1,703 research outputs found
Reproductive success through high pollinator visitation rates despite self incompatibility in an endangered wallflower
PREMISE OF THE STUDY: Self incompatibility (SI) in rare plants presents a unique challenge—SI protects plants from inbreeding depression, but requires a sufficient number of mates and xenogamous pollination. Does SI persist in an endangered polyploid? Is pollinator visitation sufficient to ensure reproductive success? Is there evidence of inbreeding/outbreeding depression? We characterized the mating system, primary pollinators, pollen limitation, and inbreeding/outbreeding depression in Erysimum teretifolium to guide conservation efforts. METHODS: We compared seed production following self pollination and within- and between-population crosses. Pollen tubes were visualized after self pollinations and between-population pollinations. Pollen limitation was tested in the field. Pollinator observations were quantified using digital video. Inbreeding/outbreeding depression was assessed in progeny from self and outcross pollinations at early and later developmental stages. KEY RESULTS: Self-pollination reduced seed set by 6.5× and quadrupled reproductive failure compared with outcross pollination. Pollen tubes of some self pollinations were arrested at the stigmatic surface. Seed-set data indicated strong SI, and fruit-set data suggested partial SI. Pollinator diversity and visitation rates were high, and there was no evidence of pollen limitation. Inbreeding depression (δ) was weak for early developmental stages and strong for later developmental stages, with no evidence of outbreeding depression. CONCLUSIONS: The rare hexaploid E. teretifolium is largely self incompatible and suffers from late-acting inbreeding depression. Reproductive success in natural populations was accomplished through high pollinator visitation rates consistent with a lack of pollen limitation. Future reproductive health for this species will require large population sizes with sufficient mates and a robust pollinator community
Epitaxial checkerboard arrangement of nanorods in ZnMnGaO4 films studied by x-ray diffraction
The intriguing nano-structural properties of a ZnMnGaO4 film epitaxially
grown on MgO (001) substrate have been investigated using synchrotron
radiation-based x-ray diffraction. The ZnMnGaO4 film consisted of a
self-assembled checkerboard (CB) structure with perfectly aligned and regularly
spaced vertical nanorods. The lattice parameters of the orthorhombic and
rotated tetragonal phases of the CB structure were analyzed using H-K, H-L, and
K-L cross sections of the reciprocal space maps measured around various
symmetric and asymmetric reflections of the spinel structure. We demonstrate
that the symmetry of atomic displacements at the phases boundaries provides the
means for coherent coexistence of two domains types within the volume of the
film
Unbound states of 32Cl and the 31S(p,\gamma)32Cl reaction rate
The 31S(p,\gamma)32Cl reaction is expected to provide the dominant break-out
path from the SiP cycle in novae and is important for understanding enrichments
of sulfur observed in some nova ejecta. We studied the 32S(3He,t)32Cl
charge-exchange reaction to determine properties of proton-unbound levels in
32Cl that have previously contributed significant uncertainties to the
31S(p,\gamma)32Cl reaction rate. Measured triton magnetic rigidities were used
to determine excitation energies in 32Cl. Proton-branching ratios were obtained
by detecting decay protons from unbound 32Cl states in coincidence with
tritons. An improved 31S(p,\gamma)32Cl reaction rate was calculated including
robust statistical and systematic uncertainties
Lights, Camera, Action! Exploring Effects of Visual Distractions on Completion of Security Tasks
Human errors in performing security-critical tasks are typically blamed on
the complexity of those tasks. However, such errors can also occur because of
(possibly unexpected) sensory distractions. A sensory distraction that produces
negative effects can be abused by the adversary that controls the environment.
Meanwhile, a distraction with positive effects can be artificially introduced
to improve user performance.
