14,607 research outputs found
Soft modes near the buckling transition of icosahedral shells
Icosahedral shells undergo a buckling transition as the ratio of Young's
modulus to bending stiffness increases. Strong bending stiffness favors smooth,
nearly spherical shapes, while weak bending stiffness leads to a sharply
faceted icosahedral shape. Based on the phonon spectrum of a simplified
mass-and-spring model of the shell, we interpret the transition from smooth to
faceted as a soft-mode transition. In contrast to the case of a disclinated
planar network where the transition is sharply defined, the mean curvature of
the sphere smooths the transitition. We define elastic susceptibilities as the
response to forces applied at vertices, edges and faces of an icosahedron. At
the soft-mode transition the vertex susceptibility is the largest, but as the
shell becomes more faceted the edge and face susceptibilities greatly exceed
the vertex susceptibility. Limiting behaviors of the susceptibilities are
analyzed and related to the ridge-scaling behavior of elastic sheets. Our
results apply to virus capsids, liposomes with crystalline order and other
shell-like structures with icosahedral symmetry.Comment: 28 pages, 6 figure
Active Learning on Center Stage: Theater as a Tool for Medical Education
Introduction:
Knowledge and skill development related to communication must incorporate both affective and behavioral components, which are often difficult to deliver in a learning activity. Using theater techniques and principles can provide medical educators with tools to teach communication concepts.
Methods:
This 75-minute faculty development workshop presents a variety of techniques from theater and adapts them for use in medical education. Using examples related to diversity and inclusion, this session addresses general educational and theater principles, role-play, sociodrama, applied improvisation, and practical aspects of involving theater partners. The session materials include a PowerPoint presentation with facilitator notes, interactive activities to demonstrate each modality, and an evaluation. The sessions can be extended to longer formats as needed.
Results:
Forty-five participants at Learn Serve Lead 2016: The AAMC Annual Meeting attended the 75-minute session. We emailed 32 participants 5 months after the conference, and eight responded. Participants reported that their confidence level in using theater techniques as a tool for medical education increased from low-to-medium confidence presession to high confidence postsession. All survey respondents who were actively teaching said they had made changes to their teaching based on the workshop. All commented that they appreciated the active learning in the session. Many indicated they would appreciate video or other follow-up resources.
Discussion:
Principles and techniques from theater are effective tools to convey difficult-to-teach concepts related to communication. This workshop presents tools to implement activities in teaching these difficult concepts
Space shuttle abort separation pressure investigation. Volume 2, Part B: Orbiter data at Mach 5
For abstract, see
Nonaffine Correlations in Random Elastic Media
Materials characterized by spatially homogeneous elastic moduli undergo
affine distortions when subjected to external stress at their boundaries, i.e.,
their displacements \uv (\xv) from a uniform reference state grow linearly
with position \xv, and their strains are spatially constant. Many materials,
including all macroscopically isotropic amorphous ones, have elastic moduli
that vary randomly with position, and they necessarily undergo nonaffine
distortions in response to external stress. We study general aspects of
nonaffine response and correlation using analytic calculations and numerical
simulations. We define nonaffine displacements \uv' (\xv) as the difference
between \uv (\xv) and affine displacements, and we investigate the
nonaffinity correlation function
and related functions. We introduce four model random systems with random
elastic moduli induced by locally random spring constants, by random
coordination number, by random stress, or by any combination of these. We show
analytically and numerically that scales as A |\xv|^{-(d-2)}
where the amplitude is proportional to the variance of local elastic moduli
regardless of the origin of their randomness. We show that the driving force
for nonaffine displacements is a spatial derivative of the random elastic
constant tensor times the constant affine strain. Random stress by itself does
not drive nonaffine response, though the randomness in elastic moduli it may
generate does. We study models with both short and long-range correlations in
random elastic moduli.Comment: 22 Pages, 18 figures, RevTeX
Research study of some RAM antennas Final report, 18 Nov. 1964 - 18 Jun. 1965
Input impedance and radiation pattern determinations for cylindrical gap, waveguide excited and circular waveguide slot antenna array
Thermally assisted adiabatic quantum computation
We study the effect of a thermal environment on adiabatic quantum computation
using the Bloch-Redfield formalism. We show that in certain cases the
environment can enhance the performance in two different ways: (i) by
introducing a time scale for thermal mixing near the anticrossing that is
smaller than the adiabatic time scale, and (ii) by relaxation after the
anticrossing. The former can enhance the scaling of computation when the
environment is superohmic, while the latter can only provide a prefactor
enhancement. We apply our method to the case of adiabatic Grover search and
show that performance better than classical is possible with a superohmic
environment, with no a priori knowledge of the energy spectrum.Comment: 4 pages, 2 figures, Final version to appear in PR
Temporal overlap and repeatability of feather corticosterone levels: Practical considerations for use as a biomarker
