Systematic Review of Medicine-Related Problems in Adult Patients with Atrial Fibrillation on Direct Oral Anticoagulants

New oral anticoagulant agents continue to emerge on the market and their safety requires assessment to provide evidence of their suitability for clinical use. There-fore, we searched standard databases to summarize the English language literature on medicine-related problems (MRPs) of direct oral anticoagulants DOACs (dabigtran, rivaroxban, apixban, and edoxban) in the treatment of adults with atri-al fibrillation. Electronic databases including Medline, Embase, International Pharmaceutical Abstract (IPA), Scopus, CINAHL, the Web of Science and Cochrane were searched from 2008 through 2016 for original articles. Studies pub-lished in English reporting MRPs of DOACs in adult patients with AF were in-cluded. Seventeen studies were identified using standardized protocols, and two reviewers serially abstracted data from each article. Most articles were inconclusive on major safety end points including major bleeding. Data on major safety end points were combined with efficacy. Most studies inconsistently reported adverse drug reactions and not adverse events or medication error, and no definitions were consistent across studies. Some harmful drug effects were not assessed in studies and may have been overlooked. Little evidence is provided on MRPs of DOACs in patients with AF and, therefore, further studies are needed to establish the safety of DOACs in real-life clinical practice

An Integration Framework for Open Tool Environments

Tool environments supporting the development of complex products need to be open and flexible. These requirements cannot be fulfilled in an adequate way by predefined coordination structures and interfaces. Based on the notion of component–oriented software development this paper presents a framework for open tool environments. Besides the runtime environment this framework provides language support for describing tool interconnections in an implementation–independent manner

Prozessintegration in integrierten Entwurfsumgebungen

SIGLEAvailable from TIB Hannover: RR 4485(1999,21) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

An Integration Framework for Open Tool Environments

Tool environments supporting the development of complex products need to be open and flexible. These requirements cannot be fulfilled in an adequate way by predefined coordination structures and interfaces. Based on the notion of component--oriented software development this paper presents a framework for open tool environments. Besides the runtime environment this framework provides language support for describing tool interconnections in an implementation--independent manner. Keywords Tool integration, software composition, configuration language 1 INTRODUCTION The development of complex technical products requires the use of computer based tools. These tools provide services for the user to accomplish his tasks. For efficient use these tools must be integrated. Tool environments provide the required mechanisms for the integration. In order to describe the different dimensions of the integration, one usually identifies three aspects: data, control and presentation integration (Sche..

Konzepte zur Prozessintegration in Rechnerunterstuetzten Ingenieursystemen

Available from TIB Hannover: RR 4485(1998,17) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

13. GI-Workshop 'Grundlagen von Datenbanken', Arbeitskreis 'Grundlagen von Informationssystemen' im GI-Fachausschuss 2.5 Tagungsband

SIGLEAvailable from TIB Hannover: RR 4485(2001,10) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Foederierungsdienst fuer heterogene Dokumentenquellen Abschlussbericht

Available from TIB Hannover: RR 4485(2003,4) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

New building of holiday apartment hotel on Dzintaru prospekts 50, Jurmala

Maģistra darba mērķis ir nodrošināt vidēja līmeņa tūristus ar naktsmītnēm Jūrmalā līdz 2016. gadam. Maģistra darbs ietver Jūrmalastūrisma nozares attīstības izpēti un analīzi, risinājuma piedāvājumu, kura realizācijai par pamatu tiks celts jauns dzīvokļa tipa viesu nams. Pētījuma rezultātā tiek noteikta problēma: „Vidēja līmeņa tūristiem Jūrmalas pilsētā nav nodrošinātas iespējas ilgstoši uzturēties tiem pieejamos viesu namos.”. Problēmas risināšanai darba autors izstrādā projektu, kura ietvaros tiek nodibināts uzņēmums, uzcelts jauns labiekārtots dzīvokļa tipa viesu nams, izstrādāta mājas lapa, iegādātas nepieciešamās tehnikas iekārtas un noslēgti līgumi ar pakalpojumu sniedzējiem saimnieciskās darbības nodrošināšanai. Maģistra darbs sastāv no 97 lappusēm un 31 pielikuma.Target of Master'stask is to provide intermediate-level tourists with accommodation in Jurmala by 2016th year. Master's task includes Jurmala tourism development research and analysis, solutions off the realization of new built apartment type holiday guest house. In research will be fixed the problem, “mid-level” tourists in Jurmala have not places for along-stay guest houses with affordable prices to them". To solve these problems, the author develops a project, creating new company, build new apartment type holiday guest house, designing website, purchase the necessary technical equipment and create contracts with providers of economic activity. Master’s work containes 97 pages and 31 attachment