Prospectus, November 12, 1980

WINTERTIME CAN MEAN MUCH MORE THAN SNOWDRIFTS AND STUCK CARS; Letter to the editor: Scott apologizes, Student services looking to fill positions; Cancer Society Challenge: Can you quit for a day?; Parkland Bookstore stocked with all kinds of goodies for Christmas; Burnham has new tape on Toxic Shock; Reaching Out Series discusses violence; C-U Community Theatre moves to PC; Spring Semester Course Reservation set for November 17-December 2; Classifieds; Did You Know That...?; PACT to present Talking with Children About Death ; Student inaction reflects lack of self-interest; On The Cover: Winter--skiing, warm fires, cool drinks, and good friends; Barry Manilow awes crowd of all kinds; Commodores will prove to C-U audience they shouldn\u27t be taken for granted; Dirty Weekend describes Van Halen to a tee; PCFers hear Creation vs. Evolution ; Snyder to appear as Women\u27s Movement leader; NFC Central up for grabs; U of I gymnastics team faces Japan All-Stars; Pi Sigma Iota to sponsor road rally; PC to host Chautauqua short courses; Spikers end season; Fast Freddy Contest; Naturals upset Swags in IM final game; Look out! this week is the toughest; Cobras face Lincoln in rare morning game; Cobras basketball: \u27You won\u27t get bored\u27https://spark.parkland.edu/prospectus_1980/1013/thumbnail.jp

Functional Analysis of the Chemokine Receptor CCR3 on Airway Epithelial Cells

The function of chemokine receptors on structural cells is only partially known. We previously reported the expression of a functional CCR3 receptor on airway epithelial cells (EC). We speculated that CCR3 might drive wound repair and expression of inflammatory genes in epithelium. The human airway EC lines BEAS-2B, 16-HBE, and primary bronchial EC were used to test the effect of in vitro challenge with the CCR3 ligands CCL11/eotaxin, CCL24/eotaxin-2, or CCL26/eotaxin-3 on 1) wound repair, using an established wound model; 2) cell proliferation and chemotaxis, using specific fluorometric assays; and 3) gene expression, using pathway-specific arrays for inflammatory and profibrotic cytokines, chemokines, and chemokine receptor genes. Agonist specificity was tested by cell pretreatment with an AstraZeneca CCR3 antagonist (10(-8) - 10(-6) M). CCL24 challenge significantly accelerated epithelial wound closure, with similar effects exerted by CCL11 and CCL26. This effect was time dependent, submaximal at 1 nM, and comparable in potency to epidermal growth factor. CCL24 induced a concentration-dependent increase in EC proliferation and chemotaxis, with significant effects observed at 10 nM. The AstraZeneca compound selectively inhibited these CCL24-mediated responses. CCL11 induced the up-regulation of several profibrogenic molecules such as fibroblast growth factor 1 and 5 and of several CC and CXC chemokines. Epithelial immunostaining for CCR3 was stronger in bronchial biopsies of asthmatics displaying marked inflammatory changes than in nondiseased samples. Epithelial CCR3 participates in key functions for wound repair, amplifies the expression of profibrogenic and chemokine transcripts, and appears up-regulated in inflamed asthmatic airways

Lessons learned in coupling atmospheric models across scales for onshore and offshore wind energy

The Mesoscale to Microscale Coupling team, part of the U.S. Department of Energy Atmosphere to Electrons (A2e) initiative, has studied various important challenges related to coupling mesoscale models to microscale models for the use case of wind energy development and operation. Several coupling methods and techniques for generating turbulence at the microscale that is subgrid to the mesoscale have been evaluated for a variety of cases. Case studies included flat-terrain, complex-terrain, and offshore environments. Methods were developed to bridge the terra incognita, which scales from about 100 m through the depth of the boundary layer. The team used wind-relevant metrics and archived code, case information, and assessment tools and is making those widely available. Lessons learned and discerned best practices are described in the context of the cases studied for the purpose of enabling further deployment of wind energy.</p

Performance Standards and Employee Effort: Evidence from Teacher Absences

The 2001 No Child Left Behind Act (NCLB) increased accountability pressure in U.S. public schools by threatening to impose sanctions on Title 1 schools that failed to make adequate yearly progress (AYP) in consecutive years. Difference-in-difference estimates of the effect of failing AYP in the first year of NCLB on teacher effort in the subsequent year suggest that, on average, teacher absences in North Carolina fell by about 10 percent, and the probability of being absent 15 or more times fell by about 30 percent. Reductions in teacher absences were driven by within-teacher increases in effort and were larger among more effective teachers

The schizophrenic's social world : [an honors thesis (HONRS 499)]

The following discussion of the social experiences of people afflicted with schizophrenia is based on related psychological research studies. While people with schizophrenia obviously experience a wide range of problems in life, the focus here is limited to social problems. This discussion of the social deficiencies of schizophrenics considers three points: (1) The relationship between schizophrenia and crime, including a discussion of which subgroups of schizophrenics might be more prone to committing crime, (2) less serious social deficits associated with schizophrenia, such as anxiety toward interpersonal interactions, and (3) therapy aimed at alleviating those less serious social deficits.Thesis (B.?.)Honors Colleg