4 research outputs found
Experimental Data
The x, y coordinates for fish in groups of n=10, at temporal resolution of 25 Hz (i.e. the frame rate)
Simulated Data
The x, y coordinates for simulated fish in groups of n=10, derived from the agent-based model
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
Elevated blood pressure is the leading heritable risk factor for cardiovascular disease
worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse
pressure) among UK Biobank participants of European ancestry with independent replication
in other cohorts, leading to discovery and validation of 107 novel loci. We also identify new
independent variants at 11 previously reported blood pressure loci. Combined with results
from a range of in-silico functional analyses and wet bench experiments, our findings highlight
new biological pathways for blood pressure regulation enriched for genes expressed in
vascular tissues and identify potential therapeutic targets for hypertension. Results from
genetic risk score models raise the possibility of a precision medicine approach through early
lifestyle intervention to offset the impact of blood pressure raising variants on future
cardiovascular disease risk
Exome-wide association study of plasma lipids in >300,000 individuals.
We screened variants on an exome-focused genotyping array in >300,000 participants (replication in >280,000 participants) and identified 444 independent variants in 250 loci significantly associated with total cholesterol (TC), high-density-lipoprotein cholesterol (HDL-C), low-density-lipoprotein cholesterol (LDL-C), and/or triglycerides (TG). At two loci (JAK2 and A1CF), experimental analysis in mice showed lipid changes consistent with the human data. We also found that: (i) beta-thalassemia trait carriers displayed lower TC and were protected from coronary artery disease (CAD); (ii) excluding the CETP locus, there was not a predictable relationship between plasma HDL-C and risk for age-related macular degeneration; (iii) only some mechanisms of lowering LDL-C appeared to increase risk for type 2 diabetes (T2D); and (iv) TG-lowering alleles involved in hepatic production of TG-rich lipoproteins (TM6SF2 and PNPLA3) tracked with higher liver fat, higher risk for T2D, and lower risk for CAD, whereas TG-lowering alleles involved in peripheral lipolysis (LPL and ANGPTL4) had no effect on liver fat but decreased risks for both T2D and CAD