Students’ experiences with challenge-based learning at TU/e innovation Space:overview of five key characteristics across a broad range of courses

Challenge-based learning (CBL) has emerged in the last decade as a response to the complexity of problems faced by modern society, new competencies needed for the workplace, and insights from cognitive sciences on knowledge acquisition and learner motivation. In CBL, students work on real-world problems which are open-ended and require interdisciplinary knowledge and entrepreneurial mindset. In the last three years, over 70 CBL experiments have been initiated at Eindhoven University of Technology (TU/e), in order to develop a broad range of CBL teaching practices. Half of these courses have taken place at TU/e innovation Space, which is a learning hub and expertise centre for CBL and entrepreneurship education. We use students’ evaluation surveys to analyse the experiences of Bachelor and Masters students in these courses. In particular, we are focusing on responses to five key course design characteristics set by the teaching staff as important: how interdisciplinary and challenge-based (or linked to real-life problems) the courses are, how entrepreneurial and hands-on they are, and how much they contributed to students’ personal development, as well as their team development. The results show that what attracts students to these CBL courses matches closely these five characteristics, and we discuss why this might be the case. Interestingly, some of the more hands-on aspects of the courses do not seem to have been affected by the COVID-19 disruption in the 2019-2020 academic year

Фінансовий контролінг як інструмент управління діяльністю суб'єкта господарювання

PURPOSE: Multiple imaging techniques are nowadays available for clinical in-vivo visualization of tumour biology. FDG PET/CT identifies increased tumour metabolism, hypoxia PET visualizes tumour oxygenation and dynamic contrast-enhanced (DCE) CT characterizes vasculature and morphology. We explored the relationships among these biological features in patients with non-small-cell lung cancer (NSCLC) at both the patient level and the tumour subvolume level. METHODS: A group of 14 NSCLC patients from two ongoing clinical trials (NCT01024829 and NCT01210378) were scanned using FDG PET/CT, HX4 PET/CT and DCE CT prior to chemoradiotherapy. Standardized uptake values (SUV) in the primary tumour were calculated for the FDG and hypoxia HX4 PET/CT scans. For hypoxia imaging, the hypoxic volume, fraction and tumour-to-blood ratio (TBR) were also defined. Blood flow and blood volume were obtained from DCE CT imaging. A tumour subvolume analysis was used to quantify the spatial overlap between subvolumes. RESULTS: At the patient level, negative correlations were observed between blood flow and the hypoxia parameters (TBR >1.2): hypoxic volume (−0.65, p = 0.014), hypoxic fraction (−0.60, p = 0.025) and TBR (−0.56, p = 0.042). At the tumour subvolume level, hypoxic and metabolically active subvolumes showed an overlap of 53 ± 36 %. Overlap between hypoxic sub-volumes and those with high blood flow and blood volume was smaller: 15 ± 17 % and 28 ± 28 %, respectively. Half of the patients showed a spatial mismatch (overlap <5 %) between increased blood flow and hypoxia. CONCLUSION: The biological imaging features defined in NSCLC tumours showed large interpatient and intratumour variability. There was overlap between hypoxic and metabolically active subvolumes in the majority of tumours, there was spatial mismatch between regions with high blood flow and those with increased hypoxia. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00259-015-3169-4) contains supplementary material, which is available to authorized users

Nitroglycerin as a radiosensitizer in non-small cell lung cancer: Results of a prospective imaging-based phase II trial

Background: Nitroglycerin is proposed as an agent to reduce tumour hypoxia by improving tumour perfusion. We investigated the potent

Entrepreneurs’ mental health and well-being:A review and research agenda

Interest in entrepreneurs’ mental health and well-being (MWB) is growing in recognition of the role of MWB in entrepreneurs’ decision making, motivation, and action. Yet relevant knowledge is dispersed across disciplines, which makes what we currently understand about entrepreneurs’ MWB unclear. In this systematic review I integrate insights from 144 empirical studies. These studies show that research is focused on three research questions: (1) Do different types of entrepreneurs differ in their MWB? What are the (2) antecedents and (3) consequences of entrepreneurs’ MWB? The review systematizes evidence on known antecedents and consequences of entrepreneurs’ MWB but also reveals overlooked and undertheorized sources and outcomes of entrepreneurs’ MWB. The review provides a mapping and framework that advance research on entrepreneurs’ MWB and help to position entrepreneurs’ MWB more centrally in management and entrepreneurship research. It calls for researchers to go beyond applying models developed for employees to understand entrepreneurs. Instead, the findings point the way to developing a dedicated theory of entrepreneurial work and MWB that is dynamic, socialized, and open to considering context and acknowledges variability and fluidity across entrepreneurs’ life domains, as well as the centrality of work for entrepreneurs’ identity

Cover Design by Cliff Hasham Improving Design Processes through Structured Reflection A Domain-independent Approach

All rights reserved. No part of this publication may be stored in a retrieval system, transmitted, or reproduced, in any form or by any means, including but not limited to photocopy, photograph, magnetic or other record, without prior agreement and written permission of the author

Effectuation for organizing design processes?

Design Science Methodology is the title of a course I developed/am developing. It tries to bridge design in engineering and social science, with the goal to learn industrial engineering and management students notions of design. With an engineering background (Architecture and some Computing Science), I am now Assistant Professor Design Processes in the Organization Science and Marketing group of Prof. Romme. I lecture in the Innovation Management Program of the Eindhoven University of Technology. I am very interested in thinking about new ways of organizing design processes and about how to deal with the new challenges of design science. My research focuses around "The design of processes for artifact creation", where artifacts can be new products, systems, discourse, businesses, markets, ... . I am also involved in a new initiative that plans to organize a workshop on Organizational Design and Engineering, which I like to share with the audience

Meningoradiculoneuritis due to acyclovir-resistant varicella-zoster virus in a patient with aids

SCOPUS: ar.jinfo:eu-repo/semantics/publishe