Translational aspects of cardiac cell therapy.

Cell therapy has been intensely studied for over a decade as a potential treatment for ischaemic heart disease. While initial trials using skeletal myoblasts, bone marrow cells and peripheral blood stem cells showed promise in improving cardiac function, benefits were found to be short-lived likely related to limited survival and engraftment of the delivered cells. The discovery of putative cardiac 'progenitor' cells as well as the creation of induced pluripotent stem cells has led to the delivery of cells potentially capable of electromechanical integration into existing tissue. An alternative strategy involving either direct reprogramming of endogenous cardiac fibroblasts or stimulation of resident cardiomyocytes to regenerate new myocytes can potentially overcome the limitations of exogenous cell delivery. Complimentary approaches utilizing combination cell therapy and bioengineering techniques may be necessary to provide the proper milieu for clinically significant regeneration. Clinical trials employing bone marrow cells, mesenchymal stem cells and cardiac progenitor cells have demonstrated safety of catheter based cell delivery, with suggestion of limited improvement in ventricular function and reduction in infarct size. Ongoing trials are investigating potential benefits to outcome such as morbidity and mortality. These and future trials will clarify the optimal cell types and delivery conditions for therapeutic effect

Magic Doping Fractions in High-Temperature Superconductors

We report hole-doping dependence of the in-plane resistivity \rho_{ab} in a cuprate superconductor La_{2-x}Sr_{x}CuO_{4}, carefully examined using a series of high-quality single crystals. Our detailed measurements find a tendency towards charge ordering at particular rational hole doping fractions of 1/16, 3/32, 1/8, and 3/16. This observation appears to suggest a specific form of charge order and is most consistent with the recent theoretical prediction of the checkerboard-type ordering of the Cooper pairs at rational doping fractions x = (2m+1)/2^n, with integers m and n.Comment: 5 pages, 3 figure, resubmitted to Phys. Rev. Lett. The Tc vs. x diagram has been added and the discussions have been modified to focus more on the experimental result

Hartree-Fock-Bogoliubov Theory of Dipolar Fermi Gases

We construct a fully self-consistent Hartree-Fock-Bogoliubov theory that describes a spinless Fermi gas with long-range interaction. We apply this theory to a system of uniform dipolar fermionic polar molecules, which has attracted much attention recently, due to rapid experimental progress in achieving such systems. By calculating the anisotropic superfluid order parameter, and the critical temperature $T_{c}$, we show that, "hign $T_c$" superfluid can be achieved with a quite modest value of interaction strength for polar molecules. In addition, we also show that the presence of the Fock exchange interaction enhances superfluid pairing.Comment: 4.1 pages, 4 figure

Phenomenology of a lepton triplet

The most general phenomenological model involving a lepton triplet with hypercharge $\pm 1$ is constructed. A distinctive feature of this model is the prediction of a doubly charged lepton, and a new heavy Dirac neutrino. We study the phenomenology of these exotic leptons in both low-energy experiments and at the LHC. The model predicts FCNC processes such as rare muon decays, which are studied in detail in order to constrain the model parameters. All the decay channels of the exotic leptons are described for a wide range of parameters. It is found that, if the mixing parameters between the exotic and light leptons are not too small ($>10^{-6}$), then they can be observable to a $3-5\sigma$ statistical significance at the 7 TeV LHC with 10-50 fb$^{-1}$ luminosity for a 400 GeV mass, and 14 TeV with 100-300 fb$^{-1}$ luminosity for a 800 GeV mass.Comment: 28 pages, 17 figures. Version to appear in PR

Determining the physical conditions of extremely young Class 0 circumbinary disk around VLA1623A

