1,466 research outputs found
Adjoint string breaking in the pseudoparticle approach
We apply the pseudoparticle approach to SU(2) Yang-Mills theory and perform a
detailed study of the potential between two static charges for various
representations. Whereas for charges in the fundamental representation we find
a linearly rising confining potential, we clearly observe string breaking, when
considering charges in the adjoint representation. We also demonstrate Casimir
scaling and compute gluelump masses for different spin and parity. Numerical
results are in qualitative agreement with lattice results.Comment: 9 pages, 6 figures; added reference
Preferential Myosin Heavy Chain Isoform B Expression May Contribute to the Faster Velocity of Contraction in Veins versus Arteries
Smooth muscle myosin heavy chains occur in 2 isoforms, SMA (slow) and SMB (fast). We hypothesized that the SMB isoform is predominant in the faster-contracting rat vena cava compared to thoracic aorta. We compared the time to half maximal contraction in response to a maximal concentration of endothelin-1 (ET-1; 100 nM), potassium chloride (KCl; 100 mM) and norepinephrine (NE; 10 ”M). The time to half maximal contraction was shorter in the vena cava compared to aorta (aorta: ET-1 = 235.8 ± 13.8 s, KCl = 140.0 ± 33.3 s, NE = 19.8 ± 2.7 s; vena cava: ET-1 = 121.8 ± 15.6 s, KCl = 49.5 ± 6.7 s, NE = 9.0 ± 3.3 s). Reverse-transcription polymerase chain reaction supported the greater expression of SMB in the vena cava compared to aorta. SMB was expressed to a greater extent than SMA in the vessel wall of the vena cava. Western analysis determined that expression of SMB, relative to total smooth muscle myosin heavy chains, was 12.5 ± 4.9-fold higher in the vena cava compared to aorta, while SMA was 4.9 ± 1.2-fold higher in the aorta than vena cava. Thus, the SMB isoform is the predominant form expressed in rat veins, providing one possible mechanism for the faster response of veins to vasoconstrictors
On the halide hydration study: Development of first-principles halide ion-water interaction potential based on a polarizable model
The development of first-principles halide-water interaction potentials for fluoride and iodide anions is presented. The model adopted is the mobile charge densities in harmonic oscillator that allows for a flexible and polarizable character of the interacting particles. The set of points of the quantum mechanical potential energy surfaces are calculated up to the MP2 level. The nonadditive many-body contributions were included explicitly at the three-body terms. Structural and energetic properties of the [ X(H2O)n ]- clusters (n=1 â 6) are studied with the new interaction potentials developed. Halide aqueous solutions are also studied by means of Monte Carlo simulations. The agreement between experimental and our predicted estimations shows the good behavior of the proposed potentials. The developed potentials are able to properly describe both the microsolvation of clusters in gas phase and their hydration in aqueous solutions. The different nature of the interactions among F-, Br-, I- and water appears in the set of studied properties, thus giving a gradual change in the behavior along the group.DirecciĂłn General de Investigaciones CientĂficas y TĂ©cnicas BQU2002-0221
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Gut thinking: the gut microbiome and mental health beyond the head
Background: In recent decades, dominant models of mental illness have become increasingly focused on the head, with mental disorders being figured as brain disorders. However, research into the active role that the microbiome-gut-brain axis plays in affecting mood and behaviour may lead to the conclusion that mental health is more than an internalised problem of individual brains.
Objective: This article explores the implications of shifting understandings about mental health that have come about through research into links between the gut microbiome and mental health problems such as depression and anxiety. It aims to analyse the different ways that the lines between mind and body and mental and physical health are re-shaped by this research, which is starting to inform clinical and public understanding.
Design: As mental health has become a pressing issue of political and public concern it has become increasingly constructed in socio-cultural and personal terms beyond clinical spaces, requiring a conceptual response that exceeds biomedical inquiry. This article argues that an interdisciplinary critical medical humanities approach is well positioned to analyse the impact of microbiome-gut-brain research on conceptions of mind.
Results: The entanglement of mind and matter evinced by microbiome-gut-brain axis research potentially provides a different way to conceptualise the physical and social concomitants of mental distress.
Conclusion: Mental health is not narrowly located in the head but is assimilated by the physical body and intermingled with the natural world, requiring different methods of research to unfold the meanings and implications of gut thinking for conceptions of human selfhood
'The world is full of big bad wolves': investigating the experimental therapeutic spaces of R.D. Laing and Aaron Esterson
In conjunction with the recent critical assessments of the life and work of R.D. Laing, this paper seeks to demonstrate what is revealed when Laingâs work on families and created spaces of mental health care are examined through a geographical lens. The paper begins with an exploration of Laingâs time at the Tavistock Clinic in London during the 1960s, and of the co-authored text with Aaron Esterson entitled, Sanity, Madness and the Family (1964). The study then seeks to demonstrate the importance Laing and his colleague placed on the time-space situatedness of patients and their worlds. Finally, an account is provided of Laingâs and Estersonâs spatial thinking in relation to their creation of both real and imagined spaces of therapeutic care
Psychopolitics: Peter Sedgwickâs legacy for mental health movements
This paper re-considers the relevance of Peter Sedgwick's Psychopolitics (1982) for a politics of mental health. Psychopolitics offered an indictment of âanti-psychiatryâ the failure of which, Sedgwick argued, lay in its deconstruction of the category of âmental illnessâ, a gesture that resulted in a politics of nihilism. âThe radical who is only a radical nihilistâ, Sedgwick observed, âis for all practical purposes the most adamant of conservativesâ. Sedgwick argued, rather, that the concept of âmental illnessâ could be a truly critical concept if it was deployed âto make demands upon the health service facilities of the society in which we liveâ. The paper contextualizes Psychopolitics within the âcrisis tendenciesâ of its time, surveying the shifting welfare landscape of the subsequent 25 years alongside Sedgwick's continuing relevance. It considers the dilemma that the discourse of âmental illnessâ â Sedgwick's critical concept â has fallen out of favour with radical mental health movements yet remains paradigmatic within psychiatry itself. Finally, the paper endorses a contemporary perspective that, while necessarily updating Psychopolitics, remains nonetheless âSedgwickianâ
Estimating Eigenenergies from Quantum Dynamics: A Unified Noise-Resilient Measurement-Driven Approach
Ground state energy estimation in physics and chemistry is one of the most
promising applications of quantum computing. In this paper, we introduce a
novel measurement-driven approach that finds eigenenergies by collecting
real-time measurements and post-processing them using the machinery of dynamic
mode decomposition (DMD). We provide theoretical and numerical evidence that
our method converges rapidly even in the presence of noise and show that our
method is isomorphic to matrix pencil methods developed independently across
various scientific communities. Our DMD-based strategy can systematically
mitigate perturbative noise and stands out as a promising hybrid
quantum-classical eigensolver
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