7,791 research outputs found
Stereoisomer libraries: Total synthesis of all 16 stereoisomers of the pine sawfly sex pheromone by a fluorous mixture-synthesis approach
All 16 stereoisomers of the sex pheromone of pine sawfly (3,7,11-trimethylundecanol propanoate ester) have been synthesized on a 10- to 20-mg scale by a split-parallel fluorous mixture-synthesis approach. Spectral data obtained for all 32 compounds (16 alcohols and the corresponding propionates) matched well with published data, thereby validating the fluorous-tag encoding of diastereoisomers. This fluorous-tag encoding method is recommended for the efficient synthesis of multiple stereoisomers for spectroscopic studies, biological tests, or other structure-function relationships
Detection of broad 21-cm absorption at z = 0.656 in the complex sight-line towards 3C336
We report the detection of 21-cm absorption at z = 0.656 towards 1622+238
(3C336). The line is very broad with a Full-Width Half Maximum (FWHM) of 235
km/s, giving a velocity integrated optical depth of 2.2 km/s. The centroid of
the line is offset from that of the known damped Lyman-alpha absorption (DLA)
system by 50 km/s, and if the Lyman-alpha and 21-cm absorption are due to the
same gas, we derive a spin temperature of < 60 K, which would be the lowest yet
in a DLA. The wide profile, which is over four times wider than that of any
other DLA, supports the hypothesis that the hydrogen absorption is occurring
either in the disk of a large underluminous spiral or a group of dim
unidentified galaxies, associated with the single object which has been
optically identified at this redshift.Comment: 5 pages, 3 figures, accepted by MNRAS Letter
Observed Faraday Effects in Damped Lyman-Alpha Absorbers and Lyman Limit Systems: The Magnetised Environment of Galactic Building Blocks at Redshift=2
Protogalactic environments are typically identified using quasar absorption
lines, and these galactic building blocks can manifest as Damped Lyman-Alpha
Absorbers (DLAs) and Lyman Limit Systems (LLSs). We use radio observations of
Faraday effects to test whether DLAs and LLSs host a magnetised medium, by
combining DLA and LLS detections throughout the literature with 1.4 GHz
polarization data from the NRAO VLA Sky Survey (NVSS). We obtain a control, a
DLA, and a LLS sample consisting of 114, 19, and 27 lines-of-sight respectively
- all of which are polarized at to ensure Rician bias is
negligible. Using a Bayesian framework, we are unable to detect either coherent
or random magnetic fields in DLAs: the regular coherent magnetic fields within
the DLAs must be G, and the lack of depolarization is consistent
with the weakly magnetised gas in DLAs being non-turbulent and quiescent.
However, we find mild suggestive evidence that LLSs have coherent magnetic
fields: after controlling for the redshift-distribution of our data, we find a
71.5% probability that LLSs have a higher RM than a control sample. We also
find strong evidence that LLSs host random magnetic fields, with a 95.5%
probability that LLS lines-of-sight have lower polarized fractions than a
control sample. The regular coherent magnetic fields within the LLSs must be
G, and the magnetised gas must be highly turbulent with a typical
scale on the order of -20 pc, which is similar to that of the Milky
Way. This is consistent with the standard dynamo pedagogy, whereby magnetic
fields in protogalaxies increase in coherence and strength as a function of
cosmic time. Our results are consistent with a hierarchical galaxy formation
scenario, with the DLAs, LLSs, and strong magnesium II (MgII) systems exploring
three different stages of magnetic field evolution in galaxies.Comment: Submitted to Ap
Coca-Cola Refreshments Class 8 Diesel Electric Hybrid Tractor Evaluation: 13-Month Final Report
This 13-month evaluation used five Kenworth T370 hybrid tractors and five Freightliner M2106 standard diesel tractors at a Coca Cola Refreshments facility in Miami, Florida. The primary objective was to evaluate the fuel economy, emissions, and operational field performance of hybrid electric vehicles when compared to similar-use conventional diesel vehicles. A random dispatch system ensures the vehicles are used in a similar manner. GPS logging, fueling, and maintenance records and laboratory dynamometer testing are used to evaluate the performance of these hybrid tractors. Both groups drive similar duty cycles with similar kinetic intensity (0.95 vs. 0.69), average speed (20.6 vs. 24.3 mph), and stops per mile (1.9 vs. 1.5). The study demonstrated the hybrid group had a 13.7% fuel economy improvement over the diesel group. Laboratory fuel economy and field fuel economy study showed similar trends along the range of KI and stops per mile. Hybrid maintenance costs were 51% lower per mile; hybrid fuel costs per mile were 12% less than for the diesels; and hybrid vehicle total cost of operation per mile was 24% less than the cost of operation for the diesel group
Partial synchronisation of stochastic oscillators through hydrodynamic coupling
Holographic optical tweezers are used to construct a static bistable optical
potential energy landscape where a Brownian particle experiences restoring
forces from two nearby optical traps and undergoes thermally activated
transitions between the two energy minima. Hydrodynamic coupling between two
such systems results in their partial synchronisation. This is interpreted as
an emergence of higher mobility pathways, along which it is easier to overcome
barriers to structural rearrangement.Comment: 4 pages, 4 figures, submitted to Phys. Rev. Let
Recommended from our members
Dexamethasone Attenuates Hyperexcitability Provoked by Experimental Febrile Status Epilepticus.
