79 research outputs found

    Urbanization, legacies of elite capture, and multi-dimensional exclusions in Ghana: towards just housing and neighborhood policies in African cities

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    Persisting housing challenges in Africa’s cities are often theorized as driven by rapid demographic expansion outstripping housing supply or by the urbanization of poverty which puts the cost of adequate and serviced housing beyond the reach of many urban dwellers. This theorization links the problem of inadequate supply and low quality of housing to ahistorical, apolitical factors such as the size and income/poverty characteristics of Africa’s urban population and ignores legacies of elite capture and multi-dimensional exclusions reflected in policies and practices. Yet these policies and practices shape urban governance and who gains access to land, housing finance and ultimately serviced housing and neighborhoods. Drawing on a review of policies, media sources and literature on housing in Ghana and taking a critical postcolonial institutional theoretic approach, we argue that a more complete conceptualization of Africa’s urban housing crises should involve a close look at the regressive historical patterns of urban investments and persisting elite biases in institutions managing land, finance and housing. This re-framing of housing problems creates a more holistic framework and better articulates the unjust foundations of regressive and exclusionary policies and practices. Further, it highlights elite capture and multi-dimensional exclusions that perpetuate current housing and service failure in African cities. An explicit focus on power, exclusion and injustice is necessary to formulate and advocate alternative policies that are more likely to produce inclusive livable housing and neighborhoods. These include moratoriums on evictions, expanded slum upgrading, progressive property and land taxation, more inclusive planning systems, better regulation of rental housing and improved delivery of land and finance for transit oriented affordable public and rental housing

    The electric vehicle transition: a blessing or a curse for improving extractive industries and mineral supply chains?

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    Concern is growing that new mineral demand pressures associated with transport electrification will exacerbate existing supply chain sustainability and resiliency risks and escalate global environmental injustices. In response, private and public actors in the extractive sector have signaled that they are retooling mineral production, sourcing and stewardship governance systems, practices, and processes to meet the sustainability demands of the electric vehicle (EV) transition. Currently, however, the specific components of many of these initiatives remain less well known, with little scholarly review of their potential to address the longstanding systemic deficiencies in mineral supply chains. Instead, research and policy conversations are oriented largely towards what can be described as a demand-reduction approach, focused on minimizing the intensity of metal mining as a strategy for ensuring the sustainability imperatives of the transition. This Perspective argues that 1) the EV transition offers a critical impetus for tackling head-on longstanding systemic deficiencies in responsible global mineral production, sourcing, and stewardship 2) addressing the deficiencies will also better position mineral demand-reduction measures to yield their intended sustainability outcomes and 3) historically, new initiatives introduced to reform the extractive sector rarely address the root problems that first gave impetus to the initiatives. Accordingly, questions about retooling existing mineral procurement governance systems, practices and processes should be an integral part of EV transition research. It recommends moving research, policy, action, and investment towards prioritizing addressing persisting systemic deficiencies in global mineral supply chains as part of strategies for ensuring ethical transport decarbonization

    Accessibility across transport modes and residential developments in Nairobi

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    A key goal of urban transportation planning is to provide people with access to a greater number of opportunities for interaction with people and places. Measures of accessibility are gaining attention globally for use in planning, yet few studies measure accessibility in cities in low-income countries, and even fewer incorporate semi-formal bus systems, also called paratransit. Drawing on rich datasets available for Nairobi, Kenya this analysis quantifies place-based accessibility for walking, paratransit, and driving using three different measures: a mobility measure quantifying how many other locations in Nairobi can be reached in 60 min, a contour measure quantifying the number of health facilities that can be reached in 60 min, and a gravity measure quantifying the number of health facilities weighted by a time-decay function. Health facilities are used because they are an essential service that people need physical access to and as a representation of the spatial distribution of activities more broadly. The findings show that place-based accessibility is highest for driving, then paratransit, then walking, and that there are high levels of access to health facilities near the Central Business District (CBD) for all modes. Additionally, paratransit accessibility is comparatively better in the contour and gravity measures, which may mean that paratransit is efficiently providing access based on the spatial distribution of services. The contour measure results are also compared across different residential levels, which are grouped based on neighborhood characteristics and ordered by income. Counterintuitively, the wealthiest areas have very low levels of place-based accessibility for all modes, while poor areas have comparatively better walking access to health facilities. Interestingly, the medium low residential level, characterized in part by tenement apartment buildings, has significantly higher accessibility than other residential types. One way to reduce inequality in access across income groups is to increase spatial accessibility for the modes used by low- and middle-income households, for example with policies that prioritize public transport and non-motorized travel, integrate paratransit with land use development, and provide safe, efficient, and affordable options

    Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque

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    Carotid intima media thickness (cIMT) and plaque determined by ultrasonography are established measures of subclinical atherosclerosis that each predicts future cardiovascular disease events. We conducted a meta-analysis of genome-wide association data in 31,211 participants of European ancestry from nine large studies in the setting of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. We then sought additional evidence to support our findings among 11,273 individuals using data from seven additional studies. In the combined meta-analysis, we identified three genomic regions associated with common carotid intima media thickness and two different regions associated with the presence of carotid plaque (P < 5 × 10 -8). The associated SNPs mapped in or near genes related to cellular signaling, lipid metabolism and blood pressure homeostasis, and two of the regions were associated with coronary artery disease (P < 0.006) in the Coronary Artery Disease Genome-Wide Replication and Meta-Analysis (CARDIoGRAM) consortium. Our findings may provide new insight into pathways leading to subclinical atherosclerosis and subsequent cardiovascular events

    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.

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    Multiple sclerosis is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermittent neurological disturbance followed by progressive accumulation of disability. Epidemiological studies have shown that genetic factors are primarily responsible for the substantially increased frequency of the disease seen in the relatives of affected individuals, and systematic attempts to identify linkage in multiplex families have confirmed that variation within the major histocompatibility complex (MHC) exerts the greatest individual effect on risk. Modestly powered genome-wide association studies (GWAS) have enabled more than 20 additional risk loci to be identified and have shown that multiple variants exerting modest individual effects have a key role in disease susceptibility. Most of the genetic architecture underlying susceptibility to the disease remains to be defined and is anticipated to require the analysis of sample sizes that are beyond the numbers currently available to individual research groups. In a collaborative GWAS involving 9,772 cases of European descent collected by 23 research groups working in 15 different countries, we have replicated almost all of the previously suggested associations and identified at least a further 29 novel susceptibility loci. Within the MHC we have refined the identity of the HLA-DRB1 risk alleles and confirmed that variation in the HLA-A gene underlies the independent protective effect attributable to the class I region. Immunologically relevant genes are significantly overrepresented among those mapping close to the identified loci and particularly implicate T-helper-cell differentiation in the pathogenesis of multiple sclerosis
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