30 research outputs found

    Π‘ΠΎΠ²Ρ€Π΅ΠΌΠ΅Π½Π½ΠΎΠ΅ состояниС ΠΏΡ€ΠΎΠ±Π»Π΅ΠΌΡ‹ систСмной красной Π²ΠΎΠ»Ρ‡Π°Π½ΠΊΠΈ Π² ΠšΠ°Π·Π°Ρ…ΡΡ‚Π°Π½Π΅

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    Objective: to analyze the provision of medical, including rheumatology, care in Kazakhstan, to study the incidence of systemic lupus erythematosus (SLE), and to develop a registry of patients with this condition.Material and methods. The investigators analyzed the guidelines for the organization of medical, including rheumatology, care in the republic and the official statistical materials of the Ministry of Health of the Republic of Kazakhstan in the period 2012 to 2017. Articles were searched to select activity indices, organ damages and to assess the quality of life and treatment programs in order to create a registry of patients with SLE.Results and discussion. The paper presents the basic principles of providing medical, including rheumatology, care in the republic. It gives data on the issues of providing SLE patients with medicines in outpatient and inpatient settings. It also analyzes trends in the incidence of SLE in the population of Kazakhstan in 2012 to 2017. There were 4,448 SLE patients, including 3,986 women; a comparative analysis of indicators demonstrated a 62.8% increase in the incidence of SLE from 2012 to 2017. The purpose and objectives of the registry of patients with SLE were substantiated.Conclusion. An analysis of morbidity rates suggests that SLE remains to be significant in the republic. The incidence of SLE has been noted to increase in the period from 2012 to 2017; there is a female preponderance (89.6%). The application of the SLE registry in clinical practice will be able to improve the diagnosis of the disease in the early stage and to prevent possible complications. ЦСль исслСдования – Π°Π½Π°Π»ΠΈΠ· оказания мСдицинской, Π² Ρ‚ΠΎΠΌ числС рСвматологичСской, ΠΏΠΎΠΌΠΎΡ‰ΠΈ Π² ΠšΠ°Π·Π°Ρ…ΡΡ‚Π°Π½Π΅, ΠΈΠ·ΡƒΡ‡Π΅Π½ΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»Π΅ΠΉ заболСваСмости ΠΈ Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠ° рСгистра ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с систСмной красной Π²ΠΎΠ»Ρ‡Π°Π½ΠΊΠΎΠΉ (Π‘ΠšΠ’).ΠœΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π» ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹. ΠŸΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠ»ΡΡ Π°Π½Π°Π»ΠΈΠ· руководящих Π΄ΠΎΠΊΡƒΠΌΠ΅Π½Ρ‚ΠΎΠ² ΠΏΠΎ ΠΎΡ€Π³Π°Π½ΠΈΠ·Π°Ρ†ΠΈΠΈ мСдицинской, Π² Ρ‚ΠΎΠΌ числС рСвматологичСской, ΠΏΠΎΠΌΠΎΡ‰ΠΈ Π² рСспубликС ΠΈ ΠΎΡ„ΠΈΡ†ΠΈΠ°Π»ΡŒΠ½Ρ‹Ρ… статистичСских ΠΌΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»ΠΎΠ² ΠœΠΈΠ½ΠΈΡΡ‚Π΅Ρ€ΡΡ‚Π²Π° здравоохранСния РСспублики ΠšΠ°Π·Π°Ρ…ΡΡ‚Π°Π½ (ΠœΠ— РК) Π·Π° ΠΏΠ΅Ρ€ΠΈΠΎΠ΄ с 2012 ΠΏΠΎ 2017 Π³. Π’Ρ‹ΠΏΠΎΠ»Π½Π΅Π½ поиск статСй для ΠΎΡ‚Π±ΠΎΡ€Π° индСксов активности, поврСТдСния ΠΎΡ€Π³Π°Π½ΠΎΠ², ΠΎΡ†Π΅Π½ΠΊΠΈ качСства ΠΆΠΈΠ·Π½ΠΈ ΠΈ ΠΏΡ€ΠΎΠ³Ρ€Π°ΠΌΠΌΡ‹ Ρ‚Π΅Ρ€Π°ΠΏΠΈΠΈ с Ρ†Π΅Π»ΡŒΡŽ создания рСгистра ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с Π‘ΠšΠ’.Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ ΠΈ обсуТдСниС. ΠŸΡ€Π΅Π΄ΡΡ‚Π°Π²Π»Π΅Π½Ρ‹ основныС ΠΏΡ€ΠΈΠ½Ρ†ΠΈΠΏΡ‹ оказания мСдицинской, Π² Ρ‚ΠΎΠΌ числС рСвматологичСской, ΠΏΠΎΠΌΠΎΡ‰ΠΈ Π² рСспубликС. ΠŸΡ€ΠΈΠ²Π΅Π΄Π΅Π½Ρ‹ Π΄Π°Π½Π½Ρ‹Π΅ ΠΏΠΎ вопросам обСспСчСния ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с Π‘ΠšΠ’ лСкарствСнными срСдствами Π½Π° Π°ΠΌΠ±ΡƒΠ»Π°Ρ‚ΠΎΡ€Π½ΠΎΠΌ ΠΈ стационарном этапС. ΠŸΡ€ΠΎΠ²Π΅Π΄Π΅Π½ Π°Π½Π°Π»ΠΈΠ· Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΈ заболСваСмости Π‘ΠšΠ’ насСлСния ΠšΠ°Π·Π°Ρ…ΡΡ‚Π°Π½Π° Π·Π° ΠΏΠ΅Ρ€ΠΈΠΎΠ΄ с 2012 ΠΏΠΎ 2017 Π³. Число ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с Π‘ΠšΠ’ составило 4448 Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊ (ΠΈΠ· Π½ΠΈΡ… ΠΆΠ΅Π½Ρ‰ΠΈΠ½ – 3986), ΡΡ€Π°Π²Π½ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹ΠΉ Π°Π½Π°Π»ΠΈΠ· ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»Π΅ΠΉ Π·Π° ΠΏΠ΅Ρ€ΠΈΠΎΠ΄ с 2012 ΠΏΠΎ 2017 Π³. продСмонстрировал ΡƒΠ²Π΅Π»ΠΈΡ‡Π΅Π½ΠΈΠ΅ заболСваСмости Π½Π° 62,8%. ΠžΠ±ΠΎΡΠ½ΠΎΠ²Ρ‹Π²Π°ΡŽΡ‚ΡΡ Ρ†Π΅Π»ΡŒ ΠΈ Π·Π°Π΄Π°Ρ‡ΠΈ рСгистра ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с Π‘ΠšΠ’.Π—Π°ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΠ΅. Анализ ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»Π΅ΠΉ заболСваСмости ΡΠ²ΠΈΠ΄Π΅Ρ‚Π΅Π»ΡŒΡΡ‚Π²ΡƒΡŽΡ‚ ΠΎ сохранСнии значимости Π‘ΠšΠ’ Π² рСспубликС. ΠžΡ‚ΠΌΠ΅Ρ‡Π΅Π½Ρ‹ прирост заболСваСмости Π‘ΠšΠ’ Π² ΠΏΠ΅Ρ€ΠΈΠΎΠ΄ с 2012 ΠΏΠΎ 2017 Π³., ΠΏΡ€Π΅ΠΎΠ±Π»Π°Π΄Π°Π½ΠΈΠ΅ Π»ΠΈΡ† ТСнского ΠΏΠΎΠ»Π° (89,6%). ИспользованиС рСгистра ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с Π‘ΠšΠ’ Π² клиничСской ΠΏΡ€Π°ΠΊΡ‚ΠΈΠΊΠ΅ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΡ‚ ΡƒΠ»ΡƒΡ‡ΡˆΠΈΡ‚ΡŒ диагностику заболСвания Π½Π° Ρ€Π°Π½Π½Π΅ΠΌ этапС ΠΈ ΠΏΡ€Π΅Π΄ΠΎΡ‚Π²Ρ€Π°Ρ‚ΠΈΡ‚ΡŒ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½Ρ‹Π΅ ослоТнСния.

