Projecting prevalence by stage of care for prostate cancer and estimating future health service needs: protocol for a modelling study

Introduction Current strategies for the management of prostate cancer are inadequate in Australia. We will, in this study, estimate current service needs and project the future needs for prostate cancer patients in Australia. Methods and analysis First, we will project the future prevalence of prostate cancer for 2010-2018 using data for 1972-2008 from the New South Wales (NSW) Central Cancer Registry. These projections, based on modelled incidence and survival estimates, will be estimated using PIAMOD (Prevalence, Incidence, Analysis MODel) software. Then the total prevalence will be decomposed into five stages of care: initial care, continued monitoring, recurrence, last year of life and long-term survivor. Finally, data from the NSW Prostate Cancer Care and Outcomes Study, including data on patterns of treatment and associated quality of life, will be used to estimate the type and amount of services that will be needed by prostate cancer patients in each stage of care. In addition, Central Cancer Registry episode data will be used to estimate transition rates from localised or locally advanced prostate cancer to metastatic disease. Medicare and Pharmaceutical Benefits data, linked with Prostate Cancer Care and Outcomes Study data, will be used to complement the Cancer Registry episode data. The methods developed will be applied Australia-wide to obtain national estimates of the future prevalence of prostate cancer for different stages of clinical care. Ethics and dissemination This study was approved by the NSW Population and Health Services Research Ethics Committee. Results of the study will be disseminated widely to different interest groups and organisations through a report, conference presentations and peer-reviewed articles.This work is supported by the Prostate Cancer Foundation of Australia (grant number: PCFA – YI 0410). Both David Smith and Xue Qin Yu are supported by an Australian NHMRC Training Fellowship (Ref 1016598, 550002). Mark Clements is supported by an Australian NHMRC Career Development Award (Ref 471491)

Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder

Mammalian microRNAs are emerging as key regulators of the development and function of the immune system. Here, we report a strong but transient induction of miR-155 in mouse bone marrow after injection of bacterial lipopolysaccharide (LPS) correlated with granulocyte/monocyte (GM) expansion. Demonstrating the sufficiency of miR-155 to drive GM expansion, enforced expression in mouse bone marrow cells caused GM proliferation in a manner reminiscent of LPS treatment. However, the miR-155–induced GM populations displayed pathological features characteristic of myeloid neoplasia. Of possible relevance to human disease, miR-155 was found to be overexpressed in the bone marrow of patients with certain subtypes of acute myeloid leukemia (AML). Furthermore, miR-155 repressed a subset of genes implicated in hematopoietic development and disease. These data implicate miR-155 as a contributor to physiological GM expansion during inflammation and to certain pathological features associated with AML, emphasizing the importance of proper miR-155 regulation in developing myeloid cells during times of inflammatory stress

NF-κB dysregulation in microRNA-146a–deficient mice drives the development of myeloid malignancies

MicroRNA miR-146a has been implicated as a negative feedback regulator of NF-κB activation. Knockout of the miR-146a gene in C57BL/6 mice leads to histologically and immunophenotypically defined myeloid sarcomas and some lymphomas. The sarcomas are transplantable to immunologically compromised hosts, showing that they are true malignancies. The animals also exhibit chronic myeloproliferation in their bone marrow. Spleen and marrow cells show increased transcription of NF-κB–regulated genes and tumors have higher nuclear p65. Genetic ablation of NF-κB p50 suppresses the myeloproliferation, showing that dysregulation of NF-κB is responsible for the myeloproliferative disease

Isotopic analysis of faunal material from South Uist, Western Isles, Scotland

This paper reports on the results from stable isotope analysis of faunal bone collagen from a number of Iron Age and later sites on the island of South Uist, in the Western Isles, Scotland. This preliminary investigation into the isotopic signatures of the fauna is part of a larger project to model the interaction between humans, animals, and the broader environment in the Western Isles. The results demonstrate that the island fauna data fall within the range of expected results for the UK, with the terrestrial herbivorous diets of cattle and sheep confi rmed. The isotopic composition for pigs suggests that some of these animals had an omnivorous diet, whilst a single red deer value might be suggestive of the consumption of marine foods, such as by grazing on seaweed. However, further analysis is needed in order to verify this anomalous isotopic ratio