The goal of this work is to explore the effects of visual stimuli on the
performance of security-critical tasks. To this end, we experimented with a
large number of subjects who were exposed to a range of unexpected visual
stimuli while attempting to perform Bluetooth Pairing. Our results clearly
demonstrate substantially increased task completion times and markedly lower
task success rates. These negative effects are noteworthy, especially, when
contrasted with prior results on audio distractions which had positive effects
on performance of similar tasks. Experiments were conducted in a novel (fully
automated and completely unattended) experimental environment. This yielded
more uniform experiments, better scalability and significantly lower financial
and logistical burdens. We discuss this experience, including benefits and
limitations of the unattended automated experiment paradigm
Excitation of superconducting qubits from hot non-equilibrium quasiparticles
Superconducting qubits probe environmental defects such as non-equilibrium
quasiparticles, an important source of decoherence. We show that "hot"
non-equilibrium quasiparticles, with energies above the superconducting gap,
affect qubits differently from quasiparticles at the gap, implying qubits can
probe the dynamic quasiparticle energy distribution. For hot quasiparticles, we
predict a non-neligable increase in the qubit excited state probability P_e. By
injecting hot quasiparticles into a qubit, we experimentally measure an
increase of P_e in semi-quantitative agreement with the model and rule out the
typically assumed thermal distribution.Comment: Main paper: 5 pages, 5 figures. Supplement: 1 page, 1 figure, 1
table. Updated to user-prepared accepted version. Key changes: Supplement
added, Introduction rewritten, Figs.2,3,5 revised, Fig.4 adde
Adult beginner distance language learner perceptions and use of assignment feedback
This qualitative study examines perceptions and use of assignment feedback among adult beginner modern foreign language learners on higher education distance learning courses. A survey of responses to feedback on assignments by 43 Open University students on beginner language courses in Spanish, French, and German indicated that respondents can be classified into three groups: those who use feedback strategically by integrating it into the learning process and comparing it with, for example, informal feedback from interaction with native speakers, those who take note of feedback, but seem not to use it strategically, and those who appear to take little account of either marks or feedback. The first group proved to be the most confident and most likely to maintain their motivation in the longer term. The conclusion discusses some of the pedagogical and policy implications of the findings
Changes in drug use during ages 18-32
https://deepblue.lib.umich.edu/bitstream/2027.42/137887/1/occ39.pd
A method for the reconstruction of unknown non-monotonic growth functions in the chemostat
We propose an adaptive control law that allows one to identify unstable
steady states of the open-loop system in the single-species chemostat model
without the knowledge of the growth function. We then show how one can use this
control law to trace out (reconstruct) the whole graph of the growth function.
The process of tracing out the graph can be performed either continuously or
step-wise. We present and compare both approaches. Even in the case of two
species in competition, which is not directly accessible with our approach due
to lack of controllability, feedback control improves identifiability of the
non-dominant growth rate.Comment: expansion of ideas from proceedings paper (17 pages, 8 figures),
proceedings paper is version v
Antitumor activity and safety of the PARP inhibitor rucaparib in patients with high grade ovarian carcinoma and a germline or somatic BRCA1 or BRCA2 mutation: integrated analysis of data from Study 10 and ARIEL2
Objective:
An integrated analysis was undertaken to characterize the antitumor activity and safety profile of the oral poly(ADP-ribose) polymerase inhibitor rucaparib in patients with relapsed high-grade ovarian carcinoma (HGOC).
Methods:
Eligible patients from Study 10 (NCT01482715) and ARIEL2 (NCT01891344) who received a starting dose of oral rucaparib 600 mg twice daily (BID) with or without food were included in these analyses. The integrated efficacy population included patients with HGOC and a deleterious germline or somatic BRCA1 or BRCA2 (BRCA1/2) mutation who received at least two prior chemotherapies and were sensitive, resistant, or refractory to platinum-based chemotherapy. The primary endpoint was investigator-assessed confirmed objective response rate (ORR). Secondary endpoints included duration of response (DOR) and progression-free survival (PFS). The integrated safety population included patients with HGOC who received at least one dose of rucaparib 600 mg BID, irrespective of BRCA1/2 mutation status and prior treatments.
Results:
In the efficacy population (n = 106), ORR was 53.8% (95% confidence interval [CI], 43.8–63.5); 8.5% and 45.3% of patients achieved complete and partial responses, respectively. Median DOR was 9.2 months (95% CI, 6.6–11.6). In the safety population (n = 377), the most frequent treatment-emergent adverse events (AEs) were nausea, asthenia/fatigue, vomiting, and anemia/hemoglobin decreased. The most common grade ≥ 3 treatment-emergent AE was anemia/hemoglobin decreased. Treatment-emergent AEs led to treatment interruption, dose reduction, and treatment discontinuation in 58.6%, 45.9%, and 9.8% of patients, respectively. No treatment-related deaths occurred.
Conclusions:
Rucaparib has antitumor activity in advanced BRCA1/2-mutated HGOC and a manageable safety profile
Ecological Invasion, Roughened Fronts, and a Competitor's Extreme Advance: Integrating Stochastic Spatial-Growth Models
Both community ecology and conservation biology seek further understanding of
factors governing the advance of an invasive species. We model biological
invasion as an individual-based, stochastic process on a two-dimensional
landscape. An ecologically superior invader and a resident species compete for
space preemptively. Our general model includes the basic contact process and a
variant of the Eden model as special cases. We employ the concept of a
"roughened" front to quantify effects of discreteness and stochasticity on
invasion; we emphasize the probability distribution of the front-runner's
relative position. That is, we analyze the location of the most advanced
invader as the extreme deviation about the front's mean position. We find that
a class of models with different assumptions about neighborhood interactions
exhibit universal characteristics. That is, key features of the invasion
dynamics span a class of models, independently of locally detailed demographic
rules. Our results integrate theories of invasive spatial growth and generate
novel hypotheses linking habitat or landscape size (length of the invading
front) to invasion velocity, and to the relative position of the most advanced
invader.Comment: The original publication is available at
www.springerlink.com/content/8528v8563r7u2742
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