1,155 research outputs found
The 21-SPONGE HI Absorption Survey I: Techniques and Initial Results
We present methods and results from "21-cm Spectral Line Observations of
Neutral Gas with the EVLA" (21-SPONGE), a large survey for Galactic neutral
hydrogen (HI) absorption with the Karl G. Jansky Very Large Array (VLA). With
the upgraded capabilities of the VLA, we reach median root-mean-square (RMS)
noise in optical depth of per
channel for the 31 sources presented here. Upon
completion, 21-SPONGE will be the largest HI absorption survey with this high
sensitivity. We discuss the observations and data reduction strategies, as well
as line fitting techniques. We prove that the VLA bandpass is stable enough to
detect broad, shallow lines associated with warm HI, and show that bandpass
observations can be combined in time to reduce spectral noise. In combination
with matching HI emission profiles from the Arecibo Observatory (
angular resolution), we estimate excitation (or spin) temperatures ()
and column densities for Gaussian components fitted to sightlines along which
we detect HI absorption (30/31). We measure temperatures up to for individual lines, showing that we can probe the
thermally unstable interstellar medium (ISM) directly. However, we detect fewer
of these thermally unstable components than expected from previous
observational studies. We probe a wide range in column density between
and for individual HI clouds. In addition,
we reproduce the trend between cold gas fraction and average found by
synthetic observations of a hydrodynamic ISM simulation by Kim et al. (2014).
Finally, we investigate methods for estimating HI and discuss their
biases.Comment: Accepted for publication in ApJ; 24 pages, 14 figure
A GBT Survey of the HALOGAS Galaxies and Their Environments I: Revealing the full extent of HI around NGC891, NGC925, NGC4414 & NGC4565
We present initial results from a deep neutral hydrogen (HI) survey of the
HALOGAS galaxy sample, which includes the spiral galaxies NGC891, NGC925,
NGC4414, and NGC4565, performed with the Robert C. Byrd Green Bank Telescope
(GBT). The resulting observations cover at least four deg around these
galaxies with an average 5 detection limit of 1.210
cm over a velocity range of 20 km s and angular scale of 9.1.
In addition to detecting the same total flux as the GBT data, the spatial
distribution of the GBT and original Westerbork Synthesis Radio Telescope
(WSRT) data match well at equal spatial resolutions. The HI mass fraction below
HI column densities of 10 cm is, on average, 2\%. We discuss the
possible origins of low column density HI of nearby spiral galaxies. The
absence of a considerable amount of newly detected HI by the GBT indicates
these galaxies do not have significant extended diffuse HI structures, and
suggests future surveys planned with the SKA and its precursors must go
\textit{at least} as deep as 10 cm in column density to
significantly increase the probability of detecting HI associated with the
cosmic web and/or cold mode accretion.Comment: Accepted for publication in The Astrophysical Journal; 28 pages, 15
figure
Collinear helium under periodic driving: stabilization of the asymmetric stretch orbit
The collinear eZe configuration of helium, with the electrons on opposite
sides of the nucleus, is studied in the presence of an external electromagnetic
(laser or microwave) field. We show that the classically unstable "asymmetric
stretch" orbit, on which doubly excited intrashell states of helium with
maximum interelectronic angle are anchored, can be stabilized by means of a
resonant driving where the frequency of the electromagnetic field equals the
frequency of Kepler-like oscillations along the orbit. A static magnetic field,
oriented parallel to the oscillating electric field of the driving, can be used
to enforce the stability of the configuration with respect to deviations from
collinearity. Quantum Floquet calculations within a collinear model of the
driven two-electron atom reveal the existence of nondispersive wave packets
localized on the stabilized asymmetric stretch orbit, for double excitations
corresponding to principal quantum numbers of the order of N > 10.Comment: 13 pages, 12 figure
Local biochemical and morphological differences in human Achilles tendinopathy: a case control study
