413 research outputs found
A first-principles study of tunneling magnetoresistance in Fe/MgAl2O4/Fe(001) magnetic tunnel junctions
We investigated the spin-dependent transport properties of Fe/MgAl2O4/Fe(001)
magnetic tunneling junctions (MTJs) on the basis of first-principles
calculations of the electronic structures and the ballistic conductance. The
calculated tunneling magnetoresistance (TMR) ratio of a Fe/MgAl2O4/Fe(001) MTJ
was about 160%, which was much smaller than that of a Fe/MgO/Fe(001) MTJ
(1600%) for the same barrier thickness. However, there was an evanescent state
with delta 1 symmetry in the energy gap around the Fermi level of normal spinel
MgAl2O4, indicating the possibility of a large TMR in Fe/MgAl2O4/Fe(001) MTJs.
The small TMR ratio of the Fe/MgAl2O4/Fe(001) MTJ was due to new conductive
channels in the minority spin states resulting from a band-folding effect in
the two-dimensional (2-D) Brillouin zone of the in-plane wave vector (k//) of
the Fe electrode. Since the in-plane cell size of MgAl2O4 is twice that of the
primitive in-plane cell size of bcc Fe, the bands in the boundary edges are
folded, and minority-spin states coupled with the delta 1 evanescent state in
the MgAl2O4 barrier appear at k//=0, which reduces the TMR ratio of the MTJs
significantly.Comment: 5 pages, 6 figures, 1 tabl
Description of an advanced practice nursing consultative model to reduce restrictive siderail use in nursing homes
Researchers have demonstrated that the use of physical restraints in nursing homes can be reduced, particularly where advanced practice nurses (APNs) are utilized. We examined the link between APN practice, siderail reduction, and the costs of siderail alternatives in 273 residents in four Philadelphia nursing homes. The majority of participants were cognitively and physically impaired with multiple co-morbidities. APNs recommended a total of 1,275 siderail-alternative interventions aimed at reducing fall risk. The median cost of siderail alternatives to prevent falls per resident was $135. Residents with a fall history experienced a significantly higher cost of recommendation compared to non-fallers. Findings suggest that an APN consultation model can effectively be implemented through comprehensive, individualized assessment without incurring substantial costs to the nursing home. © 2007 Wiley Periodicals, Inc. Res Nurs Health 30: 131–140, 2007Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/56001/1/20185_ftp.pd
An Ecological Approach to Prospective and Retrospective Timing of Long Durations: A Study Involving Gamers
To date, most studies comparing prospective and retrospective timing have failed to use long durations and tasks with a certain degree of ecological validity. The present study assessed the effect of the timing paradigm on playing video games in a “naturalistic environment” (gaming centers). In addition, as it involved gamers, it provided an opportunity to examine the effect of gaming profile on time estimation. A total of 116 participants were asked to estimate prospectively or retrospectively a video game session lasting 12, 35 or 58 minutes. The results indicate that time is perceived as longer in the prospective paradigm than in the retrospective one, although the variability of estimates is the same. Moreover, the 12-minute session was perceived as longer, proportionally, than the 35- and 58-minute sessions. The study also revealed that the number of hours participants spent playing video games per week was a significant predictor of time estimates. To account for the main findings, the differences between prospective and retrospective timing are discussed in quantitative terms using a proposed theoretical framework, which states that both paradigms use the same cognitive processes, but in different proportions. Finally, the hypothesis that gamers play more because they underestimate time is also discussed
A Mobile App For Delirium Screening
Objective: The objective of this study is to describe the algorithm and technical implementation of a mobile app that uses adaptive testing to assess an efficient mobile app for the diagnosis of delirium.
Materials and Methods: The app was used as part of a NIH-funded project to assess the feasibility, effectiveness, administration time, and costs of the 2-step delirium identification protocol when performed by physicians and nurses, and certified nursing assistants (CNA). The cohort included 535 hospitalized patients aged 79.7 (SD¼6.6) years enrolled at 2 different sites. Each patient was assessed on 2 consecutive days by the research associate who performed the reference delirium assessment. Thereafter, physicians, nurses, and CNAs performed adaptive delirium assessments using the app. Qualitative data to assess the experience of administering the 2-step protocol, and the app usability were also collected and analyzed from 50 physicians, 189 nurses, and 83 CNAs. We used extensible hypertext markup language (XHTML) and JavaScript to develop the app for the iOS–based iPad. The App was linked to Research Electronic Data Capture (REDCap), a relational database system, via a REDCap application programming interface (API) that sent and received data from/to the app. The data from REDCap were sent to the Statistical Analysis System for statistical analysis.
