Implementing Punishment in Building Characters of Students at Pondok Pesantren DDI Mangkoso

Penelitian ini menganalisis penerapan hukuman oleh guru sebagai upaya pembinaan karakter jujur, disiplin, dan tanggung jawab santri pada Pondok Pesantren DDI Mangkoso, dengan tiga fokus masalah, yaitu: 1) bentuk penerapan hukuman dalam pembinaan karakter santri; 2) ragam hambatan penerapan hukuman dalam pembinaan karakter santri beserta solusinya, dan 3) hasil penerapan hukuman dalam pembinaan karakter santri. Jenis penelitian ini adalah kualitatif dengan pendekatan pedagogik, psikologis, yuridis, dan normatif teologis. Sumber data terdiri atas informan-informan dari berbagai unsur Pondok Pesantren DDI Mangkoso, yaitu: pimpinan, guru, santri, dan orang tua santri. Data dikumpulkan melalui observasi, wawancara, dan dokumentasi. Hasil penelitian menunjukkan bahwa bentuk hukuman yang diterapkan adalah teguran, pemberian tugas, hukuman psikis, dan hukuman fisik; hambatan-hambatannya adalah Undang-undang Perlindungan Anak, problem lingkungan, dan kreativitas guru; dan hukuman fisik lebih optimal dalam pembinaan karakter santri bila didukung oleh kerja sama yang baik dengan orang tua santri

Hakikat Manusia sebagai Makhluk Pedagogik

This study aimed to analyze the essence of humans as pedagogic beings by focusing on optimizing fitrah, hearing, sight, and heart as human basic potential, as well as the implications of these various potentials for Islamic education. This study is a literature study whose data comes from documents and analyzed using content analysis method. The results of the study indicate that optimizing fitrah as a basic human potential must be through education and the creation of a conducive environment. Optimization of hearing, sight, and heart as a basic human potential by always directing it to respond to empirical stimuli not only to something that is material in nature but also to something that brings it closer to God. The essence of humans as pedagogical beings has implications for (1) the Islamic education system must be built on the integration between qalbiyah and aqliyah education; (2) Islamic education must be directed at being able to carry out the functions and objectives of the creation of humans (khalifah and ‘abd)

Prolyl isomerase Pin1 is highly expressed in Her2-positive breast cancer and regulates erbB2 protein stability

Overexpression of HER-2/Neu occurs in about 25–30% of breast cancer patients and is indicative of poor prognosis. While Her2/Neu overexpression is primarily a result of erbB2 amplification, it has recently been recognized that erbB2 levels are also regulated on the protein level. However, factors that regulate Her2/Neu protein stability are less well understood. The prolyl isomerase Pin1 catalyzes the isomerization of specific pSer/Thr-Pro motifs that have been phosphorylated in response to mitogenic signaling. We have previously reported that Pin1-catalyzed post-phosphorylational modification of signal transduction modulates the oncogenic pathways downstream from c-neu. The goal of this study was to examine the expression of prolyl isomerase Pin1 in human Her2+ breast cancer, and to study if Pin1 affects the expression of Her2/Neu itself

Causes of Microcephaly in the Zika Era in Argentina: A Retrospective Study

There are gaps in understanding the causes and consequences of microcephaly. This paper describes the epidemiological characteristics, clinical presentations, and etiologies of children presenting microcephaly during the Zika outbreak in Argentina. This observational retrospective study conducted in the pediatric hospital of Juan P. Garrahan reviewed the medical records of 40 children presenting microcephaly between March 2017 and November 2019. The majority (60%) were males and born full-term. At first evaluation, microcephaly was defined as congenital (31/40, 77%) and associated with other features (68%) such as seizures, developmental delay, non-progressive chronic encephalopathy, and West Syndrome. It was found manifestations restricted to central nervous system (55%), ocular (8/40, 20%), and acoustic (9/40, 23%) defects, and abnormal neuroimaging findings (31/39, 79%). Non-infectious diseases were the primary cause of isolated microcephaly (21/37, 57%), largely related to genetic diseases (13/21, 62%). Only 3 were children were diagnosed with Congenital Zika infection (3/16, 7.5%)

Influencia de las estaciones climáticas en la presencia de leptospirosis canina en el norte y centro de Lima, Perú

