Theoretical Setting of Inner Reversible Quantum Measurements

We show that any unitary transformation performed on the quantum state of a closed quantum system, describes an inner, reversible, generalized quantum measurement. We also show that under some specific conditions it is possible to perform a unitary transformation on the state of the closed quantum system by means of a collection of generalized measurement operators. In particular, given a complete set of orthogonal projectors, it is possible to implement a reversible quantum measurement that preserves the probabilities. In this context, we introduce the concept of "Truth-Observable", which is the physical counterpart of an inner logical truth.Comment: 11 pages. More concise, shortened version for submission to journal. References adde

Self-reported pregnancy exposures and placental DNA methylation in the MARBLES prospective autism sibling study.

Human placenta is a fetal-derived tissue that offers a unique sample of epigenetic and environmental exposures present in utero. In the MARBLES prospective pregnancy study of high-risk younger siblings of children with autism spectrum disorder (ASD), pregnancy and environmental factors collected by maternal interviews were examined as predictors of placental DNA methylation, including partially methylated domains (PMDs), an embryonic feature of the placental methylome. DNA methylation data from MethylC-seq analysis of 47 placentas of children clinically diagnosed at 3 years with ASD or typical development using standardized assessments were examined in relation to: child's gestational age, birth-weight, and diagnosis; maternal pre-pregnancy body mass index, smoking, education, parity, height, prenatal vitamin and folate intake; home ownership; pesticides professionally applied to lawns or gardens or inside homes, pet flea/tick pouches, collars, or soaps/shampoos used in the 3 months prior to or during pregnancy. Sequencing run, order, and coverage, and child race and sex were considered as potential confounders. Akaike information criterion was used to select the most parsimonious among candidate models. Final prediction models used sandwich estimators to produce homoscadisticity-robust estimates of the 95% confidence interval (CI) and P-values controlled the false discovery rate at 5%. The strongest, most robust associations were between pesticides professionally applied outside the home and higher average methylation over PMDs [0.45 (95% CI 0.17, 0.72), P = 0.03] and a reduced proportion of the genome in PMDs [-0.42 (95% CI - 0.67 to -0.17), P = 0.03]. Pesticide exposures could alter placental DNA methylation more than other factors

A Calculus of Bounded Capacities

Resource control has attracted increasing interest in foundational research on distributed systems. This paper focuses on space control and develops an analysis of space usage in the context of an ambient-like calculus with bounded capacities and weighed processes, where migration and activation require space. A type system complements the dynamics of the calculus by providing static guarantees that the intended capacity bounds are preserved throughout the computation

We Have Always Been Virtual: Gilles Deleuze and the Computer-Generated Image

The use of computer-generated imagery is becoming increasingly ubiquitous across many fields including media, advertising, architecture and art. This represents a fundamental shift within visual culture, as imagery can now be produced routinely by means of rendering algorithms based on spatial representations. We propose that the account of the image provided by Gilles Deleuze in his books on cinema provides a rich philosophical framework for understanding such contemporary imaging practices. By providing a Deleuzian reading of James Kajiya\u27s 1986 rendering equation we argue that there is a tacit ontology of the image underwriting both Deleuze’s work on cinema and current computer graphics technologies. This ontology frees the image from traditional transcendent categories of subject positions or vantage points and instead revolves around the concept of an immanent image. We argue that these considerations lead us to a reformulation of the notion of the virtual, one that challenges its rigid segregation from the real

Hard X-ray variability of the black-hole candidate GRO J0422+32 during its 1992 outburst

We have studied the hard X-ray variability of the soft X-ray transient GRO J0422+32 with BATSE in the 20-100 keV energy band. Our analysis covers 180 days following the first X-ray detection of the source on 1992 August 5, fully covering its primary and secondary X-ray outburst. We computed power density spectra (PDSs) in the 20-50, 50-100, and 20-100 keV energy bands, in the frequency interval 0.002-0.488 Hz. The PDSs of GRO J0422+32 are approximately flat up to a break frequency, and decay as a power law above, with index ~1. The canonical anticorrelation between the break frequency and the power density at the break, observed in Cyg X-1 and other BHCs in the low state, is not observed in the PDSs of GRO J0422+32. We compare our results with those of similar variability studies of Cyg X-1. The relation between the spectral slope and the amplitude of the X-ray variations of GRO J0422+32 is similar to that of Cyg X-1; however, the relation between the hard X-ray flux and the amplitude of its variation is opposite to what has been found in Cyg X-1. Phase lags between the X-ray flux variations of GRO J0422+32 at high and low photon energies, could only be derived during the first 30 days of its outburst. During this period, the variations in the 50-100 keV lag those in the 20-50 keV energy band by an approximately constant phase difference of 0.039(3) rad in the frequency interval 0.02-0.20 Hz.Comment: 33 pages, including 14 postscript figures, AASTEX. To appear in ApJ 1999, March 1, vol. 513 #

Many Disease-Associated Variants of hTERT Retain High Telomerase Enzymatic Activity

Mutations in the gene for telomerase reverse transcriptase (hTERT) are associated with diseases including dyskeratosis congenita, aplastic anemia, pulmonary fibrosis and cancer. Understanding the molecular basis of these telomerase-associated diseases requires dependable quantitative measurements of telomerase enzyme activity. Furthermore, recent findings that the human POT1-TPP1 chromosome end-binding protein complex stimulates telomerase activity and processivity provide incentive for testing variant telomerases in the presence of these factors. In the present work, we compare multiple disease-associated hTERT variants reconstituted with the RNA subunit hTR in two systems (rabbit reticulocyte lysates and human cell lines) with respect to telomerase enzymatic activity, processivity and activation by telomere proteins. Surprisingly, many of the previously reported disease-associated hTERTalleles give near-normal telomerase enzyme activity. It is possible that a small deficit in telomerase activity is sufficient to cause telomere shortening over many years. Alternatively, mutations may perturb functions such as the recruitment of telomerase to telomeres, which are essential in vivo but not revealed by simple enzyme assays

Hard X-ray lags in GRO J1719-24

We have used the Fourier cross spectra of GRO J1719-24, as obtained with BATSE, to estimate the phase lags between the X-ray flux variations in the 20--50 and 50--100 keV energy bands as a function of Fourier frequency in the interval 0.002--0.488 Hz. Our analysis covers the entire ~80 day X-ray outburst of this black-hole candidate, following the first X-ray detection on 1993 September 25. The X-ray variations in the 50--100 keV band lag those in the 20--50 keV energy band by an approximately constant phase difference of 0.072 +/- 0.010 rad in the frequency interval 0.02--0.20 Hz. The peak phase lags in the interval 0.02--0.20 Hz are about twice those of Cyg X-1 and GRO J0422+32.These results are consistent with models for Comptonization regions composed of extended non-uniform clouds around the central source.Comment: 10 pages, including 4 postscript figures, AASTEX. Accepted for publication by Ap