13,273 research outputs found
Plate tectonics: When ancient continents collide
The geological record preserves scant evidence for early plate tectonics. Analysis of eclogites â metamorphic rocks formed in subduction zones â in the Trans-Hudson mountain belt suggests modern-style subduction may have operated 1,800 million years ago
The politics of punishment in colonial Mauritius, 1766-1887
The history of imprisonment in British colonial Mauritius is intertwined with its political economy, most especially the relationship between metropolitan government and plantation owners. Whether labour was predominantly enslaved, apprenticed or indentured, incarceration was part of a broader process through which the regulation of the colonial workforce was taken from the private to the public sphere and became associated with economic development. Nevertheless, prisoners both challenged and used prison regimes as vehicles for the improvement of their lives. Mauritian jails were intensely political arenas in which the changing nature of colonial relations and the regulation of labour was both expressed and contested
Emotion processing and social participation following stroke : study protocol
Peer reviewedPublisher PD
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Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes.
We previously demonstrated that a spontaneous Th1 response against glutamate decarboxylase (GAD65) arises in NOD mice at four weeks in age and subsequently T cell autoimmunity spreads both intramolecularly and intermolecularly. Induction of passive tolerance to GAD65, through inactivation of reactive T cells before the onset of autoimmunity, prevented determinant spreading and the development of insulin-dependent diabetes mellitus (IDDM). Here, we examined whether an alternative strategy, designed to induce active tolerance via the engagement of Th2 immune responses to GAD65, before the spontaneous onset of autoimmunity, could inhibit the cascade of Th1 responses that lead to IDDM. We observed that a single intranasal administration of GAD65 peptides to 2-3-wk-old NOD mice induced high levels of IgG1 antibodies to GAD65. GAD65 peptide treated mice displayed greatly reduced IFN gamma responses and increased IL-5 responses to GAD65, confirming the diversion of the spontaneous GAD65 Th1 response toward a Th2 phenotype. Consistent with the induction of an active tolerance mechanism, splenic CD4+ (but not CD8+) T cells from GAD65 peptide-treated mice, inhibited the adoptive transfer of IDDM to NOD-scid/scid mice. This active mechanism not only inhibited the development of proliferative T cell responses to GAD65, it also limited the expansion of autoreactive T cell responses to other beta cell antigens (i.e., determinant spreading). Finally, GAD65 peptide treatment reduced insulitis and long-term IDDM incidence. Collectively, these data suggest that the nasal administration of GAD65 peptides induces a Th2 cell response that inhibits the spontaneous development of autoreactive Th1 responses and the progression of beta cell autoimmunity in NOD mice
First Order Premelting Transition of Vortex Lattices
Vortex lattices in the high temperature superconductors undergo a first order
phase transition which has thus far been regarded as melting from a solid to a
liquid. We point out an alternative possibility of a two step process in which
there is a first order transition from an ordinary vortex lattice to a soft
vortex solid followed by another first order melting transition from the soft
vortex solid to a vortex liquid. We focus on the first step. This premelting
transition is induced by vacancy and interstitial vortex lines. We obtain good
agreement with the experimental transition temperature versus field, latent
heat, and magnetization jumps for YBCO and BSCCO.Comment: revised version replaces 9705092, 5 pages, Latex, 2 postscript
figures, defect line wandering is included, 2 step melting is propose
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Rotational 3D Printing of Sensor Devices using Reactive Ink Chemistries
This paper charts progress in three key areas of a project supported by both UK
government and UK industry to manufacture novel sensor devices using rotary 3D printing
technology and innovative ink chemistries; (1) the development of an STL file slicing algorithm
that returns constant Z height 2D contour data at a resolution that matches the given print head
setup, allowing digital images to be generated of the correct size without the need for scaling;
(2) the development of image transformation algorithms which allow images to be printed at
higher resolutions using tilted print heads and; (3) the formulation of multi part reaction inks
which combine and react on the substrate to form solid material layers with a finite thickness. A
Direct Light Projection (DLP) technique demonstrated the robustness of the slice data by
constructing fine detailed three dimensional test pieces which were comparable to identical parts
built in an identical way from slice data obtained using commercial software. Material systems
currently under investigation include plaster, stiff polyamides and epoxy polymers and
conductive metallicâs. Early experimental results show conductivities of silver approaching
1.42x105 Siemens/m.Mechanical Engineerin
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The effects of minimal tillage, contour cultivation and in-field vegetative barriers on soil erosion and phosphorus loss.