    The current status of the problem with systemic lupus erythematosus in Kazakhstan

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    Objective: to analyze the provision of medical, including rheumatology, care in Kazakhstan, to study the incidence of systemic lupus erythematosus (SLE), and to develop a registry of patients with this condition.Material and methods. The investigators analyzed the guidelines for the organization of medical, including rheumatology, care in the republic and the official statistical materials of the Ministry of Health of the Republic of Kazakhstan in the period 2012 to 2017. Articles were searched to select activity indices, organ damages and to assess the quality of life and treatment programs in order to create a registry of patients with SLE.Results and discussion. The paper presents the basic principles of providing medical, including rheumatology, care in the republic. It gives data on the issues of providing SLE patients with medicines in outpatient and inpatient settings. It also analyzes trends in the incidence of SLE in the population of Kazakhstan in 2012 to 2017. There were 4,448 SLE patients, including 3,986 women; a comparative analysis of indicators demonstrated a 62.8% increase in the incidence of SLE from 2012 to 2017. The purpose and objectives of the registry of patients with SLE were substantiated.Conclusion. An analysis of morbidity rates suggests that SLE remains to be significant in the republic. The incidence of SLE has been noted to increase in the period from 2012 to 2017; there is a female preponderance (89.6%). The application of the SLE registry in clinical practice will be able to improve the diagnosis of the disease in the early stage and to prevent possible complications

