1,778 research outputs found
Analysis of the Spectral Energy Distributions of Fermi bright blazars
Blazars are a small fraction of all extragalactic sources but, unlike other
objects, they are strong emitters across the entire electromagnetic spectrum.
In this study we have conducted a detailed investigation of the broad-band
spectral properties of the gamma-ray selected blazars of the Fermi-LAT Bright
AGN Sample (LBAS). By combining the accurately estimated Fermi gamma-ray
spectra with Swift, radio, NIR-Optical and hard-X/gamma-ray data, collected
within three months of the LBAS data taking period, we were able to assemble
high-quality and quasi-simultaneous Spectral Energy Distributions (SED) for 48
LBAS blazars.Comment: 6 pages, 8 figures, "2009 Fermi Symposium", "eConf Proceedings
C091122
Unidentifed gamma-ray sources: hunting gamma-ray blazars
One of the main scientific objectives of the ongoing Fermi mission is
unveiling the nature of the unidentified gamma-ray sources (UGSs). Despite the
large improvements of Fermi in the localization of gamma-ray sources with
respect to the past gamma-ray missions, about one third of the Fermi-detected
objects are still not associated to low energy counterparts. Recently, using
the Wide-Field Infrared Survey Explorer (WISE) survey, we discovered that
blazars, the rarest class of Active Galactic Nuclei and the largest population
of gamma-ray sources, can be recognized and separated from other extragalactic
sources on the basis of their infrared (IR) colors. Based on this result, we
designed an association method for the gamma-ray sources to reognize if there
is a blazar candidate within the positional uncertainty region of a generic
gamma-ray source. With this new IR diagnostic tool, we searched for gamma-ray
blazar candidates associated to the UGS sample of the second Fermi gamma-ray
catalog (2FGL). We found that our method associates at least one gamma-ray
blazar candidate as a counterpart each of 156 out of 313 UGSs analyzed. These
new low-energy candidates have the same IR properties as the blazars associated
to gamma-ray sources in the 2FGL catalog.Comment: 24 pages, 4 figures, Accepted for publication on the Astrophysical
Journa
NAMPT: A critical driver and therapeutic target for cancer
Nicotinamide phosphoribosyltransferase (NAMPT) possesses a vital role in mammalian cells due to its activity as a rate-limiting enzyme in the biosynthesis of nicotinamide adenine dinucleotide (NAD) from nicotinamide. NAD is an essential redox cofactor, but it also functions as a substrate for NAD-consuming enzymes, regulating multiple cellular processes such as DNA repair and gene expression, fundamental to sustain tumor growth and survival and energetic needs. A common strategy that several tumor types adopt to sustain NAD synthesis is to over-express NAMPT. However, beside its intracellular functions, this enzyme has a second life outside of cells exerting cytokine-like functions and mediating pro-inflammatory conditions activating signaling pathways. While the effects of NAMPT/NAD axis on energetic metabolism in tumors has been well-established, increasing evidence demonstrated the impact of NAMPT over-expression (intra-/extra-cellular) on several tumor cellular processes, including DNA repair, gene expression, signaling pathways, proliferation, invasion, stemness, phenotype plasticity, metastatization, angiogenesis, immune regulation, and drug resistance. For all these reasons, NAMPT targeting has emerged as promising anti-cancer strategy to deplete NAD and impair cellular metabolism, but also to counteract the other NAMPT-related functions. In this review, we summarize the key role of NAMPT in multiple biological processes implicated in cancer biology and the impact of NAMPT inhibition as therapeutic strategy for cancer treatment
Natural sealed fractures in mudrocks: A case study tied to burial history from the Barnett Shale, Fort Worth Basin, Texas, USA
The Mississippian Barnett Shale (Texas, USA), consisting of organic-rich shales and limestones, hosts the largest gas fields of North America. This study examines sealed fractures from core and outcrop samples of the Barnett Shale of the Fort Worth Basin and aims to: 1) characterize the phases occurring in the fractures from samples having experienced different burial histories; 2) establish a paragenetic sequence to relate the timing of fracture origin and sealing with the burial history of the basin; and 3) contribute to the understanding of the mechanisms of fracture formation in shales, including overpressure origin. Four fracture generations were distinguished in the most deeply buried core samples by characterizing the sealing minerals petrographically and geochemically. The generations were inserted into the framework of a reconstructed burial history for the Fort Worth Basin, which allowed a time sequence for fracture development to be established. This in turn allowed inference of conditions of fracture development, and consideration of fracture mechanisms as well as the origin of the parent fluids of sealing minerals.Type 1 fractures formed during early mechanical compaction (at a few 10s to 100m of depth) of still not fully cemented sediments. Type 2 fractures formed during moderate burial (~2km), from slightly modified seawater. Their timing is consistent with overpressure generated during rapid deposition and differential compaction of Pennsylvanian lithologies during the onset of the Ouachita compressional event. Type 3 fractures formed during deep burial (>3km) from silica-rich basinal brines possibly derived from clay diagenesis. Type 4 fractures formed at very deep burial (>4km), from hot and 18O-rich fluids, carrying light oil (20-30 API) and record the opening of the fluid system after hydrocarbon migration.Differences are highlighted between the timing and thermal regimes under which fractures formed in Barnett lithologies from different areas of the basin, this suggesting that extrapolation of outcrop observations to subsurface must be used with due care
