Air cushion vehicles: A briefing

Experience and characteristics; the powering, uses, and implications of large air cushion vehicles (ACV); and the conceptual design and operation of a nuclear powered ACV freighter and supporting facilities are described

Crystallization of a Mos1 transposase-inverted-repeat DNA complex: biochemical and preliminary crystallographic analyses

A complex formed between Mos1 transposase and its inverted-repeat DNA has been crystallized. The crystals diffract to 3.25 Å resolution and exhibit monoclinic (P2(1)) symmetry, with unit-cell parameters a = 120.8, b = 85.1, c = 131.6 Å, β = 99.3°. The X-ray diffraction data display noncrystallographic twofold symmetry and characteristic dsDNA diffraction at ∼3.3 Å. Biochemical analyses confirmed the presence of DNA and full-length protein in the crystals. The relationship between the axis of noncrystallographic symmetry, the unit-cell axes and the DNA diffraction pattern are discussed. The data are consistent with the previously proposed model of the paired-ends complex containing a dimer of the transposase

Different Motion Cues Are Used to Estimate Time-to-arrival for Frontoparallel and Loming Trajectories

Estimation of time-to-arrival for moving objects is critical to obstacle interception and avoidance, as well as to timing actions such as reaching and grasping moving objects. The source of motion information that conveys arrival time varies with the trajectory of the object raising the question of whether multiple context-dependent mechanisms are involved in this computation. To address this question we conducted a series of psychophysical studies to measure observers’ performance on time-to-arrival estimation when object trajectory was specified by angular motion (“gap closure” trajectories in the frontoparallel plane), looming (colliding trajectories, TTC) or both (passage courses, TTP). We measured performance of time-to-arrival judgments in the presence of irrelevant motion, in which a perpendicular motion vector was added to the object trajectory. Data were compared to models of expected performance based on the use of different components of optical information. Our results demonstrate that for gap closure, performance depended only on the angular motion, whereas for TTC and TTP, both angular and looming motion affected performance. This dissociation of inputs suggests that gap closures are mediated by a separate mechanism than that used for the detection of time-to-collision and time-to-passage. We show that existing models of TTC and TTP estimation make systematic errors in predicting subject performance, and suggest that a model which weights motion cues by their relative time-to-arrival provides a better account of performance

Two mechanisms for optic flow and scale change processing of looming

Published in final edited form as: J Vis. ; 11(3): . doi:10.1167/11.3.5.The detection of looming, the motion of objects in depth, underlies many behavioral tasks, including the perception of self-motion and time-to-collision. A number of studies have demonstrated that one of the most important cues for looming detection is optic flow, the pattern of motion across the retina. Schrater et al. have suggested that changes in spatial frequency over time, or scale changes, may also support looming detection in the absence of optic flow (P. R. Schrater, D. C. Knill, & E. P. Simoncelli, 2001). Here we used an adaptation paradigm to determine whether the perception of looming from optic flow and scale changes is mediated by single or separate mechanisms. We show first that when the adaptation and test stimuli were the same (both optic flow or both scale change), observer performance was significantly impaired compared to a dynamic (non-motion, non-scale change) null adaptation control. Second, we found no evidence of cross-cue adaptation, either from optic flow to scale change, or vice versa. Taken together, our data suggest that optic flow and scale changes are processed by separate mechanisms, providing multiple pathways for the detection of looming.We thank Jonathan Victor and the anonymous reviewers of the paper for feedback and suggestions regarding the stimuli used here. This work was supported by NIH grant R01NS064100 to LMV. (R01NS064100 - NIH)Accepted manuscrip

