Kaluza-Klein gauge and minimal integrable extension of OSp(4|6)/(SO(1,3) x U(3)) sigma-model

Basing upon experience from performing double-dimensional reduction of the D=11 supermembrane on AdS_4 x S^7 background to Type IIA superstring on AdS_4 x CP^3 we introduce Kaluza-Klein (partial) kappa-symmetry gauge as a vanishing condition of the contribution to the D=11 supervielbein components tangent to D=10 space-time proportional to the differential of the coordinate parametrizing compact 11-th space-time dimension, that is identified with the supermembrane world-volume compact dimension. For AdS_4 x S^7 supermembrane Kaluza-Klein gauge removes half Grassmann coordinates associated with 8 space-time supersymmetries, broken by the AdS_4 x CP^3 superbackground, by imposing D=3 (anti-)Majorana condition on them. The consideration relies on the realization of osp(4|8) isometry superalgebra of the AdS_4 x S^7 superbackground as D=3 N=8 superconformal algebra. Requiring further vanishing of the D=10 dilaton leaves in the sector of broken supersymmetries just two Grassmann coordinates organized into D=3 (anti-)Majorana spinor that defines minimal SL(2,R)-covariant extension of the OSp(4|6)/(SO(1,3)x U(3)) sigma-model. Among 4 possibilities of such a minimal extension we consider in detail one, that corresponds to picking out D=3 Majorana coordinate related to broken Poincare supersymmetry, and show that the AdS_4 x CP^3 superstring equations of motion in this partial kappa-symmetry gauge are integrable. Also the relation between the OSp(4|6)/(SO(1,3) x U(3)) sigma-model and the AdS_4 x CP^3 superstring is revisited.Comment: LaTeX, 22 pages; v2: minor improvements in the text, typos corrected, references adde

Evaluation of the Efficacy and Safety of a Marine-Derived Bacillus Strain for Use as an In-Feed Probiotic for Newly Weaned Pigs

peer-reviewedForty eight individual pigs (8.7±0.26 kg) weaned at 28±1 d of age were used in a 22-d study to evaluate the effect of oral administration of a Bacillus pumilus spore suspension on growth performance and health indicators. Treatments (n = 16) were: (1) non-medicated diet; (2) medicated diet with apramycin (200 mg/kg) and pharmacological levels of zinc oxide (2,500 mg zinc/kg) and (3) B. pumilus diet (non-medicated diet + 1010 spores/day B. pumilus). Final body weight and average daily gain tended to be lower (P = 0.07) and feed conversion ratio was worsened (P<0.05) for the medicated treatment compared to the B. pumilus treatment. Ileal E. coli counts were lower for the B. pumilus and medicated treatments compared to the non-medicated treatment (P<0.05), perhaps as a result of increased ileal propionic acid concentrations (P<0.001). However, the medicated treatment reduced fecal (P<0.001) and cecal (P<0.05) Lactobacillus counts and tended to reduce the total cecal short chain fatty acid (SCFA) concentration (P = 0.10). Liver weights were lighter and concentrations of liver enzymes higher (P<0.05) in pigs on the medicated treatment compared to those on the non-medicated or B. pumilus treatments. Pigs on the B. pumilus treatment had lower overall lymphocyte and higher granulocyte percentages (P<0.001) and higher numbers of jejunal goblet cells (P<0.01) than pigs on either of the other two treatments or the non-medicated treatment, respectively. However, histopathological examination of the small intestine, kidneys and liver revealed no abnormalities. Overall, the B. pumilus treatment decreased ileal E. coli counts in a manner similar to the medicated treatment but without the adverse effects on growth performance, Lactobacillus counts, cecal SCFA concentration and possible liver toxicity experienced with the medicated treatment.The study was funded by the Higher Education Authority/Institutes of Technology Ireland Technological Sector Research Strand III Programme

Light-cone gauge Hamiltonian for AdS_4 x CP^3 superstring

It is developed the phase-space formulation for the Type IIA superstring on the AdS_4 x CP^3 background in the kappa-symmetry light-cone gauge for which the light-like directions are taken from the D=3 Minkowski boundary of AdS_4. After fixing bosonic light-cone gauge the superstring Hamiltonian is expressed as a function of the transverse physical variables and in the quadratic approximation corresponds to the light-cone gauge-fixed IIA superstring in flat space.Comment: 12 pages, LaTeX; v2 minor improvements of the text, misprints corrected, reference added; v3: missing terms in Eqs.(8),(53) and (56) adde

On the Fermionic Frequencies of Circular Strings

We revisit the semiclassical computation of the fluctuation spectrum around different circular string solutions in AdS_5xS^5 and AdS_4xCP^3, starting from the Green-Schwarz action. It has been known that the results for these frequencies obtained from the algebraic curve and from the worldsheet computations sometimes do not agree. In particular, different methods give different results for the half-integer shifts in the mode numbers of the frequencies. We find that these discrepancies can be removed if one carefully takes into account the transition matrices in the spin bundle over the target space.Comment: 13 pages, 1 figur

Towards More Accurate Automatic Sleep Staging via Deep Transfer Learning.