The role of neuroinflammation in the mechanisms of epilepsy development is important because inflammatory mediators provide tractable targets for intervention. Inflammation is intrinsically involved in the generation of childhood febrile seizures (FSs), and prolonged FS [febrile status epilepticus (FSE)] precedes a large proportion of adult cases of temporal lobe epilepsy (TLE). As TLE is often refractory to therapy and is associated with serious cognitive and emotional problems, we investigated whether its development can be prevented using anti-inflammatory strategies. Using an immature rat model of FSE [experimental FSE (eFSE)], we administered dexamethasone (DEX), a broad anti-inflammatory agent, over 3 d following eFSE. We assessed eFSE-provoked hippocampal network hyperexcitability by quantifying the presence, frequency, and duration of hippocampal spike series, as these precede and herald the development of TLE-like epilepsy. We tested whether eFSE provoked hippocampal microgliosis, astrocytosis, and proinflammatory cytokine production in male and female rats and investigated blood-brain barrier (BBB) breaches as a potential contributor. We then evaluated whether DEX attenuated these eFSE sequelae. Spike series were not observed in control rats given vehicle or DEX, but occurred in 41.6% of eFSE-vehicle rats, associated with BBB leakage and elevated hippocampal cytokines. eFSE did not induce astrocytosis or microgliosis but provoked BBB disruption in 60% of animals. DEX significantly reduced spike series prevalence (to 7.6%) and frequency, and abrogated eFSE-induced cytokine production and BBB leakage (to 20%). These findings suggest that a short, postinsult intervention with a clinically available anti-inflammatory agent potently attenuates epilepsy-predicting hippocampal hyperexcitability, potentially by minimizing BBB disruption and related neuroinflammation
Electron-impact ionization of atomic hydrogen at 2 eV above threshold
The convergent close-coupling method is applied to the calculation of fully
differential cross sections for ionization of atomic hydrogen by 15.6 eV
electrons. We find that even at this low energy the method is able to yield
predictive results with small uncertainty. As a consequence we suspect that the
experimental normalization at this energy is approximately a factor of two too
high.Comment: 10 page
Trends in aerosol abundances and distributions
The properties of aerosols that reside in the upper atmosphere are described. Special emphasis is given to the influence these aerosols have on ozone observation systems, mainly through radiative effects, and on ambient ozone concentrations, mainly through chemical effects. It has long been appreciated that stratospheric particles can interfere with the remote sensing of ozone distribution. The mechanism and magnitude of this interference are evaluated. Separate sections deal with the optical properties of upper atmospheric aerosols, long-term trends in stratospheric aerosols, perturbations of the stratospheric aerosol layer by volcanic eruptions, and estimates of the impacts that such particles have on remotely measured ozone concentrations. Another section is devoted to a discussion of the polar stratospheric clouds (PSC's). These unique clouds, recently discovered by satellite observation, are now thought to be intimately connected with the Antarctic ozone hole. Accordingly, interest in PSC's has grown considerably in recent years. This chapter describes what we know about the morphology, physical chemistry, and microphysics of PSC's
- …