A Bridging Mechanism in the Homogenization of Brittle Composites with Soft Inclusions

We provide a homogenisation result for the energy-functional associated with a purely brittle composite whose microstructure is characterised by soft periodic inclusions embedded in a stiffer matrix. We show that the two constituents as above can be suitably arranged on a microscopic scale \u3b5 to obtain, in the limit as \u3b5 tends to zero, a homogeneous macroscopic energy-functional explicitly depending on the opening of the crack

A variational model for infin ite perimeter segmentations based on lipschitz level set functions: Denoising while keeping finely oscillatory boundaries

We propose a new model for segmenting piecewise constant images with irregular object boundaries: a variant of the Chan-Vese model [T. F. Chan and L. A. Vese, IEEE Trans. Image Process., 10 (2000), pp. 266-277], where the length penalization of the boundaries is replaced by the area of their neighborhood of thickness e. Our aim is to keep fine details and irregularities of the boundaries while denoising additive Gaussian noise. For the numerical computation we revisit the classical BV level set formulation [S. Osher and J. A. Sethian, J. Comput. Phys., 79 (1988), pp. 12-49] considering suitable Lipschitz level set functions instead of BV ones

Presence and fate of microplastics in the water sources: focus on the role of wastewater and drinking water treatment plants

Microplastics are nowadays considered as ubiquitous pollutants since have been found widespread in all environmental compartments, particularly in the water sources. In the urban water cycle, the drinking water treatment plants and the wastewater treatment plants are the first and last barriers to microplastics pollution, respectively. The present work aims at presenting the information available on microplastic presence in the urban water cycle, reporting and linking what is known at the different stages. Focus is on the water sources and on the role of the water treatment plants as source and control of microplastics pollution. Aspects evaluated are microplastics abundance, characterization in terms of morphology, size and polymer composition, spatial and temporal variations, factors influencing their distribution and abundance, effects of treatments on their removal. Up to now there is no common framework for microplastics collection, sample pre-treatment, identification, quantification and classification. Data comparison is hindered due to the various analytical protocols implemented; hence the conclusions driven are mostly indicative or of very local significance. The available information is not evenly distributed among the urban water cycle components. For the establishment of proper microplastics pollution control strategies, the relative role of wastewater and drinking water treatment plants needs to be better deepened in terms of both quantity and quality effects. All these aspects are afforded in the present review which is based on the more recent data published by the specialized literature

Equilibria determination of elastic articulated duoskelion beams in 2D via a Riks-type algorithm

The overall behavior of an articulated beam structure constituted by elements arranged according to a specific chirality is studied. The structure as a whole, due to its slenderness and geometry, is called duoskelion beam. The name duoskelion is a neologism which is inspired by the Greek word δύοσκέλιον (two-legged). A discrete model for shearable beams, formulated recently, is exploited to investigate its mechanics. A purposely designed numerical scheme, adapting the Riks rationale, is used to calculate large displacement and deformation equilibria of duoskelion beams. Aimed at computing the current step correction, the Riks arc-length method is modified and made more efficient by applying a specific orthogonality condition, defined via the stiffness matrix, to an adapted extrapolation step. The robustness of the resulting scheme and its capability to follow equilibrium branches allows, in principle, for the exploration of the whole set of local energy minima in the introduced space of configurations, by using suitably modulated perturbative external loads. The developed numerical tool can be used to understand the mechanics of duoskelion beams. It is proved that there exists a stable principal equilibrium branch in which only compression is observed for any compression load. Additional stable equilibrium branches are found in compression such that the clamped–clamped compressed beam assumes a characteristic S shape which, upon reaching a critical load, is significantly amplified. A mechanically relevant stable equilibrium is also found in extension, being observed the S-shaped configuration experimentally found in Misra et al. (2020)

