Recent results and future prospects for the MINOS experiment

The MINOS experiment uses the intense NuMI beam created at Fermilab and two magnetized tracking calorimeters, one located at Fermilab and one located 735km away at the Soudan Mine in Minnesota, to study lepton-flavor violation in the neutrino sector. We present results of the precise measurement of the atmospheric neutrino oscillation parameters, from the search for sterile neutrinos and from the search for the θ13 mixing angle by searching for νe appearance in the νμ beam. Future prospects for measurements by MINOS will also be discussed

Recent results and future prospects for the MINOS experiment

The MINOS experiment uses the intense NuMI beam created at Fermilab and two magnetized tracking calorimeters, one located at Fermilab and one located 735km away at the Soudan Mine in Minnesota, to study lepton-flavor violation in the neutrino sector. We present results of the precise measurement of the atmospheric neutrino oscillation parameters, from the search for sterile neutrinos and from the search for the θ13 mixing angle by searching for νe appearance in the νμ beam. Future prospects for measurements by MINOS will also be discussed

Temporal and dimensional effects in evolutionary graph theory

The spread in time of a mutation through a population is studied analytically and computationally in fully-connected networks and on spatial lattices. The time, t_*, for a favourable mutation to dominate scales with population size N as N^{(D+1)/D} in D-dimensional hypercubic lattices and as N ln N in fully-connected graphs. It is shown that the surface of the interface between mutants and non-mutants is crucial in predicting the dynamics of the system. Network topology has a significant effect on the equilibrium fitness of a simple population model incorporating multiple mutations and sexual reproduction. Includes supplementary information.Comment: 6 pages, 4 figures Replaced after final round of peer revie

The Pathway Tools cellular overview diagram and Omics Viewer

The Pathway Tools cellular overview diagram is a visual representation of the biochemical network of an organism. The overview is automatically created from a Pathway/Genome Database describing that organism. The cellular overview includes metabolic, transport and signaling pathways, and other membrane and periplasmic proteins. Pathway Tools supports interrogation and exploration of cellular biochemical networks through the overview diagram. Furthermore, a software component called the Omics Viewer provides visual analysis of whole-organism datasets using the overview diagram as an organizing framework. For example, gene expression and metabolomics measurements, alone or in combination, can be painted onto the overview, as can computed whole-organism datasets, such as predicted reaction-flux values. The cellular overview and Omics Viewer provide a mechanism whereby biologists can apply the pattern-recognition capabilities of the human visual system to analyze large-scale datasets in a biologically meaningful context. SRI's BioCyc.org website provides overview diagrams for more than 200 organisms. This article describes enhancements to the overview made since a 1999 publication, including the automatic layout capability, expansion of the cellular machinery that it includes, new semantic zooming and poster-generating capabilities, and extension of the Omics Viewer to support painting of metabolites, animations and zooming to individual pathway diagrams

Intraocular human cytomegaloviruses of ocular diseases are distinct from those of viremia and are capable of escaping from innate and adaptive immunity by exploiting HLA-E-mediated peripheral and central tolerance

Human cytomegalovirus (HCMV) infections develop into CMV diseases that result in various forms of manifestations in local organs. CMV-retinitis is a form of CMV disease that develops in immunocompromised hosts with CMV-viremia after viruses in the peripheral circulation have entered the eye. In the HCMV genome, extensive diversification of the UL40 gene has produced peptide sequences that modulate NK cell effector functions when loaded onto HLA-E and are subsequently recognized by the NKG2A and NKG2C receptors. Notably, some HCMV strains carry UL40 genes that encode peptide sequences identical to the signal peptide sequences of specific HLA-A and HLA-C allotypes, which enables these CMV strains to escape HLA-E-restricted CD

Evidence for Rapid Oxidative Phosphorylation and Lactate Fermentation in Motile Human Sperm by Hyperpolarized 13C Magnetic Resonance Spectroscopy

Poor sperm motility is a common cause of male infertility for which there are no empirical therapies. Sperm motility is powered by adenosine triphosphate but the relative importance of lactate fermentation and Oxidative Phosphorylation (OxPhos) is debated. To study the relationship between energy metabolism and sperm motility we used dissolution Dynamic Nuclear Polarization (dDNP) for the first time to show the rapid conversion of 13C1-pyruvate to lactate and bicarbonate, indicating active glycolytic and OxPhos metabolism in sperm. The magnitude of both lactate and bicarbonate signals were positively correlated with the concentration of progressively motile sperm. After controlling for sperm concentration, increased progressive sperm motility generated more pyruvate conversion to lactate and bicarbonate. The technique of dDNP allows ‘snapshots’ of sperm metabolism to be tracked over the different stages of their life. This may provide help to uncover the causes of poor sperm motility and suggest new approaches for novel treatments or therapies

Recent Results and Future Prospects from MINOS

The MINOS experiment uses the intense NuMI beam created at Fermilab and two magnetized tracking calorimeters, one located at Fermilab and one located 735 km away at the Soudan Mine in Minnesota, to make precise measurements of {nu}{sub {mu}} disappearance oscillation parameters. We present recent results from the first two years of NuMI beam operations, including the precise measurement of the atmospheric neutrino oscillation parameters and the search for sterile neutrinos. Future prospects for MINOS will also be discussed, including an improved limit on the {theta}{sub 13} mixing angle by searching for {nu}{sub e} appearance in the {nu}{sub {mu}} beam

The Late Time Behavior of False Vacuum Decay: Possible Implications for Cosmology and Metastable Inflating States

We describe here how the late time behavior of the decaying states, which is predicted to deviate from an exponential form, while normally of insignificant consequence, may have important cosmological implications in the case of false vacuum decay. It may increase the likelihood of eternal inflation, and may help explain the likelihood of observing a small vacuum energy at late times, as well as arguing against decay into a large negative energy (anti-de Sitter space), vacuum state as has been motivated by some string theory considerations. Several interesting open questions are raised, including whether observing the cosmological configuration of a metastable universe can constrain its inferred lifetime.Comment: 4 pages, submitted to PRL, one reference changed, and changes to abstract and concluding sentences to stem possible confusions regarding observation and metastabilit

Task-Specific Ionic Liquids for Mars Exploration (Green Chemistry for a Red Planet)

Ionic Liquids (ILs) are organic salts with low melting points that are liquid at or near room temperature. The combinations of available ions and task-specific molecular designability make them suitable for a huge variety of tasks. Because of their low flammability, low vapor pressure, and stability in harsh environments (extreme temperatures, hard vacuum) they are generally much safer and "greener" than conventional chemicals and are thus suitable for a wide range of applications that support NASA exploration goals. This presentation describes several of the ongoing applications that are being developed at MSFC