Effective Confinement as Origin of the Equivalence of Kinetic Temperature and Fluctuation-Dissipation Ratio in a Dense Shear Driven Suspension

We study response and velocity autocorrelation functions for a tagged particle in a shear driven suspension governed by underdamped stochastic dynamics. We follow the idea of an effective confinement in dense suspensions and exploit a time-scale separation between particle reorganization and vibrational motion. This allows us to approximately derive the fluctuation-dissipation theorem in a "hybrid" form involving the kinetic temperature as an effective temperature and an additive correction term. We show numerically that even in a moderately dense suspension the latter is negligible. We discuss similarities and differences with a simple toy model, a single trapped particle in shear flow

Role of External Flow and Frame Invariance in Stochastic Thermodynamics

For configurational changes of soft matter systems affected or caused by external hydrodynamic flow, we identify applied work, exchanged heat, and entropy change on the level of a single trajectory. These expressions guarantee invariance of stochastic thermodynamics under a change of frame of reference. As criterion for equilibrium \textit{vs.} nonequilibrium, zero \textit{vs.} nonzero applied work replaces detailed balance \textit{vs.} nonvanishing currents, since both latter criteria are shown to depend on the frame of reference. Our results are illustrated quantitatively by calculating the large deviation function for the entropy production of a dumbbell in shear flow

The Age and Sex Incidence of Keloids / Hypertrophic Scars in Calabar Metropolis, Cross River State from 2001-2006

Hypertrophic scars and keloids have been seen to occur frequently among burnt and accident patients. Keloids and hypertrophic scars result from excessive collagen deposition. They are dermal fibro proliferative disorders unique humans and occur as a complication of healing of wounds following trauma, inflammation, surgery, burns and sometimes occur spontaneously. Clinically, these scars can be disfiguring functionally and aesthetically or both. A retrospective study of patients with keloids and hypertrophic scars was carried out in University of Calabar Teaching Hospital (UCTH) using medical records of 41 patients that were diagnosed and / or treated. Sex, age, provisional diagnosis, manifestations and treatment procedures were extracted from their folders. The result of the study was statistically analyzed which revealed that keloids and hypertrophic scars increase with years and occur a little more in females than in males (M:F ratio = 48.8%:51.2%). The age range that was mostly affected was 15 to 45 years. Keywords: keloid, hypertrophic scar, sex, age, trib

Monoiodoacetic acid induces arthritis and synovitis in rats in a dose- and time-dependent manner: proposed model-specific scoring systems

SummaryObjectiveIn a rat monoiodoacetic acid (MIA)-induced arthritis model, the amount of MIA commonly used was too high, resulting in rapid bone destruction. We examined the effect of MIA concentrations on articular cartilage and infrapatellar fat pad (IFP). We also established an original system for “macroscopic cartilage and bone score” and “IFP inflammation score” specific to the rat MIA-induced arthritis model.DesignMale Wistar rats received a single intra-articular injection of MIA in the knee. The amount of MIA was 0.1, 0.2, 0.5, and 1 mg respectively. Articular cartilage was evaluated at 2–12 weeks. IFP was also observed at 3–14 days.ResultsMacroscopically, low MIA doses induced punctate depressions on the cartilage surface, and cartilage erosion proceeded slowly over 12 weeks, while higher MIA doses already induced cartilage erosion at 2 weeks, followed by bone destruction. MIA macroscopic cartilage and bone score, OARSI histological score, and Mankin score increased in a dose- and time-dependent manner. The IFP inflammation score peaked at 5 days in low dose groups, then decreased, while in high dose groups, the IFP score continued to increase over 14 days due to IFP fibrosis.ConclusionsPunctate depressions, cartilage erosion, and bone destruction were observed in the MIA-induced arthritis model. The macroscopic cartilage and bone scoring enabled the quantification of cartilage degeneration and demonstrated that MIA-induced arthritis progressed in a dose- and time-dependent manner. IFP inflammation scores revealed that 0.2 mg MIA induced reversible synovitis, while 1 mg MIA induced fibrosis of the IFP body

Escape from a metastable well under a time-ramped force

Thermally activated escape of an over-damped particle from a metastable well under the action of a time-ramped force is studied. We express the mean first passage time (MFPT) as the solution to a partial differential equation, which we solve numerically for a model case. We discuss two approximations of the MFPT, one of which works remarkably well over a wide range of loading rates, while the second is easy to calculate and can provide a valuable first estimate.Comment: 9 pages, including 2 figure

An Analytical Study of Coupled Two-State Stochastic Resonators

The two-state model of stochastic resonance is extended to a chain of coupled two-state elements governed by the dynamics of Glauber's stochastic Ising model. Appropriate assumptions on the model parameters turn the chain into a prototype system of coupled stochastic resonators. In a weak-signal limit analytical expressions are derived for the spectral power amplification and the signal-to-noise ratio of a two-state element embedded into the chain. The effect of the coupling between the elements on both quantities is analysed and array-enhanced stochastic resonance is established for pure as well as noisy periodic signals. The coupling-induced improvement of the SNR compared to an uncoupled element is shown to be limited by a factor four which is only reached for vanishing input noise.Comment: 29 pages, 5 figure

Observation of Multi-Tev Diffuse Gamma Rays from the Galactic Plane with the Tibet Air Shower Array

Data from the Tibet-III air shower array (with energies around 3 TeV) and from the Tibet-II array (with energies around 10 TeV) have been searched for diffuse gamma rays from the Galactic plane. These arrays have an angular resolution of about 0.9 degrees. The sky regions searched are the inner Galaxy, 20 degrees <= l <= 55 degrees, and outer Galaxy, 140 degrees <= l <= 225 degrees, and |b| <= 2 degrees or <= 5 degrees. No significant Galactic plane gamma-ray excess was observed. The 99% confidence level upper limits for gamma-ray intensity obtained are (for |b| <= 2 degrees) 1.1 times 10^{-15} cm^{-2}s^{-1}sr^{-1}MeV^{-1} at 3 TeV and 4.1 times 10^{-17} cm^{-2}s^{-1}sr^{-1}MeV^{-1} at 10 TeV for the inner Galaxy, and 3.6 times 10^{-16} cm^{-2}s^{-1}sr^{-1}MeV^{-1} at 3 TeV and 1.3 times 10^{-17} cm^{-2}s^{-1}sr^{-1}MeV^{-1} at 10 TeV for the outer Galaxy, assuming a differential spectral index of 2.4. The upper limits are significant in the multi-TeV region when compared to those from Cherenkov telescopes in the lower energy region and other air shower arrays in the higher energy region; however, the results are not sufficient to rule out the inverse Compton model with a source electron spectral index of 2.0.Comment: 22 pages, 8 figures, Accepted for publication in Ap