Mitochondrial translocation of APE1 relies on the MIA pathway

APE1 is a multifunctional protein with a fundamental role in repairing nuclear and mitochondrial DNA lesions caused by oxidative and alkylating agents. Unfortunately, comprehensions of the mechanisms regulating APE1 intracellular trafficking are still fragmentary and contrasting. Recent data demonstrate that APE1 interacts with the mitochondrial import and assembly protein Mia40 suggesting the involvement of a redox-assisted mechanism, dependent on the disulfide transfer system, to be responsible of APE1 trafficking into the mitochondria. The MIA pathway is an import machinery that uses a redox system for cysteine enriched proteins to drive them in this compartment. It is composed by two main proteins: Mia40 is the oxidoreductase that catalyzes the formation of the disulfide bonds in the substrate, while ALR reoxidizes Mia40 after the import. In this study, we demonstrated that: (i) APE1 and Mia40 interact through disulfide bond formation; and (ii) Mia40 expression levels directly affect APE1's mitochondrial translocation and, consequently, play a role in the maintenance of mitochondrial DNA integrity. In summary, our data strongly support the hypothesis of a redox-assisted mechanism, dependent on Mia40, in controlling APE1 translocation into the mitochondrial inner membrane space and thus highlight the role of this protein transport pathway in the maintenance of mitochondrial DNA stability and cell survival

Triple peptide vaccination as consolidation treatment in women affected by ovarian and breast cancer: clinical and immunological data of a phase I/II clinical trial

Vaccination with priming and expansion of tumour reacting T cells is an important therapeutic option to be used in combination with novel checkpoint inhibitors to increase the specificity of the T cell infiltrate and the efficacy of the treatment. In this phase I/II study, 14 high-risk disease-free ovarian (OC) and breast cancer (BC) patients after completion of standard therapies were vaccinated with MUC1, ErbB2 and carcinoembryonic antigen (CEA) HLA-A2+-restricted peptides and Montanide. Patients were subjected to 6 doses of vaccine every two weeks and a recall dose after 3 months. ECOG grade 2 toxicity was observed at the injection site. Eight out of 14 patients showed specific CD8+ T cells to at least one antigen. None of 4 patients vaccinated for compassionate use showed a CD8 activation. An OC patient who suffered from a lymph nodal recurrence, showed specific anti-ErbB2 CD8+ T cells in the bulky aortic lymph nodes suggesting homingof the activated T cells. Results confirm that peptide vaccination strategy is feasible, safe and well tolerated. In particular OC patients appear to show a higher response rate compared to BC patients. Vaccination generates a long-lasting immune response, which is strongly enhanced by recall administrations. The clinical outcome of patients enrolled in the trial appears favourable, having registered no deceased patients with a minimum follow-up of 8 years. These promising data, in line with the results of similar studies, the high compliance of patients observed and the favourable toxicity profile, support future trials of peptide vaccination in clinically disease-free patients who have completed standard treatments

Capecitabine and Temozolomide (CAPTEM) in advanced neuroendocrine neoplasms (NENs): a systematic review and pooled analysis

Background Retrospective studies and single center experiences suggest a role of capecitabine combined with temozolomide (CAPTEM) in neuroendocrine tumors (NENs). Methods We performed a systematic review to assess the efficacy and safety of CAPTEM in patients affected with NENs, with the aim to better clarify the role of this regimen in the therapeutic algorithm of NENs. Results A total of 42 articles and 1818 patients were included in our review. The overall disease control rate was 77% (range 43.5%-100%). The median progression free survival ranged from 4 to 38.5 months, while the median overall survival ranged from 8 to 103 months. Safety analysis showed an occurrence of G3-G4 toxicities in 16.4% of the entire population. The most common toxicities were hematological (27.2%), gastrointestinal (8.3%,) and cutaneous (3.2%). Conclusion This systematic review demonstrated that CAPTEM was an effective and relatively safe treatment for patients with advanced well-moderate differentiated NENs of gastroenteropancreatic, lung and unknown origin