Runoff, sediment, total phosphorus and total dissolved phosphorus losses in overland flow were measured for two years on unbounded plots cropped with wheat and oats. Half of the field was cultivated with minimum tillage (shallow tillage with a tine cultivator) and half was conventionally ploughed. Within each cultivation treatment there were different treatment areas (TA). In the first year of the experiment, one TA was cultivated up and down the slope, one TA was cultivated on the contour, with a beetle bank acting as a vegetative barrier partway up the slope, and one had a mixed direction cultivation treatment, with cultivation and drilling conducted up and down the slope and all subsequent operations conducted on the contour. In the second year, this mixed treatment was replaced with contour cultivation. Results showed no significant reduction in runoff, sediment losses or total phosphorus losses from minimum tillage when compared to the conventional plough treatment, but there were increased losses of total dissolved phosphorus with minimum tillage. The mixed direction cultivation treatment increased surface runoff and losses of sediment and phosphorus. Increasing surface roughness with contour cultivation reduced surface runoff compared to up and down slope cultivation in both the plough and minimum tillage treatment areas, but this trend was not significant. Sediment and phosphorus losses in the contour cultivation treatment followed a very similar pattern to runoff. Combining contour cultivation with a vegetative barrier in the form of a beetle bank to reduce slope length resulted in a non-significant reduction in surface runoff, sediment and total phosphorus when compared to up and down-slope cultivation, but there was a clear trend towards reduced losses. However, the addition of a beetle bank did not provide a significant reduction in runoff, sediment losses or total phosphorus losses when compared to contour cultivation, suggesting only a marginal additional benefit. The economic implications for farmers of the different treatment options are investigated in order to assess their suitability for implementation at a field scale
A âhealthy babyâ: The double imperative of preimplantation genetic diagnosis
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2010 The Authors.This article reports from a study exploring the social processes, meanings and institutions that frame and produce âethical problemsâ and clinical dilemmas for practitioners, scientists and others working in the specialty of preimplantation genetic diagnosis (PGD). A major topic in the data was that, in contrast to IVF, the aim of PGD is to transfer to the womanâs womb only those embryos likely to be unaffected by serious genetic disorders; that is, to produce âhealthy babiesâ. Staff described the complex processes through which embryos in each treatment cycle must meet a double imperative: they must be judged viable by embryologists and âunaffectedâ by geneticists. In this article, we focus on some of the ethical, social and occupational issues for staff ensuing from PGDâs double imperative.The Wellcome Trus
Layer by layer generation of cluster states
Cluster states can be used to perform measurement-based quantum computation.
The cluster state is a useful resource, because once it has been generated only
local operations and measurements are needed to perform universal quantum
computation. In this paper, we explore techniques for quickly and
deterministically building a cluster state. In particular we consider
generating cluster states on a qubus quantum computer, a computational
architecture which uses a continuous variable ancilla to generate interactions
between qubits. We explore several techniques for building the cluster, with
the number of operations required depending on whether we allow the ability to
destroy previously created controlled-phase links between qubits. In the case
where we can not destroy these links, we show how to create an n x m cluster
using just 3nm -2n -3m/2 + 3 operations. This gives more than a factor of 2
saving over a naive method. Further savings can be obtained if we include the
ability to destroy links, in which case we only need (8nm-4n-4m-8)/3
operations. Unfortunately the latter scheme is more complicated so choosing the
correct order to interact the qubits is considerably more difficult. A half way
scheme, that keeps a modular generation but saves additional operations over
never destroying links requires only 3nm-2n-2m+4 operations. The first scheme
and the last scheme are the most practical for building a cluster state because
they split up the generation into the repetition of simple sections.Comment: 16 pages, 11 figure
Structure and dynamics of colloidal depletion gels: coincidence of transitions and heterogeneity
Transitions in structural heterogeneity of colloidal depletion gels formed
through short-range attractive interactions are correlated with their dynamical
arrest. The system is a density and refractive index matched suspension of 0.20
volume fraction poly(methyl methacyrlate) colloids with the non-adsorbing
depletant polystyrene added at a size ratio of depletant to colloid of 0.043.
As the strength of the short-range attractive interaction is increased,
clusters become increasingly structurally heterogeneous, as characterized by
number-density fluctuations, and dynamically immobilized, as characterized by
the single-particle mean-squared displacement. The number of free colloids in
the suspension also progressively declines. As an immobile cluster to gel
transition is traversed, structural heterogeneity abruptly decreases.
Simultaneously, the mean single-particle dynamics saturates at a localization
length on the order of the short-range attractive potential range. Both
immobile cluster and gel regimes show dynamical heterogeneity. Non-Gaussian
distributions of single particle displacements reveal enhanced populations of
dynamical trajectories localized on two different length scales. Similar
dependencies of number density fluctuations, free particle number and dynamical
length scales on the order of the range of short-range attraction suggests a
collective structural origin of dynamic heterogeneity in colloidal gels.Comment: 14 pages, 10 figure
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