The measurement of corticosterone (CORT) levels in feathers has recently become an appealing tool for the conservation toolbox, potentially providing a non-invasive, integrated measure of stress activity throughout the time of feather growth. However, because the mechanism of CORT deposition, storage and stability in feathers is not fully understood, it is unclear how reliable this measure may be, especially when there is an extended interval between growth and feather collection. We compared CORT levels of naturally grown feathers from tree swallows (Tachycineta bicolor) that were moulted and regrown concurrently and therefore expected to have similar CORT levels. Specifically, we compared the same feather from the left and right wing (moulted symmetrically) and different types of feathers (wing, back and tail) expected to have been moulted within the same time period. We found that larger, heavier feathers held more CORT per unit length. In addition, we found a lack of concordance in CORT levels both within the same feather type and between different feather types, even after taking into account differences in feather density. Our results indicate that naturally grown feathers may not consistently provide an indication of stress status. Additionally, conflict in results may arise depending on the feather assayed, and total feather volume may be an important consideration when interpreting feather CORT levels. Future work is necessary to determine explicitly the mechanisms of CORT deposition, the effects of environmental exposure and feather wear on the permanence of the feather CORT signal, and the influence of responses to wild stressors on feather CORT levels, before feather CORT can be implemented effectively as a tool for ecological and conservation applications
Temporal overlap and repeatability of feather corticosterone levels: Practical considerations for use as a biomarker
The measurement of corticosterone (CORT) levels in feathers has recently become an appealing tool for the conservation toolbox, potentially providing a non-invasive, integrated measure of stress activity throughout the time of feather growth. However, because the mechanism of CORT deposition, storage and stability in feathers is not fully understood, it is unclear how reliable this measure may be, especially when there is an extended interval between growth and feather collection. We compared CORT levels of naturally grown feathers from tree swallows (Tachycineta bicolor) that were moulted and regrown concurrently and therefore expected to have similar CORT levels. Specifically, we compared the same feather from the left and right wing (moulted symmetrically) and different types of feathers (wing, back and tail) expected to have been moulted within the same time period. We found that larger, heavier feathers held more CORT per unit length. In addition, we found a lack of concordance in CORT levels both within the same feather type and between different feather types, even after taking into account differences in feather density. Our results indicate that naturally grown feathers may not consistently provide an indication of stress status. Additionally, conflict in results may arise depending on the feather assayed, and total feather volume may be an important consideration when interpreting feather CORT levels. Future work is necessary to determine explicitly the mechanisms of CORT deposition, the effects of environmental exposure and feather wear on the permanence of the feather CORT signal, and the influence of responses to wild stressors on feather CORT levels, before feather CORT can be implemented effectively as a tool for ecological and conservation applications
Highly specific PCR-RFLP assays for karyotyping the widespread 2Rb inversion in malaria vectors of the Anopheles gambiae complex
Background: Chromosomal inversion polymorphisms play a role in adaptation to heterogeneous environments. Inversion polymorphisms are implicated in the very high ecological flexibility of the three main malaria vector species of the Afrotropical Anopheles gambiae complex, facilitating the exploitation of anthropogenic environmental modifications and promoting a strong association with humans. In addition to extending the species' spatial and temporal distribution, inversions are associated with epidemiologically relevant mosquito behavior and physiology, underscoring their medical importance. We here present novel PCR-RFLP based assays strongly predictive of genotype for the cosmopolitan 2Rb inversion in An. coluzzii and An. gambiae, a development which overcomes the numerous constraints inherent to traditional cytological karyotyping. Methods: We designed PCR-RFLP genotyping assays based on tag SNPs previously computationally identified as strongly predictive (> 95%) of 2Rb genotype. We targeted those tags whose alternative allelic states destroyed or created the recognition site of a commercially available restriction enzyme, and designed assays with distinctive cleavage profiles for each inversion genotype. The assays were validated on 251 An. coluzzii and 451 An. gambiae cytologically karyotyped specimens from nine countries across Africa and one An. coluzzii laboratory colony. Results: For three tag SNPs, PCR-RFLP assays (denoted DraIII, MspAI, and TatI) reliably produced robust amplicons and clearly distinguishable electrophoretic profiles for all three inversion genotypes. Results obtained with the DraIII assay are ≥ 95% concordant with cytogenetic assignments in both species, while MspAI and TatI assays produce patterns highly concordant with cytogenetic assignments only in An. coluzzii or An. gambiae, respectively. Joint application of species-appropriate pairs of assays increased the concordance levels to > 99% in An. coluzzii and 98% in An. gambiae. Potential sources of discordance (e.g. imperfect association between tag and inversion, allelic dropout, additional polymorphisms in the restriction target site, incomplete or failed restriction digestion) are discussed. Conclusions: The availability of highly specific, cost effective and accessible molecular assays for genotyping 2Rb in An. gambiae and An. coluzzii allows karyotyping of both sexes and all developmental stages. These novel tools will accelerate deeper investigations into the role of this ecologically and epidemiologically important chromosomal inversion in vector biology.[Figure not available: see fulltext.
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