АКТУАЛЬНІ ПРОБЛЕМИ ОРГАНІЗАЦІЇ ТА НАДАННЯ МЕДИЧНОЇ ДОПОМОГИ НА КОНТРОЛЬНОМУ ПУНКТІ ВʼЇЗДУ-ВИЇЗДУ «СТАНИЦЯ ЛУГАНСЬКА» В ЛУГАНСЬКІЙ ОБЛАСТІ ЗА УМОВ ПРОВЕДЕННЯ АНТИТЕРОРИСТИЧНОЇ ОПЕРАЦІЇ – ОПЕРАЦІЇ ОБʼЄДНАНИХ СИЛ

The article highlights the problems of organization and provision of medical care at the entry-exit checkpoint (EECP) “Stanytsia-Luhanska” in Luhansk region as a result of the anti-terroristic operation – joint forces operation. Emphasis is placed on the inadequacies and in some issues the lack of access of the civilian population to medical care at the EECP along the line of demarcation.У статті висвітлено проблеми організації та надання медичної допомоги на контрольному пункті вʼїзду-виїзду «Станиця Луганська» в Луганській області в результаті проведення антитерористичної операції – Операції обʼєднаних сил. Акцентовано увагу на недостатності та в деяких питаннях відсутності забез­печення доступу цивільного населення до медичної допомоги на контрольному пункті вʼїзду-виїзду впродовж лінії розмежування

Закордонний досвід проведення регуляторних реформ та застосування «регуляторної гільйотини»

The foreign experience of regulatory reform implementation is considered. Particular attention is paid to the experience gained and the results of the use of “regulatory guillotine” as one of the kinds of regulatory reforms. The authors analyze the main preconditions and results of regulatory reforms and their impact on improved governance, creation of favorable conditions for business development, creating a positive investment climate. A certain degree of regulatory reform has become the standard for developed markets and for developing countries and are trying to take their place on stage one of the most developed countries. Study abroad experience in regulatory reforms in different countries of the world leads to the conclusion that the foundation for regulatory reform is a special system development and adoption of a special kind of legal acts - regulations. Unlike most legal acts, regulations, at the stage of the project should be accompanied by assessment or regulatory impact analysis, which provides comprehensive information about the possible positive or negative effects of the introduction of state regulation. Such adjustment shall be taken only when the overall benefits of regulation dominate the total cost of its implementation. The authors provide recommendations on the use of foreign experience in Ukraine.У статті розглядається закордонний досвід проведення регуляторних реформ. Особливу увагу приділено аналізу досвіду та результатів застосування «регуляторної гільйотини» як одного з різновидів регуляторних реформ. Автори аналізують основні передумови та результати регуляторних реформ, а також їх вплив на вдосконалення державного управління, створення сприятливих умов для розвитку підприємництва, формування позитивного інвестиційного іміджу. Певним чином проведення регуляторних реформ стало стандартом як для країн із розвинутою економікою, так і для країн, що розвиваються та намагаються зайняти своє місце на одному щаблі із найбільш розвинутими країнами світу. Дослідження закордонного досвіду проведення регуляторних реформ у різних кранах світу дозволяє зробити висновки, що основою подібних регуляторних реформ є створення спеціальної системи розроблення та прийняття особливого різновиду нормативно-правових актів – регуляторних актів. На відміну від більшості нормативно-правових актів регуляторні акти, ще на етапі проекту, мають супроводжуватися оцінкою або аналізом регуляторного впливу, в якому наводиться вичерпна інформація про можливі позитивні або негативні наслідки від запровадження державного регулювання. Подібні регулювання приймаються лише у випадку, коли загальні вигоди від регулювання переважають загальні витрати від його запровадження. Автори надають рекомендації щодо використання закордонного досвіду в Україні

Hemochromatosis - modern condition of the problem

The iron overload syndrome can be associated with various acquired states and hereditary factors. Hereditary hemochromatosis is the most common genetic disorder. Without therapeutic intervention the disease can lead to the development of life-threatening complications such as cirrhosis, hepatocellular carcinoma. The article presents data on pathogenesis, diagnosis and treatment of hereditary hemochromatosis. Own clinical observation is given

