2,829 research outputs found

    Effects of Maternal Exposure to LPS on the Inflammatory Response in the Offspring

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    Climatic signals of tree-ring in Quercus gussonei (Borz\uec) Brullo in the Mediterranean region

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    Change in growth is among the primary response of trees to environmental variation. Tree-rings contain a wealth of information related to the climatic conditions. A dendroclimatic study on Quercus gussonei (Borz\uec) Brullo was carried out in the Nature Reserve of \u201cBosco della Ficuzza, Rocca Busambra, Bosco Del Cappelliere, Gorgo Del Drago\u201d (southern Italy). Q. gussonei is an endemic deciduous oak and thermophilous form of Quercus cerris L. that is found only in Sicily, although with clear sign of decline. The knowledge of ecology of this species should help to establish criteria for forest conservation in the Mediterranean region. For definining the ecological character and understanding the potential causes of the oak decline, we collected cores from ten trees with an increment borer. Precipitation and temperature data were obtained from a meteorological station located nearby from the stand. Annual ring widths, earlywood and latewood analyses were used in order to investigate and better understand the climatic dynamics influencing the oaks\u2019 growth. We determined the stable isotope discrimination of carbon (D13C) in the wood in order to investigate wateruse efficiency variations and the expression of possible plant adaptive traits. Climate-growth relationship, for the chronology 1951-2008, were analyzed using response, correlation and moving correlation functions. Our finding mostly highlight relationships between tree-rings width and climate data. Furthermore, D13C in treerings was used to identify long-term adjustments in water-use efficiency

    Larval digeneans in Biomphalaria snails from the Salto Grande Dam area in the Uruguay River

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    Fil: Martorelli, Sergio Roberto. Centro de Estudios en ParasitologĂ­a y Vectores (CEPAVE). Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; ArgentinaFil: Marcotegui, Paula Soledad. Centro de Estudios en ParasitologĂ­a y Vectores (CEPAVE). Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; ArgentinaFil: La Sala, Luciano Francisco. Departamento de BiologĂ­a BioquĂ­mica y Farmacia. Universidad Nacional del Sur. BahĂ­a Blanca; ArgentinaFil: Montes, MartĂ­n M.. Centro de Estudios en ParasitologĂ­a y Vectores (CEPAVE). Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; Argentin

    An Optimal Decision Procedure for MPNL over the Integers

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    Interval temporal logics provide a natural framework for qualitative and quantitative temporal reason- ing over interval structures, where the truth of formulae is defined over intervals rather than points. In this paper, we study the complexity of the satisfiability problem for Metric Propositional Neigh- borhood Logic (MPNL). MPNL features two modalities to access intervals "to the left" and "to the right" of the current one, respectively, plus an infinite set of length constraints. MPNL, interpreted over the naturals, has been recently shown to be decidable by a doubly exponential procedure. We improve such a result by proving that MPNL is actually EXPSPACE-complete (even when length constraints are encoded in binary), when interpreted over finite structures, the naturals, and the in- tegers, by developing an EXPSPACE decision procedure for MPNL over the integers, which can be easily tailored to finite linear orders and the naturals (EXPSPACE-hardness was already known).Comment: In Proceedings GandALF 2011, arXiv:1106.081

    The safety of care focused on patient identity: an observational study

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    BACKGROUND AND AIM: Healthcare organizations, in order to reduce errors and extend the number of safe practices, are looking for possible solutions to enhance the clients' health quality care and trying to spread the culture of safety healthcare. Although in the literature the field of research "patient safety" is very debated, there are few empirical studies that investigate about the strategies undertaken by nursing students for the patients identification process during their care pathway. The aim of this study is to investigate the knowledge of the Ministerial Recommendation No. 3/2008 among nursing students, a specific Italian directive that aims to guarantee the safety of cares. METHODS: A four-weeks single-center observational study was conducted, involving a convenient sample of 112 students of the 2nd and 3rd  year of the Nursing Course Degree of the University of Parma. The survey was conducted using an ad-hoc questionnaire. RESULTS: The use of the identification wristband is considered one of the most important strategy to make sure the patient identification; unfortunately it is in practice used just in few occasions and only when performed specific procedures; it is furthermore noted that patients are not enough informed about the use and finalities of the identification wristband. CONCLUSIONS: Considering the importance of the patient identification process to guarantee the  safety of cares, the results produced, suggest that this investigation field deserves further insights in order to collect more substantial data and expand knowledge on the specific subject, so as to fill  knowledge gaps and sensitize nursing students to the correct use of the identification wristband

    Vegetation dynamics within afforested coastal areas: regeneration by native species or invasion by alien species?

