Method for calculating dynamic loads and energy consumption of a sucker rod installation with an automatic balancing system

The efficiency of sucker rod pump installations, which have become widespread in mechanized lift practice, is largely determined by the balance of the drive. During the operation of sucker rod installations, the balance of loads acting on the rod string and the drive can change significantly due to changes in the dynamic fluid level, which leads to a decrease in balance and an increase in loads on the pumping equipment units. The increase and decrease in the dynamic level in accordance with the pumping and accumulation cycle occurs in wells operating in the periodic pumping mode. It is shown that during the operation of equipment in a periodic mode, fluctuations in the dynamic level and, accordingly, in the loads acting on the nodes occur. This leads to the need for dynamic adjustment of the balancing weights to ensure the balance of the pumping unit. A system for automatic balancing of the rod drive has been developed, including a balancing counterweight, an electric motor that moves the load along the balance beam, a propeller and a computing unit. To study the effectiveness of the proposed device, a complex mathematical model of the joint operation of the reservoir - well - sucker rod pump - rod string – pumping unit has been developed. It is shown that due to the dynamic adjustment of the balance counterweight position, the automatic balancing system makes it possible to significantly reduce the amplitude value of the torque on the crank shaft (in comparison with the traditional rod installation) and provide a more uniform load of the electric motor. Equalization of torque and motor load reduces the power consumption of the unit

Pharmacological blockade of cannabinoid type II receptors and mesenchymal stem cell transplantation in a model of peripheral neuropathic pain

Objective. To evaluate the anti-nociceptive and reparative effects of adipose-derived mesenchymal stem cells (ADMSCs) under the pharmacological blockade of cannabinoid CB2 receptors in a model of peripheral neuropathic pain.Material and methods. In 40 male Wistar rats, modeling of peripheral neuropathy (NP) was performed by excising a sciatic nerve. On day 7 of the study, ADMSCs (1 × 106 cells/kg) were transplanted into the area of sciatic nerve injury without additional influences or after administration of the CB2 receptor antagonist AM630, as well as after incubation with AM630. Within 90  days, nociceptive sensitivity was studied, as well as a detailed analysis of gait using CatWalk XT (Noldus, Netherlands). On day 21 and day 90, histostructure of the distal segment of the sciatic nerve was assessed.Results. Pharmacological blockade of CB2 receptors both on the ADMSCs and in the soft tissues surrounding the site of sciatic nerve injury led to a decrease in withdrawal threshold and withdrawal latency from day 28 of the study compared with the group of rats with NP and transplantation of ADMSCs only. Local injection of AM630 before transplantation of ADMSCs contributed to the development of  NP-induced gait disturbances and increase of the number of damaged nerve fibers in the distal segment of sciatic nerve. Transplantation of ADMSCs pretreated with  AM630 did not significantly affect the rate of recovery of gait parameters, and decreased the number of damaged nerve fibers by day 90 of study.Conclusion. Blockade of CB2 receptors, both on the membranes of MSCs and in the area of damage to the peripheral nerve, has a negative effect on the development of the anti-nociceptive and reparative effects of MSCs

COMPARATIVE CHARACTERISTICS OF THE RHYTHM OF THE SEASONAL DEVELOPMENT OF SCUTELLARIA BAICALENSIS GEORGI IN THE NON-CHERNOZEM ZONE AND ON THE SOUTH COAST OF THE CRIMEA

Scutellaria baicalensis is a valuable medicinal plant and a protected species of the East Asian flora. Therefore, work on its introduction is underway in many regions of Russian Federation. Studying of the influence of meteorological factors on the phenology of the S. baicalensis in regions of Russian Federation with contrasting climatic conditions is important in grounds of climate change. Materials and methods. The object of the study is the population of the S. baicalensis biocollections of All-Russian Scientific Research Institute of Medicinal and Aromatic Plants and Nikitsky Botanical Garden. Meteorological indicators: sum of active temperatures, sum of precipitation. Statistical analysis: Tau-b-Kendall correlation coefficient. Results. The duration of the growing season in each region has little variability, independently of the weather conditions of the year. The interval between the onset of phenological phases in the Crimea was characterized by weaker variability than in the Non-Chernozem zone. A significantly smaller amount of active temperatures was required for the onset of phenological phases In the Non-Chernozem zone compared to the southern coast of Crimea. The difference in the average sum of active temperatures across the regions reached 1694.6°C by the end of the growing season. The amount of precipitation had sharp fluctuations in both regions and in all years of research. Conclusion. Secondary flowering, wide amplitudes of the duration of phenological phases and the growing season as a whole, the sum of active temperatures and precipitation indicate the ecological plasticity of the S. baicalensis and the availability of conditions for its cultivation in both regions

ESTIMATION OF STATE OF PANCREAS AND CHANGE OF REGIONAL HEMODYNAMICS IN PATIENTS WITH EDEMATOUS FORM OF ACUTE PANCREATITIS WITH RECOVERY OUTCOME

The article shows peculiarities of regional circulation of the blood in patients with acute pancreatitis during conservative treatment. Obtained data allows to estimate state of pancreas objectively and also to control adequacy of the treatment

Use of national and international growth charts for studying height in european children: Development of up-to-date european height-for-age charts

Background: Growth charts based on data collected in different populations and time periods are key tools to assess children's linear growth. We analyzed the impact of geographic factors and the secular trend on height-for-age charts currently used in European populations, developed up-to-date European growth charts, and studied the effect of u

