed in two groups. The experimental group included 15 patients aged 20β22 years with rampant caries and the 25(OH)D plasma level of < 20 ng / ml. The control group encompassed 15 healthy age-matched volunteers with the 25(OH)D plasma level of 20β100 ng / ml. The concentrations of B7.2 (CD86), free active TGF-Ξ²1, CTLA-4, PD-1, Tim-3, LAG-3, IGFBP-4, and ICAM-1 were assessed using flow cytometry. The levels of LL-37 and secretory immunoglobulin A (sIgA) were measured using ELISA. The Spearmanβs rank correlation coefficient was used to reveal a correlation between the indicated proteins and the 25(OH)D plasma level.Results. A decrease in B7.2 (CD86), PD-1, Tim-3, sIgA, and LL-37 and elevation of IGFBP-4 and ICAM-1 saliva levels were detected in patients with rampant caries and 25-hydroxyvitamin D deficiency. A positive Spearmanβs rank correlation coefficient was revealed between plasma 25(OH)D and saliva levels of free active TGF-Ξ²1, CTLA4, B7.2 (CD86), LL-37, and sIgA. A negative correlation was revealed between 25(OH)Dand ICAM-1.Conclusion. 25(OH)D deficiency in patients with rampant caries is associated with decreased levels of B7.2 (CD86), PD-1, Tim-3, sIgA, and LL-37 and elevated levels of IGFBP-4 and ICAM-1 in the saliva.Β Π¦Π΅Π»Ρ β ΠΎΡΠ΅Π½ΠΈΡΡ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅Π³ΡΠ»ΡΡΠΎΡΠ½ΡΡ
ΠΌΠΎΠ»Π΅ΠΊΡΠ» Π² ΡΠ»ΡΠ½Π΅ Ρ Π»ΠΈΡ Ρ ΠΌΠ½ΠΎΠΆΠ΅ΡΡΠ²Π΅Π½Π½ΡΠΌ ΠΊΠ°ΡΠΈΠ΅ΡΠΎΠΌ ΠΈ Π΄Π΅ΡΠΈΡΠΈΡΠΎΠΌ 25(OH)D3 ΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·ΠΈ ΠΈΡ
Π²Π΅Π»ΠΈΡΠΈΠ½ Ρ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠ΅ΠΉ 25(OH)D3 Π² ΠΊΡΠΎΠ²ΠΈ.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Ρ Π΄Π²Π΅ Π³ΡΡΠΏΠΏΡ Π»ΠΈΡ Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ 20β22 Π»Π΅Ρ. Π ΠΎΠ΄Π½Ρ Π²ΠΊΠ»ΡΡΠ΅Π½Ρ 15 ΡΠ΅Π»ΠΎΠ²Π΅ΠΊ Ρ ΠΊΠ°ΡΠΈΠ΅ΡΠΎΠΌ ΠΈ ΡΡΠΎΠ²Π½Π΅ΠΌ 25(OH)D3 ΠΌΠ΅Π½Π΅Π΅ 20 Π½Π³/ΠΌΠ», Π² Π΄ΡΡΠ³ΡΡ (ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΡΡ) β 15 Π·Π΄ΠΎΡΠΎΠ²ΡΡ
ΡΠ΅Π»ΠΎΠ²Π΅ΠΊ Ρ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ΠΌ 25(OH)D3 30β100 Π½Π³/ΠΌΠ». Π ΡΠΎΡΠΎΠ²ΠΎΠΉ ΠΆΠΈΠ΄ΠΊΠΎΡΡΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ ΡΠ°ΡΡΠ²ΠΎΡΠΈΠΌΡΡ
