351 research outputs found
Developing the control system of a syringe infusion pump
Infusion pumps have multiple uses according to their location. According to its use, there is a need to control
specific parameters. The objective of this work is to implement and to assembly all the modules of an infusion
pump, controlling all the functions. The control was implemented with the microcontroller board based Arduino
and a webpage was developed to assist the user to record, retrieve and access information about the operating
conditions.N/
Casimir forces in binary liquid mixtures
If two ore more bodies are immersed in a critical fluid critical fluctuations
of the order parameter generate long ranged forces between these bodies. Due to
the underlying mechanism these forces are close analogues of the well known
Casimir forces in electromagnetism. For the special case of a binary liquid
mixture near its critical demixing transition confined to a simple parallel
plate geometry it is shown that the corresponding critical Casimir forces can
be of the same order of magnitude as the dispersion (van der Waals) forces
between the plates. In wetting experiments or by direct measurements with an
atomic force microscope the resulting modification of the usual dispersion
forces in the critical regime should therefore be easily detectable. Analytical
estimates for the Casimir amplitudes Delta in d=4-epsilon are compared with
corresponding Monte-Carlo results in d=3 and their quantitative effect on the
thickness of critical wetting layers and on force measurements is discussed.Comment: 34 pages LaTeX with revtex and epsf style, to appear in Phys. Rev.
Boundary critical behaviour at -axial Lifshitz points: the special transition for the case of a surface plane parallel to the modulation axes
The critical behaviour of -dimensional semi-infinite systems with
-component order parameter is studied at an -axial bulk
Lifshitz point whose wave-vector instability is isotropic in an -dimensional
subspace of . Field-theoretic renormalization group methods are
utilised to examine the special surface transition in the case where the
potential modulation axes, with , are parallel to the surface.
The resulting scaling laws for the surface critical indices are given. The
surface critical exponent , the surface crossover exponent
and related ones are determined to first order in
\epsilon=4+\case{m}{2}-d. Unlike the bulk critical exponents and the surface
critical exponents of the ordinary transition, is -dependent already
at first order in . The \Or(\epsilon) term of is
found to vanish, which implies that the difference of and
the bulk exponent is of order .Comment: 21 pages, one figure included as eps file, uses IOP style file
Renormalized couplings and scaling correction amplitudes in the N-vector spin models on the sc and the bcc lattices
For the classical N-vector model, with arbitrary N, we have computed through
order \beta^{17} the high temperature expansions of the second field derivative
of the susceptibility \chi_4(N,\beta) on the simple cubic and on the body
centered cubic lattices. (The N-vector model is also known as the O(N)
symmetric classical spin Heisenberg model or, in quantum field theory, as the
lattice
O(N) nonlinear sigma model.) By analyzing the expansion of \chi_4(N,\beta) on
the two lattices, and by carefully allowing for the corrections to scaling, we
obtain updated estimates of the critical parameters and more accurate tests of
the hyperscaling relation d\nu(N) +\gamma(N) -2\Delta_4(N)=0 for a range of
values of the spin dimensionality N, including
N=0 [the self-avoiding walk model], N=1 [the Ising spin 1/2 model],
N=2 [the XY model], N=3 [the classical Heisenberg model]. Using the recently
extended series for the susceptibility and for the second correlation moment,
we also compute the dimensionless renormalized four point coupling constants
and some universal ratios of scaling correction amplitudes in fair agreement
with recent renormalization group estimates.Comment: 23 pages, latex, no figure
Improved high-temperature expansion and critical equation of state of three-dimensional Ising-like systems
High-temperature series are computed for a generalized Ising model with
arbitrary potential. Two specific ``improved'' potentials (suppressing leading
scaling corrections) are selected by Monte Carlo computation. Critical
exponents are extracted from high-temperature series specialized to improved
potentials, achieving high accuracy; our best estimates are:
, , , ,
. By the same technique, the coefficients of the small-field
expansion for the effective potential (Helmholtz free energy) are computed.