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    During the last century, massive reforestation projects along the dunes of the southern Sicily have been carried out. Such interventions, far from being in line with the current trends of close-to-nature silviculture, are, however, particularly interesting to assess the vegetation dynamics in afforestation areas. Furthermore, these kind of interventions may determine two opposite effects, that is renaturalization by native woody species or invasion by alien species. Acacia spp. are among the most widespread and prominent invaders within Mediterranean-climate areas, where they have already shown the capability to deeply change the characters and the functioning of native ecosystems. For instance, Acacia longifolia (Andrews) Willd. may successfully invade the understory of pine forests, causing the alteration of the water balance and carbon storage of the whole forest ecosystem. In Sicily, especially in the last decades, Acacia saligna started to abundantly regenerate in many natural and semi-natural areas, with a stark preference for dune and coastal afforested sites. The nature reserve \u201cFoce del Fiume Platani\u201d represents an excellent case study in this respect

    Trojan hosts: the menace of invasive vertebrates as vectors of pathogens in the Southern Cone of South America

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    Invasive alien species (IAS) can act as vectors for the introduction of pathogens in ecosystems and their transmission to threatened native species (TNS), leading to biodiversity loss, population reductions and extinctions. We assessed pathogens potentially occurring in a set of IAS in the Southern Cone of South America and identified TNS potentially vulnerable to their effects. Also, we assessed how risk analysis systems proposed or adopted by national authorities in the study region value the importance of pathogens. We identified 324 pathogens in the selected IAS, which could potentially affect 202 TNS. Wild boar (Sus scrofa) was the IAS with the largest number of pathogens (91), followed by domestic dog (Canis familiaris) (62), red deer (Cervus elaphus) (58), rock dove (Columba livia) (37), American vison (Neovison vison) (18), European hare (Lepus europaeus) (17), common starling (Sturnus vulgaris) (12), common slider (Trachemys scripta) (6), and American bullfrog (Lithobates catesbeianus) (2). Most TNS were in the “vulnerable” IUCN category, followed by “endangered” and “critically endangered” species. Bacteria were the most frequently represented pathogens (112), followed by ectoparasites (78), viruses (69), protozoa and other (65). The direct effects of IAS on native wildlife are beginning to be addressed in South America, and their potential impact as pathogen spreaders to native wildlife has remained largely unexplored. Risk analysis systems associated with the introduction of IAS are scarce in this region. Although the existing systems contemplate hazard analyses for the co-introduction of pathogens, they underestimate the potential impact of diseases on TNS. Conservation efforts in the region would benefit from systems which give pathogen risk a relevant place, and from government agencies promoting targeted disease surveillance in IAS and wildlife.Fil: la Sala, Luciano Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; ArgentinaFil: Burgos, Julian M.. Marine And Freshwater Research Institute; IslandiaFil: Scorolli, Alberto Luis. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Grupo de Estudios en Conservación y Manejo; ArgentinaFil: VanderWaal, Kimberly. University of Minnesota; Estados UnidosFil: Zalba, Sergio Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Grupo de Estudios en Conservación y Manejo; Argentin

    Chronic obstructive pulmonary disease and neutrophil infiltration: role of cigarette smoke and cyclooxygenase products

