The determinants of foreign direct investment: a panel data study for the OECD countries

This study examines panel data evidence concerning empirical relevance between Foreign Direct Investment (FDI) attraction and its determinative effects. The main bulk of FDI is among the developed countries. Indeed, OECD countries has probably been the most potential group in undertaking FDI by caring out about 95% of the total outward FDI while, on average, 75% of the world FDI was directed into OECD countries. In this paper, we first present and analyse the theoretical/empirical findings on FDI, then we focus on assessing the relative significance of the factors that may attract FDI via a panel data regression analysis for a sample consisting of 20 OECD countries for 23 years (1975-1997). Our findings suggest that certain variables such as human capital and trade regime, as well as, the density of infrastructure appear to be robust under different specifications. Positive significance of the agglomeration factor is also observed, confirming the relevant theoretical propositions. However certain deferential variables, such as the governmental policy effect, could not be fully captured due to the statistical homogeneity of the sample

Tsunami vulnerability assessment and its implications for coastal hazard analysis and disaster management planning, Gulf of Corinth, Greece

International audienceWe apply a new tsunami vulnerability assessment method to two coastal villages in the Gulf of Corinth, Greece using the 7th February 1963 tsunami as a worse case scenario. In Akoli, 46.5% of all buildings are classified highly vulnerable (BV). Approximately, 26.3% of all households are located within buildings with a High BV classification whereas 85% of all businesses are located within buildings with a High BV classification and 13.7% of the population is located within buildings with a High BV classification. In Selianitika, 28.8% of all buildings are classified with a High BV and 11% of all households are located within buildings with a High BV classification. Also 29.3% of all businesses and 33.4% of all services are located within buildings with a High BV classification and 6.7% of the population is located within buildings with a High BV classification. We estimate the minimum costs of a hypothetical tsunami with a wave run-up (H(m)max) of + 5 m. The results are considered significant because they have important implications for coastal risk assessment, resource allocation and disaster management planning

Elements at risk as a framework for assessing the vulnerability of communities to landslides

International audienceThe assessment of the vulnerability of communities prone to landslide related disasters is a topic that is growing in importance. Few studies discuss this issue and limited research has been carried out on the relationship between types of landslide and their potential impact on buildings and infrastructure. We outline a framework to undertake an assessment of the vulnerability of buildings to landslide utilising a similar framework used for assessing the vulnerability of buildings to tsunami damage. The framework is based on the development of an "elements at risk database" that takes into consideration the characteristics and use of the buildings, their importance for the local economy and the characteristics of the inhabitants (population density, age and so forth). The attributes that affect vulnerability are imported and examined within a GIS database which is used to visualise the physical, human and economic vulnerability. The results may have important implications for disaster management and emergency planning, and the database can be used by various end-users and stakeholders such as insurance companies, local authorities and the emergency services. The approach presented here can be integrated in to a wider more detailed "Framework for Landslide Risk and Vulnerability Assessment for Communities". We illustrate the potential of this framework and present preliminary results from Lichtenstein, Baden Württemberg, Germany

Genetic Variants of Surfactant Proteins A, B, C, and D in Bronchopulmonary Dysplasia

BPD_28D (O2 dependency at 28 days of life) and BPD_36W (O2 dependency at 36 wks post-menstrual age) are diseases of prematurely born infants exposed to mechanical ventilation and/or oxygen supplementation. In order to determine whether genetic variants of surfactant proteins (SPs-A, B, C, and D) and SP-B-linked microsatellite markers are risk factors in BPD, we performed a family based association study using a Greek study group of 71 neonates (<30 wks gestational age) from 60 families with, 52 BPD_28D and 19 BPD_36W, affected infants. Genotyping was performed using newly designed pyrosequencing assays and previously published methods. Associations between genetic variants of SPs and BPD subgroups were determined using Transmission Disequilibrium Test (TDT) and Family Based Association Test (FBAT). Significant associations (p ≤ 0.01) were observed for alleles of SP-B and SP-B-linked microsatellite markers, and haplotypes of SP-A, SP-D, and SP-B. Specifically, allele B-18_C associated with susceptibility in BPD_36W. Microsatellite marker AAGG_6 associated with susceptibility in BPD_28D/36W group. Haplotype analysis revealed ten susceptibility and one protective haplotypes for SP-B and SP-B-linked microsatellite markers and two SP-A-SP-D protective haplotypes. The data indicate that SP loci are linked to BPD. Studies in different study groups and/or of larger sample size are warranted to confirm these observations and delineate genetic background of BPD subgroups

Matrix metalloproteinases 2 and 9 (gelatinases A and B) expression in malignant mesothelioma and benign pleura

Matrix metalloproteinases (MMPs), in particular the gelatinases (MMP-2 and -9), play a significant role in tumour invasion and angiogenesis. The expression and activities of MMPs have not been characterised in malignant mesothelioma (MM) tumour samples. In a prospective study, gelatinase activity was evaluated in homogenised supernatants of snap frozen MM (n = 35), inflamed pleura (IP, n = 12) and uninflammed pleura (UP, n = 14) tissue specimens by semiquantitative gelatin zymography. Matrix metalloproteinases were correlated with clinicopathological factors and with survival using Kaplan-Meier and Cox proportional hazard models. In MM, pro- and active MMP-2 levels were significantly greater than for MMP-9 (P = 0.006, P<0.001). Active MMP-2 was significantly greater in MM than in UP (P=0.04). MMP-2 activity was equivalent between IP and MM, but both pro- and active MMP-9 activities were greater in IP (P=0.02, P=0.009). While there were trends towards poor survival with increasing total and pro-MMP-2 activity (P=0.08) in univariate analysis, they were both independent poor prognostic factors in multivariate analysis in conjunction with weight loss (pro-MMP-2 P = 0.03, total MMP-2 P = 0.04). Total and pro-MMP-2 also contributed to the Cancer and Leukemia Group B prognostic groups. MMP-9 activities were not prognostic. Matrix metalloproteinases, and in particular MMP-2, the most abundant gelatinase, may play an important role in MM tumour growth and metastasis. Agents that reduce MMP synthesis and/or activity may have a role to play in the management of MM. © 2003 Cancer Research UK