1,732 research outputs found
Development of an Interrupted Pulse Expanding Ring Test
An interrupted pulse electromagnetic (EM) expanding ring test is being developed at the
University of Waterloo to study the high rate behaviour of sheet metals. In a classic EM
expanding ring test, a ring is expanded radially using the forces induced on the ring by a
high frequency high intensity current flowing in a nearby coil. If the driving force and the
acceleration of the ring are known, then the stress-strain history of the ring can be
determined. Coil currents are typically generated by large capacitor banks that produce a
current discharge in the shape of a damped sinusoid. To properly determine the stress of the
ring, the forces induced on the ring by the current pulse must be known, which is difficult to
do in practice. The approach taken in this work is to interrupt the current by means of an
exploding wire switch to eliminate the Lorentz forces and achieve a free flight condition,
where the stress can be determined using only the measured velocity and density of the ring.
The velocity of the rings was measured using a photon Doppler velocimeter (PDV). With
this technique significant periods of free-flight were obtained, with the corresponding stressstrain
data. Results for 1.5 mm sheet of AA 5182-O are presented
Towards a Mini-App for Smoothed Particle Hydrodynamics at Exascale
The smoothed particle hydrodynamics (SPH) technique is a purely Lagrangian
method, used in numerical simulations of fluids in astrophysics and
computational fluid dynamics, among many other fields. SPH simulations with
detailed physics represent computationally-demanding calculations. The
parallelization of SPH codes is not trivial due to the absence of a structured
grid. Additionally, the performance of the SPH codes can be, in general,
adversely impacted by several factors, such as multiple time-stepping,
long-range interactions, and/or boundary conditions. This work presents
insights into the current performance and functionalities of three SPH codes:
SPHYNX, ChaNGa, and SPH-flow. These codes are the starting point of an
interdisciplinary co-design project, SPH-EXA, for the development of an
Exascale-ready SPH mini-app. To gain such insights, a rotating square patch
test was implemented as a common test simulation for the three SPH codes and
analyzed on two modern HPC systems. Furthermore, to stress the differences with
the codes stemming from the astrophysics community (SPHYNX and ChaNGa), an
additional test case, the Evrard collapse, has also been carried out. This work
extrapolates the common basic SPH features in the three codes for the purpose
of consolidating them into a pure-SPH, Exascale-ready, optimized, mini-app.
Moreover, the outcome of this serves as direct feedback to the parent codes, to
improve their performance and overall scalability.Comment: 18 pages, 4 figures, 5 tables, 2018 IEEE International Conference on
Cluster Computing proceedings for WRAp1
Contributing Factors to the Increased Formability Observed in Electromagnetically Formed Aluminum Alloy Sheet
This paper summarizes the results of an experimental and numerical program carried out to study the formability of aluminum alloy sheet formed using electromagnetic forming (EMF). Free-formed and conical samples of AA5754 aluminum alloy sheet were studied. The experiments showed significant increases in formability for the conical samples, but no significant increase for the free-formed parts. It was found that relatively little damage growth occurred and that the failure modes of the materials changed from those observed in quasi-static forming to those observed in high hydrostatic stress environments. Numerical simulations were performed using the explicit finite element code LS-DYNA with an analytical EM force distribution. The numerical models revealed that a complex stress state is generated when the sheet interacts with the tool, which is characterized by high hydrostatic stresses that create a stress state favourable to damage suppression increasing ductility. Shear stresses and strains are also produced at impact with the die which help the material achieve additional deformation. The predicted peak strain rates for the free formed parts were on the order of 1000 s^(-1) and for the conical parts the rates are on the order of 10,000 s^(-1). Although aluminum is typically considered to be strain-rate insensitive, the strain rates predicted could be playing a role in the increased formability. The predicted strain paths for the conical samples were highly non-linear. The results from this study indicate that there is an increase in formability for AA5754 when the alloy is formed into a die using EMF. This increase in formability is due to a combination of high hydrostatic stresses, shear stresses, high strain rates, and non-linear strain paths
Contribution to the search for binaries among Am stars - VII. Orbital elements of seven new spectroscopic binaries, implications on tidal effects
International audienceWe present the results of a radial-velocity study of seven Am stars (HD 3970, 35035, 93946, 151746, 153286, 204751 and 224002) observed at the Observatoire de Haute-Provence (OHP) and the Cambridge Observatories with CORAVEL instruments. We find that these systems are single-lined spectroscopic binaries whose orbital elements are determined for the first time. Among this sample, HD 35035 and 153286 have long periods, with P = 2.8 and 9.5yr, respectively, which is rather unusual for Am stars. Four systems have orbits with large eccentricities (with e >= 0.4). Physical parameters are inferred from this study for the primaries of those systems. We then investigate the influence of tidal interaction, which has already led to the synchronism of the primaries and/or to the circularization of the orbits of some systems belonging to this sample. We extend this study to the list of 33 objects studied in this series of papers and derive values of the critical fractional radii r = R/a for circularization and synchronization of Am-type binaries. We find that the stars with r >~ 0.15 are orbiting on circular orbits and that synchronism is likely for all components with r >~ 0.20
SPH-EXA: Enhancing the Scalability of SPH codes Via an Exascale-Ready SPH Mini-App
Numerical simulations of fluids in astrophysics and computational fluid
dynamics (CFD) are among the most computationally-demanding calculations, in
terms of sustained floating-point operations per second, or FLOP/s. It is
expected that these numerical simulations will significantly benefit from the
future Exascale computing infrastructures, that will perform 10^18 FLOP/s. The
performance of the SPH codes is, in general, adversely impacted by several
factors, such as multiple time-stepping, long-range interactions, and/or
boundary conditions. In this work an extensive study of three SPH
implementations SPHYNX, ChaNGa, and XXX is performed, to gain insights and to
expose any limitations and characteristics of the codes. These codes are the
starting point of an interdisciplinary co-design project, SPH-EXA, for the
development of an Exascale-ready SPH mini-app. We implemented a rotating square
patch as a joint test simulation for the three SPH codes and analyzed their
performance on a modern HPC system, Piz Daint. The performance profiling and
scalability analysis conducted on the three parent codes allowed to expose
their performance issues, such as load imbalance, both in MPI and OpenMP.
