Soliton generation by internal tidal beams impinging on a pycnocline: laboratory experiments

In this paper, we present the first laboratory experiments that show the generation of internal solitary waves by the impingement of a quasi-two-dimensional internal wave beam on a pycnocline. These experiments were inspired by observations of internal solitary waves in the deep ocean from synthetic aperture radar (SAR) imagery, where this so-called mechanism of 'local generation' was argued to be at work, here in the form of internal tidal beams hitting the thermocline. Nonlinear processes involved here are found to be of two kinds. First, we observe the generation of a mean flow and higher harmonics at the location where the principal beam reflects from the surface and pycnocline; their characteristics are examined using particle image velocimetry (PIV) measurements. Second, we observe internal solitary waves that appear in the pycnocline, detected with ultrasonic probes; they are further characterized by a bulge in the frequency spectrum, distinct from the higher harmonics. Finally, the relevance of our results for understanding ocean observations is discussed

Asymmetry Function of Interstellar Scintillations of Pulsars

A new method for separating intensity variations of a source's radio emission having various physical natures is proposed. The method is based on a joint analysis of the structure function of the intensity variations and the asymmetry function, which is a generalization of the asymmetry coefficient and characterizes the asymmetry of the distribution function of the intensity fluctuations on various scales for the inhomogeneities in the diffractive scintillation pattern. Relationships for the asymmetry function in the cases of a logarithmic normal distribution of the intensity fluctuations and a normal distribution of the field fluctuations are derived. Theoretical relationships and observational data on interstellar scintillations of pulsars (refractive, diffractive, and weak scintillations) are compared. Pulsar scintillations match the behavior expected for a normal distribution of the field fluctuations (diffractive scintillation) or logarithmic normal distribution of the intensity fluctuations (refractive and weak scintillation). Analysis of the asymmetry function is a good test for distinguishing scintillations against the background of variations that have different origins

Vision transformer models to measure solar irradiance using sky images in temperate climates

Solar Irradiance measurements are critical for a broad range of energy systems, including evaluating performance ratios of photovoltaic systems, as well as forecasting power generation. Using sky images to evaluate solar irradiance, allows for a low-cost, low-maintenance, and easy integration into Internet-of-things network, with minimal data loss. This work demonstrates that a vision transformer-based machine learning model can produce accurate irradiance estimates based on sky-images without any auxiliary data being used. The training data utilizes 17 years of global horizontal, diffuse and direct data, based on a high precision pyranometer and pyrheliometer sun-tracked system; in-conjunction with sky images from a standard lens and a fish-eye camera. The vision transformer-based model learns to attend to relevant features of the sky-images and to produce highly accurate estimates for both global horizontal irradiance (RMSE =52 W/m2) and diffuse irradiance (RMSE = 31 W/m2). This work compares the model's performance on wide field of view all-sky images as well as images from a standard camera and shows that the vision transformer model works best for all-sky images. For images from a normal camera both vision transformer and convolutional architectures perform similarly with the convolution-based architecture showing an advantage for direct irradiance with an RMSE of 155 W/m2

Solar Irradiance Anticipative Transformer

This paper proposes an anticipative transformer-based model for short-term solar irradiance forecasting. Given a sequence of sky images, our proposed vision transformer encodes features of consecutive images, feeding into a transformer decoder to predict irradiance values associated with future unseen sky images. We show that our model effectively learns to attend only to relevant features in images in order to forecast irradiance. Moreover, the proposed anticipative transformer captures long-range dependencies between sky images to achieve a forecasting skill of 21.45 % on a 15 minute ahead prediction for a newly introduced dataset of all-sky images when compared to a smart persistence model

A platform for the discovery of new macrolide antibiotics.

The chemical modification of structurally complex fermentation products, a process known as semisynthesis, has been an important tool in the discovery and manufacture of antibiotics for the treatment of various infectious diseases. However, many of the therapeutics obtained in this way are no longer effective, because bacterial resistance to these compounds has developed. Here we present a practical, fully synthetic route to macrolide antibiotics by the convergent assembly of simple chemical building blocks, enabling the synthesis of diverse structures not accessible by traditional semisynthetic approaches. More than 300 new macrolide antibiotic candidates, as well as the clinical candidate solithromycin, have been synthesized using our convergent approach. Evaluation of these compounds against a panel of pathogenic bacteria revealed that the majority of these structures had antibiotic activity, some efficacious against strains resistant to macrolides in current use. The chemistry we describe here provides a platform for the discovery of new macrolide antibiotics and may also serve as the basis for their manufacture

