A chemically driven fluctuating ratchet model for actomyosin interaction

With reference to the experimental observations by T. Yanagida and his co-workers on actomyosin interaction, a Brownian motor of fluctuating ratchet kind is designed with the aim to describe the interaction between a Myosin II head and a neighboring actin filament. Our motor combines the dynamics of the myosin head with a chemical external system related to the ATP cycle, whose role is to provide the energy supply necessary to bias the motion. Analytical expressions for the duration of the ATP cycle, for the Gibbs free energy and for the net displacement of the myosin head are obtained. Finally, by exploiting a method due to Sekimoto (1997, J. Phys. Soc. Jpn., 66, 1234), a formula is worked out for the amount of energy consumed during the ATP cycle.Comment: 15 pages. 1 figur

Magnetization curve of the kagome-strip-lattice antiferromagnet

We study the magnetization curve of the Heisenberg model on the quasi-one-dimensional kagome-strip lattice that shares the same lattice structure in the inner part with the two-dimensional kagome lattice. Our numerical calculations based on the density matrix renormalization group method reveal that the system shows several magnetization plateaus between zero magnetization and the saturated one; we find the presence of the magnetic plateaus with the n=7 height of the saturation for n =1,2,3,4,5 and 6 in the S =1/2 case, whereas we detect only the magnetic plateaus of n =1,3,5 and 6 in the S =1 case. In the cases of n =2,4 and 6 for the S=1/2 system, the Oshikawa-Yamanaka-Affleck condition suggests the occurrence of the translational symmetry breaking (TSB). We numerically confirm this non-trivial TSB in our results of local magnetizations. We have also found that the macroscopic jump appears near the saturation field irrespective of the spin amplitude as well as the two-dimensional kagome model.Comment: 6pages, 3figures, accepted for publication in Journal of Low Temperature Physic

Characterization of Knots and Links Arising From Site-specific Recombination on Twist Knots

We develop a model characterizing all possible knots and links arising from recombination starting with a twist knot substrate, extending previous work of Buck and Flapan. We show that all knot or link products fall into three well-understood families of knots and links, and prove that given a positive integer $n$, the number of product knots and links with minimal crossing number equal to $n$ grows proportionally to $n^5$. In the (common) case of twist knot substrates whose products have minimal crossing number one more than the substrate, we prove that the types of products are tightly prescribed. Finally, we give two simple examples to illustrate how this model can help determine previously uncharacterized experimental data.Comment: 32 pages, 7 tables, 27 figures, revised: figures re-arranged, and minor corrections. To appear in Journal of Physics

Demonstration of unconditional one-way quantum computations for continuous variables

Quantum computing promises to exploit the laws of quantum mechanics for processing information in ways fundamentally different from today's classical computers, leading to unprecedented efficiency. One-way quantum computation, sometimes referred to as the cluster model of quantum computation, is a very promising approach to fulfil the capabilities of quantum information processing. The cluster model is realizable through measurements on a highly entangled cluster state with no need for controlled unitary evolutions. Here we demonstrate unconditional one-way quantum computation experiments for continuous variables using a linear cluster state of four entangled optical modes. We implement an important set of quantum operations, linear transformations, in the optical phase space through one-way computation. Though not sufficient, these are necessary for universal quantum computation over continuous variables, and in our scheme, in principle, any such linear transformation can be unconditionally and deterministically applied to arbitrary single-mode quantum states.Comment: 9 pages, 3 figure

Ferrimagnetism of the Heisenberg Models on the Quasi-One-Dimensional Kagome Strip Lattices

We study the ground-state properties of the S=1/2 Heisenberg models on the quasi-onedimensional kagome strip lattices by the exact diagonalization and density matrix renormalization group methods. The models with two different strip widths share the same lattice structure in their inner part with the spatially anisotropic two-dimensional kagome lattice. When there is no magnetic frustration, the well-known Lieb-Mattis ferrimagnetic state is realized in both models. When the strength of magnetic frustration is increased, on the other hand, the Lieb-Mattis-type ferrimagnetism is collapsed. We find that there exists a non-Lieb-Mattis ferrimagnetic state between the Lieb-Mattis ferrimagnetic state and the nonmagnetic ground state. The local magnetization clearly shows an incommensurate modulation with long-distance periodicity in the non-Lieb-Mattis ferrimagnetic state. The intermediate non-Lieb-Mattis ferrimagnetic state occurs irrespective of strip width, which suggests that the intermediate phase of the two-dimensional kagome lattice is also the non-Lieb-Mattis-type ferrimagnetism.Comment: 9pages, 11figures, accepted for publication in J. Phys. Soc. Jp