Isospin Character of the Pygmy Dipole Resonance in 124Sn

The pygmy dipole resonance has been studied in the proton-magic nucleus 124Sn with the (a,a'g) coincidence method at E=136 MeV. The comparison with results of photon-scattering experiments reveals a splitting into two components with different structure: one group of states which is excited in (a,a'g) as well as in (g,g') reactions and a group of states at higher energies which is only excited in (g,g') reactions. Calculations with the self-consistent relativistic quasiparticle time-blocking approximation and the quasiparticle phonon model are in qualitative agreement with the experimental results and predict a low-lying isoscalar component dominated by neutron-skin oscillations and a higher-lying more isovector component on the tail of the giant dipole resonance

Extended Theory of Finite Fermi Systems: Application to the collective and non-collective E1 strength in 208^{208}Pb

The Extended Theory of Finite Fermi Systems is based on the conventional Landau-Migdal theory and includes the coupling to the low-lying phonons in a consistent way. The phonons give rise to a fragmentation of the single-particle strength and to a compression of the single-particle spectrum. Both effects are crucial for a quantitative understanding of nuclear structure properties. We demonstrate the effects on the electric dipole states in $^{208}$Pb (which possesses 50% more neutrons then protons) where we calculated the low-lying non-collective spectrum as well as the high-lying collective resonances. Below 8 MeV, where one expects the so called isovector pygmy resonances, we also find a strong admixture of isoscalar strength that comes from the coupling to the high-lying isoscalar electric dipole resonance, which we obtain at about 22 MeV. The transition density of this resonance is very similar to the breathing mode, which we also calculated. We shall show that the extended theory is the correct approach for self-consistent calculations, where one starts with effective Lagrangians and effective Hamiltonians, respectively, if one wishes to describe simultaneously collective and non-collective properties of the nuclear spectrum. In all cases for which experimental data exist the agreement with the present theory results is good.Comment: 21 figures corrected typos in author fiel

SN 2006bp: Probing the Shock Breakout of a Type II-P Supernova

HET optical spectroscopy and unfiltered ROTSE-III photometry spanning the first 11 months since explosion of the Type II-P SN 2006bp are presented. Flux limits from the days before discovery combined with the initial rapid brightening suggest the supernova was first detected just hours after shock breakout. Optical spectra obtained about 2 days after breakout exhibit narrow emission lines corresponding to HeII 4200, HeII 4686, and CIV 5805 in the rest frame, and these features persist in a second observation obtained 5 hours later; however, these emission lines are not detected the following night nor in subsequent observations. We suggest that these lines emanate from material close to the explosion site, possibly in the outer layers of the progenitor that have been ionized by the high energy photons released at shock breakout. A P-Cygni profile is observed around 4450 A in the +2 and +3 day spectra. Previous studies have attributed this feature to high velocity H-beta, but we discuss the possibility that this profile is instead due to HeII 4687. Further HET observations (14 nights in total) covering the spectral evolution across the photometric plateau up to 73 days after breakout and during the nebular phase around day +340 are presented, and expansion velocities are derived for key features. The measured decay slope for the unfiltered light curve is 0.0073 +/- 0.0004 mag/day between days +121 and +335, which is significantly slower than the decay of rate 56Co. We combine our HET measurements with published X-ray, UV, and optical data to obtain a quasi-bolometric light curve through day +60. We see a slow cooling over the first 25 days, but no sign of an early sharp peak; any such feature from the shock breakout must have lasted less than ~1 day.[ABRIDGED]Comment: ApJ accepted, 43 page

Violations of cell-molecular mechanisms of bone remodeling under influence of glucocorticoids

