1,020 research outputs found
Low energy excitations in crystalline perovskite oxides: Evidence from noise experiments
In this paper we report measurements of 1/f noise in a crystalline metallic
oxide with perovskite structure down to 4.2K. The results show existence of
localized excitations with average activation energy 70-80 meV which
produce peak in the noise at T 35-40K. In addition, it shows clear
evidence of tunnelling type two-level-systems (as in glasses) which show up in
noise measurements below 30K.Comment: 11 pages, 4 figures, to appear in Phys Rev B, vol 58, 1st Dec issu
Interactions of Neuroimmune Signaling and Glutamate Plasticity in Addiction
Chronic use of drugs of abuse affects neuroimmune signaling; however, there are still many open questions regarding the interactions between neuroimmune mechanisms and substance use disorders (SUDs). Further, chronic use of drugs of abuse can induce glutamatergic changes in the brain, but the relationship between the glutamate system and neuroimmune signaling in addiction is not well understood. Therefore, the purpose of this review is to bring into focus the role of neuroimmune signaling and its interactions with the glutamate system following chronic drug use, and how this may guide pharmacotherapeutic treatment strategies for SUDs. In this review, we first describe neuroimmune mechanisms that may be linked to aberrant glutamate signaling in addiction. We focus specifically on the nuclear factor-kappa B (NF-κB) pathway, a potentially important neuroimmune mechanism that may be a key player in driving drug-seeking behavior. We highlight the importance of astroglial-microglial crosstalk, and how this interacts with known glutamatergic dysregulations in addiction. Then, we describe the importance of studying non-neuronal cells with unprecedented precision because understanding structure-function relationships in these cells is critical in understanding their role in addiction neurobiology. Here we propose a working model of neuroimmune-glutamate interactions that underlie drug use motivation, which we argue may aid strategies for small molecule drug development to treat substance use disorders. Together, the synthesis of this review shows that interactions between glutamate and neuroimmune signaling may play an important and understudied role in addiction processes and may be critical in developing more efficacious pharmacotherapies to treat SUDs
Electron Glass in Ultrathin Granular Al Films at Low Temperatures
Quench-condensed granular Al films, with normal-state sheet resistance close
to 10 k, display strong hysteresis and ultraslow, non-exponential
relaxation in the resistance when temperature is varied below 300 mK. The
hysteresis is nonlinear and can be suppressed by a dc bias voltage. The
relaxation time does not obey the Arrhenius form, indicating the existence of a
broad distribution of low energy barriers. Furthermore, large resistance
fluctuations, having a 1/f-type power spectrum with a low-frequency cut-off,
are observed at low temperatures. With decreasing temperature, the amplitude of
the fluctuation increases and the cut-off frequency decreases. These
observations combine to provide a coherent picture that there exists a new
glassy electron state in ultrathin granular Al films, with a growing
correlation length at low temperatures.Comment: RevTeX 3.1, 4 pages, 4 figures (EPS files) (Minor Additions
Radiative Correction to the Transferred Polarization in Elastic Electron-Proton Scattering
Model independent radiative correction to the recoil proton polarization for
the elastic electron-proton scattering is calculated within method of electron
structure functions. The explicit expressions for the recoil proton
polarization are represented as a contraction of the electron structure and the
hard part of the polarization dependent contribution into cross-section. The
calculation of the hard part with first order radiative correction is
performed. The obtained representation includes the leading radiative
corrections in all orders of perturbation theory and the main part of the
second order next-to-leading ones. Numerical calculations illustrate our
analytical results.Comment: 14 pages, 4 figure
Phylogenetic congruence of Plasmodium spp. and wild ungulate hosts in the Peruvian Amazon
Malaria parasites are known to infect a variety of vertebrate hosts, including ungulates. However, ungulates of Amazonia have not been investigated. We report for the first time, the presence of parasite lineages closely related to Plasmodium odocoilei clade 1 and clade 2 in free-ranging South American red-brocket deer (Mazama americana; 44.4%, 4/9) and gray-brocket deer (Mazama nemorivaga; 50.0%, 1/2). We performed PCR-based analysis of blood samples from 47 ungulates of five different species collected during subsistence hunting by an indigenous community in the Peruvian Amazon. We detected Plasmodium malariae/brasilianum lineage in a sample from red-brocket deer. However, no parasite DNA was detected in collared peccary (Pecari tajacu; 0.0%, 0/10), white-lipped peccary (Tayassu pecari; 0.0%, 0/15), and tapir (Tapirus terrestris; 0.0%, 0/11). Concordant phylogenetic analyses suggested a possible co-evolutionary relationship between the Plasmodium lineages found in American deer and their hosts
Noise Probe of the Dynamic Phase Separation in La2/3Ca1/3MnO3
Giant Random Telegraph Noise (RTN) in the resistance fluctuation of a
macroscopic film of perovskite-type manganese oxide La2/3Ca1/3MnO3 has been
observed at various temperatures ranging from 4K to 170K, well below the Curie
temperature (TC = 210K). The amplitudes of the two-level-fluctuations (TLF)
vary from 0.01% to 0.2%. We use a statistical analysis of the life-times of the
TLF to gain insight into the microscopic electronic and magnetic state of this
manganite. At low temperature (below 30K) The TLF is well described by a
thermally activated two-level model. An estimate of the energy difference
between the two states is inferred. At higher temperature (between 60K and
170K) we observed critical effects of the temperature on the life-times of the