Results: The app graphical interface was successfully implemented by XHTML and JavaScript. The API facilitated the instant updating and retrieval of delirium status data between REDCap and the app. Clinicians performed 881 delirium assessments using the app for 535 patients. The transmission of data between the app and the REDCap system showed no errors. Qualitative data indicated that the users were enthusiastic about using the app with no negative comments, 82% positive comments, and 18% suggestions of improvement. Delirium administration time for the 2-step protocol showed similar total time between nurses and physicians (103.9 vs 106.5 seconds). Weekly enrollment reports of the app data were generated for study tracking purposes, and the data are being used for statistical analyses for publications.
Discussion: The app developed using iOS could be easily converted to other operating systems such as Android and could be linked to other relational databases beside REDCap, such as electronic health records to facilitate better data retrieval and updating of patient’s delirium status
Possible astrophysical signatures of heavy stable neutral relics in supergravity models
We consider heavy stable neutral particles in the context of supergravity and
show that a gravitationally suppressed inflaton decay can produce such
particles in cosmologically interesting abundances within a wide mass range
. In gravity-mediated
supersymmetry breaking models, a heavy particle can decay into its superpartner
and a photon-photino pair or a gravitino. Such decays only change the identity
of a possible dark matter candidate. However, for , astrophysical bounds from gamma-ray background and
photodissociation of light elements can be more stringent than the overclosure
bound, thus ruling out the particle as a dark matter candidate.Comment: 12 page
Non-thermal leptogenesis with almost degenerate superheavy neutrinos
We present a model with minimal assumptions for non-thermal leptogenesis with
almost degenerate superheavy right-handed neutrinos in a supersymmetric set up.
In this scenario a gauge singlet inflaton is directly coupled to the
right-handed (s)neutrinos with a mass heavier than the inflaton mass. This
helps avoiding potential problems which can naturally arise otherwise. The
inflaton decay to the Standard Model leptons and Higgs, via off-shell
right-handed (s)neutrinos, reheats the Universe. The same channel is also
responsible for generating the lepton asymmetry, thus requiring no stage of
preheating in order to excite superheavy (s)neutrinos. The suppressed decay
rate of the inflaton naturally leads to a sufficiently low reheat temperature,
which in addition, prevents any wash out of the yielded asymmetry. We will
particularly elaborate on important differences from leptogenesis with on-shell
(s)neutrinos. It is shown that for nearly degenerate neutrinos a successful
leptogenesis can be accommodated for a variety of inflationary models with a
rather wide ranging inflationary scale.Comment: 10 revtex pages, 2 figure (uses axodraw). The derivation of the
asymmetry parameter for the general case and one figure added. Final version
to appear in Phys. Rev.
Leptogenesis from a sneutrino condensate revisited
We re--examine leptogenesis from a right--handed sneutrino condensate, paying
special attention to the term associated with the see--saw Majorana mass.
This term generates a lepton asymmetry in the condensate whose time average
vanishes. However, a net asymmetry will result if the sneutrino lifetime is not
much longer than the period of oscillations. Supersymmetry breaking by thermal
effects then yields a lepton asymmetry in the standard model sector after the
condensate decays. We explore different possibilities by taking account of both
the low--energy and Hubble terms. It will be shown that the desired baryon
asymmetry of the Universe can be obtained for a wide range of Majorana mass.Comment: 17 revtex pages, 3 figures, 1 table. Slightly modified and references
added. Final version accepted for publication in Phys. Rev.
An essential function for the ATR-Activation-Domain (AAD) of TopBP1 in mouse development and cellular senescence
ATR activation is dependent on temporal and spatial interactions with partner proteins. In the budding yeast model, three proteins – Dpb11TopBP1, Ddc1Rad9 and Dna2 - all interact with and activate Mec1ATR. Each contains an ATR activation domain (ADD) that interacts directly with the Mec1ATR:Ddc2ATRIP complex. Any of the Dpb11TopBP1, Ddc1Rad9 or Dna2 ADDs is sufficient to activate Mec1ATR in vitro. All three can also independently activate Mec1ATR in vivo: the checkpoint is lost only when all three AADs are absent. In metazoans, only TopBP1 has been identified as a direct ATR activator. Depletion-replacement approaches suggest the TopBP1-AAD is both sufficient and necessary for ATR activation. The physiological function of the TopBP1 AAD is, however, unknown. We created a knock-in point mutation (W1147R) that ablates mouse TopBP1-AAD function. TopBP1-W1147R is early embryonic lethal. To analyse TopBP1-W1147R cellular function in vivo, we silenced the wild type TopBP1 allele in heterozygous MEFs. AAD inactivation impaired cell proliferation, promoted premature senescence and compromised Chk1 signalling following UV irradiation. We also show enforced TopBP1 dimerization promotes ATR-dependent Chk1 phosphorylation. Our data suggest that, unlike the yeast models, the TopBP1-AAD is the major activator of ATR, sustaining cell proliferation and embryonic development
Autoimmune syndromes in major histocompatibility complex (MHC) congenic strains of nonobese diabetic (NOD) mice. The NOD MHC is dominant for insulitis and cyclophosphamide-induced diabetes.
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