Comment on "Are periodic solar wind number density structures formed in the solar corona?" by N. M. Viall et al., 2009, Geophys. Res. Lett., 36, L23102, doi:10.1029/2009GL041191

Location of formation of periodic solar wind number density structures is discussed. Observation of proton and alpha anticorrelation in these structures [Viall et al., 2009] indicates that taking into account that bulk velocity of aplha-particles is higher than that of proton the place of formation for these structures should be located at distance less 0.002 AU from place of observation.Comment: 6 pages, submitted in GR

Secular interactions between inclined planets and a gaseous disk

In a planetary system, a secular particle resonance occurs at a location where the precession rate of a test particle (e.g. an asteroid) matches the frequency of one of the precessional modes of the planetary system. We investigate the secular interactions of a system of mutually inclined planets with a gaseous protostellar disk that may contain a secular nodal particle resonance. We determine the normal modes of some mutually inclined planet-disk systems. The planets and disk interact gravitationally, and the disk is internally subject to the effects of gas pressure, self-gravity, and turbulent viscosity. The behavior of the disk at a secular resonance is radically different from that of a particle, owing mainly to the effects of gas pressure. The resonance is typically broadened by gas pressure to the extent that global effects, including large-scale warps, dominate. The standard resonant torque formula is invalid in this regime. Secular interactions cause a decay of the inclination at a rate that depends on the disk properties, including its mass, turbulent viscosity, and sound speed. For a Jupiter-mass planet embedded within a minimum-mass solar nebula having typical parameters, dissipation within the disk is sufficient to stabilize the system against tilt growth caused by mean-motion resonances.Comment: 30 pages, 6 figures, to be published in The Astrophysical Journa

Contributions to the Fourth Solar Wind Conference

Recent results in interplanetary physics are examined. These include observations of shock waves and post-shock magnetic fields made by Voyager 1, 2; observations of the electron temperature as a function of distance between 1.36 AU and 2.25 AU; and observations of the structure of sector boundaries observed by Helios 1. A theory of electron energy transport in the collisionless solar wind is presented, and compared with observations. Alfven waves and Alvenic fluctuations in the solar wind are also discussed

Cancer Precision Medicine: Why More Is More and DNA Is Not Enough

Every tumour is different. They arise in patients with different genomes, from cells with different epigenetic modifications, and by random processes affecting the genome and/or epigenome of a somatic cell, allowing it to escape the usual controls on its growth. Tumours and patients therefore often respond very differently to the drugs they receive. Cancer precision medicine aims to characterise the tumour (and often also the patient) to be able to predict, with high accuracy, its response to different treatments, with options ranging from the selective characterisation of a few genomic variants considered particularly important to predict the response of the tumour to specific drugs, to deep genome analysis of both tumour and patient, combined with deep transcriptome analysis of the tumour. Here, we compare the expected results of carrying out such analyses at different levels, from different size panels to a comprehensive analysis incorporating both patient and tumour at the DNA and RNA levels. In doing so, we illustrate the additional power gained by this unusually deep analysis strategy, a potential basis for a future precision medicine first strategy in cancer drug therapy. However, this is only a step along the way of increasingly detailed molecular characterisation, which in our view will, in the future, introduce additional molecular characterisation techniques, including systematic analysis of proteins and protein modification states and different types of metabolites in the tumour, systematic analysis of circulating tumour cells and nucleic acids, the use of spatially resolved analysis techniques to address the problem of tumour heterogeneity as well as the deep analyses of the immune system of the patient to, e.g., predict the response of the patient to different types of immunotherapy. Such analyses will generate data sets of even greater complexity, requiring mechanistic modelling approaches to capture enough of the complex situation in the real patient to be able to accurately predict his/her responses to all available therapies