Potent antiviral activity against HSV-1 and SARS-CoV-2 by antimicrobial peptoids

Viral infections, such as those caused by Herpes Simplex Virus-1 (HSV-1) and SARS-CoV-2, affect millions of people each year. However, there are few antiviral drugs that can effectively treat these infections. The standard approach in the development of antiviral drugs involves the identification of a unique viral target, followed by the design of an agent that addresses that target. Antimicrobial peptides (AMPs) represent a novel source of potential antiviral drugs. AMPs have been shown to inactivate numerous different enveloped viruses through the disruption of their viral envelopes. However, the clinical development of AMPs as antimicrobial therapeutics has been hampered by a number of factors, especially their enzymatically labile structure as peptides. We have examined the antiviral potential of peptoid mimics of AMPs (sequence-specific N-substituted glycine oligomers). These peptoids have the distinct advantage of being insensitive to proteases, and also exhibit increased bioavailability and stability. Our results demonstrate that several peptoids exhibit potent in vitro antiviral activity against both HSV-1 and SARS-CoV-2 when incubated prior to infection. In other words, they have a direct effect on the viral structure, which appears to render the viral particles non-infective. Visualization by cryo-EM shows viral envelope disruption similar to what has been observed with AMP activity against other viruses. Furthermore, we observed no cytotoxicity against primary cultures of oral epithelial cells. These results suggest a common or biomimetic mechanism, possibly due to the differences between the phospholipid head group makeup of viral envelopes and host cell membranes, thus underscoring the potential of this class of molecules as safe and effective broad-spectrum antiviral agents. We discuss how and why differing molecular features between 10 peptoid candidates may affect both antiviral activity and selectivity

Урожайность и биохимический состав сортов фасоли овощной (Phaseolus vulgaris L.) в условиях Московской области

Relevance. Increased demand in Russia for common bean (Phaseolus vulgaris L.) varieties of domestic breeding has stimulated the Federal Scientific Vegetable Center of breeding to intensify research on the creation of new asparagus bean varieties of vegetable direction.Materials and methods. Four vegetable bean varieties – Secunda, Lika, Ulyasha, Si Bemol of the laboratory of selection and seed production of vegetable Legume crops of the Federal Scientific Vegetable Center were used as the material for the study. The counts and observations were made according to the Methodology of the State Variety Trial of Agricultural Crops, 1975. The count of productivity was carried out in the technical stage of ripeness by replications. Harvesting was carried out when the biological stage of ripeness was reached. Biochemical studies of plants were carried out in the laboratoryanalytical department of the FSBSI FSVC. The biochemical composition of vegetable bean (green bean) varieties was studied according to the following indicators: determination of the total content of water-soluble antioxidants, ascorbic acid, dry matter, polyphenols, monosaccharides, total sugar content and starch.Results. Evaluation of samples by aggregate factors contributes to the selection of the most promising and high-quality varieties for their introduction into production. As a result of the research of vegetable bean on the main economically valuable features and biochemical composition for the period from 2018 to 2020, the varieties Lika and Ulyasha were selected. They were distinguished by high productivity of beans and seeds. Green bean variety Lika was noted for the highest total content of water-soluble antioxidants, ascorbic acid and the total of sugars content, the green bean variety "lobio" Ulyasha - high content of polyphenols and the total of antioxidants in the alcohol extract. Stable high yield, adaptive potential and high quality of beans, confirmed by the results of biochemical evaluation, allow us to recommend these varieties for consumption by the population as part of the diet and as an alternative to meat and dairy products. Актуальность. Увеличение спроса в России на сорта фасоли отечественной селекции стимулировало в Федеральном научном центре овощеводства активизацию исследований по созданию новых спаржевых сортов овощного направления.Материалы и методы. Материалом для исследования послужили четыре сорта фасоли овощной – Секунда, Лика, Ульяша, Си Бемоль лаборатории селекции и семеноводства овощных бобовых культур Федерального научного центра овощеводства. Учеты и наблюдения проводили по Методике Государственного сортоиспытания сельскохозяйственных культур, 1975 г. Учет продуктивности (урожайности) бобов проводили в начале технической стадии спелости по повторностям. Уборку урожая проводили при достижении биологической стадии спелости. Биохимические исследования растений проводили в лабораторно-аналитическом отделе ФГБНУ ФНЦО. Был изучен биохимический состав бобов сортов фасоли овощной по следующим показателям: определение суммарного содержания водорастворимых антиоксидантов, аскорбиновой кислоты, сухого вещества, полифенолов, моносахаров, суммы сахаров и крахмала.Результаты. Оценка образцов по совокупности факторов способствует отбору наиболее перспективных и высококачественных сортов для их внедрения в производство. В результате проведенных исследований фасоли овощной по основным хозяйственно ценным признакам и биохимическому составу за период с 2018 по 2020 годы выделены сорта Лика и Ульяша. Они отличались высокой продуктивностью бобов и семян. Спаржевый сорт Лика отмечен наибольшим содержанием суммы водорастворимых антиоксидантов, аскорбиновой кислоты и суммы сахаров, сорт типа “лобио” Ульяша – высоким содержанием полифенолов и суммы антиоксидантов в спиртовом экстракте. Стабильно высокая урожайность, адаптивный потенциал и высокое качество бобов, подтвержденное результатами биохимической оценки, позволяют рекомендовать эти сорта для потребления населением в рамках диетического питания и как альтернативу мясомолочной продукции.

Considerable variations in growth hormone policy and prescription in paediatric end-stage renal disease across European countries—a report from the ESPN/ERA-EDTA registry

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