Potential Influences of Graphic Design, And Critical Thinking on Publishing Scientific Products and Performance of Academic Services

Graphic design is a creative process that includes art and technology to convey thoughts, particularly if it is accompanied with creative skills based on strong academic knowledge. It can be used to reflect ideas, trends, and tendencies and this helps touching their reality. This research is mainly aiming at studying how critical presentation of scientific findings, data and applications with graphic and creative designs using an expressive visual language would help enhancing data dissemination and simplifying difficult scientific data and phenomenon making them more convenient for a wide range of audiences and better understood by various levels of background and professionality

Mesenchymal and stemness transdifferentiation via in-vitro infection of T24 cell line with Klebsiella pneumoniae

أثبتت الدراسات الحديثة أن وجود البكتيريا داخل أنسجة الورم له أثرعلى بيئة الورم وبالتالي يؤثرفى سلوك السرطان وتطوره واستجابة الخلايا  للعلاج. فى هذا البحث تم دراسة التحول التمايزى لخلايا سرطان المثانة الظاهرية الى خلايا ميزنكيمية و خلايا جذعية نتيجة لاحداث العدوى البكتيرية. وذلك من خلال إحداث عدوى لسلالة خلايا سرطان المثانة البولية (T24) ببكتيريا الكلبسيلا الرئوية لمدة يومين وأربعة أيام. تم قياس التعبير الجينى باستخدام جهاز البلمرة المتسلسل.وأظهرت النتائج زيادة في صفات الخلايا الميزنكيمية ؛ فزاد التعبير الجينى لجين الفيمنتين ، ونقص التعبيرالجينى للسيتوكيراتين، وعزز تحليل كيمياء الهيستولوجية المناعية هذه النتيجة. علاوة على ذلك، زاد التعبيرالجينى للجينات الدالة على الخلايا الجذعية. العدوى البكتيرية للخلايا السرطانية قد تسبب التمايز الخلوى، مما قد يؤدى الى تحسن قدرة الخلايا السرطانية على الانتشار والتجدد الذاتي. وبالتالي، قد تساهم البكتيريا في تطور سرطان المثانة وإنتشاره.Klebsiella pneumoniae has been found in the urinary tract of some bladder cancer patients. Bacterial presence within tumor tissue may affect the tumor-microenvironment and consequently influence cancer behavior, development, and treatment response. This study investigated mesenchymal and stemness transdifferentiation of bladder cancer cell line due to environmental stress of K. pneumoniae. Cultures of urothelial bladder cancer cell line (T24) were infected with K. pneumoniae with different multiplicity of infection (MOI) for two and four days. Transdifferentiation-associated features were morphologically assessed. Moreover, transdifferentiation markers were estimated using Q-PCR and immunohistochemistry. Q-PCR data showed an increase in mesenchymal transdifferentiation traits; vimentin expression was upregulated, and cytokeratin19 expression downregulated significantly (P<0.001) compared with controls, which were emphasized by immunohistochemistry results. Moreover, stemness transdifferentiation markers expression increased significantly (P<0.001). The heterogeneous tumor cell population may be altered by bacterial infection, which improves cancer cells' migration and self-renewal ability. Thus, bacteria may be engaged in cancer progression and metastases.

Low-Loss Super-Wide Band Antenna over Customized Substrate

In this work, a super wide band antenna is proposed to operate in the frequency band 2.3-23 GHz. The antenna has two planar arms with a modified diamond shape printed on the opposite faces of three-layer dielectric substrate. Each arm of the antenna is capacitively coupled to circular sector near its end to increase the impedance matching bandwidth. The dielectric substrate is customized to fit the shape of the antenna arms and the parasitic elements to reduce the dielectric loss. The substrate material is composed of three layers. The upper and lower layers are Rogers RO3003TM of 0.13 mm thickness and the middle layer is made of paper of 2.3 dielectric constant and 2.7 mm thickness. The antenna is fed through a wide band impedance matching balun. The antenna design stages are performed through electromagnetic simulations concerned with the parametric study to get the optimum antenna dimensions to numerically investigate the role of the parasitic element to enhance the antenna performance. A prototype of the proposed antenna is fabricated to validate the simulation results. The experimental measurements come in good agreement with the simulation results and both of them show that the antenna operates efficiently over the frequency band 2.3-23 GHz with minimum radiation efficiency of 97% and maximum gain of 5.2 dBi. The antenna has bandwidth to dimension ratio (BDR) of 1360

An overview of NMR-based metabolomics to identify secondary plant compounds involved in host plant resistance

Secondary metabolites provide a potential source for the generation of host plant resistance and development of biopesticides. This is especially important in view of the rapid and vast spread of agricultural and horticultural pests worldwide. Multiple pests control tactics in the framework of an integrated pest management (IPM) programme are necessary. One important strategy of IPM is the use of chemical host plant resistance. Up to now the study of chemical host plant resistance has, for technical reasons, been restricted to the identification of single compounds applying specific chemical analyses adapted to the compound in question. In biological processes however, usually more than one compound is involved. Metabolomics allows the simultaneous detection of a wide range of compounds, providing an immediate image of the metabolome of a plant. One of the most universally used metabolomic approaches comprises nuclear magnetic resonance spectroscopy (NMR). It has been NMR which has been applied as a proof of principle to show that metabolomics can constitute a major advancement in the study of host plant resistance. Here we give an overview on the application of NMR to identify candidate compounds for host plant resistance. We focus on host plant resistance to western flower thrips (Frankliniella occidentalis) which has been used as a model for different plant species

International lower limb collaborative (INTELLECT) study: a multicentre, international retrospective audit of lower extremity open fractures

Trauma remains a major cause of mortality and disability across the world1, with a higher burden in developing nations2. Open lower extremity injuries are devastating events from a physical3, mental health4, and socioeconomic5 standpoint. The potential sequelae, including risk of chronic infection and amputation, can lead to delayed recovery and major disability6. This international study aimed to describe global disparities, timely intervention, guideline-directed care, and economic aspects of open lower limb injuries

Sensitivity analysis and optimization of building operations

Operator decisions regarding daily and seasonal scheduling of systems’ availability and setpoints play an important role in building performance. This paper reviews the key operational parameters of 14 office buildings in Ottawa, Canada. The results revealed that over 60% of the air handling units (AHUs) were not turned off outside of normal occupied hours, and most of them did not have an economizer cycle. The indoor temperature setpoints were between 20 and 24 °C. Based on these insights, a building performance simulation (BPS)-based sensitivity analysis was conducted to better understand the energy and comfort performance implications of common operator decisions. Eight operational parameters were studied: AHU start and stop times, seasonal switchover to heating and cooling times, heating and cooling season temperature setpoints, and ventilation rate and mode (i.e., constant or occupancy-based). The results revealed that the AHU start and stop times and the ventilation rate are the most critical oper