<p>Abstract</p> <p>Background</p> <p>The incidence of Achilles tendinopathy is high and underlying etiology as well as biochemical and morphological pathology associated with the disease is largely unknown. The aim of the present study was to describe biochemical and morphological differences in chronic Achilles tendinopathy. The expressions of growth factors, inflammatory mediators and tendon morphology were determined in both chronically diseased and healthy tendon parts.</p> <p>Methods</p> <p>Thirty Achilles tendinopathy patients were randomized to an expression-study (<it>n </it>= 16) or a structural-study (<it>n </it>= 14). Biopsies from two areas in the Achilles tendon were taken and structural parameters: fibril density, fibril size, volume fraction of cells and the nucleus/cytoplasm ratio of cells were determined. Further gene expressions of various genes were analyzed.</p> <p>Results</p> <p>Significantly smaller collagen fibrils and a higher volume fraction of cells were observed in the tendinopathic region of the tendon. Markers for collagen and its synthesis collagen 1, collagen 3, fibronectin, tenascin-c, transforming growth factor-β fibromodulin, and markers of collagen breakdown matrix metalloproteinase-2, matrix metalloproteinase-9 and metallopeptidase inhibitor-2 were significantly increased in the tendinopathic region. No altered expressions of markers for fibrillogenesis, inflammation or wound healing were observed.</p> <p>Conclusion</p> <p>The present study indicates that an increased expression of factors stimulating the turnover of connective tissue is present in the diseased part of tendinopathic tendons, associated with an increased number of cells in the injured area as well as an increased number of smaller and thinner fibrils in the diseased tendon region. As no fibrillogenesis, inflammation or wound healing could be detected, the present data supports the notion that tendinopathy is an ongoing degenerative process.</p> <p>Trial registration</p> <p>Current Controlled Trials <a href="http://www.controlled-trials.com/ISRCTN20896880">ISRCTN20896880</a></p
Miocene surface uplift and orogenic evolution of the southern Andean Plateau (central Puna), northwestern Argentina
We present stable hydrogen-isotope analyses of volcanic glass (δDg) and radiometric ages (U–Pb zircon, U–Th calcite, AMS14C) from deformed sedimentary deposits in the vicinity of the intermontane Pocitos Basin in the central Puna of the Andean Plateau at about 24.5°S. Our results demonstrate 2-km surface uplift since the middle to late Miocene and protracted shortening that persists until the present day, while other sectors of the Puna show evidence for tectonically neutral and/or extensional settings. These findings are at odds with previous studies suggesting near-modern elevations (4 km) of the Puna Plateau since the late Eocene and formation of the intermontane Miocene Arizaro-Pocitos Basin associated with gravitational foundering of a dense lithosphere. Geophysical and geochemical data support the removal of continental lithosphere beneath the Puna, but the timing and mechanisms by which this removal occurs have remained controversial. We hypothesize that intermontane basin formation in the central Puna is the result of crustal shortening since about 20 Ma, followed by rapid surface uplift, likely related to lithospheric delamination
Dysregulated NK cell PLCγ2 signaling and activity in juvenile dermatomyositis
Juvenile dermatomyositis (JDM) is a debilitating pediatric autoimmune disease manifesting with characteristic rash and muscle weakness. To delineate signaling abnormalities in JDM, mass cytometry was performed with PBMCs from treatment-naive JDM patients and controls. NK cell percentages were lower while frequencies of naive B cells and naive CD4+ T cells were higher in JDM patients than in controls. These cell frequency differences were attenuated with cessation of active disease. A large number of signaling differences were identified in treatment-naive JDM patients compared with controls. Classification models incorporating feature selection demonstrated that differences in phospholipase Cγ2 (PLCγ2) phosphorylation comprised 10 of 12 features (i.e., phosphoprotein in a specific immune cell subset) distinguishing the 2 groups. Because NK cells represented 5 of these 12 features, further studies focused on the PLCγ2 pathway in NK cells, which is responsible for stimulating calcium flux and cytotoxic granule movement. No differences were detected in upstream signaling or total PLCγ2 protein levels. Hypophosphorylation of PLCγ2 and downstream mitogen-activated protein kinase-activated protein kinase 2 were partially attenuated with cessation of active disease. PLCγ2 hypophosphorylation in treatment-naive JDM patients resulted in decreased calcium flux. The identification of dysregulation of PLCγ2 phosphorylation and decreased calcium flux in NK cells provides potential mechanistic insight into JDM pathogenesis
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