Cannabis through the looking glass: chemo- and enantio-selective separation of phytocannabinoids by enantioselective ultra high performance supercritical fluid chromatography
By using the Inverted Chirality Columns Approach (ICCA) we have developed an enantioselective UHPSFC method to determine the enantiomeric excess (ee) of (-)-Δ(9)-THC in medicinal marijuana (Bedrocan®). The ee was high (99.73%), but the concentration of the (+)-enantiomer (0.135%) was not negligible, and it is worth a systematic evaluation of bioactivity
Blazar surveys with WMAP and Swift
We present the preliminary results from two new surveys of blazars that have
direct implications on the GLAST detection of extragalactic sources from two
different perspectives: microwave selection and a combined deep X-ray/radio
selection. The first one is a 41 GHz flux-limited sample extracted from the
WMAP 3-yr catalog of microwave point sources. This is a statistically well
defined sample of about 200 blazars and radio galaxies, most of which are
expected to be detected by GLAST. The second one is a new deep survey of
Blazars selected among the radio sources that are spatially coincident with
serendipitous sources detected in deep X-ray images (0.3-10 keV) centered on
the Gamma Ray Bursts (GRB) discovered by the Swift satellite. This sample is
particularly interesting from a statistical viewpoint since a) it is unbiased
as GRBs explode at random positions in the sky, b) it is very deep in the X-ray
band (\fx \simgt \ergs) with a position accuracy of a few
arc-seconds, c) it will cover a fairly large (20-30 square deg.) area of sky,
d) it includes all blazars with radio flux (1.4 GHz) larger than 10 mJy, making
it approximately two orders of magnitude deeper than the WMAP sample and about
one order of magnitude deeper than the deepest existing complete samples of
radio selected blazars, and e) it can be used to estimate the amount of
unresolved GLAST high latitude gamma-ray background and its anisotropy
spectrum.Comment: 3 pages, 3 figures, to appear in Proc. of the 1st GLAST Symposium,
Feb 5-8, 2007, Stanford, AIP, Eds. S. Ritz, P. F. Michelson, and C. Meega
Dynamic of a lacustrine sedimentary system during late rifting at the Cretaceous‐Palaeocene transition: Example of the Yacoraite Formation, Salta Basin, Argentina
The architecture of lacustrine systems is the result of the complex interaction between tectonics, climate and environmental parameters, and constitute the main forcing parameters on the lake dynamics. Field analogue studies have been performed to better assess such interactions, and their impact on the facies distribution and the stratigraphic architecture of lacustrine systems. The Yacoraite Formation (Late Cretaceous/Early Palaeocene), deposited during the sag phase of the Salta rift basin in Argentina, is exposed in world-class outcrops that allowed the dynamics of this lacustrine system to be studied through facies analysis and stratigraphic evolution. On the scale of the Alemania-Met\ue1n-El Rey Basin, the Yacoraite Formation is organized with a siliciclastic-dominated margin to the west, and a carbonate-dominated margin to the east. The Yacoraite can be subdivided into four main \u2018mid-term\u2019 sequences and further subdivided into \u2018short-term\u2019 sequences recording high frequency climate fluctuations. Furthermore, the depositional profiles and identified system tracts have been grouped into two end-members at basin scale: (a) a balanced \u2018perennial\u2019 depositional system for the lower part of the Yacoraite Formation and (b) a highly alternating \u2018ephemeral\u2019 depositional system for the upper part of the Yacoraite Formation. The transition from a perennial system to an ephemeral system indicates a change in the sedimentary dynamics of the basin, which was probably linked with the Cretaceous/Tertiary boundary that induced a temporary shutdown of carbonate production and an increase in siliciclastic supply
Hands-on Tutorial on a Modeling Framework for Projections of Climate Change Impacts on Health.
Reliable estimates of future health impacts due to climate change are needed to inform and contribute to the design of efficient adaptation and mitigation strategies. However, projecting health burdens associated to specific environmental stressors is a challenging task because of the complex risk patterns and inherent uncertainty of future climate scenarios. These assessments involve multidisciplinary knowledge, requiring expertise in epidemiology, statistics, and climate science, among other subjects. Here, we present a methodologic framework to estimate future health impacts under climate change scenarios based on a defined set of assumptions and advanced statistical techniques developed in time-series analysis in environmental epidemiology. The proposed methodology is illustrated through a step-by-step hands-on tutorial structured in well-defined sections that cover the main methodological steps and essential elements. Each section provides a thorough description of each step, along with a discussion on available analytical options and the rationale on the choices made in the proposed framework. The illustration is complemented with a practical example of study using real-world data and a series of R scripts included as Supplementary Digital Content; http://links.lww.com/EDE/B504, which facilitates its replication and extension on other environmental stressors, outcomes, study settings, and projection scenarios. Users should critically assess the potential modeling alternatives and modify the framework and R code to adapt them to their research on health impact projections
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