Impact of Community Pharmacists on Management of Cancer Chemotherapy and the Resulting Side Effects

The severe side effects of chemotherapy negatively affect quality of life and may limit the amount of life-saving drug delivered to patients with cancer. These adverse events can be difficult to manage and evidence-based guidelines are lacking. Insufficient supportive care can amplify common side effects, such as chemotherapy-induced nausea and vomiting (CINV), myelosuppression, alopecia, gastrointestinal effects and neuropathy. Therefore, it is important to recognize the most commonly dispensed chemotherapy agents and the side effects that accompany them. Community pharmacists, as easily accessible health care professionals, can provide valuable supportive care to help manage potentially debilitating side effects. However, a major limitation when managing side effects secondary to chemotherapy is the limited access to patient information in most community pharmacies. By allowing community pharmacists increased access to patient health records using technology, limitations experienced in practice can be averted and quality care provided

Arene oxidation with malonoyl peroxides

Malonoyl peroxide 7, prepared in a single step from the commercially available diacid, is an effective reagent for the oxidation of aromatics. Reaction of an arene with peroxide 7 at room temperature leads to the corresponding protected phenol which can be unmasked by aminolysis. An ionic mechanism consistent with the experimental findings and supported by isotopic labeling, Hammett analysis, EPR investigations and reactivity profile studies is proposed

Investigating Ca II emission in the RS CVn binary ER Vulpeculae using the Broadening Function Formalism

The synchronously rotating G stars in the detached, short-period (0.7 d), partially eclipsing binary, ER Vul, are the most chromospherically active solar-type stars known. We have monitored activity in the Ca II H & K reversals for almost an entire orbit. Rucinski's Broadening Function Formalism allows the photospheric contribution to be objectively subtracted from the highly blended spectra. The power of the BF technique is also demonstrated by the good agreement of radial velocities with those measured by others from less crowded spectral regions. In addition to strong Ca II emission from the primary and secondary, there appears to be a high-velocity stream flowing onto the secondary where it stimulates a large active region on the surface 30 - 40 degrees in advance of the sub-binary longitude. A model light curve with a spot centered on the same longitude also gives the best fit to the observed light curve. A flare with approximately 13% more power than at other phases was detected in one spectrum. We suggest ER Vul may offer a magnified view of the more subtle chromospheric effects synchronized to planetary revolution seen in certain `51 Peg'-type systems.Comment: Accepted to AJ; 17 pages and 16 figure

Training Deep Learning Models via Synthetic Data: Application in Unmanned Aerial Vehicles

This paper describes preliminary work in the recent promising approach of generating synthetic training data for facilitating the learning procedure of deep learning (DL) models, with a focus on aerial photos produced by unmanned aerial vehicles (UAV). The general concept and methodology are described, and preliminary results are presented, based on a classification problem of fire identification in forests as well as a counting problem of estimating number of houses in urban areas. The proposed technique constitutes a new possibility for the DL community, especially related to UAV-based imagery analysis, with much potential, promising results, and unexplored ground for further research.Comment: Workshop on Deep-learning based computer vision for UAV in conjunction with CAIP 2019, Salerno, italy, September 201

Glutamate 270 plays an essential role in K activation and domain closure of Thermus thermophilus isopropylmalate dehydrogenase

The mutant E270A of Thermus thermophilus 3-isopropylmalate dehydrogenase exhibits largely reduced (∼1%) catalytic activity and negligible activation by K+ compared to the wild-type enzyme. A 3–4 kcal/mol increase in the activation energy of the catalysed reaction upon this mutation could also be predicted by QM/MM calculations. In the X-ray structure of the E270A mutant a water molecule was observed to take the place of K+. SAXS and FRET experiments revealed the essential role of E270 in stabilisation of the active domain-closed conformation of the enzyme. In addition, E270 seems to position K+ into close proximity of the nicotinamide ring of NAD+ and the electron-withdrawing effect of K+ may help to polarise the aromatic ring in order to aid the hydride-transfer

VLBI for Gravity Probe B. VII. The Evolution of the Radio Structure of IM Pegasi

We present measurements of the total radio flux density as well as very-long-baseline interferometry (VLBI) images of the star, IM Pegasi, which was used as the guide star for the NASA/Stanford relativity mission Gravity Probe B. We obtained flux densities and images from 35 sessions of observations at 8.4 GHz (wavelength = 3.6 cm) between 1997 January and 2005 July. The observations were accurately phase-referenced to several extragalactic reference sources, and we present the images in a star-centered frame, aligned by the position of the star as derived from our fits to its orbital motion, parallax, and proper motion. Both the flux density and the morphology of IM Peg are variable. For most sessions, the emission region has a single-peaked structure, but 25% of the time, we observed a two-peaked (and on one occasion perhaps a three-peaked) structure. On average, the emission region is elongated by 1.4 +- 0.4 mas (FWHM), with the average direction of elongation being close to that of the sky projection of the orbit normal. The average length of the emission region is approximately equal to the diameter of the primary star. No significant correlation with the orbital phase is found for either the flux density or the direction of elongation, and no preference for any particular longitude on the star is shown by the emission region.Comment: Accepted for publication in the Astrophysical Journal Supplement Serie

Molecular Spiders in One Dimension

Molecular spiders are synthetic bio-molecular systems which have "legs" made of short single-stranded segments of DNA. Spiders move on a surface covered with single-stranded DNA segments complementary to legs. Different mappings are established between various models of spiders and simple exclusion processes. For spiders with simple gait and varying number of legs we compute the diffusion coefficient; when the hopping is biased we also compute their velocity.Comment: 14 pages, 2 figure