The aim of this study was to identify the behaviour of canine leptospirosis and its relationship with climatic seasons in the city of Lima, Peru. A retrospective study was designed analysing the results of canine sera that were evaluated with the micro-agglutination test (MAT) and its association with climatic data obtained from the National Meteorology and Hydrology System of Peru (SENAMHI) between 2014 and 2017. A generalized linear model was used to evaluate the association between positive cases to canine leptospirosis and the seasons, together with the adjustment of risk factors. The probability of presenting canine leptospirosis was higher in the spring-summer seasons compared to the autumn-winter season (p<0.05). Dogs diagnosed as positive were exposed to an air temperature of 20.6 °C and a relative humidity of 83.1%. Age, sex and place of origin showed no statistical association with the positive cases of Leptospira sp. It is concluded that the hottest seasons of the year (spring-summer) in the city of Lima are associated with canine leptospirosis.El objetivo del estudio fue identificar el comportamiento de la leptospirosis canina y su relación con las estaciones climáticas en la ciudad de Lima, Perú. Se diseñó un estudio retrospectivo analizando los resultados de sueros caninos que fueron evaluados con la prueba de microaglutinación (MAT) y su asociación con datos climáticos obtenidos del Sistema Nacional de Meteorología e Hidrología del Perú (SENAMHI) entre los años 2014 al 2017. Para el análisis de datos se utilizó un modelo lineal generalizado para evaluar la asociación entre los casos positivos a leptospirosis canina y las estaciones del año, junto al ajuste de factores de riesgo. La probabilidad de presentación de leptospirosis canina fue mayor en las estaciones de primavera-verano con respecto a la estación de otoño-invierno (p<0.05). Los canes diagnosticados como positivos estuvieron expuestos a una mediana de temperatura ambiental de 20.6 °C y una mediana de humedad relativa de 83.1%. La edad, el sexo y el lugar de procedencia no mostraron asociación estadística con los casos positivos a Leptospira sp. Se concluye que las estaciones del año más calurosas (primavera-verano) en la ciudad de Lima están asociadas con la leptospirosis canina

Association between childhood trauma and mental health disorders in adolescents during the second pandemic wave of COVID-19, Chiclayo-Peru

"Introduction: The COVID-19 pandemic has significantly affected mental health, with children and adolescents being particularly vulnerable. Evidence on the association between childhood trauma and mental health outcomes in schoolchildren during the pandemic is limited. This study aimed to evaluate this relationship in Chiclayo city, northern Peru, during the second wave of COVID-19. Methods: A cross-sectional secondary data study was conducted, measuring childhood trauma using the Marshall’s Trauma Scale, depressive symptomatology (PHQ-9), and anxiety symptomatology (GAD-7). Additional variables assessed were alcohol use (AUDIT), resilience (abbreviated CD-RISC), and socio-educational data. Prevalence ratios were estimated using generalized linear models. Results: Among 456 participants, 88.2% were female, with a mean age of 14.5 years (SD: 1.33). Depressive symptomatology prevalence was 76.3% (95%CI: 72.14– 80.15) and increased by 23% in schoolchildren with childhood trauma (PR: 1.23; 95%CI: 1.10–1.37). Factors positively associated with depressive symptomatology included increasing age, seeking mental health help during the pandemic, and severe family dysfunction. Anxiety symptomatology prevalence was 62.3% (95%CI: 57.65–66.75) and increased by 55% in schoolchildren with childhood trauma (PR: 1.55; 95%CI: 1.31–1.85). Anxiety symptomatology was positively associated with mild, moderate, and severe family dysfunction. Conclusion: Schoolchildren exposed to childhood trauma are at increased risk for depressive and anxiety symptoms. Monitoring the impact of the COVID-19 pandemic on adolescent mental health is vital. These findings can assist schools in establishing effective measures to prevent mental health outcomes

Cell fate takes a slug in BRCA1-associated breast cancer

Understanding why BRCA1 mutation carriers have a predilection for developing clinically aggressive basal-like breast tumors could inform the development of targeted treatment or prevention strategies. Analysis of both mouse and human mammary epithelial cells has identified a role for BRCA1 in orchestrating differentiation. The ability to isolate discrete epithelial subpopulations from mammary tissue has recently directed attention to luminal progenitor cells - the descendants of mammary stem cells - as the likely 'cells-of-origin' in BRCA1-associated breast cancer. A new publication has confirmed the importance of aberrant luminal cells as key culprits and provided insights on how BRCA1 haploinsufficiency biases luminal cells toward a basal-like fate through aberrant expression of the transcription factor SLUG

Rural Community Transit Strategies: Building on, Expanding, and Enhancing Existing Assets and Programs

(c)1036342 (wo) 12This project involved the development of innovative sharing-economy strategies to address rural transit challenges in Greater Minnesota. Many transit services and transportation network companies (TNC\u2019s) like Uber and Lyft do not provide services to commuters outside metro areas, forcing most residents in Greater Minnesota to own automobiles. Meanwhile, many communities have school bus systems and substantial vehicle capacity that remain parked and unused much of the day. This project uses a human-centered design approach to engage a community in Greater Minnesota with a population of less than 10,000 people to develop a pilot for rural community transit that could be a model for similar communities across the state. The research seeks to answer the question of whether a shared, mobility services approach to rural transit transportation in Greater Minnesota could meet people's needs at a lower cost, with more convenience, and with greater positive impacts on the local economy than current transit practices and services. Our research developed a menu of strategies that uses existing community assets to promote walking, biking, car sharing, bus sharing, and car and van pooling

Visualizing Nudivirus Assembly and Egress

Enveloped viruses hijack cellular membranes in order to provide the necessary material for virion assembly. In particular, viruses that replicate and assemble inside the nucleus have developed special approaches to modify the nuclear landscape for their advantage. We used electron microscopy to investigate cellular changes occurring during nudivirus infection and we characterized a unique mechanism for assembly, packaging, and transport of new virions across the nuclear membrane and through the cytoplasm. Our three-dimensional reconstructions describe the complex remodeling of the nuclear membrane necessary to release vesicle-associated viruses into the cytoplasm. This is the first report of nuclear morphological reconfigurations that occur during nudiviral infection