A conceptual framework highlighting e-learning implementation barriers

Purpose– E-learning has gained much focus from educators and researchers, with many extolling e-learning over traditional learning. Despite this focus, implementation of e-learning systems often fails. Literature considers a range of barriers, impacting the success of e-learning implementations, yet to the best of our knowledge no conceptual framework is able to consolidate existing research. Design/methodology/approach– This paper undertook an in-depth review of literature concerning e-learning implementation barriers. Papers were extracted from established journals and open sources. Articles not related to e-learning implementation barriers were discarded. A total of 259 papers were identified, published between 1990 and 2016. Hermeneutics and data-driven qualitative content analysis was used to define 68 unique barriers. Findings– The 68 unique barriers were thematically grouped into four conceptual categories, i.e. Technology (T), Individual (I), Pedagogy (P) and Enabling Conditions (EC). These 4 categories led to the conceptualization of ‘TIPEC’ Framework, which highlights the key concepts hindering e-learning implementation and delivery. Results show that most articles only consider a narrow range of success barriers. Practical implications – The proposed TIPEC framework acts as a guide for education practitioners, system developers, policy makers and researchers. It provides stakeholders with a summary of e-learning barriers. Originality/Value – This paper fulfils an identified need for a conceptual framework that consolidates all current research related to E-learning implementation barriers

Adaptive Filters Revisited - RFI Mitigation in pulsar observations

Pulsar detection and timing experiments are applications where adaptive filters seem eminently suitable tools for radio-frequency-interference (RFI) mitigation. We describe a novel variant which works well in field trials of pulsar observations centred on an observing frequency of 675 MHz, a bandwidth of 64 MHz and with 2-bit sampling. Adaptive filters have generally received bad press for RFI mitigation in radio astronomical observations with their most serious drawback being a spectral echo of the RFI embedded in the filtered signals. Pulsar observations are intrinsically less sensitive to this as they operate in the (pulsar period) time domain. The field trials have allowed us to identify those issues which limit the effectiveness of the adaptive filter. We conclude that adaptive filters can significantly improve pulsar observations in the presence of RFI.Comment: Accepted for publication in Radio Scienc

Genetic correlations and little genetic variance for reaction norms may limit potential for adaptation to pollution by ionic and nanoparticulate silver in a whitefish (Salmonidae).

For natural populations to adapt to anthropogenic threats, heritable variation must persist in tolerance traits. Silver nanoparticles, the most widely used engineered nanoparticles, are expected to increase in concentrations in freshwaters. Little is known about how these particles affect wild populations, and whether genetic variation persists in tolerance to permit rapid evolutionary responses. We sampled wild adult whitefish and crossed them in vitro full factorially. In total, 2896 singly raised embryos of 48 families were exposed to two concentrations (0.5 μg/L; 100 μg/L) of differently sized silver nanoparticles or ions (silver nitrate). These doses were not lethal; yet higher concentrations prompted embryos to hatch earlier and at a smaller size. The induced hatching did not vary with nanoparticle size and was stronger in the silver nitrate group. Additive genetic variation for hatching time was significant across all treatments, with no apparent environmental dependencies. No genetic variation was found for hatching plasticity. We found some treatment-dependent heritable variation for larval length and yolk volume, and one instance of additive genetic variation for the reaction norm on length at hatching. Our assessment suggests that the effects of silver exposure on additive genetic variation vary according to trait and silver source. While the long-term fitness consequences of low-level silver exposure on whitefish embryos must be further investigated to determine whether it is, in fact, detrimental, our results suggest that the evolutionary potential for adaptation to these types of pollutants may be low

Inhibition of NAD(P)H oxidase reduces apoptosis and avascular retina in an animal model of retinopathy of prematurity

Purpose: To study the mechanisms of action of the antioxidants, n-acetylcysteine (NAC), and the nicotinamide adenine dinucleotide phosphate (NAPDH) oxidase oxidase inhibitor, apocynin, on intravitreous neovascularization (IVNV), and retinal avascularity in a rat model of retinopathy of prematurity (ROP). Methods: Newborn rats exposed to oxygen-induced retinopathy underwent intraperitoneal (IP) injections of NAC (150 mg/kg) at post-natal day (p)2, p6, p10 (early NAC-treated), or p12 through p17 (late NAC-treated), apocynin (10 mg/kg) from p12 through p17, or phosphate buffered saline (PBS; controls). Lipid hydroperoxide (LHP) was measured in early NAC-treated oxygen-induced retinopathy (OIR) at p7, p14 and p18. Pups were placed in room air at p14. At p18, retinal flat mounts were scored for IVNV and avascular/total retinal area, or retinas were assayed for cleaved caspase-3 and vascular endothelial growth factor (VEGF) protein. In non-injected OIR pups, retinas were assayed for gp91phox. Cryosections were stained with isolectin B4, cleaved caspase-3, CD68, CD31, gp91phox, neuron-glial antigen 2 (NG-2), or anti-glial fibrillary acidic protein (GFAP) and visualized with confocal microscopy. Results: LHP increased over time in retinas from OIR exposed pups in association with IVNV. Early NAC-treated retinas had significantly reduced LHP compared to PBS-control at p18 (p<0.012). However, neither early nor late treatment with NAC had an effect on IVNV or retinal avascularity. Although apocynin had no effect on IVNV, it reduced both avascular retina (p=0.017) and retinal cleaved caspase-3 determined by western blot (p=0.021). In cryosections from OIR eyes, cleaved caspase-3 positive cells co-labeled with some lectin-stained vessels, NG2 labeled cells, and with GFAP positive cells in the inner nuclear layer. We found that the intravascular expression of gp91phox co-localized mostly with CD31 and some CD68 positive cells. Conclusions: Our results do not support the antioxidant properties of NAC as effective in reducing IVNV or avascular retina in the 50/10 OIR rat model. Apocynin reduced avascularity and apoptosis in the OIR model perhaps through pathways triggered by ROS generation but upstream from LHP production. Further study and consideration may be given to apocynin or NAD(P)H oxidase inhibitors as adjunctive therapy for ROP to reduce the avascular retina