Upper Cervical Spine Trauma: WFNS Spine Committee Recommendations

Craniovertebral junction (CVJ) trauma is a challenging clinical condition. Being a highly mobile functional unit at the junction of the skull and the vertebral column, traumatic events in this area may produce devastating neurological complications and death. Additionally, many of the CVJ traumatic injuries can be left undiagnosed or even raise difficult treatment dilemmas. We present a literature review in the format of recommendations on the diagnosis and management of different scenarios for upper cervical trauma and produce recommendations, which can be applicable to various areas of the globe.info:eu-repo/semantics/publishedVersio

Li+D Reaction in Pd and Au for 30<E_d<75 keV(I. Nuclear Physics)

Thick target yields of α particles emitted in the ^Li (d, α) ^He reactions in PdLi_x and AuLi_x were measured as a function of the bombarding energy between 30 and 75 keV. It was found that the reaction rate in Pd at lower energies is enhanced strongly over the one predicted by the cross section for the reaction with bare nuclei, but no enhancement is observed in Au. A screening energy is introduced to reproduce the excitation function of the thick target yield for each metal. The deduced value for Pd amounts to 1500±310 eV, whereas it is only 60±150 eV for Au. The enhancement in the Pd case cannot be explained by electron screening alone but suggests the existence of an additional and important mechanism of screening in metal

Synchronization of uncoupled oscillators by common gamma impulses: from phase locking to noise-induced synchronization

Nonlinear oscillators can mutually synchronize when they are driven by common external impulses. Two important scenarios are (i) synchronization resulting from phase locking of each oscillator to regular periodic impulses and (ii) noise-induced synchronization caused by Poisson random impulses, but their difference has not been fully quantified. Here we analyze a pair of uncoupled oscillators subject to common random impulses with gamma-distributed intervals, which can be smoothly interpolated between regular periodic and random Poisson impulses. Their dynamics are charac- terized by phase distributions, frequency detuning, Lyapunov exponents, and information-theoretic measures, which clearly reveal the differences between the two synchronization scenarios.Comment: 18 page

Ethyl pyruvate improves pulmonary function in mice with bleomycin-induced lung injury as monitored with hyperpolarized 129Xe MR imaging

Purpose: High Mobility Group Box1 (HMGB1), which is one of the damage-associated molecular pattern molecules relating to various inflammatory diseases, has gained interest as a therapeutic target because of its involvement in wound healing processes. In the present study, we investigated HMGB1 as a potential therapeutic target in a model of lung fibrosis using a preclinical hyperpolarized 129Xe (HPXe) MRI system. Methods: Lung injury was induced by intra-peritoneal injection of bleomycin (BLM) in 19 mice. Three weeks post-injection (when fibrosis was confirmed histologically), administration of ethyl pyruvate (EP) and alogliptin (ALG), which are down- and up-regulators of HMGB1, respectively, was commenced in six and seven of the 19 mice, respectively, and continued for a further 3 weeks. A separate sham-instilled group was formed of five mice, which were administered with saline for 6 weeks. Over the second 3-week period, the effects of disease progression and pharmacological therapy in the four groups of mice were monitored by HPXe MRI metrics of fractional ventilation and gas-exchange function. Results: Gas-exchange function in BLM mice was significantly reduced after 3 weeks of BLM challenge compared to sham-instilled mice (P < 0.05). Ethyl pyruvate was found to improve HPXe MRI metrics of both ventilation and gas exchange, and repair tissue damage (assessed histologically), to a similar level as sham-instilled mice (P < 0.05), whilst ALG treatment caused no significant improvement of pulmonary function. Conclusion: This study demonstrates the down-regulator of HMGB1, EP, as a potential therapeutic agent for pulmonary fibrosis, as assessed by a non-invasive HPXe MRI protocol