THE "OLIVA ASCOLANA DEL PICENO DOP": PRODUCTION ASPECTS AND SELF-CONTROL PROGRAMS IN FACTORIES OF MARCHE REGION

The "Oliva Ascolana del Piceno" is a traditional product of the central part of Italy, which obtained the official designation of Denomination of Protected Origin (DOP) in 2006. This study analyzes the production aspects and the self-control programs in different tipologies of industries in Marche Region. The artisanal production is still used, but lately is growing up the industrial one. The industrial product shows an improvement of the healthy standards, but is not always able to ensure the preservation of the full taste and flavour. . The scrupulous respect of GMP and CCP in the handmade product can ensure, on the other hand, hight healthy standards and, at the same time, a better preservation of the organoleptic features

Simulating the infrared sky with a Spritz

Current hydrodynamical and semi-empirical simulations of galaxy formation and evolution have difficulties in reproducing the number densities of IR-detected galaxies. Therefore, a versatile, phenomenological new simulation tool is necessary to reproduce current and predict future observations at IR wavelengths. In this work we generate simulated catalogues starting from the Herschel infrared luminosity functions of different galaxy populations, in order to consider in a consistent way different populations of galaxies and active galactic nuclei. We associated a spectral energy distribution and physical properties, such as stellar mass, star-formation-rate and AGN contribution, to each simulated galaxy using a broad set of empirical relations. We compare the resulting simulated galaxies, extracted up to z$=$10, with a broad set of observational relations. The Spectro-Photometric Realisations of Infrared-selected Targets at all-z (SPRITZ) simulation will allow us to obtain in a fully consistent way simulated observations for a broad set of current and future facilities with photometric capabilities as well as low-resolution IR spectroscopy, like the James Webb Space Telescope (JWST) or the Origin Space Telescope (OST). The derived simulated catalogue contains galaxies and active galactic nuclei that by construction reproduce the observed IR galaxy number density, but it is also in agreement with the observed number counts from UV to far-IR wavelengths, the observed stellar mass function, the star-formation-rate vs. stellar mass plane and the luminosity function from the radio to the X-ray. The proposed simulation is therefore ideal to make predictions for current and future facilities, in particular, but not limited to, those operating at IR wavelengths. The SPRITZ simulation will be publicly available.Comment: Accepted for publication in A&A, 32 pages, 30 figure

Simulating the infrared sky with a S PRITZ

Aims. Current hydrodynamical and semi-empirical simulations of galaxy formation and evolution have difficulties in reproducing the number densities of infrared-detected galaxies. Therefore, a phenomenological simulation tool that is new and versatile is necessary to reproduce current and predict future observations at infrared (IR) wavelengths. Methods. In this work we generate simulated catalogues starting from the Herschel IR luminosity functions of different galaxy populations to consider different populations of galaxies and active galactic nuclei (AGN) in a consistent way. We associated a spectral energy distribution and physical properties, such as stellar mass, star formation rate, and AGN contribution, with each simulated galaxy using a broad set of empirical relations. We compared the resulting simulated galaxies, extracted up to z = 10, with a broad set of observational relations. Results. Spectro-Photometric Realisations of IR-Selected Targets at all-z (SPRITZ) simulations allow us to obtain, in a fully consistent way, simulated observations for a broad set of current and future facilities with photometric capabilities as well as low-resolution IR spectroscopy, such as the James Webb Space Telescope (JWST) or the Origin Space Telescope (OST). The derived simulated catalogue contains galaxies and AGN that by construction reproduce the observed IR galaxy number density, but this catalogue also agrees with the observed number counts from UV to far-IR wavelengths, the observed stellar mass function, the star formation rate versus stellar mass plane, and the luminosity function from the radio to X-ray wavelengths. The proposed simulation is therefore ideal to make predictions for current and future facilities, in particular, but not limited to, those operating at IR wavelengths