Smart integrated adaptive centralized controller for islanded microgrids under minimized load shedding

In this paper, a smart integrated adaptive centralized controller is proposed for monitoring and controlling integrated renewable energy sources (RESs), both for intentional and unintentional islanding modes of operation for microgrids, as well as, for a variable range of transient load shedding and fault scenarios corresponding to electrical power system outages. It is demonstrated that the proposed smart adaptive controller is capable of instructing fast frequency response by proper coordination of the dispatch of RESs units such as, mini-hydro, Photovoltaic (PV), Battery Energy Storage System (BESS) and standby diesel generators. In particular, the BESS used as power reserve, at the early stage of fault events can prevent detrimental and uncontrollable system frequency decline and the extent of load shedding. In summary, the performance of a centralized controller in terms of a fast frequency response recovery feature is validated for an actual microgrid distribution network of Malaysia. The demonstration of this intelligent control scheme highlights the advantage of utilizing the fast power recovery response of energy storage and standby generator, which fulfil the criteria for minimal load shedding from the main grid, during the unintentional microgrid islanding conditions

Weak radiative hyperon decays, Hara's theorem and the diquark

Weak radiative hyperon decays are discussed in the diquark-level approach. It is pointed out that in the general diquark formalism one may reproduce the experimentally suggested pattern of asymmetries, while maintaining Hara's theorem in the SU(3) limit. At present, however, no detailed quark-based model of parity-violating diquark-photon coupling exists that would have the necessary properties.Comment: 10 pages, LaTe

Thermoelectric transport properties of a T-shaped double quantum dot system in the Coulomb blockade regime

We investigate the thermoelectric properties of a T-shaped double quantum dot system described by a generalized Anderson Hamiltonian. The system's electrical conduction (G) and the fundamental thermoelectric parameters such as the Seebeck coefficient ($S$) and the thermal conductivity ($\kappa$), along with the system's thermoelectric figure of merit (ZT) are numerically estimated based on a Green's function formalism that includes contributions up to the Hartree-Fock level. Our results account for finite onsite Coulomb interaction terms in both component quantum dots and discuss various ways leading to an enhanced thermoelectric figure of merit for the system. We demonstrate that the presence of Fano resonances in the Coulomb blockade regime is responsible for a strong violation of the Wiedemann-Franz law and a considerable enhancement of the system's figure of merit ($ZT$).Comment: 7 pages, 10 figure

Nonfactorization in Hadronic Two-body Cabibbo-favored decays of D^0 and D^+

With the inclusion of nonfactorized amplitudes in a scheme with $N_c=3$, we have studied Cabibbo-favored decays of $D^0$ and $D^+$ into two-body hadronic states involving two isospins in the final state. We have shown that it is possible to understand the measured branching ratios and determined the sizes and signs of nonfactorized amplitudes required.Comment: 15 pages, Late

Characterization of plasma thiol redox potential in a common marmoset model of aging☆

Due to its short lifespan, ease of use and age-related pathologies that mirror those observed in humans, the common marmoset (Callithrix jacchus) is poised to become a standard nonhuman primate model of aging. Blood and extracellular fluid possess two major thiol-dependent redox nodes involving cysteine (Cys), cystine (CySS), glutathione (GSH) and glutathione disulfide (GSSG). Alteration in these plasma redox nodes significantly affects cellular physiology, and oxidation of the plasma Cys/CySS redox potential (EhCySS) is associated with aging and disease risk in humans. The purpose of this study was to determine age-related changes in plasma redox metabolites and corresponding redox potentials (Eh) to further validate the marmoset as a nonhuman primate model of aging. We measured plasma thiol redox states in marmosets and used existing human data with multivariate adaptive regression splines (MARS) to model the relationships between age and redox metabolites. A classification accuracy of 70.2% and an AUC of 0.703 were achieved using the MARS model built from the marmoset redox data to classify the human samples as young or old. These results show that common marmosets provide a useful model for thiol redox biology of aging

Hyperon Nonleptonic Weak Decays Revisited

We first review the current algebra - PCAC approach to nonleptonic octet baryon 14 weak decay B (\to) (B^{\prime})(\pi) amplitudes. The needed four parameters are independently determined by (\Omega \to \Xi \pi),(\Lambda K) and (\Xi ^{-}\to \Sigma ^{-}\gamma) weak decays in dispersion theory tree order. We also summarize the recent chiral perturbation theory (ChPT) version of the eight independent B (\to) (B^{\prime}\pi) weak (\Delta I) = 1/2 amplitudes containing considerably more than eight low-energy weak constants in one-loop order.Comment: 10 pages, RevTe