We present detailed analysis of high-resolution C18O (2-1), SO (88-77), CO (3-2) and DCO+ (3-2) data obtained by the Atacama Large Millimeter/sub-millimeter Array (ALMA) towards a Class 0 Keplerian circumbinary disk around VLA1623A, which represents one of the most complete analysis towards a Class 0 source. From the dendrogram analysis, we identified several accretion flows feeding the circumbinary disk in a highly anisotropic manner. Stream-like SO emission around the circumbinary disk reveals the complicated shocks caused by the interactions between the disk, accretion flows and outflows. A wall-like structure is discovered south of VLA1623B. The discovery of two outflow cavity walls at the same position traveling at different velocities suggests the two outflows from both VLA1623A and VLA1623B overlays on top of each other in the plane of sky. Our detailed flat and flared disk modeling shows that Cycle 2 C18O J = 2-1 data is inconsistent with the combined binary mass of 0.2 Msun as suggested by early Cycle 0 studies. The combined binary mass for VLA1623A should be modified to 0.3 ~ 0.5 Msun.Comment: 26 pages, 20 figures, accepted by ApJ 2020.2.2

5G Wireless Backhaul Networks: Challenges and Research Advance

5G networks are expected to achieve gigabit-level throughput in future cellular networks. However, it is a great challenge to treat 5G wireless backhaul traffic in an effective way. In this article, we analyze the wireless backhaul traffic in two typical network architectures adopting small cell and millimeter wave commmunication technologies. Furthermore, the energy efficiency of wireless backhaul networks is compared for different network architectures and frequency bands. Numerical comparison results provide some guidelines for deploying future 5G wireless backhaul networks in economical and highly energy-efficient ways

(Sr_3Sc_2O_5)Fe_2As_2 as a possible parent compound for FeAs-based superconductors

A new compound with the FeAs-layers, namely (Sr_3Sc_2O_5)Fe_2As_2 (abbreviated as FeAs-32522), was successfully fabricated. It has a layered structure with the space group of I4/mmm, and with the lattice constants a = 4.069 $\AA$ and c = 26.876 $\AA$. The in-plane Fe ions construct a square lattice which is close to that of other FeAs-based superconductors, such as REFeAsO (RE = rare earth elements) and (Ba,Sr)Fe_2As_2. However the inter FeAs-layer spacing in the new compound is greatly enlarged. The temperature dependence of resistivity exhibits a weak upturn in the low temperature region, but a metallic behavior was observed above about 60 K. The magnetic susceptibility shows also a non-monotonic behavior. Interestingly, the well-known resistivity anomaly which was discovered in all other parent compounds, such as REFeAsO, (Ba,Sr)Fe_2As_2 and (Sr,Ca,Eu)FeAsF and associated with the Spin-Density-Wave (SDW)/structural transition has not been found in the new system either on the resistivity data or the magnetization data. This could be induced by the large spacing distance between the FeAs-planes, therefore the antiferromagnetic correlation between the moments of Fe ions in neighboring FeAs-layers cannot be established. Alternatively it can also be attributed to the self-doping effect between Fe and Sc ions. The Hall coefficient R_H is negative but strongly temperature dependent in wide temperature region, which indicates the dominance of electrical conduction by electron-like charge carriers and probably a multi-band effect or a spin related scattering effect. It is found that the magnetoresistance cannot be described by the Kohler's rule, which gives further support to above arguments.Comment: 5 pages, 5 figures, some contents added, and one figure adde

Top quark chromomagnetic dipole moment in the littlest Higgs model with T-parity

The littlest Higgs model with T-parity, which is called $LHT$ model, predicts the existence of the new particles, such as heavy top quark, heavy gauge bosons, and mirror fermions. We calculate the one-loop contributions of these new particles to the top quark chromomagnetic dipole moment $(CMDM)$ $\Delta K$. We find that the contribution of the $LHT$ model is one order of magnitude smaller than the standard model prediction value.Comment: latex files, 12 pages, 3 figure

Partitioning and modularity of graphs with arbitrary degree distribution

We solve the graph bi-partitioning problem in dense graphs with arbitrary degree distribution using the replica method. We find the cut-size to scale universally with . In contrast, earlier results studying the problem in graphs with a Poissonian degree distribution had found a scaling with ^1/2 [Fu and Anderson, J. Phys. A: Math. Gen. 19, 1986]. The new results also generalize to the problem of q-partitioning. They can be used to find the expected modularity Q [Newman and Grivan, Phys. Rev. E, 69, 2004] of random graphs and allow for the assessment of statistical significance of the output of community detection algorithms.Comment: Revised version including new plots and improved discussion of some mathematical detail