Confinement in a Higgs Model on R3×S1R^{3}\times S^{1}

We determine the phase structure of an SU(2) gauge theory with an adjoint scalar on $R^{3}\times S^{1}$ using semiclassical methods. There are two global symmetries: a $Z(2)_{H}$ symmetry associated with the Higgs field and a $Z(2)_{C}$ center symmetry. We analyze the order of the deconfining phase transition when different deformation terms are used. After finding order parameters for the global symmetries, we show that there are four distinct phases: a deconfined phase, a confined phase, a Higgs phase, and a mixed confined phase. The mixed confined phase occurs where one might expect a phase in which there is both confinement and the Higgs mechanism, but the behavior of the order parameters distinguishes the two phases. In the mixed confined phase, the $Z(2)_{C}\times Z(2)_{H}$ global symmetry breaks spontaneously to a Z(2) subgroup that acts non-trivially on both the scalar field and the Polyakov loop. We find explicitly the BPS and KK monopole solutions of the Euclidean field equations in the BPS limit. In the mixed phase, a linear combination of $\phi$ and $A_{4}$ enters into the monopole solutions. In all four phases, Wilson loops orthogonal to the compact direction are expected to show area-law behavior. We show that this confining behavior can be attributed to a dilute monopole gas in a broad region that includes portions of all four phases. A duality argument similar to that applied recently [Poppitz and Unsal, 2011] to the Seiberg-Witten model on $R^3 \times S^1$ shows that the monopole gas picture, arrived at using Euclidean instanton methods, can be interpreted as a gas of finite-energy dyons.Comment: 23 pages, 5 figure

Interaction of the solar wind with Venus

Two topics related to the interaction of the solar wind with Venus are considered. First, a short review of the experimental evidence with particular attention to plasma measurements carried out on Mariner-5 and Mariner-10 is given. Secondly, the results of some recent theoretical work on the interaction of the solar wind with the ionosphere of Venus are summarized

Making Sense of a New Transport System: An Ethnographic Study of the Cambridgeshire Guided Busway

An increase in public transport use has the potential to contribute to improving population health, and there is growing interest in innovative public transport systems. Yet how new public transport infrastructure is experienced and integrated (or not) into daily practice is little understood. We investigated how the Cambridgeshire Guided Busway, UK, was used and experienced in the weeks following its opening, using the method of participant observation (travelling on the busway and observing and talking to passengers) and drawing on Normalization Process Theory to interpret our data. Using excerpts of field notes to support our interpretations, we describe how the ease with which the new transport system could be integrated into existing daily routines was important in determining whether individuals would continue to use it. It emerged that there were two groups of passengers with different experiences and attitudes. Passengers who had previously travelled frequently on regular bus services did not perceive the new system to be an improvement; consequently, they were frustrated that it was differentiated from and not coherent with the regular system. In contrast, passengers who had previously travelled almost exclusively by car appraised the busway positively and perceived it to be a novel and superior form of travel. Our rich qualitative account highlights the varied and creative ways in which people learn to use new public transport and integrate it into their everyday lives. This has consequences for the introduction and promotion of future transport innovations. It is important to emphasise the novelty of new public transport, but also the ways in which its use can become ordinary and routine. Addressing these issues could help to promote uptake of other public transport interventions, which may contribute to increasing physical activity and improving population health. © 2013 Jones et al

A First Principles Estimate of Finite Size Effects in Quark-Gluon Plasma Formation

Using lattice simulations of quenched QCD we estimate the finite size effects present when a gluon plasma equilibrates in a slab geometry, i.e., finite width but large transverse dimensions. Significant differences are observed in the free energy density for the slab when compared with bulk behavior. A small shift in the critical temperature is also seen. The free energy required to liberate heavy quarks relative to bulk is measured using Polyakov loops; the additional free energy required is on the order of 30-40 MeV at 2-3 T_c.Comment: 10 pages, 5 figures, RevTeX; revised version includes comparison with the Bjorken model and various small improvement

Warp propagation in astrophysical discs

Astrophysical discs are often warped, that is, their orbital planes change with radius. This occurs whenever there is a non-axisymmetric force acting on the disc, for example the Lense-Thirring precession induced by a misaligned spinning black hole, or the gravitational pull of a misaligned companion. Such misalignments appear to be generic in astrophysics. The wide range of systems that can harbour warped discs - protostars, X-ray binaries, tidal disruption events, quasars and others - allows for a rich variety in the disc's response. Here we review the basic physics of warped discs and its implications.Comment: To be published in Astrophysical Black Holes by Haardt et al., Lecture Notes in Physics, Springer 2015. 19 pages, 2 figure