Bio-activité des huiles essentielles de l’Armoise blanche Artemessia herba alba : effet sur la reproduction et la mortalité des adultes d’un ravageur des denrées stockées Ephestia kuehniella (Lepidoptera)

Notre travail révèle un effet insecticide de l’huile essentielle extraite de la plante aromatique Artemissia herba alba, sur la population d’insectes ravageurs des denrées stockées Ephestia kuehniella (Lepidoptera). Le bio-pesticide agit avec un double mécanisme d’action. Administré chez les adultes, l’huile essentielle provoque un taux de mortalité significatif par rapport aux témoins. Alors que son administration sur les chrysalides, prolonge leur développement nymphal et perturbe la reproduction des adultes, en prolongeant la période de préoviposition et en réduisant la période de dépôt des œufs puisque les femelles fécondées, ne pouvant vivre plus d’un ou deux jours, ce qui réduit le nombre d’œufs déposés.Bio-activity of essential oils of Artemisia herba alba : effects on reproduction and adult mortality of a pest of stored Ephestia kuehniella (Lepidoptera)Our work reveals an insecticidal effect of essential oils extracted from aromatic plant Artemissia herba alba on population of insect pests Ephestia kuehniella. The biopesticide is adual mechanism of action. Administered in adults, the essential oil causes significant mortality compared with controls. Whilehis administration on pupae, it extending their pupal development and disrupts reproductive adults by extending the preoviposition period and reducing the period for depositing eggs asfertilized females, who can’t live more than one or two days, which reduces the number of eggs deposited

Fatigue in teriflunomide-treated patients with relapsing remitting multiple sclerosis in the real-world Teri-FAST study

BACKGROUND: Fatigue is a frequent and disabling symptom of multiple sclerosis (MS) often associated with impaired quality of life (QoL) in patients. Teriflunomide is a once-daily oral immunomodulator used for the treatment of relapsing remitting forms of MS. However, its effect on fatigue is not well known in real life practice. We evaluated the impact of teriflunomide on fatigue in patients with relapsing remitting MS (RRMS) after 2 years of treatment in the real-world Teri-FAST study. METHODS: Teri-FAST was a 2-year, prospective, observational study conducted in France in RRMS patients treated with teriflunomide 14 mg. Fatigue was assessed using the French version of the modified fatigue impact scale (EMIF-SEP). The primary endpoint was the change from baseline in EMIF-SEP score after 2 years of treatment. Secondary endpoints included evaluation of depression (Beck Depression Inventory [BDI]), health-related QoL (Two-Life Scale TLS-QoL 10), self-reported physical activity, and adverse events. RESULTS: 210 eligible patients were included in the study with a mean age of 45.4 years and a mean ± SD Expanded Disability Status Scale score of 1.76 ± 1.43 at baseline. About half (52.4%) of patients had no previous treatment for MS. In the 163 patients who completed at least 1 follow-up visit, the mean change in EMIF-SEP score at Year 2 was -1.54 (95% CI: -4.02, 0.94) indicating that fatigue remained stable. Similarly, there were no changes in depression level and QoL after 2 years of treatment. Physical activity slightly improved with 57% of patients reporting being physically active after 2 years as compared to 46% at baseline. The safety profile of teriflunomide was consistent with that seen during clinical development, and compliance with treatment was high. CONCLUSION: Fatigue scores remained stable in RRMS patients treated with teriflunomide 14 mg over 2 years in real-life setting. Teriflunomide did not negatively impact depression or QoL

Recherches sur les populations tunisiennes ; études séro-anthropologiques, XII.

Gherib Gr., Nicoli R.-M., Ranque J., Battaglini P.-F. Recherches sur les populations tunisiennes ; études séro-anthropologiques, XII.. In: Bulletins et Mémoires de la Société d'anthropologie de Paris, XI° Série. Tome 7 fascicule 2, 1965. pp. 165-170

Evaluation of Utility System Impacts and Benefits of Optimally Dispatched Plug-In Hybrid Electric Vehicles (Revised)

Hybrid electric vehicles with the capability of being recharged from the grid may provide a significant decrease in oil consumption. These ''plug-in'' hybrids (PHEVs) will affect utility operations, adding additional electricity demand. Because many individual vehicles may be charged in the extended overnight period, and because the cost of wireless communication has decreased, there is a unique opportunity for utilities to directly control the charging of these vehicles at the precise times when normal electricity demand is at a minimum. This report evaluates the effects of optimal PHEV charging, under the assumption that utilities will indirectly or directly control when charging takes place, providing consumers with the absolute lowest cost of driving energy. By using low-cost off-peak electricity, PHEVs owners could purchase the drive energy equivalent to a gallon of gasoline for under 75 cents, assuming current national average residential electricity prices

HIV-1 Tat protein inhibits neurosecretion by binding to phosphatidylinositol 4,5-bisphosphate

International audienc

Chemical composition and bioactivity of essential oils and Ethanolic extracts of Ocimum basilicum L. and Thymus algeriensis Boiss. & Reut. from the Algerian Saharan Atlas.

BACKGROUND: There is increasing interest in the pharmaceutical and food industries to substitute synthetic chemicals with naturally occurring compounds possessing bioactive properties. Plants are valuable sources of bioactive compounds. The present study investigates the chemical composition and antioxidant, antimicrobial, and anticancer activities of ethanolic extracts (EEs) and essential oils (EOs) from two species in the Lamiaceae family, Ocimum basilicum L. and Thymus algeriensis Boiss. & Reut., cultivated in the Algerian Saharan Atlas. METHODS: The total flavonoid contents of the plants' ethanolic extracts were determined by the aluminium chloride method, while the total phenols were determined using the Folin-Ciocalteu method. Essential oils were obtained by hydrodistillation of the aerial parts of the plants and were analysed by GC-MS. The free radical-scavenging ability and antioxidant potential of the plants' EEs and EOs were probed using the 2, 2-diphenyl-picrylhydrazyl radical-scavenging, ABTS radical-scavenging, ferric-reducing power and phosphomolybdenum assays. The antimicrobial activities were evaluated against several pathogens characteristic of gram-negative bacteria (three species), gram-positive bacteria (three species) and fungi (two species). The microdilution method was used to estimate the minimum inhibitory concentrations (MICs). The oils' anticancer potential against several cancer types was also studied using the MTT assay and reported as the toxic doses that resulted in a 50% reduction in cancer cell growth (LD(50)). RESULTS: Phenolic compounds in the EEs from both plants were analysed by HPLC and demonstrated a rich flavonoid content. Chemical analysis of the essential oil from Ocimum basilicum revealed 26 unique compounds, with linalool (52.1%) and linalyl acetate (19.1%) as the major compounds. A total of 29 compounds were identified in the essential oil from Thymus algeriensis, with α-terpinyl acetate (47.4%), neryl acetate (9.6%), and α-pinene (6.8%) as the major compounds. The ethanolic extracts and essential oils from both plants exhibited moderate antioxidant activities and moderate to weak antimicrobial activities. Furthermore, anticancer activities against the examined human cancer cell lines were associated with only the EOs from both plants, with LD(50) values ranging between 300 and 1000 μg/mL. CONCLUSION: The results suggest that the bioactive compounds found in the ethanolic extracts and essential oils from Ocimum basilicum and Thymus algeriensis, with diverse antioxidant, antimicrobial and anticancer activities, may have beneficial applications in nutraceutical and pharmaceutical technologies

Suivi longitudinal de lésions actives en SEP par imagerie du transfert d’aimantation inhomogène (ihMT) – résultats préliminaires à 1.5T

National audienc