Role of the particle's stepping cycle in an asymmetric exclusion process: A model of mRNA translation

Messenger RNA translation is often studied by means of statistical-mechanical models based on the Asymmetric Simple Exclusion Process (ASEP), which considers hopping particles (the ribosomes) on a lattice (the polynucleotide chain). In this work we extend this class of models and consider the two fundamental steps of the ribosome's biochemical cycle following a coarse-grained perspective. In order to achieve a better understanding of the underlying biological processes and compare the theoretical predictions with experimental results, we provide a description lying between the minimal ASEP-like models and the more detailed models, which are analytically hard to treat. We use a mean-field approach to study the dynamics of particles associated with an internal stepping cycle. In this framework it is possible to characterize analytically different phases of the system (high density, low density or maximal current phase). Crucially, we show that the transitions between these different phases occur at different parameter values than the equivalent transitions in a standard ASEP, indicating the importance of including the two fundamental steps of the ribosome's biochemical cycle into the model.Comment: 9 pages, 9 figure

The boson-fermion model: An exact diagonalization study

The main features of a generic boson-fermion scenario for electron pairing in a many-body correlated fermionic system are: i) a cross-over from a poor metal to an insulator and finally a superconductor as the temperature decreases, ii) the build-up of a finite amplitude of local electron pairing below a certain temperature $T^*$, followed by the onset of long-range phase correlations among electron pairs below a second characteristic temperature $T_{\phi}$, iii) the opening of a pseudogap in the DOS of the electrons below $T^*$, rendering these electrons poorer and poorer quasi-particles as the temperature decreases, with the electron transport becoming ensured by electron pairs rather than by individual electrons. A number of these features have been so far obtained on the basis of different many-body techniques, all of which have their built-in shortcomings in the intermediate coupling regime, which is of interest here. In order to substantiate these features, we investigate them on the basis of an exact diagonalization study on rings up to eight sites. Particular emphasis has been put on the possibility of having persistent currents in mesoscopic rings tracking the change-over from single- to two-particle transport as the temperature decreases and the superconducting state is approached.Comment: 7 pages, 8 figures; to be published in Phys. Rev.

Ribosome recycling induces optimal translation rate at low ribosomal availability

Funding statement The authors thank BBSRC (BB/F00513/X1, BB/I020926/1 and DTG) and SULSA for funding. Acknowledgement The authors thank R. Allen, L. Ciandrini, B. Gorgoni and P. Greulich for very helpful discussions and careful reading of the manuscript.Peer reviewedPublisher PD

Control of spin relaxation in semiconductor double quantum dots

We propose a scheme to manipulate the spin relaxation in vertically coupled semiconductor double quantum dots. Up to {\em twelve} orders of magnitude variation of the spin relaxation time can be achieved by a small gate voltage applied vertically on the double dot. Different effects such as the dot size, barrier height, inter-dot distance, and magnetic field on the spin relaxation are investigated in detail. The condition to achieve a large variation is discussed.Comment: 5 pages, 4 figures, to be published in PR

Teleportation is necessary for faithful quantum state transfer through noisy channels of maximal rank

Quantum teleportation enables deterministic and faithful transmission of quantum states, provided a maximally entangled state is pre-shared between sender and receiver, and a one-way classical channel is available. Here, we prove that these resources are not only sufficient, but also necessary, for deterministically and faithfully sending quantum states through any fixed noisy channel of maximal rank, when a single use of the cannel is admitted. In other words, for this family of channels, there are no other protocols, based on different (and possibly cheaper) sets of resources, capable of replacing quantum teleportation.Comment: 4 pages, comments are welcom

Hospital environment as a reservoir for cross transmission. Cleaning and disinfection procedures

Background. Healthcare associated infections (HAIs) represent a serious problem for public health, as they increase the morbidity and mortality rates, present a relevant financial burden, and significantly contribute to the antimicrobial resistance. Methods. The aim of this review was to investigate the literature about HAIs, with particular reference to hospital environments and the role of cleaning and disinfection procedures. Hospital environments are an essential reservoir for HAIs cross transmission, and the application of appropriate procedures related to hand hygiene and disinfection/sterilization of surfaces and instruments remain key strategies for controlling HAIs. Results. Different procedures, based on the risk associated with the healthcare procedure, are recommended for hand hygiene: washing with soap and water, antiseptic rubbing with alcohol-based disinfectants, antiseptic and surgical hand washing. Environmental surfaces can be treated with different products, and the mostly used are chlorine-based and polyphenolic disinfectant. The reprocessing of instruments is related to their use according to the Spaulding's classification. In addition, scientific evidence demonstrated the great relevance of the "bundles" (small set of practices performed together) in controlling HAIs. Conclusions. Research agenda should include the improvement of well-known effective preventive procedures and the development of new bundles devoted to high-risk procedures and specific microorganisms