The fact is disturbance of the processes of bone tissue remodeling leads to a change in the balance between synthesis and resorption of bone and the development of osteoporosis. The most common cause of secondary osteoporosis is the use of glucocorticoid therapy. The aim of this study is to investigate the cellular-molecular mechanisms of disturbance of the processes of bone remodeling regulation, reflected by hormones and intercellular mediators (for example parathyroid hormone, calcitonin, RANKL, osteoprotegerin, P-selectin, interleukin-17, transforming growth factor-β1, adiponectin and visfatin) on the background experimental glucocorticoid osteoporosis. The experimental study carried out in two groups of white female rats. Disturbance of bone tissue remodeling was verified by histological examination of the femoral head, vertebrae of the thoracic and lumbar spine of rats and the measurement of bone density. The study of the levels of hormones and intercellular mediators in the blood serum of animals was carried out by the method of enzyme immunoassay. The bone mineral density of the experimental group was reduced compared to the bone mineral density of the control group. The study of the histostructure of the femoral head and vertebrae in rats of the experimental group in comparison with the animals of the control group revealed changes in the structural organization of bone tissue, confirmed by histomorphometry, indicating inhibition of the processes of osteosynthesis. The article analyzes the nature of the involvement of hormones and cytokines in pathogenetic mechanisms of development of bone tissue disorders. The levels of cytokines RANKL, osteoprotegerin, interleukin-17 and calcitonin in the blood serum of animals of the group with the violation of bone tissue remodeling by glucocorticoids were higher than in intact animals. Serum levels of P-selectin, parathyroid hormone, transforming growth factor-β1, adiponectin and visfatin were lower than similar levels in animals from the control group. The use of glucocorticoids increases the expression of RANKL and inhibits the synthesis of osteoprotegerin, resulting in stimulation of bone resorption. The effect of glucocorticoids in the experimental model is realized by changing the production of the studied hormones, cytokines and adhesion molecules. These changes stimulate the apoptosis of osteoblasts and inhibit their proliferation and differentiation, which is another mechanism of bone loss. Correlations found during the study reflect the relationship in the system of regulation of bone tissue remodeling under the influence of glucocorticoids. A complex system for regulating bone remodeling, which includes many regulatory pathways and their interactions, requires further study

Interaction of the single-particle and collective degrees of freedom in non-magic nuclei: the role of phonon tadpole terms

A method of a consistent consideration of the phonon contributions to mass and gap operators in non-magic nuclei is developed in the so-called g^2 approximation, where g is the low-lying phonon creation amplitude. It includes simultaneous accounting for both the usual non-local terms and the phonon tadpole ones. The relations which allow the tadpoles to be calculated without any new parameters are derived. As an application of the results, the role of the phonon tadpoles in the single-particle strength distribution and in the single-particle energies and gap values has been considered. Relation to the problem of the surface nature of pairing is discussed.Comment: 22 pages, 7 figure

Structure of the bacteriophage PhiKZ non-virion RNA polymerase

Bacteriophage ΦKZ (PhiKZ) is the archetype of a family of massive bacterial viruses. It is considered to have therapeutic potential as its host, Pseudomonas aeruginosa, is an opportunistic, intrinsically antibiotic resistant, pathogen that kills tens of thousands worldwide each year. ΦKZ is an incredibly interesting virus, expressing many systems that the host already possesses. On infection, it forms a ‘nucleus’, erecting a barrier around its genome to exclude host endonucleases and CRISPR-Cas systems. ΦKZ infection is independent of the host transcriptional apparatus. It expresses two different multi-subunit RNA polymerases (RNAPs): the virion RNAP (vRNAP) is injected with the viral DNA during infection to transcribe early genes, including those encoding the non-virion RNAP (nvRNAP), which transcribes all further genes. ΦKZ nvRNAP is formed by four polypeptides thought to represent homologues of the eubacterial β/β′ subunits, and a fifth with unclear homology, but essential for transcription. We have resolved the structure of ΦKZ nvRNAP to better than 3.0 Å, shedding light on its assembly, homology, and the biological role of the fifth subunit: it is an embedded, integral member of the complex, the position, structural homology and biochemical role of which imply that it has evolved from an ancestral homologue to σ-factor