Mobile Daily Centre (Mdc) for Elder People with Cognitive Impairment: a Retrospective Observational Study

Introduction Trieste is a city characterized by a high mean age of the resident population, with 6,000 people with a cognitive impairment. Evidences show that is necessary to have a multidisciplinary approach, making alliances with the social network and families, while dealing with people with cognitive impairment. Because of this, the 3rd catchment district has developed a Mobile Daily Centre that aims to promote health, abilities and socialization giving the possibilities for these people to stay in a social context. Objectives Evaluating the impact of the Mobile Daily Centre on QoL of people with Cognitive Impairment. Aims Considering the rate of hospitalization and access to the first aid unit at the general hospital. Methods Retrospective Observational Study for the period between 01.01.2012 and 30.04.2014 on people in charge to the MDC. We have considered socio-demographic variables such as age, gender, care-givers; clinical variables such as psychopharmacotherapy and acetylcolinesterase-inhibitors drugs; rates of hospitalization, number of accesses to the first aid unit and of interventions of the MDC. Results in the period of the study 20 patients have been followed by the MDC; half of them had a psycho-pharmacological prescription. Very low rates of institutionalization have been detected. Conclusions MDC, in these small numbers, has shown to reduce the number of improper institutionalizations while guaranteeing to the elder people to maintain their abilities and socialization and to their care-givers periods of relief. Moreover, it promotes social inclusion and destigmatization. These results suggest that more territorial work and further studies should be done

Long-term effects of the new direct antiviral agents (DAAs) therapy for HCV-related mixed cryoglobulinaemia without renal involvement: a multicentre open-label study

Objective. To investigate the long-term effects and safety of new direct antiviral agents (DAAs) in patients with hepatitis C virus (HCV)-related mixed cryoglobulinaemia (MC) without renal involvement.Methods. The study enrolled 22 consecutive patients, 19 received sofosbuvir-based regimen and three patients received other DAAs, individually tailored according to latest guidelines. As of December 2016, the median length of follow-up was 17 months (range 13-21).Results. Extra-hepatic manifestations at enrollment were: purpura and arthralgia (12 cases), peripheral neuropathy (10 cases) and marginal zone Blymphomas (2 cases). After a four-week DAA therapy, all patients became HCV-negative. Moreover, after 48 weeks since the beginning of DAA treatment, sustained regression of purpura and arthralgias was observed respectively in eight and in nine cases; peripheral neuropathy improved in seven cases, and cryocrit median values decreased from three (1-20) at baseline to two (1-12) after 48 weeks. Two cases with indolent marginal zone lymphomas did not show any haematological response: size and number of the involved nodes remained unchanged. In addition, the monoclonal B-cell population found in the peripheral blood in four cases did not disappear after recovery from HCV-RNA. Mild side effects occurred in nine patients, but six patients developed ribavirin-related anaemia requiring reduction of ribavirin dose.Conclusion. DAA therapy is safe and effective to eradicate HCV in MC, but seems associated with satisfactory clinical response in mild or moderate cryoglobulinaemic vasculitis and no response in B-NHL

Acquired Haemophilia A. Which is the best therapeutic choice in older adults? Single center study of 4 cases

Acquired haemophilia A (AHA) is a rare bleeding disorder due to autoantibodies directed against coagulation factor VIII. The treatment is based on recombinant activated factor VII and activated prothrombin complex concentrate. However, mainly in older patients, severe thrombotic complications have been reported. Here we report the different therapeutic approaches in 4 cases of elderly patients with AHA and co-morbidities

Books in Arabic Script

The chapter approaches the book in Arabic script as the indispensable means for the transmission of knowledge across Eurasia and Africa, within cultures and across cultural boundaries, since the seventh century ad. The state of research can be divided into manuscript and print studies, but there is not yet a history of the book in Arabic script that captures its plurilinear development for over fourteen hundred years. The chapter explores the conceptual and practical challenges that impede the integration of the book in Arabic script into book history at large and includes an extensive reference list that reflects its diversity. The final published version was slightly updated, and includes seven illustrations of six Qurans from the holdings of Columbia University Libraries, four manuscripts and two printed versions. Moreover, the illustrations are images of historical artifacts which are in the public domain - despite Wiley's copyright claim

Infrared spectrum and rovibrational analysis of the ν6 band of vinyl chloride by diode laser spectroscopy

The gas-phase infrared spectrum of natural CH2CHCl has been measured in the ν6 band region near 1281 cm-1 at a resolution of about 0.002 cm-1 using a tunable diode laser spectrometer. This vibration of symmetry species A′ is expected to give rise to an a b hybrid band, which resulted mainly composed by a-type transitions. The spectrum investigated exhibits patterns characteristic of molecules approaching to the prolate symmetric-top limit; the rovibrational analysis in the P, Q, and R branches led to the assignment of more than 1000 lines with J ≤ 40 and Ka ≤ 14. The band was found to be affected by Coriolis-type resonance and the ν9 + ν11 state seems to be involved in the perturbation. From a simultaneous fit of the obtained ground state combination differences, together with microwave data available in the literature, a set of ground state constants up to the quartic coefficients has been determined using the Watson's A-reduction Hamiltonian in the I′ representation. A least-squares fit of the assigned transitions yielded a set of effective constants for the first excited vibrational state of the ν6 of CH2CH 35Cl. © 1992

Infrared spectrum and rovibrational analysis of the ν6 band of vinyl chloride by diode laser spectroscopy

The gas-phase infrared spectrum of natural CH2CHCl has been measured in the ν6 band region near 1281 cm-1 at a resolution of about 0.002 cm-1 using a tunable diode laser spectrometer. This vibration of symmetry species A′ is expected to give rise to an a b hybrid band, which resulted mainly composed by a-type transitions. The spectrum investigated exhibits patterns characteristic of molecules approaching to the prolate symmetric-top limit; the rovibrational analysis in the P, Q, and R branches led to the assignment of more than 1000 lines with J ≤ 40 and Ka ≤ 14. The band was found to be affected by Coriolis-type resonance and the ν9 + ν11 state seems to be involved in the perturbation. From a simultaneous fit of the obtained ground state combination differences, together with microwave data available in the literature, a set of ground state constants up to the quartic coefficients has been determined using the Watson's A-reduction Hamiltonian in the I′ representation. A least-squares fit of the assigned transitions yielded a set of effective constants for the first excited vibrational state of the ν6 of CH2CH 35Cl. © 1992