Initial correlations effects on decoherence at zero temperature

We consider a free charged particle interacting with an electromagnetic bath at zero temperature. The dipole approximation is used to treat the bath wavelengths larger than the width of the particle wave packet. The effect of these wavelengths is described then by a linear Hamiltonian whose form is analogous to phenomenological Hamiltonians previously adopted to describe the free particle-bath interaction. We study how the time dependence of decoherence evolution is related with initial particle-bath correlations. We show that decoherence is related to the time dependent dressing of the particle. Moreover because decoherence induced by the T=0 bath is very rapid, we make some considerations on the conditions under which interference may be experimentally observed.Comment: 16 pages, 1 figur

Husimi Transform of an Operator Product

It is shown that the series derived by Mizrahi, giving the Husimi transform (or covariant symbol) of an operator product, is absolutely convergent for a large class of operators. In particular, the generalized Liouville equation, describing the time evolution of the Husimi function, is absolutely convergent for a large class of Hamiltonians. By contrast, the series derived by Groenewold, giving the Weyl transform of an operator product, is often only asymptotic, or even undefined. The result is used to derive an alternative way of expressing expectation values in terms of the Husimi function. The advantage of this formula is that it applies in many of the cases where the anti-Husimi transform (or contravariant symbol) is so highly singular that it fails to exist as a tempered distribution.Comment: AMS-Latex, 13 page

e^+e^- Pair Production from γ\gamma A Reactions

We present a calculation of e^+e^- production in $\gamma A$ reactions at MAMI and TJNAF energies within a semi-classical BUU transport model. Dilepton invariant mass spectra for $\gamma$C, $\gamma$Ca and $\gamma$Pb are calculated at 0.8, 1.5 and 2.2 GeV. We focus on observable effects of medium modifications of the $\rho$ and $\omega$ mesons. The in-medium widths of these mesons are taken into account in a dynamical, consistent way. We discuss the transport theoretical treatment of broad resonances.Comment: 42 pages including 16 figure

HST/STIS Spectroscopy of Five Super Star Clusters in the Starburst Galaxy M82

We present optical spectroscopy obtained with the Space Telescope Imaging Spectrograph (STIS) of five young massive star clusters in the starburst galaxy M82. A detailed analysis is performed for one cluster `M82-A1' and its immediate environment in the starburst core. From HST archive images, we find that it is elliptical with an effective radius of 3.0+/-0.5 pc and is surrounded by a compact (r=4.5+/-0.5 pc) H II region. We determine the age and reddening of M82-A1 using synthetic spectra from population synthesis models by fitting both the continuum energy distribution and the depth of the Balmer jump. We find an age of 6.4+/-0.5 Myr and a photometric mass estimate of M=7-13 x 10^5 solar masses. We associate its formation with the most recent starburst event 4-6 Myr ago. We find that the oxygen abundance of the H II region surrounding M82-A1 is solar or slightly higher. The H II region has a high pressure P/k = 1-2 x 10^7 cm^-3 K. The diffuse gas in region A has a slightly lower pressure, which together with the broad H alpha emission line width, suggests that both the thermal and turbulent pressures in the M82 starburst core are unusually high. We discuss how this environment has affected the evolution of the cluster wind for M82-A1. We find that the high pressure may have caused the pressure-driven bubble to stall. We also obtain spectroscopic ages for clusters B1-2 and B2-1 in the `fossil' starburst region and for the intermediate age clusters F and L. These are consistent with earlier studies and demonstrate that star formation activity, sufficiently intense to produce super star clusters, has been going on in M82 during the past Gyr, perhaps in discrete and localized episodes.Comment: 17 pages, accepted for publication in MNRA