TLF. We discuss this peculiar temperature dependence in terms of a sharp change
in the free energy functional of the fluctuators. We attribute the origin of
the RTN to be a dynamic mixed-phase percolative conduction process, where
manganese clusters switch back and forth between two phases that differ in
their conductivity and magnetization.Comment: 15 pages, PDF only, Phys. Rev. Lett. (in press
Recent Progress in CuInS2 Thin-Film Solar Cell Research at NASA Glenn
The National Aeronautics and Space Administration (NASA) is interested in developing low-cost highly efficient solar cells on light-weight flexible substrates, which will ultimately lower the mass-specific power (W/kg) of the cell allowing extra payload for missions in space as well as cost reduction. In addition, thin film cells are anticipated to have greater resistance to radiation damage in space, prolonging their lifetime. The flexibility of the substrate has the added benefit of enabling roll-to-roll processing. The first major thin film solar cell was the "CdS solar cell" - a heterojunction between p-type CuxS and n-type CdS. The research on CdS cells started in the late 1950s and the efficiency in the laboratory was up to about 10 % in the 1980s. Today, three different thin film materials are leading the field. They include amorphous Si, CdTe, and Cu(In,Ga)Se2 (CIGS). The best thin film solar cell efficiency of 19.2 % was recently set by CIGS on glass. Typical module efficiencies, however, remain below 15 %
Differential regulation of Knotted1-like genes during establishment of the shoot apical meristem in Norway spruce (Picea abies)
Establishment of the shoot apical meristem (SAM) in Arabidopsis embryos requires the KNOXI transcription factor SHOOT MERISTEMLESS. In Norway spruce (Picea abies), four KNOXI family members (HBK1, HBK2, HBK3 and HBK4) have been identified, but a corresponding role in SAM development has not been demonstrated. As a first step to differentiate between the functions of the four Norway spruce HBK genes, we have here analyzed their expression profiles during the process of somatic embryo development. This was made both under normal embryo development and under conditions of reduced SAM formation by treatment with the polar auxin transport inhibitor NPA. Concomitantly with the formation of an embryonic SAM, the HBK2 and HBK4 genes displayed a significant up-regulation that was delayed by NPA treatment. In contrast, HBK1 and HBK3 were up-regulated prior to SAM formation, and their temporal expression was not affected by NPA. Ectopic expression of the four HBK genes in transgenic Arabidopsis plants further supported similar functions of HBK2 and HBK4, distinct from those of HBK1 and HBK3. Together, the results suggest that HBK2 and HBK4 exert similar functions related to the SAM differentiation and somatic embryo development in Norway spruce, while HBK1 and HBK3 have more general functions during embryo development
Quantum Size Effect transition in percolating nanocomposite films
We report on unique electronic properties in Fe-SiO2 nanocomposite thin films
in the vicinity of the percolation threshold. The electronic transport is
dominated by quantum corrections to the metallic conduction of the Infinite
Cluster (IC). At low temperature, mesoscopic effects revealed on the
conductivity, Hall effect experiments and low frequency electrical noise
(random telegraph noise and 1/f noise) strongly support the existence of a
temperature-induced Quantum Size Effect (QSE) transition in the metallic
conduction path. Below a critical temperature related to the geometrical
constriction sizes of the IC, the electronic conductivity is mainly governed by
active tunnel conductance across barriers in the metallic network. The high 1/f
noise level and the random telegraph noise are consistently explained by random
potential modulation of the barriers transmittance due to local Coulomb
charges. Our results provide evidence that a lowering of the temperature is
somehow equivalent to a decrease of the metal fraction in the vicinity of the
percolation limit.Comment: 21 pages, 8 figure
Beyond the Hype: A Real-World Evaluation of the Impact and Cost of Machine Learning-Based Malware Detection
There is a lack of scientific testing of commercially available malware
detectors, especially those that boast accurate classification of
never-before-seen (i.e., zero-day) files using machine learning (ML). The
result is that the efficacy and gaps among the available approaches are opaque,
inhibiting end users from making informed network security decisions and
researchers from targeting gaps in current detectors. In this paper, we present
a scientific evaluation of four market-leading malware detection tools to
assist an organization with two primary questions: (Q1) To what extent do
ML-based tools accurately classify never-before-seen files without sacrificing
detection ability on known files? (Q2) Is it worth purchasing a network-level
malware detector to complement host-based detection? We tested each tool
against 3,536 total files (2,554 or 72% malicious, 982 or 28% benign) including
over 400 zero-day malware, and tested with a variety of file types and
protocols for delivery. We present statistical results on detection time and
accuracy, consider complementary analysis (using multiple tools together), and
provide two novel applications of a recent cost-benefit evaluation procedure by
Iannaconne & Bridges that incorporates all the above metrics into a single
quantifiable cost. While the ML-based tools are more effective at detecting
zero-day files and executables, the signature-based tool may still be an
overall better option. Both network-based tools provide substantial (simulated)
savings when paired with either host tool, yet both show poor detection rates
on protocols other than HTTP or SMTP. Our results show that all four tools have
near-perfect precision but alarmingly low recall, especially on file types
other than executables and office files -- 37% of malware tested, including all
polyglot files, were undetected.Comment: Includes Actionable Takeaways for SOC
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