Principles for an Immigration Policy to Strengthen and Expand the American Middle Class: 2007 Edition

The Drum Major Institute for Public Policy contends that any debate over immigration policy must be connected to the larger conversation about America's squeezed middle class and those striving to attain a middle-class standard of living. Accordingly, DMI offers a lens through which to evaluate immigration policy that operates from the basic principle that immigration policy is sound only if it also helps to strengthen and expand America's middle class. With that premise as our starting point, we wrote "Principles for an Immigration Policy to Strengthen and Expand the American Middle Class: 2007 Edition." First published in December 2005, "Principles" is now updated to reflect recent legislative proposals and a discussion of issues that have emerged as important. It is intended to serve as a guide for those who wish to advance a progressive immigration agenda that reflects the best interests of America's current and aspiring middle class

GABA-enhanced collective behavior in neuronal axons underlies persistent gamma-frequency oscillations

Gamma (30–80 Hz) oscillations occur in mammalian electroencephalogram in a manner that indicates cognitive relevance. In vitro models of gamma oscillations demonstrate two forms of oscillation: one occurring transiently and driven by discrete afferent input and the second occurring persistently in response to activation of excitatory metabotropic receptors. The mechanism underlying persistent gamma oscillations has been suggested to involve gap-junctional communication between axons of principal neurons, but the precise relationship between this neuronal activity and the gamma oscillation has remained elusive. Here we demonstrate that gamma oscillations coexist with high-frequency oscillations (>90 Hz). High-frequency oscillations can be generated in the axonal plexus even when it is physically isolated from pyramidal cell bodies. They were enhanced in networks by nonsomatic -aminobutyric acid type A (GABAA) receptor activation, were modulated by perisomatic GABAA receptor-mediated synaptic input to principal cells, and provided the phasic input to interneurons required to generate persistent gamma-frequency oscillations. The data suggest that high-frequency oscillations occurred as a consequence of random activity within the axonal plexus. Interneurons provide a mechanism by which this random activity is both amplified and organized into a coherent network rhythm

High-contrast Imaging from Space: Speckle Nulling in a Low Aberration Regime

High-contrast imaging from space must overcome two major noise sources to successfully detect a terrestrial planet angularly close to its parent star: photon noise from diffracted star light, and speckle noise from star light scattered by instrumentally-generated wavefront perturbation. Coronagraphs tackle only the photon noise contribution by reducing diffracted star light at the location of a planet. Speckle noise should be addressed with adaptative-optics systems. Following the tracks of Malbet, Yu and Shao (1995), we develop in this paper two analytical methods for wavefront sensing and control that aims at creating dark holes, i.e. areas of the image plane cleared out of speckles, assuming an ideal coronagraph and small aberrations. The first method, speckle field nulling, is a fast FFT-based algorithm that requires the deformable-mirror influence functions to have identical shapes. The second method, speckle energy minimization, is more general and provides the optimal deformable mirror shape via matrix inversion. With a NxN deformable mirror, the size of matrix to be inverted is either N^2xN^2 in the general case, or only NxN if influence functions can be written as the tensor product of two one-dimensional functions. Moreover, speckle energy minimization makes it possible to trade off some of the dark hole area against an improved contrast. For both methods, complex wavefront aberrations (amplitude and phase) are measured using just three images taken with the science camera (no dedicated wavefront sensing channel is used), therefore there are no non-common path errors. We assess the theoretical performance of both methods with numerical simulations, and find that these speckle nulling techniques should be able to improve the contrast by several orders of magnitude.Comment: 31 pages, 8 figures, 1 table. Accepted for publication in ApJ (should appear in February 2006

Dynamically-Coupled Oscillators -- Cooperative Behavior via Dynamical Interaction --

We propose a theoretical framework to study the cooperative behavior of dynamically coupled oscillators (DCOs) that possess dynamical interactions. Then, to understand synchronization phenomena in networks of interneurons which possess inhibitory interactions, we propose a DCO model with dynamics of interactions that tend to cause 180-degree phase lags. Employing an approach developed here, we demonstrate that although our model displays synchronization at high frequencies, it does not exhibit synchronization at low frequencies because this dynamical interaction does not cause a phase lag sufficiently large to cancel the effect of the inhibition. We interpret the disappearance of synchronization in our model with decreasing frequency as describing the breakdown of synchronization in the interneuron network of the CA1 area below the critical frequency of 20 Hz.Comment: 10 pages, 3 figure

Sorting it out: AP-2 and alternate clathrin adaptors in endocytic cargo selection

The AP-2 adaptor complex is widely viewed as a linchpin molecule in clathrin-mediated endocytosis, simultaneously binding both clathrin and receptors. This dual interaction couples cargo capture with clathrin coat assembly, but it has now been discovered that the association with cargo is tightly regulated. Remarkably, AP-2 is not obligatory for all clathrin-mediated uptake, and several alternate adaptors appear to perform similar sorting and assembly functions at the clathrin bud site

Regret Aversion and False Reference Points in Residential Real Estate

This study empirically exams the combination of regret aversion and false reference points in a residential real estate context. Survey respondents were put in a hypothetical situation, where they had purchased an investment property several years ago. Hindsight knowledge about a foregone all time high was introduced. As hypothesized, respondents on average expressed higher regret if they had actively failed to sell at the all time high (commission scenario) than if they had simply been unaware of the potential gain (omission scenario). Women were found to be more susceptible to regret aversion and false reference points than men.

Expression of connexins in human preimplantation embryos in vitro

Intercellular communication via gap junctions is required to coordinate developmental processes in the mammalian embryo. We have investigated if the connexin (Cx) isoforms known to form gap junctions in rodent preimplantation embryos are also expressed in human embryos, with the aim of identifying species differences in communication patterns in early development. Using a combination of polyA PCR and immunocytochemistry we have assessed the expression of Cx26, Cx31, Cx32, Cx40, Cx43 and Cx45 which are thought to be important in early rodent embryos. The results demonstrate that Cx31 and Cx43 are the main connexin isoforms expressed in human preimplantation embryos and that these isoforms are co-expressed in the blastocyst. Cx45 protein is expressed in the blastocyst but the protein may be translated from a generally low level of transcripts: which could only be detected in the PN to 4-cell embryos. Interestingly, Cx40, which is expressed by the extravillous trophoblast in the early human placenta, was not found to be expressed in the blastocyst trophectoderm from which this tissue develops. All of the connexin isoforms in human preimplantation embryos are also found in rodents pointing to a common regulation of these connexins in development of rodent and human early embryos and perhaps other species