290 research outputs found
Storage of up-converted telecom photons in a doped crystal
We report on an experiment that demonstrates the frequency up-conversion of
telecommunication wavelength single-photon-level pulses to be resonant with a
: crystal. We convert
the telecom photons at to using a
periodically-poled potassium titanyl phosphate nonlinear waveguide. The maximum
device efficiency (which includes all optical loss) is inferred to be
(internal efficiency
) with a signal to noise ratio exceeding 1 for
single-photon-level pulses with durations of up to 560ns. The converted
light is then stored in the crystal using the atomic frequency comb scheme with
storage and retrieval efficiencies exceeding for
predetermined storage times of up to . The retrieved light is
time delayed from the noisy conversion process allowing us to measure a signal
to noise ratio exceeding 100 with telecom single-photon-level inputs. These
results represent the first demonstration of single-photon-level optical
storage interfaced with frequency up-conversion
Effects of Intraventricular Locus Coeruleus Transplants on Seizure Severity in Genetically Epilepsy-Prone Rats Following Depletion of Brain Norepinephrine
Audiogenic seizures (AGS) in genetically
epilepsy-prone rats (GEPR) of the moderateseizure
substrain (GEPR-3s) were investigated
to determine whether norepinephrine (NE)
depletion induced by 6-hydroxydopalnine (6-OHDA)
microinfusion into the locus coeruleus
(LC) could alter the efficacy of intraventricular
NE tissue grafts in promoting reductions in
seizure severity in AGS. GEPR-3s were
stereotaxically infused with 6-OHDA
(4μg/side/rat), or vehicle into the region of the
LC. Following 6-OHDA treatment all animals
were subjected to 3 AGS tests. GEPR-3s seizure
severities were increased in 39.5% of the
animals after microinfusion of 6-OHDA into the
region of the LC. Following the third AGS test,
each rat was stereotaxicaily implanted with 17
gestational day rat fetal tissue obtained from the
dorsal pons and containing the primordia of the
LC or with tissue obtained from the neocortex
or were sham-grafted. Subsequent to grafting,
rats were subjected to 3 additional AGS tests.
53% (10/19) of 6-OHDA treated GEPRs showed
a significant reduction in seizure severity
following transplantation of fetal LC tissue. In
contrast, only 20% (1/5) of GEPRs infused with
saline rather than 6-OHDA showed, a reduction
of seizure severity following fetal LC
transplantation. NE content in the cortex and
pons/medulla was decreased by 78% and 46%
respectively following 6-OHDA microinfusion
into the LC. Prominent grafts with numerous
TH positive neurons and neurites were present
within the third ventricle of grafted animals,
while cortex grafts contained no TH
immunostained structures. These findings
suggest that the efficacy of fetal LC tissue to
promote reductions in seizure severity in GEPRs
is increased following depletion of central NE by
microinfusion of 6-OHDA
Photonic quantum state transfer between a cold atomic gas and a crystal
Interfacing fundamentally different quantum systems is key to build future
hybrid quantum networks. Such heterogeneous networks offer superior
capabilities compared to their homogeneous counterparts as they merge
individual advantages of disparate quantum nodes in a single network
architecture. However, only very few investigations on optical
hybrid-interconnections have been carried out due to the high fundamental and
technological challenges, which involve e.g. wavelength and bandwidth matching
of the interfacing photons. Here we report the first optical quantum
interconnection between two disparate matter quantum systems with photon
storage capabilities. We show that a quantum state can be faithfully
transferred between a cold atomic ensemble and a rare-earth doped crystal via a
single photon at telecommunication wavelength, using cascaded quantum frequency
conversion. We first demonstrate that quantum correlations between a photon and
a single collective spin excitation in the cold atomic ensemble can be
transferred onto the solid-state system. We also show that single-photon
time-bin qubits generated in the cold atomic ensemble can be converted, stored
and retrieved from the crystal with a conditional qubit fidelity of more than
. Our results open prospects to optically connect quantum nodes with
different capabilities and represent an important step towards the realization
of large-scale hybrid quantum networks
Planning, implementation and scientific goals of the Studies of Emissions and Atmospheric Composition, Clouds and Climate Coupling by Regional Surveys (SEAC4RS) field mission
The Studies of Emissions and Atmospheric Composition, Clouds and Climate Coupling by Regional Surveys (SEAC4RS) field mission based at Ellington Field, Texas, during August and September 2013 employed the most comprehensive airborne payload to date to investigate atmospheric composition over North America. The NASA ER-2, DC-8, and SPEC Inc. Learjet flew 57 science flights from the surface to 20 km. The ER-2 employed seven remote sensing instruments as a satellite surrogate and eight in situ instruments. The DC-8 employed 23 in situ and five remote sensing instruments for radiation, chemistry, and microphysics. The Learjet used 11 instruments to explore cloud microphysics. SEAC4RS launched numerous balloons, augmented AErosol RObotic NETwork, and collaborated with many existing ground measurement sites. Flights investigating convection included close coordination of all three aircraft. Coordinated DC-8 and ER-2 flights investigated the optical properties of aerosols, the influence of aerosols on clouds, and the performance of new instruments for satellite measurements of clouds and aerosols. ER-2 sorties sampled stratospheric injections of water vapor and other chemicals by local and distant convection. DC-8 flights studied seasonally evolving chemistry in the Southeastern U.S., atmospheric chemistry with lower emissions of NOx and SO2 than in previous decades, isoprene chemistry under high and low NOx conditions at different locations, organic aerosols, air pollution near Houston and in petroleum fields, smoke from wildfires in western forests and from agricultural fires in the Mississippi Valley, and the ways in which the chemistry in the boundary layer and the upper troposphere were influenced by vertical transport in convective clouds
