The monoid of queue actions

We investigate the monoid of transformations that are induced by sequences of writing to and reading from a queue storage. We describe this monoid by means of a confluent and terminating semi-Thue system and study some of its basic algebraic properties, e.g., conjugacy. Moreover, we show that while several properties concerning its rational subsets are undecidable, their uniform membership problem is NL-complete. Furthermore, we present an algebraic characterization of this monoid's recognizable subsets. Finally, we prove that it is not Thurston-automatic

Dependence of electrolytic cell voltage on the structure of cathode deposits of PMS11 and PML0 powders

The structure of dendritic copper deposit changes during electrolysis: the upper thin elongated branches are finally replaced by coarse globules. Therefore, it is important to determine the period of deposit growth without forming coarse globular particles. This period may be established by analyzing the dynamics of deposit growth and the variation in cathode overpotential, which is a contributor to cell voltage drop and may be used to monitor the structure of cathode deposit. Copper powders PMS11 and PML0 are used to calculate variation in the cell voltage and evaluate the change in deposit structure. The calculations have determined the period of growing homogenous deposits of the copper powders. © 2013 Springer Science+Business Media New York

Pharmacological correction of immune disorders in patients with chronic heart failure and ischemic heart disease

Currently, there are few data on the effect of cardiovascular drugs on the immune status of patients with heart failure (HF). This paper provides information on the impact of ß-adrenergic blocking agent (BAB), angiotensin-converting enzyme inhibitors (ACEI) on the maintenance of markers of immune inflammation in the blood, as well as on inhibition of synthesis of tumor necrosis factor-α (TNF-α) and on blocking of interaction between TNF-α and membrane receptor

Results of investigation of muon fluxes of superhigh energy cosmic rays with X-ray emulsion chambers

The overall data from the investigation of the cosmic ray muon flux in the range of zenith angles (0-90) deg within the energy range (3.5 to 5.0) TeV is presented. The exposure of large X-ray emulsion chambers underground was 1200 tons. year. The data were processe using the method which was applied in the experiment Pamir and differred from the earlier applied one. The obtained value of a slope power index of the differential energy spectrum of the global muon flux is =3.7 that corresponds to the slope of the pion generation differential spectrum, gamma sub PI = 2.75 + or - .04. The analysis of the muon zenith-angular distribution showed that the contribution of rapid generation muons in the total muon flux agree the best with the value .2% and less with .7% at a 90% reliability level

Development and validation of methods of quantitative determination of the new antidiabetic drug in the blood plasma of rats by high performance liquid chromatography with mass spectrometric detection

We developed a method of quantification of the new antidiabetic drug 3-(1h-benzimidazole-2-yl)-1,2,2-trimethyl-cyclopentane-carbonic acid (c7070) in the blood plasma of rats by high-performance liquid chromatography with mass-spectrometric detectio

Effect of antagonist mineralocorticoid receptors Eplerenon on the dynamics of QT interval dispersion in patients with acute elderly aged

Currently, there is an increase in the frequency of cardiovascular diseases, including acute coronary syndrome (ACS), while in the Russian Federation due to ACS there is a high mortality rate from sudden cardiac death (SCD). The aim of the work is a comparative analysis of the effect of mineralocorticoid receptor antagonists (MRA) of eplerenone on the predictors of SCD development in patients with ST elevation myocardial infarction (STEMI) with a moderately abnormal ejection fraction(EF) of the left ventricle (LV) in the early stages of the diseas

Применение скрининговых методик для ранней диагностики риска биполярного аффективного расстройства у подростков