Two-level load balancing has been successfully applied to SPHYNX to overcome
its load imbalance. The performance analysis shapes and drives the design of
the SPH-EXA mini-app towards the use of efficient parallelization methods,
fault-tolerance mechanisms, and load balancing approaches.Comment: arXiv admin note: substantial text overlap with arXiv:1809.0801
Effects of Force Distribution and Rebound on Electromagnetically Formed Sheet Metal
Electromagnetic forming (EMF) is a high speed forming process that has been shown to increase the formability of aluminum alloys under certain conditions. Many authors have reported significant increases in formability; however, there is as of yet no complete understanding of the process. Obtaining a gain in formability is not the only factor that must be considered when studying EMF. The process rapidly generates significant forces which lead to the deformation of the material at very high rates. The applied forces depend on the shape of the electromagnetic coil used, which leads to force distributions that may not be ideal for forming a particular part. Once the sheet is accelerated it will travel at high speeds until it impacts the die. This high speed impact results in the sheet rebounding from the die. Both the force distribution and the rebound affect the final shape of the part. This paper presents the results of experimental and numerical study carried out to determine the effect of the force distribution and the rebound on samples of conical and "v-channel" geometry. It was found that both sample geometries are affected by the force distribution and the rebound, with the v-channel samples being considerably more affected. The results indicate that these effects must be carefully considered when EMF processes are designed
Repeated games for eikonal equations, integral curvature flows and non-linear parabolic integro-differential equations
The main purpose of this paper is to approximate several non-local evolution
equations by zero-sum repeated games in the spirit of the previous works of
Kohn and the second author (2006 and 2009): general fully non-linear parabolic
integro-differential equations on the one hand, and the integral curvature flow
of an interface (Imbert, 2008) on the other hand. In order to do so, we start
by constructing such a game for eikonal equations whose speed has a
non-constant sign. This provides a (discrete) deterministic control
interpretation of these evolution equations. In all our games, two players
choose positions successively, and their final payoff is determined by their
positions and additional parameters of choice. Because of the non-locality of
the problems approximated, by contrast with local problems, their choices have
to "collect" information far from their current position. For integral
curvature flows, players choose hypersurfaces in the whole space and positions
on these hypersurfaces. For parabolic integro-differential equations, players
choose smooth functions on the whole space
Characterizing Metabolic Alterations in Palbociclib-Resistant ER+ Breast Cancer
Characterizing Metabolic Alterations in Palbociclib-Resistant ER+ Breast Cancer
Jessica Shunnarah1, Susan M. Dougherty2, Yoannis Imbert-Fernandez3
1ULBB Program, 2Department of Medicine, University of Louisville
Abstract
Diverse mechanisms of resistance to inhibitors of cyclin dependent kinases 4 and 6 (CDK4/6) have been described including cell cycle alterations and metabolic changes. Palbociclib was the first CDK4/6inhibitor approved against estrogen receptor positive (ER+) breast cancer however, the development of resistance has limited its success. This study investigates the changes in the expression of key metabolic enzymes using an in vivo model of palbociclib resistance. Palbociclib-resistant patient derive xenografts (PDXs) were generated by treating NSG mice that had ER+ breast cancer was implanted into the mammary fat pat of NSG mice with palbociclib until the tumors grew in the presence of the drug.. At endpoint, the tumors were harvested, flash frozen, and pulverized for western blot analysis. Our analysis shows the up regulation in some of the metabolic enzymes. We have concluded that resistance to palbociclib ER+ breast cancer increases the expression of Glutaminase (GLS1) in the presence and absence of palbociclib. Palbociclib treatment also leads to an increase 6-phosphofructo-2 kinase/fructose-2,6-biphosphotase-3 (PFKFB3) and Glucose-6-phosphate dehydrogenase (G6PDH) and transketolase in both palbociclib-sensitive and palbociclib-resistant PDX models.
Keywords: Palbociclib, estrogen receptor positive, patient derive xenograft, glutaminase, 6-phosphofructo-2 kinase/fructo, glucose-6-phosphate dehydrogenas
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