ΡΠΎΡΠΌ ΠΌΠΎΠ»Π΅ΠΊΡΠ» B7.2 (CD86), Free Active TGF-b1, CTLA-4, PD-1, Tim-3, LAG-3, IGFBP-4, ICAM-1 ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΏΡΠΎΡΠΎΡΠ½ΠΎΠΉ ΡΠΈΡΠΎΡΠ»ΡΠΎΠΌΠ΅ΡΡΠΈΠΈ, ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ ΠΊΠ°ΡΠ΅Π»ΠΈΡΠΈΠ΄ΠΈΠ½Π° LL-37, ΡΠ΅ΠΊΡΠ΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡΠ½ΠΎΠ³Π»ΠΎΠ±ΡΠ»ΠΈΠ½Π° A (IgA) ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π°. ΠΠ΅ΠΆΠ΄Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ΅ΠΌΡΠΌΠΈ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌΠΈ ΡΠ°ΡΡΡΠΈΡΠ°Π½ ΠΊΡΠΈΡΠ΅ΡΠΈΠΉ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΈ Π‘ΠΏΠΈΡΠΌΠ΅Π½Π°.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π£ Π»ΠΈΡ Ρ ΠΊΠ°ΡΠΈΠ΅ΡΠΎΠΌ ΠΈ Π΄Π΅ΡΠΈΡΠΈΡΠΎΠΌ Π²ΠΈΡΠ°ΠΌΠΈΠ½Π° D Π²ΡΡΠ²Π»Π΅Π½ΠΎ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΠΉ Free Active TGF-b1, B7.2 (CD86), PD-1, Tim-3, sIgA, ΠΊΠ°ΡΠ΅Π»ΠΈΡΠΈΠ΄ΠΈΠ½Π° LL-37 ΠΈ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ ΡΡΠΎΠ²Π½Ρ IGFBP-4 ΠΈ ICAM-1 Π² ΡΠ»ΡΠ½Π΅. ΠΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΎ Π½Π°Π»ΠΈΡΠΈΠ΅ ΠΏΡΡΠΌΡΡ
ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΎΠ½Π½ΡΡ
ΡΠ²ΡΠ·Π΅ΠΉ ΠΌΠ΅ΠΆΠ΄Ρ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎΠΌ 25(OH)D3 Π² ΠΊΡΠΎΠ²ΠΈ, Ρ ΠΎΠ΄Π½ΠΎΠΉ ΡΡΠΎΡΠΎΠ½Ρ, ΠΈ Π·Π½Π°ΡΠ΅Π½ΠΈΡΠΌΠΈ Free Active TGF-b1, CTLA-4, Π7.2 (CD86), ΡΠ΅ΠΊΡΠ΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ IgA, ΠΏΠ΅ΠΏΡΠΈΠ΄Π° LL-37 β Ρ Π΄ΡΡΠ³ΠΎΠΉ. ΠΠ°ΡΠΈΠΊΡΠΈΡΠΎΠ²Π°Π½Π° ΠΎΡΡΠΈΡΠ°ΡΠ΅Π»ΡΠ½Π°Ρ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·Ρ ΠΌΠ΅ΠΆΠ΄Ρ Π²Π΅Π»ΠΈΡΠΈΠ½Π°ΠΌΠΈ 25(OH)D3 ΠΈ ICAM-1.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠ° ΡΠΎΠ½Π΅ Π΄Π΅ΡΠΈΡΠΈΡΠ° Π²ΠΈΡΠ°ΠΌΠΈΠ½Π° D ΠΏΡΠΈ ΠΌΠ½ΠΎΠΆΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΌ ΠΊΠ°ΡΠΈΠ΅ΡΠ΅ Π² ΡΠΎΡΠΎΠ²ΠΎΠΉ ΠΆΠΈΠ΄ΠΊΠΎΡΡΠΈ ΡΠ΅Π³ΠΈΡΡΡΠΈΡΡΡΡΡΡ Π½ΠΈΠ·ΠΊΠΈΠ΅ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ Free Active TGF-b1, B7.2 (CD86), PD-1, Tim-3, ΡΠ΅ΠΊΡΠ΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ IgA, ΠΊΠ°ΡΠ΅Π»ΠΈΡΠΈΠ΄ΠΈΠ½Π° LL-37 ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΠΊΠΎΠ½ΡΡΠΎΠ»Π΅ΠΌ, Π½ΠΎ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½Ρ Π·Π½Π°ΡΠ΅Π½ΠΈΡ IGFBP-4 ΠΈ ICAM-1.
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