These results are applied to the construction of parametric representations of
the critical equation of state. A systematic approximation scheme, based on a
global stationarity condition, is introduced (the lowest-order approximation
reproduces the linear parametric model). This scheme is used for an accurate
determination of universal ratios of amplitudes. A comparison with other
theoretical and experimental determinations of universal quantities is
presented.Comment: 65 pages, 1 figure, revtex. New Monte Carlo data by Hasenbusch
enabled us to improve the determination of the critical exponents and of the
equation of state. The discussion of several topics was improved and the
bibliography was update
Parallel algebraic multilevel Schwarz preconditioners for a class of elliptic PDE systems
Algebraic multilevel preconditioners for algebraic problems arising from the discretization of a class of systems of coupled elliptic partial differential equations (PDEs) are presented. These preconditioners are based on modifications of Schwarz methods and of the smoothed aggregation technique, where the coarsening strategy and the restriction and prolongation operators are defined using a point-based approach with a primary matrix corresponding to a single PDE. The preconditioners are implemented in a parallel computing framework and are tested on two representative PDE systems. The results of the numerical experiments show the effectiveness and the scalability of the proposed methods. A convergence theory for the twolevel case is presented
YangZheng XiaoJi exerts anti-tumour growth effects by antagonising the effects of HGF and its receptor, cMET, in human lung cancer cells
BACKGROUND: Hepatocyte growth factor (HGF) is a cytokine that has a profound effect on cancer cells by stimulating migration and invasion and acting as an angiogenic factor. In lung cancer, the factor also plays a pivotal role and is linked to a poor outcome in patients. In particular, HGF is known to work in combination with EGF on lung cancer cells. In the present study, we investigated the effect of a traditional Chinese medicine reported in cancer therapies, namely YangZheng XiaoJi (YZXJ) on lung cancer and on HGF mediated migration and invasion of lung cancer cells. METHODS: Human lung cancer cells, SKMES1 and A549 were used in the study. An extract from the medicine was used. Cell migration was investigated using the EVOS and by ECIS. Cell–matrix adhesion and in vitro invasion were assessed. In vivo growth of lung cancer was tested using an in vivo xenograft tumour model and activation of the HGF receptor in lung tumours by an immunofluorescence method. RESULTS: Both lung cancer cells increased their migration in response to HGF and responded to YZXJ by reducing their speed of migration. YZXJ markedly reduced the migration and in vitro invasiveness induced by HGF. It worked synergistically with PHA665752 and SU11274, HGF receptor inhibitors on the lung cancer cells both on HGF receptor activation and on cell functions. A combination of HGF and EGF resulted in a greater increase in cell migration, which was similarly inhibited by YZXJ, and in combination with the HGF receptor and EGF receptor inhibitors. In vivo, YZXJ reduced the rate of tumour growth and potentiated the effects of PHA665752 on tumour growth. It was further revealed that YZXJ significantly reduced the degree of phosphorylation of the HGF receptor in lung tumours. CONCLUSION: YZXJ has a significant role in reducing the migration, invasion and in vivo tumour growth of lung cancer and acts to inhibit the migratory and invasive effects induced by HGF and indeed by HGF/EGF. This effect is likely attributed to the inhibition of the HGF receptor activation. These results indicate that YZXJ has a therapeutic role in lung cancer and that combined strategy with methods to block HGF and EGF should be considered. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12967-015-0639-1) contains supplementary material, which is available to authorized users
Optical imaging in vivo with a focus on paediatric disease: technical progress, current preclinical and clinical applications and future perspectives
To obtain information on the occurrence and location of molecular events as well as to track target-specific probes such as antibodies or peptides, drugs or even cells non-invasively over time, optical imaging (OI) technologies are increasingly applied. Although OI strongly contributes to the advances made in preclinical research, it is so far, with the exception of optical coherence tomography (OCT), only very sparingly applied in clinical settings. Nevertheless, as OI technologies evolve and improve continuously and represent relatively inexpensive and harmful methods, their implementation as clinical tools for the assessment of children disease is increasing. This review focuses on the current preclinical and clinical applications as well as on the future potential of OI in the clinical routine. Herein, we summarize the development of different fluorescence and bioluminescence imaging techniques for microscopic and macroscopic visualization of microstructures and biological processes. In addition, we discuss advantages and limitations of optical probes with distinct mechanisms of target-detection as well as of different bioluminescent reporter systems. Particular attention has been given to the use of near-infrared (NIR) fluorescent probes enabling observation of molecular events in deeper tissue
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