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    Cigarette smoke is the main cause of chronic obstructive pulmonary disease (COPD), where it can contribute to the observed airway inflammation. PGE(2) is produced within human airways, and both pro- and anti-inflammatory activities have been reported. We quantitated PGE(2) concentrations in induced sputum supernatants from different groups of subjects and correlated the obtained values to neutrophil infiltration as well as to the expression of cyclooxygenase-2 (COX-2). Cigarette smoke extract (CSE) was used to evaluate the effect of smoking on COX-2 and PGE(2) receptor expression as well as on PGE(2) release in neutrophils and alveolar macrophages (AM) obtained from normal donors. The effects of PGE(2) and of PGE receptor agonists and antagonists were evaluated on the adhesion of neutrophil to a human bronchial epithelial cell line (16HBE). PGE(2) levels, COX-2 expression, and neutrophil infiltration were significantly higher in normal smokers and COPD smokers (P < 0.0001) compared with controls and COPD former smokers. Induced sputum supernatant caused neutrophil adhesion to 16HBE that was significantly reduced, in COPD smokers only, by PGE(2) immunoprecipitation. In vitro experiments confirmed that CSE increased PGE(2) release and COX-2 and PGE(2) receptor expression in neutrophils and AM; PGE(2) enhanced the adhesion of neutrophils to 16HBE, and a specific E-prostanoid 4 (EP(4)) receptor antagonist blunted its effect. These results suggest that CSE promote the induction of COX-2 and contributes to the proinflammatory effects of PGE(2) in the airways of COPD subjects.Cigarette smoke is the main cause of chronic obstructive pulmonary disease (COPD), where it can contribute to the observed airway inflammation. PGE(2) is produced within human airways, and both pro- and anti-inflammatory activities have been reported. We quantitated PGE(2) concentrations in induced sputum supernatants from different groups of subjects and correlated the obtained values to neutrophil infiltration as well as to the expression of cyclooxygenase-2 (COX-2). Cigarette smoke extract (CSE) was used to evaluate the effect of smoking on COX-2 and PGE(2) receptor expression as well as on PGE(2) release in neutrophils and alveolar macrophages (AM) obtained from normal donors. The effects of PGE(2) and of PGE receptor agonists and antagonists were evaluated on the adhesion of neutrophil to a human bronchial epithelial cell line (16HBE). PGE(2) levels, COX-2 expression, and neutrophil infiltration were significantly higher in normal smokers and COPD smokers (P < 0.0001) compared with controls and COPD former smokers. Induced sputum supernatant caused neutrophil adhesion to 16HBE that was significantly reduced, in COPD smokers only, by PGE(2) immunoprecipitation. In vitro experiments confirmed that CSE increased PGE(2) release and COX-2 and PGE(2) receptor expression in neutrophils and AM; PGE(2) enhanced the adhesion of neutrophils to 16HBE, and a specific E-prostanoid 4 (EP(4)) receptor antagonist blunted its effect. These results suggest that CSE promote the induction of COX-2 and contributes to the proinflammatory effects of PGE(2) in the airways of COPD subjects

    Retrospective Cohort Study on Acute Care in Obstetrics and Gynecology. Analogies and Differences When Compared to Emergency Medicine

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    Introduction: the demand for urgent obstetric and gynecology care has progressively increased: in the United States approximately 1.4 million gynecologic visits are made to the emergency department (ED) annually, while almost 75% of women make at least 1 unscheduled visit during pregnancy. Moreover, research has recently focused on setting standards in unscheduled care, and developing quality indicators to improve patients’ health. Therefore, we investigated the characteristics of women with acute gynecological or pregnancy complaints using quality indicators developed for emergency medicine, to better define the needs of this population and improve care. Methods: Retrospective cohort study on ED, and Obstetrics and Gynecology (ObGyn) triage visits, at a tertiary care hospital in Italy, during 2012. Data were analyzed with population-averaged logistic regression and Poisson regression. Results: When compared to the 33,557 ED visits, the 9245 ObGyntriage referrals were more frequently associated with pregnancy (≤12 weeks’ gestation, OR: 30.7, 95%CI; 24.5 - 38.4; &gt;12 weeks’ gestation, OR 81.2, 95%CI; 64.8 - 101.4), vaginal bleeding (OR 156.6, 95%CI; 82.7 - 294.4), diurnal (night access OR 0.87, 95% CI; 0.78 - 0.96) and weekday access (holiday access OR 0.87, 95%CI; 0.78 - 0.95), frequent users (recurrent ED visits IRR 0.87, 95%CI; 0.83 - 0.9) and lower hospital admissions (ED admission OR 1.6, 95%CI; 1.4 - 1.8). Conclusion: ObGyn triage patients differed from ED users, and were at higher risk of “crowding”. Such diversities should be considered to improve female healthcare services and allocate resources more efficiently
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