The accretion environment of Supergiant Fast X-ray Transients probed with XMM-Newton

Supergiant fast X-ray transients (SFXTs) are characterized by a remarkable variability in the X-ray domain, widely ascribed to the accretion from a clumpy stellar wind. In this paper we performed a systematic and homogeneous analysis of sufficiently bright X-ray flares from the SFXTs observed with XMM-Newton to probe spectral variations on timescales as short as a few hundred of seconds. Our ultimate goal is to investigate if SFXT flares and outbursts are triggered by the presence of clumps and eventually reveal whether strongly or mildly dense clumps are required. For all sources, we employ a technique developed by our group, making use of an adaptive rebinned hardness ratio to optimally select the time intervals for the spectral extraction. A total of twelve observations performed in the direction of five SFXTs are reported. We show that both strongly and mildly dense clumps can trigger these events. In the former case, the local absorption column density may increase by a factor of >>3, while in the latter case, the increase is only by a factor of 2-3 (or lower). Overall, there seems to be no obvious correlation between the dynamic ranges in the X-ray fluxes and absorption column densities in SFXTs, with an indication that lower densities are recorded at the highest fluxes. This can be explained by the presence of accretion inhibition mechanism(s). We propose a classification of the flares/outbursts from these sources to drive future observational investigations. We suggest that the difference between the classes of flares/outbursts is related to the fact that the mechanism(s) inhibiting accretion can be overcome more easily in some sources compared to others. We also investigate the possibility that different stellar wind structures, rather than clumps, could provide the means to temporarily overcome the inhibition of accretion in SFXTs.Comment: Accepted for publication on A&

Effect of grain refinement on enhancing critical current density and upper critical field in undoped MgB2 ex-situ tapes

Ex-situ Powder-In-Tube MgB2 tapes prepared with ball-milled, undoped powders showed a strong enhancement of the irreversibility field H*, the upper critical field Hc2 and the critical current density Jc(H) together with the suppression of the anisotropy of all of these quantities. Jc reached 104 A/cm2 at 4.2 K and 10 T, with an irreversibility field of about 14 T at 4.2 K, and Hc2 of 9 T at 25 K, high values for not-doped MgB2. The enhanced Jc and H* values are associated with significant grain refinement produced by milling of the MgB2 powder, which enhances grain boundary pinning, although at the same time also reducing the connectivity from about 12% to 8%. Although enhanced pinning and diminished connectivity are in opposition, the overall influence of ball milling on Jc is positive because the increased density of grains with a size comparable with the mean free path produces strong electron scattering that substantially increases Hc2, especially Hc2 perpendicular to the Mg and B planes.Comment: 26 pages, 9 figures, submitted to J. Appl. Phy

Swift J1734.5-3027: a new long type-I X-ray bursting source

Swift J1734.5-3027 is a hard X-ray transient discovered by Swift while undergoing an outburst in September 2013. Archival observations showed that this source underwent a previous episode of enhanced X-ray activity in May-June 2013. In this paper we report on the analysis of all X-ray data collected during the outburst in September 2013, the first that could be intensively followed-up by several X-ray facilities. Our data-set includes INTEGRAL, Swift, and XMM-Newton observations. From the timing and spectral analysis of these observations, we show that a long type-I X-ray burst took place during the source outburst, making Swift J1734.5-3027 a new member of the class of bursting neutron star low-mass X-ray binaries. The burst lasted for about 1.9 ks and reached a peak flux of (6.0$\pm$1.8)$\times$10$^{-8}$ erg cm$^{-2}$ s$^{-1}$ in the 0.5-100 keV energy range. The estimated burst fluence in the same energy range is (1.10$\pm$0.10)$\times$10$^{-5}$ erg cm$^{-2}$. By assuming that a photospheric radius expansion took place during the first $\sim$200 s of the burst and that the accreted material was predominantly composed by He, we derived a distance to the source of 7.2$\pm$1.5 kpc.Comment: Accepted for publication on A&