Integration Mechanisms for Heading Perception

Previous studies of heading perception suggest that human observers employ spatiotemporal pooling to accommodate noise in optic flow stimuli. Here, we investigated how spatial and temporal integration mechanisms are used for judgments of heading through a psychophysical experiment involving three different types of noise. Furthermore, we developed two ideal observer models to study the components of the spatial information used by observers when performing the heading task. In the psychophysical experiment, we applied three types of direction noise to optic flow stimuli to differentiate the involvement of spatial and temporal integration mechanisms. The results indicate that temporal integration mechanisms play a role in heading perception, though their contribution is weaker than that of the spatial integration mechanisms. To elucidate how observers process spatial information to extract heading from a noisy optic flow field, we compared psychophysical performance in response to random-walk direction noise with that of two ideal observer models (IOMs). One model relied on 2D screen-projected flow information (2D-IOM), while the other used environmental, i.e., 3D, flow information (3D-IOM). The results suggest that human observers compensate for the loss of information during the 2D retinal projection of the visual scene for modest amounts of noise. This suggests the likelihood of a 3D reconstruction during heading perception, which breaks down under extreme levels of noise

Continuous-flow laboratory simulation of stream water quality changes downstream of an untreated wastewater discharge.

In regions of the world with poor provision of wastewater treatment, raw sewage is often discharged directly into surface waters. This paper describes an experimental evaluation of the fate of two organic chemicals under these conditions using an artificial channel cascade fed with a mix of settled sewage and river water at its upstream end and operated under continuous steady-state conditions. The experiments underpin an environmental risk assessment methodology based on the idea of an “impact zone” (IZ) – the zone downstream of wastewater emission in which water quality is severely impaired by high concentrations of unionised ammonia, nitrite and biochemical oxygen demand (BOD). Radiolabelled dodecane-6-benzene sulphonate (DOBS) and aniline hydrochloride were used as the model chemical and reference compound respectively. Rapid changes in 14C counts were observed with flow-time for both these materials. These changes were most likely to be due to complete mineralisation. A dissipation half-life of approximately 7.1 h was observed for the 14C label with DOBS. The end of the IZ was defined as the point at which the concentration of both unionised ammonia and nitrite fell below their respective predicted no-effect concentrations for salmonids. At these points in the cascade, approximately 83 and 90% of the initial concentration of 14C had been removed from the water column, respectively. A simple model of mineral nitrogen transformations based on Michaelis–Menten kinetics was fitted to observed concentrations of NH4, NO2 and NO3. The cascade is intended to provide a confirmatory methodology for assessing the ecological risks of chemicals under direct discharge co

TiB_2 and ZrB_2 diffusion barriers in GaAs Ohmic contact technology

The transition metal diboride compounds, ZrB_2 and TiB_2, interposed between Ni/Ge/Au Ohmic contact metallization on n‐type GaAs wafers and an overlying thick Au contact layer, have been investigated to evaluate their effectiveness in stabilizing the Ohmic contact by limiting the in‐diffusion of Au. All of the metal layers were e‐beam deposited except the ZrB_2 which was rf‐diode sputtered. The barrier layer thicknesses were 50 and 100 nm for the TiB_2 and the ZrB_2, respectively. Postdeposition alloying of the contacts was performed at 400, 425, or 450 °C. Auger electron spectroscopy depth profiling of the resultant Ohmic contacts demonstrates that the barrier layers effectively preclude penetration of Au to the Ohmic contact structure. Specific contact resistivities for such contacts are in the low 10^(−7) Ω cm^2 range; although some degradation of the contact resistivity is observed after long term annealing, the values of resistivities do not exceed 1.5×10^(−6) Ω cm^2 after 92 h at 350 °C