Aim. To assess the possibility of combined application of screening methods for early detection of risks of bipolar disorder in adolescents.Materials and methods. The study included 139 adolescents aged 13–16 years. A clinical psychopathology assessment as well as screening methods were used. The screening methods included the Bipolar Spectrum Diagnostic Scale ((BSDS), R. Pies, 2005) and the Mood Disorder Questionnaire ((MDQ), R.M. Hirschfeld, 2000).Results. The clinical psychopathology assessment was performed in accordance with criteria of ICD-10, Class V. No mental and behavioral disorders (F00-F99), including affective pathology, were identified. Following the MDQ screening, the risk of bipolar disorder was revealed in 63 individuals (45.3%; 95 % confidence interval (CI): (36.8–53.9). When the BSDS method was used, the risk of bipolar disorder was revealed in 16.2% of cases (CI: (11.9–28.3)). The combined use of the screening scales (MDQ and BSDS) confirmed their consistency in detecting values both not exceeding (48.7% of the cases) and exceeding the threshold rates (17.1% of the cases).Conclusion. Early diagnosis of a risk of bipolar disorder in adolescents, along with a clinical psychopathology assessment, may include application of screening scales. Сombined use of several screening methods is justified by polymorphism of initial hypomanic and depressive states, as well as by difficulties in subjective assessment of symptoms of bipolar disorder in adolescents.Цель. Изучение возможности комплексного применения скрининговых методик в ранней диагностике риска биполярного расстройства (БР) у подростков.Материалы и методы. В исследовании приняли участие 139 подростков в возрасте 13–16 лет. Были использованы клинико-психопатологический метод и скрининговые методы исследования: диагностическая шкала расстройств биполярного спектра (Bipolar Spectrum Diagnostic Scale, BSDS, R. Pies, 2005); вопросник расстройства настроения (Mood Disorder Questionnaire MDQ, R.M. Hirschfeld, 2000).Результаты. При клинико-психопатологическом исследовании подростков в соответствии с критериями МКБ-10 (класс V: психические расстройства и расстройства поведения (F00-F99)) психические расстройства, в том числе аффективная патология, не выявлены. По результатам скрининговой методики MDQ показан риск БР у 63 респондентов (45,3%; 95-й доверительный интервал (ДИ): 36,8–53,9). С помощью методики BSDS риск БР отмечен у 16,2% респондентов (ДИ: 11,9–28,3). Совместное использование скрининговых шкал (MDQ и BSDS) продемонстрировало согласованность их работы по выявлению значений, как не превышающих пороговые (48,7% случаев), так и превышающих пороговые показатели (17,1% случаев).Заключение. Ранняя диагностика риска БР у подростков наряду с клинико-психопатологическим методом может включать использование скрининговых шкал. Комплексное использование нескольких скрининговых методов обосновано проблемой полиморфизма начальных гипоманиакальных и депрессивных состояний, а также трудностями субъективной оценки симптомов биполярного аффективного расстройства подростками

Signal recognition and background suppression by matched filters and neural networks for Tunka-Rex

The Tunka Radio Extension (Tunka-Rex) is a digital antenna array, which measures the radio emission of the cosmic-ray air-showers in the frequency band of 30-80 MHz. Tunka-Rex is co-located with TAIGA experiment in Siberia and consists of 63 antennas, 57 of them are in a densely instrumented area of about 1 km\textsuperscript{2}. In the present work we discuss the improvements of the signal reconstruction applied for the Tunka-Rex. At the first stage we implemented matched filtering using averaged signals as template. The simulation study has shown that matched filtering allows one to decrease the threshold of signal detection and increase its purity. However, the maximum performance of matched filtering is achievable only in case of white noise, while in reality the noise is not fully random due to different reasons. To recognize hidden features of the noise and treat them, we decided to use convolutional neural network with autoencoder architecture. Taking the recorded trace as an input, the autoencoder returns denoised trace, i.e. removes all signal-unrelated amplitudes. We present the comparison between standard method of signal reconstruction, matched filtering and autoencoder, and discuss the prospects of application of neural networks for lowering the threshold of digital antenna arrays for cosmic-ray detection.Comment: ARENA2018 proceeding

TCF7L2 gene polymorphism in populations of f ive Siberian ethnic groups

Investigation of the frequencies of functionally signif icant gene variants in the context of medical biology and gene geography is a relevant issue for studying the genetic structure of human populations. The transition from a traditional to an urbanized lifestyle leads to a higher incidence of civilizational diseases associated with metabolic disorders, including type 2 diabetes mellitus. The goal of the present paper is to analyze the frequencies of functionally signif icant gene alleles in the metabolic prof iles of indigenous Siberian peoples to identify the gene pool resilience, evaluate the susceptibility of various ethnic groups to metabolic disorders under changing environmental conditions, and predict the epidemiological situation that may occur in the near future. The study was performed in the monoethnic samples of eastern and western Buryats, Teleuts, Dolgans, and two territorial groups of Yakuts. A real-time PCR was used to determine the frequencies of single nucleotide polymorphisms (SNPs) G103894T, rs12255372, and C53341T, rs7903146 in the TCF7L2 gene. The results obtained were compared to the frequencies identif ied for Russians from Eastern Siberia and the values available in the literature. The frequencies of the polymorphic variants studied in the samples from the indigenous Siberian peoples place them in between Caucasian and East Asian populations, following the geographic gradient of polymorphism distribution. A signif icantly lower occurrence of type 2 diabetes risk alleles TCF7L2 (103894T) and TCF7L2 (53341T) in the samples of indigenous Siberian peoples compared to Russians was observed, which agrees with their lower susceptibility to metabolic disorders compared to the newcomer Caucasian population. Taking into account urbanization, a reduced growth in type 2 diabetes incidence may be predicted in indigenous Siberian peoples, i. e. Buryats, Yakuts, Dolgans, and Teleuts, compared to the newcomer Caucasian population. A further study of population structure with respect to different metabolic prof ile genes is required to better understand the molecular genetic foundations of the adaptive potential of indigenous Siberian peoples