    Impact of bicarbonate, ammonium chloride, and acetazolamide on hepatic and renal SLC26A4 expression

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    SLC26A4 encodes pendrin, a transporter exchanging anions such as chloride, bicarbonate, and iodide. Loss of function mutations of SLC26A4 cause Pendred syndrome characterized by hearing loss and enlarged vestibular aqueducts as well as variable hypothyroidism and goiter. In the kidney, pendrin is expressed in the distal nephron and accomplishes HCO(3)(-) secretion and Cl(-) reabsorption. Renal pendrin expression is regulated by acid-base balance. The liver contributes to acid-base regulation by producing or consuming glutamine, which is utilized by the kidney for generation and excretion of NH(4)(+), paralleled by HCO(3)(-) formation. Little is known about the regulation of pendrin in liver. The present study thus examined the expression of Slc26a4 in liver and kidney of mice drinking tap water without or with NaHCO(3) (150 mM), NH(4)Cl (280 mM) or acetazolamide (3.6 mM) for seven days. As compared to Gapdh transcript levels, Slc26a4 transcript levels were moderately lower in liver than in renal tissue. Slc26a4 transcript levels were not significantly affected by NaHCO(3) in liver, but significantly increased by NaHCO(3) in kidney. Pendrin protein expression was significantly enhanced in kidney and reduced in liver by NaHCO(3). Slc26a4 transcript levels were significantly increased by NH(4)Cl and acetazolamide in liver, and significantly decreased by NH(4)Cl and by acetazolamide in kidney. NH(4)Cl and acetazolamide reduced pendrin protein expression significantly in kidney, but did not significantly modify pendrin protein expression in liver. The observations point to expression of pendrin in the liver and to opposite effects of acidosis on pendrin transcription in liver and kidney

    The anion exchanger pendrin (SLC26A4) and renal acid-base homeostasis

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    The anion exchanger pendrin (Pds, SLC26A4) transports various anions including bicarbonate, chloride and iodide. In the kidney, pendrin is exclusively expressed on the luminal pole of bicarbonate-secretory type B intercalated cells. Genetic ablation of pendrin in mice abolishes luminal chloride-bicarbonate exchanger activity from type B intercalated cells suggesting that pendrin is the apical bicarbonate extruding pathway. The renal expression of pendrin is developmentally adapted and pendrin positive cells originate from both the uretric bud and mesenchyme. In adult kidney, pendrin expression and activity is regulated by systemic acid-base status, dietary electrolyte intake (mostly chloride), and hormones such as angiotensin II and aldosterone which can affect subcellular localization, the relative number of pendrin expressing cells, and the overall abundance consistent with a role of pendrin in maintaining normal acid-base homeostasis. This review summarizes recent findings on the role and regulation of pendrin in the context of the kidneys role in acid-base homeostasis in health and disease

    DOCA sensitive pendrin expression in kidney, heart, lung and thyroid tissues

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    BACKGROUND/AIMS: Pendrin (SLC26A4), a transporter accomplishing anion exchange, is expressed in inner ear, thyroid gland, kidneys, lung, liver and heart. Loss or reduction of function mutations of SLC26A4 underlie Pendred syndrome, a disorder invariably leading to hearing loss with enlarged vestibular aqueducts and in some patients to hypothyroidism and goiter. Renal pendrin expression is up-regulated by mineralocorticoids such as aldosterone or deoxycorticosterone (DOCA). Little is known about the impact of mineralocorticoids on pendrin expression in extrarenal tissues. METHODS: The present study utilized RT-qPCR and Western blotting to quantify the transcript levels and protein abundance of Slc26a4 in murine kidney, thyroid, heart and lung prior to and following subcutaneous administration of 100 mg/kg DOCA. RESULTS: Slc26a4 transcript levels as compared to Gapdh transcript levels were significantly increased by DOCA treatment in kidney, heart, lung and thyroid. Accordingly pendrin protein expression was again significantly increased by DOCA treatment in kidney, heart, lung and thyroid. CONCLUSION: The observations reveal mineralocorticoid sensitivity of pendrin expression in kidney, heart, thyroid and lun
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