BACKGROUND: Despite recent significant progress in the development of automatic sleep staging methods, building a good model still remains a big challenge for sleep studies with a small cohort due to the data-variability and data-inefficiency issues. This work presents a deep transfer learning approach to overcome these issues and enable transferring knowledge from a large dataset to a small cohort for automatic sleep staging. METHODS: We start from a generic end-to-end deep learning framework for sequence-to-sequence sleep staging and derive two networks as the means for transfer learning. The networks are first trained in the source domain (i.e. the large database). The pretrained networks are then finetuned in the target domain (i.e. the small cohort) to complete knowledge transfer. We employ the Montreal Archive of Sleep Studies (MASS) database consisting of 200 subjects as the source domain and study deep transfer learning on three different target domains: the Sleep Cassette subset and the Sleep Telemetry subset of the Sleep-EDF Expanded database, and the Surrey-cEEGrid database. The target domains are purposely adopted to cover different degrees of data mismatch to the source domains. RESULTS: Our experimental results show significant performance improvement on automatic sleep staging on the target domains achieved with the proposed deep transfer learning approach. CONCLUSIONS: These results suggest the efficacy of the proposed approach in addressing the above-mentioned data-variability and data-inefficiency issues. SIGNIFICANCE: As a consequence, it would enable one to improve the quality of automatic sleep staging models when the amount of data is relatively small

Improving GANs for Speech Enhancement

Generative adversarial networks (GAN) have recently been shown to be efficient for speech enhancement. However, most, if not all, existing speech enhancement GANs (SEGAN) make use of a single generator to perform one-stage enhancement mapping. In this work, we propose to use multiple generators that are chained to perform multi-stage enhancement mapping, which gradually refines the noisy input signals in a stage-wise fashion. Furthermore, we study two scenarios: (1) the generators share their parameters and (2) the generators' parameters are independent. The former constrains the generators to learn a common mapping that is iteratively applied at all enhancement stages and results in a small model footprint. On the contrary, the latter allows the generators to flexibly learn different enhancement mappings at different stages of the network at the cost of an increased model size. We demonstrate that the proposed multi-stage enhancement approach outperforms the one-stage SEGAN baseline, where the independent generators lead to more favorable results than the tied generators. The source code is available at http://github.com/pquochuy/idsegan.Comment: This letter has been accepted for publication in IEEE Signal Processing Letter

D=3 N=6 superconformal symmetry of AdS_4 x CP^3 superstring

Invariance of the AdS_4 x CP^3 superstring under D=3 N=6 superconformal symmetry is discussed in the sector described by the OSp(4|6)/(SO(1,3) x U(3)) supercoset sigma-model action presented in the conformal basis for the osp(4|6)/(so(1,3) x u(3)) Cartan forms. Transformation rules under D=3 N=6 superconformal symmetry for the (10|24)-dimensional 'reduced' AdS_4 x CP^3 superspace coordinates are obtained and used to derive corresponding world-sheet currents.Comment: LaTeX, 23 pages; v2: presentation refined, typos corrected, references adde

Explanation at the opioid receptor level for differing toxicity of morphine and morphine 6-glucuronide.

The radiolabelled opioid receptor binding affinities of morphine and its active metabolite morphine 6-glucuronide at the total mu, mu 1, mu 2 and delta receptors were determined. Morphine 6-glucuronide was found to have a 4-fold lower affinity for the mu 2 receptor (IC50 17 nM and 82 nM for morphine and morphine 6-glucuronide respectively, P = 0.01), the receptor postulated to be responsible for mediating the respiratory depression and gastrointestinal effects after morphine. This provides a possible explanation for the reduced respiratory depression and vomiting seen following morphine 6-glucuronide in man. A similar reduction in affinity of morphine 6-glucuronide was seen at the total mu receptor whilst there was no significant difference seen at the mu 1 or delta receptor. Hence the increased analgesic potency of morphine 6-glucuronide over morphine remains unexplained

Optogalvanic Spectroscopy of Metastable States in Yb^{+}

The metastable ^{2}F_{7/2} and ^{2}D_{3/2} states of Yb^{+} are of interest for applications in metrology and quantum information and also act as dark states in laser cooling. These metastable states are commonly repumped to the ground state via the 638.6 nm ^{2}F_{7/2} -- ^{1}D[5/2]_{5/2} and 935.2 nm ^{2}D_{3/2} -- ^{3}D[3/2]_{1/2} transitions. We have performed optogalvanic spectroscopy of these transitions in Yb^{+} ions generated in a discharge. We measure the pressure broadening coefficient for the 638.6 nm transition to be 70 \pm 10 MHz mbar^{-1}. We place an upper bound of 375 MHz/nucleon on the 638.6 nm isotope splitting and show that our observations are consistent with theory for the hyperfine splitting. Our measurements of the 935.2 nm transition extend those made by Sugiyama et al, showing well-resolved isotope and hyperfine splitting. We obtain high signal to noise, sufficient for laser stabilisation applications.Comment: 8 pages, 5 figure

Spelling in adolescents with dyslexia: errors and modes of assessment

In this study we focused on the spelling of high-functioning students with dyslexia. We made a detailed classification of the errors in a word and sentence dictation task made by 100 students with dyslexia and 100 matched control students. All participants were in the first year of their bachelor’s studies and had Dutch as mother tongue. Three main error categories were distinguished: phonological, orthographic, and grammatical errors (on the basis of morphology and language-specific spelling rules). The results indicated that higher-education students with dyslexia made on average twice as many spelling errors as the controls, with effect sizes of d ≥ 2. When the errors were classified as phonological, orthographic, or grammatical, we found a slight dominance of phonological errors in students with dyslexia. Sentence dictation did not provide more information than word dictation in the correct classification of students with and without dyslexia