Reorganization of retinotopic maps after occipital lobe infarction

Published in final edited form as: J Cogn Neurosci. 2014 June ; 26(6): 1266–1282. doi:10.1162/jocn_a_00538.We studied patient JS, who had a right occipital infarct that encroached on visual areas V1, V2v, and VP. When tested psychophysically, he was very impaired at detecting the direction of motion in random dot displays where a variable proportion of dots moving in one direction (signal) were embedded in masking motion noise (noise dots). The impairment on this motion coherence task was especially marked when the display was presented to the upper left (affected) visual quadrant, contralateral to his lesion. However, with extensive training, by 11 months his threshold fell to the level of healthy participants. Training on the motion coherence task generalized to another motion task, the motion discontinuity task, on which he had to detect the presence of an edge that was defined by the difference in the direction of the coherently moving dots (signal) within the display. He was much better at this task at 8 than 3 months, and this improvement was associated with an increase in the activation of the human MT complex (hMT^+) and in the kinetic occipital region as shown by repeated fMRI scans. We also used fMRI to perform retinotopic mapping at 3, 8, and 11 months after the infarct. We quantified the retinotopy and areal shifts by measuring the distances between the center of mass of functionally defined areas, computed in spherical surface-based coordinates. The functionally defined retinotopic areas V1, V2v, V2d, and VP were initially smaller in the lesioned right hemisphere, but they increased in size between 3 and 11 months. This change was not found in the normal, left hemisphere of the patient or in either hemispheres of the healthy control participants. We were interested in whether practice on the motion coherence task promoted the changes in the retinotopic maps. We compared the results for patient JS with those from another patient (PF) who had a comparable lesion but had not been given such practice. We found similar changes in the maps in the lesioned hemisphere of PF. However, PF was only scanned at 3 and 7 months, and the biggest shifts in patient JS were found between 8 and 11 months. Thus, it is important to carry out a prospective study with a trained and untrained group so as to determine whether the patterns of reorganization that we have observed can be further promoted by training.This work was supported by NIH grant R01NS064100 to L. M. V. Lucia M. Vaina dedicates this article to Charlie Gross, who has been a long-time collaborator and friend. I met him at the INS meeting in Beaune (France), and since then we often discussed the relationship between several aspects of high-level visual processing described in his work in monkeys physiology and my work in neuropsychology. In particular, his pioneering study of biological motion in monkeys' superior temporal lobe has influenced my own work on biological motion and has led us to coauthor a paper on this topic. Working with Charlie was a uniquely enjoyable experience. Alan Cowey and I often spoke fondly about Charlie, a dear friend and close colleague to us both, whose work, exquisite sense of humor, and unbound zest of living we both deeply admired and loved. (R01NS064100 - NIH)Accepted manuscrip

A two-fluid model describing the finite-collisionality, stationary Alfvén wave in anisotropic plasma

The stationary inertial Alfvén (StIA) wave (Knudsen, 1996) was predicted for cold, collisionless plasma. The model was generalized (Finnegan et al., 2008) to include nonzero values of electron and ion collisional resistivity and thermal pressure. Here, the two-fluid model is further generalized to include anisotropic thermal pressure. A bounded range of values of parallel electron drift velocity is found that excludes periodic stationary Alfvén wave solutions. This exclusion region depends on the value of the local Alfvén speed VA, plasma beta perpendicular to the magnetic field β⊥ and electron temperature anisotropy

Differential Cortical Activation During the Perception of Moving Objects Along Different Trajectories

Detection of 3D object-motion trajectories depends on the integration of two distinct visual cues: translational displacement and looming. Electrophysiological studies have identified distinct neuronal populations, whose activity depends on the precise motion cues present in the stimulus. This distinction, however, has been less clear in humans, and it is confounded by differences in the behavioral task being performed. We analyzed whole-brain fMRI, while subjects performed a common time-to-arrival task for objects moving along three trajectories: moving directly towards the observer (collision course), with trajectories parallel to the line of sight (passage course), and with trajectories perpendicular to the line of sight (gap closure). We found that there was substantial overlap in the pattern of activation associated with each of the three tasks, with differences among conditions limited to the human motion area (hMT+), which showed greater activation extent in the gap closure condition than for either collision or passage courses. These results support a common substrate for temporal judgments of an object’s time-to-arrival, wherein the special cases of object motion directly toward, or perpendicular to, the observer represent two extremes within the broader continuum of 3D passage trajectories relative to the observer