Diffuse reflection of a Bose-Einstein condensate from a rough evanescent wave mirror

We present experimental results showing the diffuse reflection of a Bose-Einstein condensate from a rough mirror, consisting of a dielectric substrate supporting a blue-detuned evanescent wave. The scattering is anisotropic, more pronounced in the direction of the surface propagation of the evanescent wave. These results agree very well with theoretical predictions.Comment: submitted to J Phys B, 10 pages, 6 figure

A Quantum-Mechanical Equivalent-Photon Spectrum for Heavy-Ion Physics

In a previous paper, we calculated the fully quantum-mechanical cross section for electromagnetic excitation during peripheral heavy-ion collisions. Here, we examine the sensitivity of that cross section to the detailed structure of the projectile and target nuclei. At the transition energies relevant to nuclear physics, we find the cross section to be weakly dependent on the projectile charge radius, and to be sensitive to only the leading momentum-transfer dependence of the target transition form factors. We exploit these facts to derive a quantum-mechanical ``equivalent-photon spectrum'' valid in the long-wavelength limit. This improved spectrum includes the effects of projectile size, the finite longitudinal momentum transfer required by kinematics, and the response of the target nucleus to the off-shell photon.Comment: 19 pages, 5 figure

Measurement of the electron electric dipole moment using GdIG

A new method for the detection of the electron edm using a solid is described. The method involves the measurement of a voltage induced across the solid by the alignment of the samples magnetic dipoles in an applied magnetic field, H. A first application of the method to GdIG has resulted in a limit on the electron edm of 5E-24 e-cm, which is a factor of 40 below the limit obtained from the only previous solid-state edm experiment. The result is limited by the imperfect discrimination of an unexpectedly large voltage that is even upon the reversal of the sample magnetization.Comment: 10 pages, 5 figures, v2:references corrected, submitted to PRL, v3:added labels to figure

Brewing of filter coffee

We report progress on mathematical modelling of coffee grounds in a drip filter coffee machine. The report focuses on the evolution of the shape of the bed of coffee grounds during extraction with some work also carried out on the chemistry of extraction. This work was sponsored by Philips who are interested in understanding an observed correlation between the final shape of the coffee grounds and the quality of the coffee. We used experimental data gathered by Philips and ourselves to identify regimes in the coffee brewing process and relevant regions of parameter space. Our work makes it clear that a number of separate processes define the shape of the coffee bed depending on the values of the parameters involved e.g. the size of the grains and the speed of fluid flow during extraction. We began work on constructing mathematical models of the redistribution of the coffee grounds specialised to each region and on a model of extraction. A variety of analytic and numerical tools were used. Furthermore our research has progressed far enough to allow us to begin to exploit connections between this problem and other areas of science, in particular the areas of sedimentology and geomorphology, where the processes we have observed in coffee brewing have been studied

Cannabidivarin is anticonvulsant in mouse and rat in vitro and in seizure models

Summary Background and purpose: Phytocannabinoids in Cannabis sativa have diverse pharmacological targets extending beyond cannabinoid receptors and several exert notable anticonvulsant effects. For the first time, we investigated the anticonvulsant profile of the phytocannabinoid cannabidivarin (CBDV) in vitro and in in vivo seizure models. Experimental approach: The effect of CBDV (1-100μM) on epileptiform local field potentials (LFPs) induced in rat hippocampal brain slices by 4-AP application or Mg2+-free conditions was assessed by in vitro multi-electrode array recordings. Additionally, the anticonvulsant profile of CBDV (50-200 mg kg-1) in vivo was investigated in four rodent seizure models: maximal electroshock (mES) and audiogenic seizures in mice, and pentylenetetrazole (PTZ) and pilocarpine-induced seizures in rat. CBDV effects in combination with commonly-used antiepileptic drugs were investigated in rat seizures. Finally, the motor side effect profile of CBDV was investigated using static beam and gripstrength assays. Key results: CDBV significantly attenuated status epilepticus-like epileptiform LFPs induced by 4-AP and Mg2+-free conditions. CBDV had significant anticonvulsant effects in mES (≥100 mg kg-1), audiogenic (≥50 mg kg-1) and PTZ-induced seizures (≥100 mg kg-1). CBDV alone had no effect against pilocarpine-induced seizures, but significantly attenuated these seizures when administered with valproate or phenobarbital at 200 mg kg-1 CBDV. CBDV had no effect on motor function. Conclusions and Implications: These results indicate that CBDV is an effective anticonvulsant across a broad range of seizure models, does not significantly affect normal motor function and therefore merits further investigation in chronic epilepsy models to justify human trials