Global statistics of liquid water content and effective number concentration of water clouds over ocean derived from combined CALIPSO and MODIS measurements
This study presents an empirical relation that links the volume extinction coefficients of water clouds, the layer integrated depolarization ratios measured by lidar, and the effective radii of water clouds derived from collocated passive sensor observations. Based on Monte Carlo simulations of CALIPSO lidar observations, this method combines the cloud effective radius reported by MODIS with the lidar depolarization ratios measured by CALIPSO to estimate both the liquid water content and the effective number concentration of water clouds. The method is applied to collocated CALIPSO and MODIS measurements obtained during July and October of 2006, and January 2007. Global statistics of the cloud liquid water content and effective number concentration are presented
Oscillatory Shear Flow-Induced Alignment of Lamellar Melts of Hydrogen-Bonded Comb Copolymer Supramolecules
In this work we present the orientational behavior of comb copolymer-like supramolecules P4VP(PDP)1.0, obtained by hydrogen bonding between poly(4-vinylpyridine) and pentadecylphenol, during large-amplitude oscillatory shear flow experiments over a broad range of frequencies (0.001-10 Hz). The alignment diagram, presenting the macroscopic alignment in T/TODT vs ω/ωc, contains three regions of parallel alignment separated by a region of perpendicular alignment. For our material, the order-disorder temperature TODT = 67 °C and ωc, the frequency above which the distortion of the chain conformation dominates the materials’ viscoelasticity, is around 0.1 Hz at 61 °C. For the first time flipping from a pure transverse alignment via biaxial transverse/perpendicular alignment to a perpendicular alignment as a function of the strain amplitude was found.
Is thymidylate synthase a reliable predictor for response and survival during hepatic arterial infusion for hepatic metastases from colorectal cancer?
Intragenic deletions and a deep intronic mutation affecting pre-mRNA splicing in the dihydropyrimidine dehydrogenase gene as novel mechanisms causing 5-fluorouracil toxicity
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The Arctic Research of the Composition of the Troposphere from Aircraft and Satellites (ARCTAS) Mission: Design, Execution, and First Results
The NASA Arctic Research of the Composition of the Troposphere from Aircraft and Satellites (ARCTAS) mission was conducted in two 3-week deployments based in Alaska (April 2008) and western Canada (June–July 2008). Its goal was to better understand the factors driving current changes in Arctic atmospheric composition and climate, including (1) influx of mid-latitude pollution, (2) boreal forest fires, (3) aerosol radiative forcing, and (4) chemical processes. The June–July deployment was preceded by one week of flights over California (ARCTAS-CARB) focused on (1) improving state emission inventories for greenhouse gases and aerosols, (2) providing observations to test and improve models of ozone and aerosol pollution. ARCTAS involved three aircraft: a DC-8 with a detailed chemical payload, a P-3 with an extensive aerosol and radiometric payload, and a B-200 with aerosol remote sensing instrumentation. The aircraft data augmented satellite observations of Arctic atmospheric composition, in particular from the NASA A-Train. The spring phase (ARCTAS-A) revealed pervasive Asian pollution throughout the Arctic as well as significant European pollution below 2 km. Unusually large Siberian fires in April 2008 caused high concentrations of carbonaceous aerosols and also affected ozone. Satellite observations of BrO column hotspots were found not to be related to Arctic boundary layer events but instead to tropopause depressions, suggesting the presence of elevated inorganic bromine (5–10 pptv) in the lower stratosphere. Fresh fire plumes from Canada and California sampled during the summer phase (ARCTAS-B) indicated low emission factors from the fires, rapid conversion of to PAN, no significant secondary aerosol production, and no significant ozone enhancements except when mixed with urban pollution.Engineering and Applied Science
Acting on Reflection: the Effect of Reflection on Students’ Clinical Performance on a Standardized Patient Examination
BACKGROUND: Little evidence exists to support the value of reflection in the clinical setting. OBJECTIVE: To determine whether reflecting and revisiting the “patient” during a standardized patient (SP) examination improves junior medical students’ performance and to analyze students’ perceptions of its value. DESIGN: Students completed a six-encounter clinical skills examination, writing a guided assessment after each encounter to trigger reflection. SPs evaluated the students with Medical Skills and Patient Satisfaction checklists. During the last three encounters, students could opt to revisit the SP and be reevaluated with identical checklists. PARTICIPANTS: One hundred and forty-nine third year medical students. MEASUREMENTS: Changes in scores in the Medical Skills and Patient Satisfaction checklists between first visit and revisit were tested separately per case as well as across cases. RESULTS: On the medical skills and patient satisfaction checklists, mean revisit scores across cases were significantly higher than mean first visit scores [12.6 vs 12.2 (pooled SD = 2.4), P = .0001; 31.2 vs 31.0 (pooled SD = 3.5), P = .0001)]. Sixty-five percent of the time, students rated “reflect–revisit” positively, 34% neutrally, and 0.4% negatively. Five themes were identified in the positive comments: enhancement of (1) medical decision making, (2) patient education/counseling, (3) student satisfaction/confidence, (4) patient satisfaction/confidence, and (5) clinical realism. CONCLUSIONS: Offering third year medical students the option to reflect and revisit an SP during a clinical skills examination produced a small but nontrivial increase in clinical performance. Students perceived the reflect–revisit experience as enhancing patient-centered practices (counseling, education) as well as their own medical decision making and clinical confidence
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